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Matti Narkia

Why governments are selling Vitamin D short - FT.com / Reportage - - 0 views

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    "So why is Dr Vieth so frustrated? You might think he'd have cause for celebration. But for him and other vitamin D researchers around the world, the good news comes with a bitter aftertaste. They believe they can prove vitamin D could help millions live longer and be healthier and yet they have not been able to convince their own governments.

    In the US and Canada, official vitamin D policy is set by the Institute of Medicine. And in the opinion of Vieth, the current recommendations - 200 International Units per day for people under 50, 400 for people aged 51-70, and 600 for those 71 and older - are outrageously low. Bruce Hollis, professor of paediatrics at the Medical University of South Carolina, calls 400 IU a day "a joke". That's because the best research suggests that to achieve the higher vitamin D blood levels associated with disease prevention, most adults in the US would need to take 1,000-2,000 IU a day: five to 10 times more than the current official recommendation for adult

    In 1999, Reinhold Vieth (pictured right) published a review of vitamin D research in response to the IOM conclusions. In it, he argued that there was no evidence that amounts lower than 20,000 IU a day could be toxic. "Throughout my preparation of this review, I was amazed at the lack of evidence supporting statements about the toxicity of moderate doses of vitamin D," Vieth wrote.

    Studies have since shown 10,000 IU a day of vitamin D to be safe. While any substance will become toxic in excess, vitamin D researchers today accept that the current vitamin D recommendations could be more than quadrupled with no fear of toxicity.!
Matti Narkia

Safety of vitamin D3 in adults with multiple sclerosis -- Kimball et al. 86 (3): 645 --... - 0 views

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    Safety of vitamin D3 in adults with multiple sclerosis.
    Kimball SM, Ursell MR, O'Connor P, Vieth R.
    Am J Clin Nutr. 2007 Sep;86(3):645-51.
    PMID: 17823429

    Conclusions: Patients' serum 25(OH)D concentrations reached twice the top of the physiologic range without eliciting hypercalcemia or hypercalciuria. The data support the feasibility of pharmacologic doses of vitamin D3 for clinical research, and they provide objective evidence that vitamin D intake beyond the current upper limit is safe by a large margin.
Matti Narkia

Vitamin D toxicity, policy, and science. - JBMR Online - Journal of Bone and Mineral Re... - 0 views

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    Vitamin D toxicity, policy, and science.
    Vieth R.
    J Bone Miner Res. 2007 Dec;22 Suppl 2:V64-8. Review.
    PMID: 18290725
    doi: 10.1359/jbmr.07s221
Matti Narkia

Unusually prolonged vitamin D intoxication after discontinuation of vitamin D: possible... - 0 views

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    Unusually prolonged vitamin D intoxication after discontinuation of vitamin D: possible role of primary hyperparathyroidism.
    Taskapan H, Vieth R, Oreopoulos DG.
    Int Urol Nephrol. 2008;40(3):801-5. Epub 2008 Jun 5.
    PMID: 18528779
    DOI: 10.1007/s11255-008-9404-1
Matti Narkia

Vitamin D poisoning by table sugar : The Lancet - 0 views

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    Vitamin D poisoning by table sugar.
    Vieth R, Pinto TR, Reen BS, Wong MM.
    Lancet. 2002 Feb 23;359(9307):672.
    PMID: 11879864
    doi:10.1016/S0140-6736(02)07814-5
Matti Narkia

Vitamin D and Cancer Mini-Symposium: The Risk of Additional Vitamin D - 0 views

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    Vitamin D and cancer mini-symposium: the risk of additional vitamin D.
    Vieth R.
    Ann Epidemiol. 2009 Jul;19(7):441-5. Epub 2009 Apr 11. Review.
    PMID: 19364661

