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Matti Narkia

25-Hydroxyvitamin D3 is an agonistic vitamin D receptor ligand - Lou et al. - J Steroi... - 1 views

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    25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand.
    Lou YR, Molnár F, Peräkylä M, Qiao S, Kalueff AV, St-Arnaud R, Carlberg C, Tuohimaa P.
    J Steroid Biochem Mol Biol. 2009 Nov 26. [Epub ahead of print]
    PMID: 19944755
    doi:10.1016/j.jsbmb.2009.11.011

    In conclusion, 25-hydroxyvitamin D3 is an agonistic vitamin D receptor ligand with gene regulatory and anti-proliferative properties.
Matti Narkia

New topics in vitamin D research - Google Books - 1 views

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    Table of Contents

    Ch. I Is calcidiol an active hormone? 1
    Ch. II Vitamin D as a neurosteroid hormone : from neurobiological effects to behavior 29
    Ch. III Inhibitors of vitamin D hydroxylases : mechanistic tools and therapeutic aspects 67
    Ch. IV Vitamin D analogues as anti-cancer therapies 145
    Ch. V Paricalcitol : a vitamin D2 analog with anticancer effects with low calcemic activity 169
    Ch. VI Vitamin D use among older adults in U.S. : results form national surveys 1997 to 2002 181
    Ch VII Vitamin D deficiency in migrants 199

    Vitamin D is a fat-soluble steroid hormone precursor that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. Strictly speaking, it is not a vitamin since human skin can manufacture it, but it is referred to as one for historical reasons. It is often known as calciferol. The major biologic function of vitamin D is to maintain normal blood levels of calcium and phosphorus. Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. It promotes bone mineralisation in concert with a number of other vitamins, minerals and hormones. Without vitamin D, bones can become thin, brittle, soft or misshapen. Vitamin D prevents rickets in children and osteomalacia in adults -- skeletal diseases that result in defects that weaken bones. This book gathers international research on the leading-edge of the scientific front.
Matti Narkia

The Bioavailability of Vitamin D from Fortified Cheeses and Supplements Is Equivalent i... - 0 views

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    The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults.
    Wagner D, Sidhom G, Whiting SJ, Rousseau D, Vieth R.
    J Nutr. 2008 Jul;138(7):1365-71.
    PMID: 18567762

    Compared with baseline, serum parathyroid hormone decreased with both fortification (P = 0.003) and supplementation (P = 0.012). These data demonstrate that vitamin D is equally bioavailable from fortified hard cheeses and supplements, making cheese suitable for vitamin D fortification.
Matti Narkia

Bread Fortified with Cholecalciferol Increases the Serum 25-Hydroxyvitamin D Concentrat... - 0 views

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    Bread fortified with cholecalciferol increases the serum 25-hydroxyvitamin D concentration in women as effectively as a cholecalciferol supplement.
    Natri AM, Salo P, Vikstedt T, Palssa A, Huttunen M, Kärkkäinen MU, Salovaara H, Piironen V, Jakobsen J, Lamberg-Allardt CJ.
    J Nutr. 2006 Jan;136(1):123-7.
    PMID: 16365070

    Both fortified breads increased serum 25-hydroxyvitamin D concentration as effectively as the cholecalciferol supplement. Supplementation or fortification did not affect serum intact parathyroid hormone concentration or urinary calcium excretion. In conclusion, fortified bread is a safe and feasible way to improve vitamin D nutrition.
Matti Narkia

A randomised comparison of increase in serum 25-hydroxyvitamin D concentratio... - 0 views

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    A randomised comparison of increase in serum 25-hydroxyvitamin D concentration after 4 weeks of daily oral intake of 10 microg cholecalciferol from multivitamin tablets or fish oil capsules in healthy young adults.
    Holvik K, Madar AA, Meyer HE, Lofthus CM, Stene LC.
    Br J Nutr. 2007 Sep;98(3):620-5. Epub 2007 Apr 24.
    PMID: 17456248

    We conclude that fish oil capsules and multivitamin tablets containing 10 microg cholecalciferol administered over a 4-week period produced a similar mean increase in s-25(OH)D concentration.
Matti Narkia

Low vitamin D serum level is related to severe fibrosis and low responsiveness to IFN-b... - 0 views

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    Low vitamin D serum level is related to severe fibrosis and low responsiveness to IFN-based therapy in genotype 1 chronic hepatitis C
    Salvatore Petta et al.
    Hepatology, Volume 9999 Issue 999A, Page NA. Published Online: 4 Dec 2009
    DOI: 10.1002/hep.23489

