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Matti Narkia

DCA and vanadium combination - The DCA Site - Updating You on DCA and Cancer - Dichloro... - 0 views

    Simultaneously Blocking Glycolysis and Fat Metabolism

    Can the use of DCA and a fatty acid metabolism blocker together force more cancer cells into using aerobic metabolism?

    Tim McGough used green tea extract, which contains EGCG, in his fantastic response.

    DCA works by reactivating mitochondria and shifts metabolism from glycolysis to glucose oxidation. Hopefully the cancer cell will then undergo apoptosis. However, cancer cells have an alternate energy source: fat metabolism. This page explores to possibility of blocking fat metabolism to help force the cell into apoptosis.

    Oral squamous cell carcinoma is a cancer that does not respond well to DCA. This study, Head and Neck Cancer Cell Lines Are Resistant to Mitochondrial-Depolarization-Induced Apoptosis states:

    "Results: ΔΨm in head and neck cell lines started to show slight loss of ΔΨm, while HL-60 showed significant loss of ΔΨm after 30 min of treatment. All cell lines demonstrated complete mitochondrial depolarization within 24 h, however, only the control cell line HL-60 underwent apoptosis. In addition, HNSCC cell lines did not demonstrate cytoplasmic cytochrome c release despite significant mitochondrial membrane depolarization, while HL-60 cell initiated apoptosis and cytochcrome c release after 24 h of treatment. Conclusions: Head and neck cancer cell lines exhibit defects in mitochondrial-membrane-depolarization-induced apoptosis as well as impaired release of cytochrome c despite significant mitochondrial membrane depolarization. Proximal defects in the mitochondrial apoptosis pathway are a feature of HNSCC.(head and neck squamous cell carcinoma)"

    Note that although the cell lines were depolarized, apoptosis did not occur. So I checked to see if fatty acid metabolism is used by squamous cell carcinoma.
Matti Narkia

Sulbutiamine : by Ray Sahelian, M.D. - 0 views

    Sulbutiamine is a centrally acting cholinergic vitamin B analogue. One study shows sulbutiamine improve memory in rats. At this time I prefer using a combination of several B vitamins rather than relying on one vitamin B analogue. For more information on B vitamins or to purchase Vitamin B Coenzyme. Even better is to take a multivitamin that has a combination of the B vitamins along with a couple of dozen vitamins and nutrients. In most cases I think it is better to take a small amount of a number of different nutrients as opposed to a large amount of just one. Consider a very popular product that I have formulated called MultiVit-Rx.
Matti Narkia

Benfotiamine nothing but "Snake Oil" - 0 views

    A popular vitamin supplement is being advertised with claims that are demonstrably untrue, as revealed by research published in the open access journal BMC Pharmacology.

    Benfotiamine is a synthetic derivative of thiamine (vitamin B1). It is marketed heavily as a dietary supplement using a selection of unsubstantiated, 'not-quite-medical' claims that tend to characterize this field. A large part of this campaign has been built around the belief that benfotiamine is lipid-soluble and, therefore, more physiologically active. Scientific research led by Dr Lucien Bettendorff of the Center for Cellular and Molecular Neurobiology at the University of Liège, Belgium, has entirely disproved these claims.
Matti Narkia

Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of actio... - 0 views

    Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives.
    Volvert ML, Seyen S, Piette M, Evrard B, Gangolf M, Plumier JC, Bettendorff L.
    BMC Pharmacol. 2008 Jun 12;8:10.
    PMID: 18549472

    Our results show that, though benfotiamine strongly increases thiamine levels in blood and liver, it has no significant effect in the brain. This would explain why beneficial effects of benfotiamine have only been observed in peripheral tissues, while sulbutiamine, a lipid-soluble thiamine disulfide derivative, that increases thiamine derivatives in the brain as well as in cultured cells, acts as a central nervous system drug. We propose that benfotiamine only penetrates the cells after dephosphorylation by intestinal alkaline phosphatases. It then enters the bloodstream as S-benzoylthiamine that is converted to thiamine in erythrocytes and in the liver. Benfotiamine, an S-acyl derivative practically insoluble in organic solvents, should therefore be differentiated from truly lipid-soluble thiamine disulfide derivatives (allithiamine and the synthetic sulbutiamine and fursultiamine) with a different mechanism of absorption and different pharmacological properties.
Matti Narkia

Benfotiamine.Net - Diabetic Nutritional Supplement, Neuropathy Treatment, Enzyme Transk... - 0 views

    This site was established to provide visitors with comprehensive information about benfotiamine, a synthetic derivative of thiamine (vitamin B-1) which shows promise in treating a number of neurological and vascular conditions. Benfotiamine also appears to have beneficial anti-aging qualities, protecting human cells from harmful metabolic end products.

    Benfotiamine is not just for diabetics. Any population suffering from conditions brought about by unknown or inadvertent thiamine deficiencies should respond well to benfotiamine. Benfotiamine is emerging as the most effective of the thiamine compounds.
Matti Narkia

Benfotiamine - Wikipedia, the free encyclopedia - 0 views

    Benfotiamine (rINN, or S-benzoylthiamine O-monophoshate) is a synthetic S-acyl derivative of thiamine (vitamine B1). After absorption, benfotiamine can be dephosphorylated by cells bearing an ecto-alkaline phosphatase to the lipid-soluble S-benzoylthiamine.

    The primary use of this antioxidant is as an "anti-AGE" supplement.[3] In a trial, benfotiamine lowered AGE by 40%.[4] However, in Germany doctors have been known to combine benfotiamine with pyridoxine hydrochloride and use it to treat patients with nerve damage and nerve pain such as sciatica.
    At high doses, benfotiamine was shown to be effective for the treatment of diabetic retinopathy, neuropathy, and nephropathy. I
Matti Narkia

Sulbutiamine - Wikipedia, the free encyclopedia - 0 views

    Sulbutiamine (brand name: Arcalion) is a precursor to thiamine (i.e., vitamin B1). As a dimer of two structurally modified thiamine residues, sulbutiamine retains many of the features of thiamine. However, the thiazole rings are open, the alcohol groups are esterified, and a disulfide bridge connects the two thiamine analogues.

    Sulbutiamine is indicated for the treatment of asthenia.[1] Its ability to reduce fatigue is also considered desirable by athletes, and it is available for over-the-counter sale as a nutritional supplement. In one study of chronic fatigue patients, sulbutiamine did not demonstrate sustained benefits over the placebo, which raises doubts about its clinical efficacy.[2] However, the authors of that study suggest that additional research is needed to evalulate the potential usefulness of sulbutiamine in the treatment of chronic fatigue.
    Sulbutiamine may be beneficial for cognition. Indeed, the demonstrated ability of sulbutiamine to improve memory in rats[3] and patients of schizophrenia[3] suggests that it is a nootropic.
    Recent research also shows support for the use of sulbutiamine in the treatment of erectile dysfunction
Matti Narkia

Micronutrient Information Center - Linus Pauling Institute at Oregon State University - 0 views

    The Linus Pauling Institute's Micronutrient Information Center is a source for scientifically accurate information regarding the roles of vitamins, minerals, other nutrients, dietary phytochemicals (plant chemicals that may affect health), and some foods
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