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Matti Narkia

The Heart Scan Blog: This is your brain on wheat - 0 views

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    "Here's just a smattering of the studies performed over the past 30 years on the psychological effects of wheat consumption.

    Oddly, this never makes the popular press. But wheat underlies schizophrenia, bipolar illness, behavioral outbursts in autism, Huntington's disease, and attention deficit hyperactivity disorder (ADHD).

    The relationship is especially compelling with schizophrenia:

    Opioid peptides derived from food proteins: The exorphins.
    Zioudrou C et al 1979
    "Wheat gluten has been implicated by Dohan and his colleagues in the etiology of schizophrenia and supporting evidence has been provided by others. Our experiments provide a plausible biochemical mechanism for such a role, in the demonstration of the conversion of gluten into peptides with potential central nerovus system actions." "
Matti Narkia

The Heart Scan Blog: Heart Scan Blog Redux: Cheers to flavonoids - 0 views

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    "Because in Track Your Plaque we've been thinking a lot about anthocyanins, here's a rerun of a previous Heart Scan Blog post about red wine. (Anthocyanins are among the interesting flavonoids in red wine, along with resveratrol and quercetin.) "
Matti Narkia

The Heart Scan Blog: Small LDL: Perfect index of carbohydrate intake - 0 views

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    "Measuring the number of small LDL particles is the best index of carbohydrate intake I know of, better than even blood sugar and triglycerides.

    In other words, increase carbohydrate intake and small LDL particles increase. Decrease carbohydrates and small LDL particles decrease.

    Why?

    Carbohydrates increase small LDL via a multistep process:

    First step: Increased fatty acid and apoprotein B production in the liver, which leads to increased VLDL production. (Apoprotein B is the principal protein of VLDL and LDL)

    Second step: Greater VLDL availability causes triglyceride-rich VLDL to interact with other particles, namely LDL and HDL, enriching them in triglycerides (via the action of cholesteryl-ester transfer protein, or CETP). Much VLDL is converted to LDL.

    Third step: Triglyceride-rich LDL is "remodeled" by enzymes like hepatic lipase, which create small LDL"
Matti Narkia

The JELIS Trial - The Heart Scan Blog: - 0 views

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    "The Japan eicosapentaenoic acid (EPA) Lipid Intervention Study (JELIS) is a clinical trial that all Track Your Plaquers should know about.

    This enormous trial followed a simple design:

    Japanese men, between 40-75 years, and Japanese postmenopausal women aged <75 years 250 total with mg cholesterol />
Matti Narkia

Vitamin D must be an oil-based capsule, a gel-cap, not a tablet. -The Heart Scan Blog - 0 views

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    "Lisa is one of early success stories: a heart scan score of 447 in her early 40's, modest reduction of CT heart scan score three years ago.

    However, Lisa had a difficult time locating oil-based vitamin D. There has, in fact, been a national run on vitamin D and I'm told that even manufacturers are scrambling to keep up with the booming demand. So, she bought tablets instead and was taking 3000 units per day.

    She came in for a routine check. Lisa's 25-OH-vitamin D3: 17 ng/ml, signifying severe deficiency, the same as if she were taking nothing at all. (Recall that we aim for 50 ng/ml.)

    In other words, vitamin D tablets do not work. It is shameful. I see numerous women taking calcium tablets with D--the vitamin D does not work. I've actually seen blood levels of zero on these preparations. "
Matti Narkia

The Heart Scan Blog: Beating the Heart Association diet is child's play - 0 views

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    In response to the Heart Scan Blog post, Post-Traumatic Grain Disorder, Anne commented:

    While on the American Heart Association diet my lipids peaked in 2003. I even tried the Ornish diet for a short time, but found it impossible.

    Total Cholesterol: 201
    Triglycerides: 263
    HDL: 62
    LDL: 86

    After I stopped eating gluten (I am very sensitive), my lipid panel improved slightly. This past year I started eating to keep my blood sugar under control by eliminating sugars and other grains. Now this is my most recent lab:

    Total Cholesterol: 162
    Triglycerides: 80
    HDL: 71
    LDL: 75
Matti Narkia

The Heart Scan Blog: Vitamin D and HDL - 0 views

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    Add vitamin D to achieve our target serum level . . . HDL jumps to 50, 60, 70, even 90 mg/dl.

    The first few times this occurred, I thought it was an error or fluke. But now that I've witnessed this effect many dozens of time, I am convinced that it is real. Just today, I saw a 40-year old man whose starting HDL was 25 mg/dl increase to 87 mg/dl.

    Responses like this are supposed to be impossible. Before vitamin D, I had never witnessed increases of this magnitude.
Matti Narkia

The Heart Scan Blog: Vitamin D and inflammation - 0 views

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    A German group has now shown that the important inflammatory marker, tumor necrosis factor (TNF), is also reduced by vitamin D supplementation. Many studies have implicated increased TNF levels in promoting cancer.

    In this study, a modest vitamin D dose of 3320 units (83 micrograms) was given vs. placebo. The 25-hydroxy D level reached in the treated group was 34.2 ng/ml (85.5 nmol/L), which resulted in a 26.5% reduction in TNF compared with 18.7% reduction (?) in the placebo group.
Matti Narkia

The Heart Scan Blog: The Marshall Protocol and other fairy tales - 0 views

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    True to form, Dr. John Cannell has published yet another wonderfully insightful Vitamin D Newsletter.

    One item caught my eye, a response to a question about the Marshall Protocol. I, like Dr. Cannell, was inundated with questions about this so-called protocol, which amounts to little more than the unfounded speculations of a non-physician, actually someone not even involved in health care.

    In all honesty, I blew the whole issue off after I read Dr. Marshall's rants. They smack of pure quackery, though from somebody who clearly has a command of scientific lingo. To Dr. Cannell's credit, he took the time and effort to construct a rational response in the latest issue of the newsletter. I reproduce his response here:
Matti Narkia

The Heart Scan Blog: The case against vitamin D2 - 0 views

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    Why would vitamin D be prescribed when vitamin D3 is available over-the-counter?

    Let's review the known differences between vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol):

    --D3 is the human form; D2 is the non-human form found in plants.

    --Dose for dose, D3 is more effective at raising blood levels of 25-hydroxy vitamin D than D2. It requires roughly twice to 250% of the dose of D2 to match that of D3 (Trang H et al 1998).

    --D2 blood levels don't yield long-term sustained levels of 25-hydroxy vitamin D as does D3. When examined as a 28-day area under the curve (AUC--a superior measure of biologic exposure), D3 yields better than a 300% increased potency compared to D2. This means that it requires around 50,000 units D2 to match the effects of 15,000 units D3 (Armas LA et al 2004).

    --D2 has lower binding affinity for vitamin D-binding protein, compared to D3

    --Mitochondrial vitamin D 25-hydroxylase converts D3 to the 25-hydroxylated form five times more rapidly than D2.

    --As we age, the ability to metabolize D2 is dramatically reduced, while D3 is not subject to this phenomenon
Matti Narkia

The Heart Scan Blog: vitamin D - 0 views

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    Vitamin D related articles in "The Heart Scan Blog" by Dr. William Davis
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