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The effects of conjugated linoleic acid on human health-related outcomes. Tricon S, Burdge GC, Williams CM, Calder PC, Yaqoob P. Proc Nutr Soc. 2005 May;64(2):171-82. Review. PMID: 15960862 Conjugated linoleic acid (CLA) is a collective term for a mixture of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. CLA has received considerable attention as a result of animal experiments that report anti-carcinogenic, anti-atherogenic and anti-diabetic properties, and modulation of body composition and immune function. Several studies of CLA supplementation in human subjects have now been published, but in contrast to animal studies there has been marked variation between reports on the health-related outcomes. The consensus from seventeen published studies in human subjects is that CLA does not affect body weight or body composition. Some detrimental effects of the trans-10,cis-12 CLA isomer have also been reported in terms of altered blood lipid composition and impaired insulin sensitivity. Finally, CLA has only limited effects on immune functions in man. However, there have been reports of some interesting isomer-specific effects of CLA on the blood lipid profile, but not on immune function. These isomer-specific effects need further investigation. Until more is known, CLA supplementation in man should be considered with caution.

What is AHCC? The world's most researched specialty immune supplement with over 80 supporting research studies. Japan's leading alternative cancer therapy used in hundreds of cancer clinics throughout Asia. Highly effective immuno-modulator used in over 700 clinics as a standard preventative regiment for all incoming patient to reduce the risk of hospital infections. The daily immune supplement of tens of thousands of healthy people in Japan and worldwide, seeking to help their bodies to fight the formation of abnormal cells, whose growth can lead to cancer, chronic disease and infections (such as the influenza / flu virus).

Modulation of Immune Functions by Foods Shuichi Kaminogawa and Masanobu Nanno

Nevertheless, the development of immunonutrition (IMN), a special form of enteral feed supplemented with specific nutrients (omega-3 fatty acids, arginine, nucleotides and sometimes glutamine) has demonstrated a beneficial effect on patients' immune systems [8]. The advantages of IMN have been demonstrated in a number of studies [9-20]. Two recent meta-analyses have concluded that the use of IMN results in a significant reduction in infection rates, and as a consequence, shorter durations of hospital stay [21-22].

Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group. [No authors listed] Diabetologia. 1999 Jan;42(1):51-4. PMID: 10027578 DOI: 10.1007/s001250051112 In conclusion, this large multicentre trial covering many different European settings consistently showed a protective effect of vitamin D supplementation in infancy. The findings indicate that activated vitamin D might contribute to immune modulation and thereby protect or arrest an ongoing immune process initiated in susceptible people by early environmental exposures.

Medicinal mushroom modulators of molecular targets as cancer therapeutics. Zaidman BZ, Yassin M, Mahajna J, Wasser SP. Appl Microbiol Biotechnol. 2005 Jun;67(4):453-68. Epub 2005 Feb 23. Review. PMID: 15726350 DOI: 10.1007/s00253-004-1787-z

These results suggest that combination chemotherapy (FO+Cur or Lim) may favorably modulate CD4+ T-cell-mediated inflammation.D ietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice. Kim W, Fan YY, Smith R, Patil B, Jayaprakasha GK, McMurray DN, Chapkin RS. J Nutr. 2009 May;139(5):1042-8. Epub 2009 Mar 25. PMID: 19321585 doi:10.3945/jn.108.102772

Perioperative immunonutrition in head and neck cancer. Sorensen LD, McCarthy M, Baumgartner MB, Demars CS. Laryngoscope. 2009 May 20. [Epub ahead of print] PMID: 19459146 DOI: 10.1002/lary.20494