    Conclusions:
    G1 CHC patients had low 25(OH)D serum levels, possibly due to reduced CYP27A1 expression. Low vitamin D is linked to severe fibrosis and low SVR on IFN-based therapy. (HEPATOLOGY 2010.)
Matti Narkia

25-Hydroxyvitamin D3 is an agonistic vitamin D receptor ligand - ScienceDirect - The Jo... - 0 views

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    25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand.
    Lou YR, Molnár F, Peräkylä M, Qiao S, Kalueff AV, St-Arnaud R, Carlberg C, Tuohimaa P.
    J Steroid Biochem Mol Biol. 2009 Nov 26. [Epub ahead of print]
    PMID: 19944755
    doi:10.1016/j.jsbmb.2009.11.011

    In conclusion, 25-hydroxyvitamin D3 is an agonistic vitamin D receptor ligand with gene regulatory and anti-proliferative properties.
Matti Narkia

Vitamin D and prostate cancer - ScienceDirect - The Journal of Steroid Biochemistry and... - 0 views

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    Vitamin D and prostate cancer.
    Tuohimaa P, Lyakhovich A, Aksenov N, Pennanen P, Syvälä H, Lou YR, Ahonen M, Hasan T, Pasanen P, Bläuer M, Manninen T, Miettinen S, Vilja P, Ylikomi T.
    J Steroid Biochem Mol Biol. 2001 Jan-Mar;76(1-5):125-34.
    PMID: 11384870
    doi:10.1016/S0960-0760(00)00141-2
Matti Narkia

Lack of Association between Serum Levels of 25-Hydroxyvitamin D and the Subsequent Risk... - 0 views

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    Lack of association between serum levels of 25-hydroxyvitamin D and the subsequent risk of prostate cancer in Finnish men.
    Faupel-Badger JM, Diaw L, Albanes D, Virtamo J, Woodson K, Tangrea JA.
    Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2784-6.
    PMID: 18086789
    doi: 10.1158/1055-9965.EPI-07-0672
Matti Narkia

Serum 25(OH)-Vitamin D Concentration and Risk of Esophageal Squamous Dysplasia - Cancer... - 0 views

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    Serum 25(OH)-vitamin D concentration and risk of esophageal squamous dysplasia.
    Abnet CC, Chen W, Dawsey SM, Wei WQ, Roth MJ, Liu B, Lu N, Taylor PR, Qiao YL.
    Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1889-93.
    PMID: 17855710
    doi: 10.1158/1055-9965.EPI-07-0461

    Background: Squamous dysplasia is the precursor lesion for esophageal squamous cell carcinoma, and nutritional factors play an important role in the etiology of this cancer. Previous studies using a variety of measures for vitamin D exposure have reached different conclusions about the association between vitamin D and the risk of developing esophageal cancer.

    Conclusions: Higher serum 25(OH)D concentrations were associated with significantly increased risk of squamous dysplasia. No obvious source of measured or unmeasured confounding explains this finding.

    In conclusion, we found that a higher serum 25(OH)D concentration was associated with an increased risk of esophageal squamous dysplasia, the precursor lesion for ESCC. This finding concurs with our previous prospective study which found that higher vitamin D status was associated with increased risk of incident ESCC in this same population. These unexpected findings suggest that further studies of the association of vitamin D and digestive tract cancers are needed before the effect of vitamin D in different populations can be elucidated.
Matti Narkia

Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and g... - 0 views

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    Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and gastric cancers.
    Chen W, Dawsey SM, Qiao YL, Mark SD, Dong ZW, Taylor PR, Zhao P, Abnet CC.
    Br J Cancer. 2007 Jul 2;97(1):123-8. Epub 2007 Jun 5.
    PMID: 17551495

    We prospectively examined the relation between pretrial serum vitamin D status and risk of oesophageal and gastric cancers among subjects who developed cancer over 5.25 years of follow-up, including 545 oesophageal squamous cell carcinomas (ESCC), 353 gastric cardia adenocarcinomas, 81 gastric noncardia adenocarcinomas, and an age- and sex-stratified random sample of 1105 subjects.

    We found no associations for gastric cardia or noncardia adenocarcinoma. Among subjects with low vitamin D status, higher serum 25(OH)D concentrations were associated with significantly increased risk of ESCC in men, but not in women. Further refinements of the analysis did not suggest any factors, which could explain this unexpected result.

