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Matti Narkia

Dietary composition modulates brain mass and amyloid beta levels in a mouse model of ag... - 0 views

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    Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology.
    Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, Hyslop PS, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME, Gandy S.
    Mol Neurodegener. 2009 Oct 21;4:40.
    PMID: 19845940
    doi:10.1186/1750-1326-4-40

    INTERPRETATION: Dissociation of Abeta changes from brain mass changes raises the possibility that diet plays a role not only in modulating amyloidosis but also in modulating neuronal vulnerability. However, in the absence of a study of the effects of a high protein/low carbohydrate diet on nontransgenic mice, one cannot be certain how much, if any, of the loss of brain mass exhibited by high protein/low carbohydrate diet-fed TgCRND8 mice was due to an interaction between cerebral amyloidosis and diet. Given the recent evidence that certain factors favor the maintenance of cognitive function in the face of substantial structural neuropathology, we propose that there might also exist factors that sensitize brain neurons to some forms of neurotoxicity, including, perhaps, amyloid neurotoxicity. Identification of these factors could help reconcile the poor clinicopathological correlation between cognitive status and structural neuropathology, including amyloid pathology.
Matti Narkia

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease... - 0 views

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    A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease.
    Van der Auwera I, Wera S, Van Leuven F, Henderson ST.
    Nutr Metab (Lond). 2005 Oct 17;2:28.
    PMID: 16229744
    doi:10.1186/1743-7075-2-28

    CONCLUSION: Previous studies have suggested that diets rich in cholesterol and saturated fats increased the deposition of Abeta and the risk of developing AD. Here we demonstrate that a diet rich in saturated fats and low in carbohydrates can actually reduce levels of Abeta. Therefore, dietary strategies aimed at reducing Abeta levels should take into account interactions of dietary components and the metabolic outcomes, in particular, levels of carbohydrates, total calories, and presence of ketone bodies should be considered.
Matti Narkia

Weekly curry 'may fight dementia' - BBC NEWS | Health - 0 views

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    Eating a curry once or twice a week could help prevent the onset of Alzheimer's disease and dementia, a US researcher suggests.
    The key ingredient is curcumin, a component of the spice turmeric.
Matti Narkia

Sham vs. Wham: The Health Insider: Fermented Asian Food Shown to Have Possible Protecti... - 0 views

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    People in Asia have been eating fermented foods for more than 1,000 years. One vegan fermented food, renowned in Asia for its ability to protect against heart attacks, was recently shown to have a powerful ability in lab experiments to prevent formation of the clumps of tangled protein involved in Alzheimer's disease. if this works as well in the human brain as scientists expect, it will be a great addition to the tables of anyone who is concerned about this terrible disease
Matti Narkia

Amyloid-degrading ability of nattokinase from Bacillus subtilis natto. - J Agric Food C... - 0 views

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    Amyloid-degrading ability of nattokinase from Bacillus subtilis natto.
    Hsu RL, Lee KT, Wang JH, Lee LY, Chen RP.
    J Agric Food Chem. 2009 Jan 28;57(2):503-8.
    PMID: 19117402
    DOI: 10.1021/jf803072r\n
Matti Narkia

ScienceDaily: Metals Linked To Alzheimer's And Other Neurodegenerative Diseases - 0 views

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    A multi-institutional team of researchers led by Emory University has defined for the first time how metal ions bind to amyloid fibrils in the brain in a way that appears toxic to neurons. Amyloid fibrils are linked to the development of neurodegenerative
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