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Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. [No authors listed] Lancet. 1999 Aug 7;354(9177):447-55. Erratum in: Lancet 2001 Feb 24;357(9256):642. Lancet. 2007 Jan 13;369(9556):106. PMID: 10465168 Interpretation Dietary supplementation with n-3 PUFA led to a clinically important and satistically significant benefit. Vitamin E had no benefit. Its effects on fatal cardiovascular events require further exploration

"New research study published in a peer-reviewed publication Nutrition indicates that selenium may be linked to higher cholesterol readings in those who supplement. This one may push it over the edge for me on taking selenium supplements . . . Scientists at the University of Warwick Medical School said consuming too much selenium can have adverse effects. While it has strong antioxidant properties, and the above-mentioned perception that it can reduce cancer risks, there is now an apparently legitimate concern that higher quantities of selenium found in some supplements may be a bad thing. The scientists reached this conclusion after examining the relationship between plasma selenium concentrations (levels of selenium in the blood) with blood lipids (fats in the blood). A cross-sectional study of the1042 participants in the 2000-2001 National Diet and Nutrition Survey (United Kingdom) revealed that among those with higher plasma selenium (more than 1.20 µmol/L) there was an increase in the average total cholesterol level of 8 per cent (0.39 mmol/L (i.e. 15.1 mg/dL). Researchers also found a 10 per cent increase in non-HDL cholesterol levels, which is the bad cholesterol most closely linked to heart disease."

Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acid. Saw CL, Huang Y, Kong AN. Biochem Pharmacol. 2010 Feb 1;79(3):421-30. Epub 2009 Sep 8. PMID: 19744468