    In conclusion, we found a direct association between higher serum 25(OH)D concentration and increased risk of ESCC in men but not women in a large population-based prospective cohort study from rural China. We found no association with risk of gastric cardia or noncardia adenocarcinoma in either sex. Greater than 50% of our cohort had an inadequate serum 25(OH)D concentration, yet higher concentrations were associated with increased risk of ESCC compared to lower concentrations.
Matti Narkia

A Prospective Nested Case-Control Study of Vitamin D Status and Pancreatic Cancer Risk ... - 0 views

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    A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers.
    Stolzenberg-Solomon RZ, Vieth R, Azad A, Pietinen P, Taylor PR, Virtamo J, Albanes D.
    Cancer Res. 2006 Oct 15;66(20):10213-9.
    PMID: 17047087

    Higher vitamin D concentrations were associated with a 3-fold increased risk for pancreatic cancer (highest versus lowest quintile, >65.5 versus <32.0 nmol/L: OR, 2.92; 95% CI, 1.56-5.48, Ptrend = 0.001) that remained after excluding cases diagnosed early during follow-up. Contrary to expectations, subjects with higher prediagnostic vitamin D status had an increased pancreatic cancer risk compared with those with lower status. Our findings need to be replicated in other populations and caution is warranted in their interpretation and implication. Our results are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer.

    In conclusion, contrary to expectation, subjects with higher 25(OH)D concentrations were at greater risk for pancreatic cancer compared with those with lower concentrations in our prospective study with long-term follow-up. Caution is warranted in the interpretation and implication of our findings, however, as vitamin D inadequacy is an important public health problem and adequate status is desirable to prevent bone and other diseases (5). Our results, however, are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer.
Matti Narkia

Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25... - 0 views

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    Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk.
    Mikhak B, Hunter DJ, Spiegelman D, Platz EA, Hollis BW, Giovannucci E.
    Prostate. 2007 Jun 15;67(9):911-23.
    PMID: 17440943
    DOI: 10.1002/pros.20570

    RESULTS
    No association was found between these SNPs or their associated haplotypes and all PC subtypes except that haplotype 2 (A-f-b) with Cdx2 A, Fok1 f, and Bsm1 b alleles and haplotype 3 (A-F-B) with Cdx2 A, Fok1 F and Bsm1 B alleles compared to the most common haplotype (A-F-b), were associated with reduced risk of aggressive PC (high stage or Gleason sum 7; P = 0.02), both with two alleles suspected of being low risk. Carriers of the variant Cdx2 A allele who were deficient in plasma 25-hydroxyvitamin D (15 ng/ml) compared to non-carriers with normal 25-hydroxyvitamin D, had a lower risk of total and poorly differentiated PCs (Gleason sum 7) (P for interaction = 0.02 and 0.04, respectively). Plasma 1,25-dihydroxyvitamin D deficiency (26 pg/ml) was associated with a threefold risk of poorly differentiated PC (P for interaction = 0.01) when comparing carriers of the Cdx2 A allele to non-carriers with normal 1,25-dihydroxyvitamin D.

    CONCLUSION
    In this population of men, none of the VDR polymorphisms studied was associated with susceptibility to PC.

    Carriers of the variant Cdx2 A allele with low plasma 25-hydroxyvitamin D may experience a reduction in risk of total and poorly differentiated prostate cancers compared to non-carriers with adequate 25-hydroxyvitamin D.
Matti Narkia

Serum Vitamin D Concentration and Prostate Cancer Risk: A Nested Case-Control Study -- ... - 0 views

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    Serum vitamin D concentration and prostate cancer risk: a nested case-control study.
    Ahn J, Peters U, Albanes D, Purdue MP, Abnet CC, Chatterjee N, Horst RL, Hollis BW, Huang WY, Shikany JM, Hayes RB; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Project Team.
    J Natl Cancer Inst. 2008 Jun 4;100(11):796-804. Epub 2008 May 27.
    PMID: 18505967
    doi:10.1093/jnci/djn152

    CONCLUSION: The findings of this large prospective study do not support the hypothesis that vitamin D is associated with decreased risk of prostate cancer; indeed, higher circulating 25(OH)D concentrations may be associated with increased risk of aggressive disease.

