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Matti Narkia

NEJM -- Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reacti... - 0 views

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    Conclusions In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events. \n\nRosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.\nRidker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group.\nN Engl J Med. 2008 Nov 20;359(21):2195-207. Epub 2008 Nov 9.\nPMID: 18997196
Matti Narkia

NEJM -- Expanding the Orbit of Primary Prevention -- Moving beyond JUPITER - 0 views

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    Expanding the orbit of primary prevention--moving beyond JUPITER.
    Hlatky MA.
    N Engl J Med. 2008 Nov 20;359(21):2280-2. Epub 2008 Nov 9.
    PMID: 18997195
Matti Narkia

Well - A Call for Caution in the Rush to Statins - NYTimes.com - 0 views

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    Judging by recent headlines, you might think so. Last week heart researchers reported that millions of healthy people could benefit from taking statins even if they don't have high cholesterol.\n\nAlthough many doctors hailed the study as a major breakthrough, a closer look at the research suggests that statins (like Crestor, from AstraZeneca, and Lipitor, from Pfizer) are far from magic pills. While they clearly save lives in people with a previous heart attack or other serious heart problems, for an otherwise healthy person the potential benefit remains small.
Matti Narkia

Cholesterol-Fighting Drugs Show Wider Benefit - New York Times - 0 views

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    CHART: Statins Reduce Risks: A study of 18,000 people with high levels of C-reactive protein, or CRP, found that the risk of a heart attack or stroke was cut in half among those who took a statin. The study was stopped after two years, but some participants were tracked for up to five years. (Sources: Dr. Paul M. Ridker; New England Journal of Medicine) (pg.A21)
    A large new study suggests that millions more people could benefit from taking the cholesterol-lowering drugs known as statins, even if they have low cholesterol, because the drugs can significantly lower their risk of heart attacks, strokes and death.

    The study, involving nearly 18,000 people worldwide, tested statin treatment in men 50 and older and in women 60 and older who did not have high cholesterol or histories of heart disease. What they did have was high levels of a protein called high-sensitivity C-reactive protein, or CRP, which indicates inflammation in the body.
Matti Narkia

Fish consumption and risk of subclinical brain abnormalities on MRI in older adults - 0 views

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    Fish consumption and risk of subclinical brain abnormalities on MRI in older adults.
    Virtanen JK, Siscovick DS, Longstreth WT Jr, Kuller LH, Mozaffarian D.
    Neurology. 2008 Aug 5;71(6):439-46.
    PMID: 18678827
    doi: 10.1212/01.wnl.0000324414.12665.b0

    Conclusions:
    Among older adults, modest consumption of tuna/other fish, but not fried fish, was associated with lower prevalence of subclinical infarcts and white matter abnormalities on MRI examinations. Our results add to prior evidence that suggest that dietary intake of fish with higher eicosapentaenoic acid and docosahexaenoic acid content, and not fried fish intake, may have clinically important health benefits
Matti Narkia

Fish consumption and risk of major chronic disease in men -- Virtanen et al. 88 (6): 16... - 0 views

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    Fish consumption and risk of major chronic disease in men.
    Virtanen JK, Mozaffarian D, Chiuve SE, Rimm EB.
    Am J Clin Nutr. 2008 Dec;88(6):1618-25.
    PMID: 19064523
    doi:10.3945/ajcn.2007.25816

    Conclusions: Modest fish consumption was associated with a lower risk of total cardiovascular disease, consistent with cardiac mortality benefits but not with total cancer or overall major chronic disease; n-6 fatty acid consumption did not influence these relations.
Matti Narkia

Serum Vitamin D Concentration and Prostate Cancer Risk: A Nested Case-Control Study -- ... - 0 views

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    Serum vitamin D concentration and prostate cancer risk: a nested case-control study.
    Ahn J, Peters U, Albanes D, Purdue MP, Abnet CC, Chatterjee N, Horst RL, Hollis BW, Huang WY, Shikany JM, Hayes RB; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Project Team.
    J Natl Cancer Inst. 2008 Jun 4;100(11):796-804. Epub 2008 May 27.
    PMID: 18505967
    doi:10.1093/jnci/djn152

    CONCLUSION: The findings of this large prospective study do not support the hypothesis that vitamin D is associated with decreased risk of prostate cancer; indeed, higher circulating 25(OH)D concentrations may be associated with increased risk of aggressive disease.

