Arachidonate 5-lipoxygenase (5-lipoxygenase, 5-LO, 5-LOX or Alox5), which transforms EFAs into leukotrienes, is a current target for pharmaceutical intervention in a number of diseases. 5-LO is a target for pharmaceutical intervention in CAD.
Li N, Sood S, Wang S, Fang M, Wang P, Sun Z, Yang CS, Chen X.
Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.
Clin Cancer Res. 2005 Mar 1;11(5):2089-96.
PMID
Sun Z, Sood S, Li N, Ramji D, Yang P, Newman RA, Yang CS, Chen X.
Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinoge
Resolvin E2: identification and anti-inflammatory actions: pivotal role
of human 5-lipoxygenase in resolvin E series biosynthesis.
Tjonahen E, Oh SF, Siegelman J, Elangovan S, Percarpio KB, Hong S,
Arita M, Serhan CN.
Chem Biol. 2006 Nov;13(11):1193-202.
PMID: 17114001
doi:10.1016/j.chembiol.2006.09.011