    Conclusion

    The results of well-conducted trials of vitamin D lead to the conclusion that the current U.S. National Academy of Sciences-Institute of Medicine upper limit for vitamin D intake of 2000IU per day 1, 37 is excessively conservative. That intake would raise serum 25(OH)D by an average of about 50 nmol/L (20 ng/mL), well within the safe range of serum 25(OH)D concentrations that extends to 500 nmol/L (200 ng/mL). Intake of 4,000IU per day would raise serum 25(OH)D by an average of about 100 nmol/L (40 ng/mL). Even prolonged physiologic-replacement intake of 10,000IU per day of vitamin D3 would pose no known risk of adverse effects in virtually all adults.
Matti Narkia

Vitamin D and Cancer Mini-Symposium: The Risk of Additional Vitamin D - 0 views

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    Evidence from clinical trials shows, with a wide margin of confidence, that a prolonged intake of 10,000IU/d of vitamin D3 poses no risk of adverse effects for adults, even if this is added to a rather high physiologic background level of vitamin D.

    Vitamin D and cancer mini-symposium: the risk of additional vitamin D.
    Vieth R.\nAnn Epidemiol. 2009 Jul;19(7):441-5. Epub 2009 Apr 11.
    PMID: 19364661
    doi:10.1016/j.annepidem.2009.01.009
Matti Narkia

Short- and Long-Term Safety of Weekly High-Dose Vitamin D3 Supplementation in School Ch... - 0 views

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    Conclusion: Vitamin D3 at doses equivalent to 2000 IU/d for 1 yr is safe in adolescents and results in desirable vitamin D levels.

    Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children.
    Maalouf J, Nabulsi M, Vieth R, Kimball S, El-Rassi R, Mahfoud Z, El-Hajj Fuleihan G.
    J Clin Endocrinol Metab. 2008 Jul;93(7):2693-701. Epub 2008 Apr 29.
    PMID: 18445674
    doi:10.1210/jc.2007-2530
Matti Narkia

Vitamin D and Cancer Mini-Symposium: The Risk of Additional Vitamin D - ScienceDirect -... - 0 views

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    Vitamin D and Cancer Mini-Symposium: The Risk of Additional Vitamin D.
    Vieth R.
    Ann Epidemiol. 2009 Apr 11. [Epub ahead of print]
    PMID: 19364661
    doi:10.1016/j.annepidem.2009.01.009   
Matti Narkia

Long-term effects of giving nursing home residents bread fortified with 125 microg (500... - 0 views

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    Long-term effects of giving nursing home residents bread fortified with 125 microg (5000 IU) vitamin D(3) per daily serving.
    Mocanu V, Stitt PA, Costan AR, Voroniuc O, Zbranca E, Luca V, Vieth R.
    Am J Clin Nutr. 2009 Apr;89(4):1132-7. Epub 2009 Feb 25.
    PMID: 19244376
    doi:10.3945/ajcn.2008.26890
Matti Narkia

Risk assessment for vitamin D -- Hathcock et al. 85 (1): 6 -- American Journal of Clini... - 0 views

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    Hathcock JN, Shao A, Vieth R, Heaney R. \nRisk assessment for vitamin D.\nAm J Clin Nutr. 2007 Jan;85(1):6-18. Review.\nPMID: 17209171 [PubMed - indexed for MEDLINE]
Matti Narkia

Critique of the Considerations for Establishing the Tolerable Upper Intake Level for Vi... - 0 views

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    Vieth R. \nCritique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards.\nJ Nutr. 2006 Apr;136(4):1117-22.\nPMID: 16549491 [PubMed - indexed for MEDLINE]
Matti Narkia

Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect l... - 0 views

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    Vieth R, Chan PC, MacFarlane GD.Efficacy and safety of vitamin D3 intake exceeding the lowest observedadverse effect level.Am J Clin Nutr. 2001 Feb;73(2):288-94.PMID: 11157326 [PubMed - indexed for MEDLINE]
Matti Narkia

Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety -- Vieth 69 (... - 0 views

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    Vieth R.Vitamin D supplementation, 25-hydroxyvitamin D concentrations, andsafety.Am J Clin Nutr. 1999 May;69(5):842-56. Review.PMID: 10232622 [PubMed - indexed for MEDLINE]
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