    In summary, results from this large prospective study of men who underwent standardized prostate cancer screening in the context of a screening trial do not support the hypothesis that higher serum vitamin D status is associated with decreased risk of prostate cancer. The study showed no association of vitamin D level with nonaggressive disease; however, it raises the possibility that higher vitamin D level may be associated with increased risks for aggressive disease, although a clear monotonic dose-response relationship was lacking. Along with recent reports of adverse associations for higher vitamin D status and risk of pancreatic (32) and esophageal (33,34) cancer, caution should be taken in recommending high doses of vitamin D or sunlight exposure to the general public for prostate cancer prevention. Future analyses are warranted to confirm these results and to further clarify the effects of vitamin D on aggressive prostate cancer.
Matti Narkia

Tempeh and tofu, for better or worse | The Jakarta Post - 0 views

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    "Consuming tempeh can reduce the risk of developing dementia in the elderly, but eating tofu can increase it, said a joint study between universities here and in Britain on Wednesday.

    The study between University of Indonesia (UI), Indonesia Respati University, University of Loughborough and University of Oxford said people over 68 years of age who consumed tofu more than twice a day had a worse memory than those who rarely ate it.

    But if they also ate tempeh, the risk of dementia was reduced.

    "Tempeh consumption very likely offsets tofu's negative associations with memory," Professor Eef Hogervorst of the University of Loughborough said in a seminar on aging and health at UI campus in Depok, where she presented the result of the study.

    The study involved 712 respondents from Jakarta, Citengah in West Java and Yogyakarta, with ages ranging from 52 to 99 years. "
Matti Narkia

Processing Chemical Used in Tofu May Increase Risk of Dementia in the Elderly - 0 views

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    "(NaturalNews) Regularly eating high levels of tofu may increase the risk of the memory loss associated with dementia, according to a new study conducted by researchers from Loughborough University in the United Kingdom, and published in the journal Dementias and Geriatric Cognitive Disorders.

    Prior research has found that women over the age of 65 who receive hormone therapy may double their risk of dementia. This may occur because estrogen promotes cell growth, which may actually do damage to the aging brain, Hogervorst said. Alternately, high levels of estrogen might enhance the cell-damaging effects of free radicals.

    Hogervorst also noted that much of tofu consumed by study participants might have been preserved with formaldehyde, a common practice in Indonesia. Formaldehyde has been strongly linked to various forms of cell damage, and might be responsible for the memory effects observed.

    Prior research has found that older Japanese-American men who consumed high levels of tofu are also at an elevated risk for dementia, however.
    Researchers investigated the connection between memory loss and diet for 719 elderly urban and rural residents of Java, Indonesia. The found that those who ate tofu at least once per day performed significantly worse on memory tests than those who ate tofu less frequently. The effect was particularly strong among those over the age of 68."
Matti Narkia

Tofu 'may raise risk of dementia' - BBC NEWS | Have Your Say - 0 views

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    "Eating high levels of some soy products - including tofu - may raise the risk of memory loss, research suggests.

    The study focused on 719 elderly Indonesians living in urban and rural regions of Java. '

    The latest study suggests phytoestrogens - in high quantity - may actually heighten the risk of dementia.

    Lead researcher Professor Eef Hogervorst said previous research had linked oestrogen therapy to a doubling of dementia risk in the over-65s.

    She said oestrogens - and probably phytoestrogens - tended to promote growth among cells, not necessarily a good thing in the ageing brain.

