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Matti Narkia

Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-α) in pr... - 0 views

www.sciencedirect.com/science

2005 June study research in_vitro vitamin_D vitamin_D-induced up-regulation upregulation TNF-alpha TNF prostate cancer cells prostate_cancer PCa nutrition Tuohimaa apoptosis medline

shared by Matti Narkia on 16 Dec 09 - Cached
  • Matti Narkia on 16 Dec 09
     
    Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells. Golovko O, Nazarova N, Tuohimaa P. Life Sci. 2005 Jun 17;77(5):562-77. Epub 2005 Feb 25. PMID: 15904673 doi:10.1016/j.lfs.2004.10.072 Combined addition of human recombinant TNF-alpha with calcitriol or CB1093 cause enhanced effect in induction of apoptosis. We conclude that under physiological conditions vitamin D activates only the transcription of TNF-alpha gene, for TNF-alpha protein synthesis additional cofactors are required. Therefore a cooperation of vitamin D and TNF-alpha may play an important role in the control of cell growth in prostate cancer.
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