    In summary, results from this large prospective study of men who underwent standardized prostate cancer screening in the context of a screening trial do not support the hypothesis that higher serum vitamin D status is associated with decreased risk of prostate cancer. The study showed no association of vitamin D level with nonaggressive disease; however, it raises the possibility that higher vitamin D level may be associated with increased risks for aggressive disease, although a clear monotonic dose-response relationship was lacking. Along with recent reports of adverse associations for higher vitamin D status and risk of pancreatic (32) and esophageal (33,34) cancer, caution should be taken in recommending high doses of vitamin D or sunlight exposure to the general public for prostate cancer prevention. Future analyses are warranted to confirm these results and to further clarify the effects of vitamin D on aggressive prostate cancer.
Matti Narkia

Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a lo... - 0 views

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    Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study.
    Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, Arden NK, Godfrey KM, Cooper C; Princess Anne Hospital Study Group.
    Lancet. 2006 Jan 7;367(9504):36-43. Erratum in: Lancet. 2006 May 6;367(9521):1486.
    PMID: 16399151
    doi:10.1016/S0140-6736(06)67922-1

    Interpretation
    Maternal vitamin D insufficiency is common during pregnancy and is associated with reduced bone-mineral accrual in the offspring during childhood; this association is mediated partly through the concentration of umbilical venous calcium. Vitamin D supplementation of pregnant women, especially during winter months, could lead to longlasting reductions in the risk of osteoporotic fracture in their offspring.
Matti Narkia

Relationships between 25-Hydroxyvitamin D Levels and Plasma Glucose and Lipid Levels in... - 0 views

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    Relationships between 25-Hydroxyvitamin D Levels and Plasma Glucose and Lipid Levels in Pediatric Outpatients.
    Johnson MD, Nader NS, Weaver AL, Singh R, Kumar S.
    J Pediatr. 2009 Nov 17. [Epub ahead of print]
    PMID: 19926097

    Conclusions
    Low 25(OH) D levels in children and adolescents are associated with higher plasma glucose and lower HDL concentrations.
Matti Narkia

Seasonality of UV-radiation and vitamin D status at 69 degrees north. - Photochem Photo... - 1 views

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    Seasonality of UV-radiation and vitamin D status at 69 degrees north.
    Brustad M, Edvardsen K, Wilsgaard T, Engelsen O, Aksnes L, Lund E.
    Photochem Photobiol Sci. 2007 Aug;6(8):903-8. Epub 2007 Jun 27.
    PMID: 17668121

    The generally high dietary intakes of vitamin D, especially in winter, mask largely the effect of seasonal variation in UV-exposure, causing an atypical seasonal variation in vitamin D status. The UV-hour variable significantly predicted 25(OH)D levels in blood when adjusted for intakes and artificial UV-radiation exposure and sun holidays abroad.
Matti Narkia

The High Prevalence of Vitamin D Insufficiency across Australian Populations Is Only Pa... - 1 views

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    The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude.
    van der Mei IA, Ponsonby AL, Engelsen O, Pasco JA, McGrath JJ, Eyles DW, Blizzard L, Dwyer T, Lucas R, Jones G.
    Environ Health Perspect. 2007 Aug;115(8):1132-9.
    PMID: 17687438
    doi: 10.1289/ehp.9937.

    Conclusion
    Vitamin D insufficiency is common over a wide latitude range in Australia. Season appears to be more important than latitude, but both accounted for less than one-fifth of the variation in serum 25(OH)D levels, highlighting the importance of behavioral factors. Current sun exposure guidelines do not seem to fully prevent vitamin D insufficiency, and consideration should be given to their modification or to pursuing other means to achieve vitamin D adequacy.
Matti Narkia

Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patient... - 0 views

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    Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients.
    Romagnoli E, Caravella P, Scarnecchia L, Martinez P, Minisola S.
    Br J Nutr. 1999 Feb;81(2):133-7.
    PMID: 10450331

    The results of the present study emphasize the importance of 25-hydroxyvitamin D measurement, and the need to increase vitamin D intake in Italy; foodstuff fortification and supplement use must be considered in order to prevent negative effects of vitamin D deficiency on skeletal integrity.

    All hospitalized patients, both in summer and in winter,
    are characterized by the highest prevalence of hypovitaminosis
    D, especially the older patients. Medical
    inpatients may be at risk for vitamin D deficiency,
Matti Narkia

Decreased bioavailability of vitamin D in obesity -- Wortsman et al. 72 (3): 690 -- Ame... - 0 views

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    Decreased bioavailability of vitamin D in obesity.
    Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF.
    Am J Clin Nutr. 2000 Sep;72(3):690-3. Erratum in: Am J Clin Nutr. 2003 May;77(5):1342.
    PMID: 10966885

    Conclusions: Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D3 from cutaneous and dietary sources because of its deposition in body fat compartments.
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