    Alternatively, high doses of oestrogens might promote the damage caused to cells by particles known as free radicals.

    A third theory is that damage is caused not by the tofu, but by formaldehyde, which is sometimes used in Indonesia as a preservative.

    The researchers admit that more research is required to ascertain whether the same effects are found in other ethnic groups.

    However, previous research has also linked high tofu consumption to an increased risk of dementia in older Japanese American men.

    The researchers found high tofu consumption - at least once a day - was associated with worse memory, particularly among the over-68s. "
Matti Narkia

Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty aci... - 0 views

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    Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty acids.
    Ohman M, Akerfeldt T, Nilsson I, Rosen C, Hansson LO, Carlsson M, Larsson A.
    Ups J Med Sci. 2008;113(3):315-23.P
    MID: 18991244

    Today, eggs with an increased content of -3 fatty acids are available but there are few publications on the effects of consumption of such eggs on the lipoproteins and acute phase markers in humans. The aim of the present study was to evaluate the effects of consumption of standard eggs and -3 enriched eggs on lipoproteins, glucose and inflammation markers. Nineteen healthy volunteers consumed one extra egg per day of either standard eggs or omega-3 enriched eggs in a double-blind, cross-over study. The duration of each period was 1 month. The effects of the different egg diets on apolipoprotein A1 and B (Apo A1 and B), lipoprotein (a), creatinine, cystatin C, C-reactive protein, serum amyloid protein A, interleukin 6, triglycerides, glucose, total-, high-density lipoprotein and low-density lipo-protein cholesterol concentrations were analyzed. Addition of one regular egg per day to the normal diet had no negative impact on blood lipids or inflammation markers. Consumption of omega-3 enriched eggs resulted in higher levels of ApoA1, lower ApoB/ApoA1 ratio and lower plasma glucose. These effects have been associated in previous studies with a reduced risk for cardiovascular mortality and diabetes.
Matti Narkia

Egg consumption in relation to cardiovascular disease and mortality: the Phys... - 0 views

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    Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health Study.
    Djoussé L, Gaziano JM.
    Am J Clin Nutr. 2008 Apr;87(4):964-9.
    PMID: 18400720

    Results: In an average follow-up of 20 y, 1550 new myocardial infarctions (MIs), 1342 incident strokes, and 5169 deaths occurred. Egg consumption was not associated with incident MI or stroke in a multivariate Cox regression. In contrast, adjusted hazard ratios (95% CI) for mortality were 1.0 (reference), 0.94 (0.87, 1.02), 1.03 (0.95, 1.11), 1.05 (0.93, 1.19), and 1.23 (1.11, 1.36) for the consumption of <1, 1>< 0.0001). This association was stronger among diabetic subjects, in whom the risk of death in a comparison of the highest with the lowest category of egg consumption was twofold (hazard ratio: 2.01; 95% CI: 1.26, 3.20; P for interaction = 0.09).

    Conclusions: Infrequent egg consumption does not seem to influence the risk of CVD in male physicians. In addition, egg consumption was positively related to mortality, more strongly so in diabetic subjects, in the study population.
Matti Narkia

Egg consumption in relation to cardiovascular disease and mortality: the story gets mor... - 0 views

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    Egg consumption in relation to cardiovascular disease and mortality: the story gets more complex.
    Eckel RH.
    Am J Clin Nutr. 2008 Apr;87(4):799-800.
    PMID: 1840069
Matti Narkia

Cardiovascular Risk and {alpha}-Linolenic Acid: Can Costa Rica Clarify? -- Harris 118 (... - 0 views

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    Cardiovascular risk and alpha-linolenic acid: can Costa Rica clarify?
    Harris WS.
    Circulation. 2008 Jul 22;118(4):323-4. Epub 2008 Jul 7. Review. PMID: 18606912
    doi: 10.1161/CIRCULATIONAHA.108.791467
Matti Narkia

