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Matti Narkia

Ecological studies of ultraviolet B, vitamin D and cancer since 2000. - Ann Epidemiol. ... - 0 views

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    Ecological studies of ultraviolet B, vitamin D and cancer since 2000.
    Grant WB, Mohr SB.
    Ann Epidemiol. 2009 Jul;19(7):446-54. Epub 2009 Mar 9. Review.
    PMID: 19269856

    CONCLUSION: These findings provide strong evidence that vitamin D status plays an important role in controlling the outcome of cancer. Support for the UVB-vitamin D-cancer theory is now scientifically strong enough to warrant use of vitamin D in cancer prevention, and as a component of treatment. More research studies would help to explore whether there are benefits beyond the substantial effects that have been observed.
Matti Narkia

Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 ... - 0 views

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    Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 countries.
    Mohr SB, Garland CF, Gorham ED, Grant WB, Garland FC.
    Breast J. 2008 May-Jun;14(3):255-60. Epub 2008 Apr 17.
    PMID: 18422861
    DOI: 10.1111/j.1524-4741.2008.00571.x

    There was a protective effect of UVB irradiance on risk of breast cancer that was independent of fertility rate, proportion of the population overweight, alcohol intake, animal energy intake, and other covariates.
Matti Narkia

A multicountry ecologic study of risk and risk reduction factors for prostate cancer mo... - 0 views

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    A multicountry ecologic study of risk and risk reduction factors for prostate cancer mortality.
    Grant WB.
    Eur Urol. 2004 Mar;45(3):271-9.
    PMID: 15036670

    CONCLUSIONS: These results are consistent with insulin-like growth factor-I (IGF-I), being an important risk factor for prostate cancer, with alcohol and calcium being less important risk factors, and with allium family vegetables, and, to a lesser extent, vitamin D being important risk reduction factors. These results should provide guidance for additional studies on dietary and environmental links to prostate cancer.
Matti Narkia

The Association of Solar Ultraviolet B (UVB) with Reducing Risk of Cancer: Multifactori... - 0 views

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    The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates.
    Grant WB, Garland CF.
    Anticancer Res. 2006 Jul-Aug;26(4A):2687-99.
    PMID: 16886679

    CONCLUSION: These results provide additional support for the hypothesis that solar UVB, through photosynthesis of vitamin D, is inversely-associated with cancer mortality rates, and that various other cancer risk-modifying factors do not detract from this link. It is thought that sun avoidance practices after 1980, along with improved cancer treatment, led to reduced associations in the latter period. The results regarding solar UVB should be studied further with additional observational and intervention studies of vitamin D indices and cancer incidence, mortality and survival rates.
Matti Narkia

An ecologic study of dietary and solar ultraviolet-B links to breast carcinoma mortalit... - 0 views

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    An ecologic study of dietary and solar ultraviolet-B links to breast carcinoma mortality rates.
    Grant WB.
    Cancer. 2002 Jan 1;94(1):272-81.
    PMID: 11815987

    CONCLUSIONS
    It is hypothesized that animal products are associated with risk for breast carcinoma because they are associated with greater amounts of insulin-like growth factor-1and lifetime doses of estrogen. Vegetable products contain several risk reduction components including antioxidants and phytoestrogens. The association with latitude is very likely because of solar UV-B radiation and vitamin D. Alcohol modulates estrogen's effects on breasts. Fish intake is associated with risk reduction through vitamin D and n-3 oils. These results are consistent with those of many case-control and cohort studies but should be assessed in well designed cohort studies.
Matti Narkia

Geographic variation of prostate cancer mortality rates in the United States: Implicati... - 0 views

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    Geographic variation of prostate cancer mortality rates in the United States: Implications for prostate cancer risk related to vitamin D.
    Grant WB.
    Int J Cancer. 2004 Sep 1;111(3):470-1; author reply 472. No abstract available.
    PMID: 15221981
    10.1002/ijc.20220

