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Matti Narkia

n-3 Fatty acids and cardiovascular disease -- Breslow 83 (6): S1477 -- American Journal... - 0 views

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    n-3 fatty acids and cardiovascular disease.
    Breslow JL.
    Am J Clin Nutr. 2006 Jun;83(6 Suppl):1477S-1482S. Review.
    PMID: 16841857

    The results of prospective cohort studies indicate that consuming fish or fish oil containing the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is associated with decreased cardiovascular death, whereas consumption of the vegetable oil-derived n-3 fatty acid {alpha}-linolenic acid is not as effective. Randomized control trials (RCTs) in the context of secondary prevention also indicate that the consumption of EPA plus DHA is protective at doses <1 g />3 g/d, EPA plus DHA can improve cardiovascular disease risk factors, including decreasing plasma triacylglycerols, blood pressure, platelet aggregation, and inflammation, while improving vascular reactivity. Mainly on the basis of the results of RCTs, the American Heart Association recommends that everyone eat oily fish twice per week and that those with coronary heart disease eat 1 g/d of EPA plus DHA from oily fish or supplements. Directions for future research include 1) RCTs to confirm the initial trials showing that EPA plus DHA decreases cardiovascular death and additional studies to determine whether this effect is due to EPA, DHA, or the combination; the dosage of the effective components; and whether the mechanism of action in humans is prevention of fatal arrhythmias. 2) Clinical studies to determine whether the reduction in cardiovascular disease risk factors is due to EPA, DHA, or the combination and the dosage of the effective components. 3) Clinical studies to determine whether vegetable oil-derived {alpha}-linolenic acid added to a diet enriched in n-6 fatty acids can effectively substitute for fish oil-derived EPA plus DHA.
Matti Narkia

Nutritional intervention with omega-3 Fatty acids in a case of malignant fibrous histio... - 0 views

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    Nutritional intervention with omega-3 Fatty acids in a case of\nmalignant fibrous histiocytoma of the lungs.
    Pardini RS, Wilson D, Schiff S, Bajo SA, Pierce R.
    Nutr Cancer. 2005;52(2):121-9.
    PMID: 16201843
Matti Narkia

Comparison of the effects of linseed oil and different doses of fish oil on mononuclear... - 0 views

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    Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects.
    Wallace FA, Miles EA, Calder PC.
    Br J Nutr. 2003 May;89(5):679-89.
    PMID: 12720588

Matti Narkia

Nutritional intervention with omega-3 Fatty acids in a case of malignant fibrous histio... - 0 views

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    Nutritional intervention with omega-3 Fatty acids in a case of
    malignant fibrous histiocytoma of the lungs.
    Pardini RS, Wilson D, Schiff S, Bajo SA, Pierce R.
    Nutr Cancer. 2005;52(2):121-9.
    PMID: 16201843
Matti Narkia

Omega-3 fatty acid supplementation in patients with recurrent self-harm: Single-centre ... - 0 views

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    Hallahan B, Hibbeln JR, Davis JM, Garland MR.
    Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trial.
    Br J Psychiatry. 2007 Feb;190:118-22.
    PMID: 17267927 [PubMed - indexed for M
Matti Narkia

n-3 fatty acid dietary recommendations and food sources to achieve essentiality and car... - 0 views

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    n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits.
    Gebauer SK, Psota TL, Harris WS, Kris-Etherton PM.
    Am J Clin Nutr. 2006 Jun;83(6 Suppl):1526S-1535S. Review.
    PMID: 16841863

    Dietary recommendations have been made for n-3 fatty acids, including {alpha}-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) to achieve nutrient adequacy and to prevent and treat cardiovascular disease. These recommendations are based on a large body of evidence from epidemiologic and controlled clinical studies. The n-3 fatty acid recommendation to achieve nutritional adequacy, defined as the amount necessary to prevent deficiency symptoms, is 0.6-1.2% of energy for ALA; up to 10% of this can be provided by EPA or DHA. To achieve recommended ALA intakes, food sources including flaxseed and flaxseed oil, walnuts and walnut oil, and canola oil are recommended. The evidence base supports a dietary recommendation of {approx}500 mg/d of EPA and DHA for cardiovascular disease risk reduction. For treatment of existing cardiovascular disease, 1 g/d is recommended. These recommendations have been embraced by many health agencies worldwide. A dietary strategy for achieving the 500-mg/d recommendation is to consume 2 fish meals per week (preferably fatty fish). Foods enriched with EPA and DHA or fish oil supplements are a suitable alternate to achieve recommended intakes and may be necessary to achieve intakes of 1 g/d.
Matti Narkia

Effect of Molecular Forms on Distribution of Docosahexaenoic Acid into Organs in Mice - 0 views

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    Yukihisa TANAKA, Takashi OHKUBO, Nobuo FUKUDA and Hidehiko HIBINO, "Effect of Molecular Forms on Distribution of Docosahexaenoic Acid into Organs in Mice", J. Oleo Sci., Vol. 52, 89-97 (2003) .
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