{alpha}-Linolenic Acid and Risk of Nonfatal Acute Myocardial Infarction -- Campos et al... - 0 views

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    Alpha-linolenic acid and risk of nonfatal acute myocardial infarction.
    Campos H, Baylin A, Willett WC.
    Circulation. 2008 Jul 22;118(4):339-45. Epub 2008 Jul 7. Erratum in: Circulation. 2008 Sep 16;118(12):e492.
    PMID: 18606916
    doi: 10.1161/CIRCULATIONAHA.107.762419

    Conclusions - Consumption of vegetable oils rich in {alpha}-linolenic acid could confer important cardiovascular protection. The apparent protective effect of {alpha}-linolenic acid is most evident among subjects with low intakes.
Matti Narkia

Alpha-linolenic acid reduces risk of nonfatal MI - theheart.org - 0 views

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    "July 9, 2008 | Michael O'Riordan
    Boston, MA - The consumption of a diet containing vegetable oils rich in alpha-linolenic acid (ALA) is associated with significant reductions in the risk of nonfatal MI, a new study has shown [1]. Investigators say the protective effect of ALA is evident among individuals with low intakes, suggesting the greatest benefit might be in developing countries, where fatty-acid consumption is limited.

    "The potential for benefit is great when the baseline intake is low," said lead investigator Dr Hannia Campos (Harvard Medical School, Boston, MA). "In countries where people eat very little fish-and some of these countries have almost no sources of omega-3 fatty acids because they cook with corn or sunflower oils-the consumption of vegetable oils with ALA could have a major impact on heart disease."

    In an editorial accompanying the published study [2], Dr William Harris (University of South Dakota, Sioux Falls) said that the data are suggestive and would be good news for individuals who will not or cannot eat fish, but more studies are still needed. "If ALA were able to do the same 'heavy lifting' that [eicosapentaenoic acid] EPA and [docosahexaenoic acid] DHA do, this would be welcomed news, because the capacity to produce ALA is essentially limitless, whereas there are only so many fish in the sea," he writes. "
Matti Narkia

Vitamin D Deficiency and Risk of Cardiovascular Disease -- Wang et al., 10.1161/CIRCULA... - 0 views

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    Vitamin D deficiency and risk of cardiovascular disease.
    Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D'Agostino RB, Wolf M, Vasan RS.
    Circulation. 2008 Jan 29;117(4):503-11. Epub 2008 Jan 7.
    PMID: 18180395
    doi: 10.1161/CIRCULATIONAHA.107.706127

    Conclusions-Vitamin D deficiency is associated with incident cardiovascular disease. Further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease.
Matti Narkia

Effects of a short-term intervention with a paleolithic diet in healthy volunteers - Eu... - 0 views

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    Effects of a short-term intervention with a paleolithic diet in healthy volunteers.
    Osterdahl M, Kocturk T, Koochek A, Wändell PE.
    Eur J Clin Nutr. 2008 May;62(5):682-5. Epub 2007 May 16.
    PMID: 17522610

    Conclusion: This short-term intervention showed some favourable effects by the diet, but further studies, including control group, are needed.
Matti Narkia

Vitamin D and cardiovascular disease risk : Current Opinion in Clinical Nutrition & Met... - 0 views

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    Vitamin D and cardiovascular disease risk.
    Michos ED, Melamed ML.
    Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):7-12. Review.
    PMID: 18090651
    doi: 10.1097/MCO.0b013e3282f2f4dd

    Summary: Vitamin D deficiency is easy to screen for and easy to treat with supplementation. Further larger observational studies and randomized clinical trials are, however, needed to determine whether vitamin D supplementation could have any potential benefit in reducing future cardiovascular disease events and mortality risk.
Matti Narkia

African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox -- Aloia 88 (2): 54... - 0 views

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    African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox.
    Aloia JF.
    Am J Clin Nutr. 2008 Aug;88(2):545S-550S. Review.
    PMID: 18689399
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