    The implications of our results and those of Tuohimaa et al.[1] include the following. Vitamin D supplementation should be undertaken in wintertime, a period when it is impossible to produce vitamin D by solar UVB exposure in northeastern states.[13] Given these new results, the optimal vitamin D intake and production and serum 25(OH)-vitamin D3 levels for prostate cancer appear to be lower than for other cancers. However, when developing guidelines for vitamin D fortification, many factors should be included in the analysis, including all of the potential health benefits and possible risks of vitamin D, as well as age, sex, residence, child-bearing status, etc.[14] Also, the suggestion that daily vitamin D3 supplement doses of 100 g (4,000 IU)/day are safe[15] should be reexamined. Finally, in terms of preventing prostate cancer, more attention should be given to diet, which has the greatest environmental impact on risk of prostate cancer, with animal products being important risk factors and vegetable products, especially onions and other allium family members, being important risk-reduction factors.[16]
Matti Narkia

Current Impediments to Acceptance of the Ultraviolet-B-Vitamin D-Cancer Hypothesis - An... - 0 views

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    Current impediments to acceptance of the ultraviolet-B-vitamin D-cancer hypothesis.
    Grant WB, Boucher BJ.
    Anticancer Res. 2009 Sep;29(9):3597-604.
    PMID: 19667154

    The ultraviolet-B (UVB)-vitamin D-cancer hypothesis was proposed in 1980. There have been numerous ecological, observational and other studies of the hypothesis. There are about 14 types of cancer for which it seems to apply: bladder, breast, colon, endometrial, esophageal, gallbladder, gastric, ovarian, pancreatic, rectal, renal and vulvar cancer and both Hodgkin's and non-Hodgkin's lymphoma. Nonetheless, the hypothesis has not yet been accepted by public health agencies. Some of the reasons for this include a distrust of ecological studies, some mistrust of observational studies, and the existence of just one positive randomized controlled trial, an analysis of a vitamin D and calcium supplementation study involving post-menopausal women in Nebraska. Paradigm shifts such as this generally take time, in part due to opposition from those content with the status quo. In this paper, results of ecological studies in the United States using summertime solar UVB as the index of vitamin D production, which is highly asymmetrical with respect to latitude, and indices for other cancer risk-modifying factors (air pollution, alcohol consumption, dietary iron and zinc, ethnic background, socioeconomic status, smoking and urban/rural residence) are discussed in terms of supporting the hypothesis. These studies were not considered while other ecological studies were examined in recent critiques of the hypothesis. While additional randomized controlled trials would, of course, be helpful, the current evidence seems to satisfy the criteria for causality as outlined by A. Bradford Hill.
Matti Narkia

Ecological Studies Of Ultraviolet B, Vitamin D And Cancer Since 2000 - 0 views

  •  
    Ecological studies of ultraviolet B, vitamin D and cancer since 2000.
    Grant WB, Mohr SB.
    Ann Epidemiol. 2009 Jul;19(7):446-54. Epub 2009 Mar 9.
    PMID: 19269856

    CONCLUSION: These findings provide strong evidence that vitamin D status plays an important role in controlling the outcome of cancer. Support for the UVB-vitamin D-cancer theory is now scientifically strong enough to warrant use of vitamin D in cancer prevention, and as a component of treatment. More research studies would help to explore whether there are benefits beyond the substantial effects that have been observed.
Matti Narkia

Ecological Studies Of Ultraviolet B, Vitamin D And Cancer Since 2000. - ScienceDirect -... - 0 views

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    Ecological Studies Of Ultraviolet B, Vitamin D And Cancer Since 2000.
    Grant WB, Mohr SB.
    Ann Epidemiol. 2009 Mar 6. [Epub ahead of print]
    PMID: 19269856
    doi:10.1016/j.annepidem.2008.12.014
Matti Narkia

Epidemic influenza and vitamin D - CJO - Abstract - 0 views

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    Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E. Epidemic influenza and vitamin D.Epidemiol Infect. 2006 Dec;134(6):1129-40. Epub 2006 Sep 7.PMID: 16959053
    doi:10.1017/S0950268806007175
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