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Matti Narkia

Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal J... - 0 views

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    Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women.
    Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, Miyachi M, Sasaki S, Ishimi Y.
    J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):15-21.
    PMID: 19352059

    It has been reported that treatment with a pharmacological dose (45 mg/d) of menaquinone-4 (MK-4) prevents bone loss in postmenopausal women. However, it is not known whether supplementation with low dose MK-4 has beneficial effects on bone metabolism in healthy women. The aim of this study is to examine the effects of the supplementation of 1.5 mg/d MK-4 for 4 wk on bone and lipid metabolism in healthy postmenopausal Japanese women. The study was performed as a randomized double blind placebo-controlled trial. The participants aged 53-65 y were randomly assigned to 2 groups and supplemented with 1.5 mg/d of MK-4 or a placebo for 4 wk (n=20 for each group). The most marked effects of MK-4 intake were observed on serum osteocalcin (OC) concentrations. Serum undercarboxylated OC (ucOC) concentration decreased, and the gamma-carboxylated OC (GlaOC) and GlaOC/GlaOC+ucOC ratio that indicates the degree of OC gamma-carboxylation increased significantly at 2 and 4 wk compared with that at baseline in the MK-4 group. The serum ucOC and GlaOC concentrations in the MK-4 group were significantly different from those in the placebo group at 2 wk. These results suggest that supplementation with 1.5 mg/d MK-4 accelerated the degree of OC gamma-carboxylation. The concentrations of serum lipids and other indices were not different between the groups at either intervention period. Thus, the additional intake of MK-4 might be beneficial in the maintenance of bone health in postmenopausal Japanese women.
Matti Narkia

Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sun... - 0 views

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    Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?
    Pignotti GA, Genaro PS, Pinheiro MM, Szejnfeld VL, Martini LA.
    Eur J Nutr. 2009 Nov 28. [Epub ahead of print]
    PMID: 19946776

    CONCLUSION: The dose given (400 IU/day) was not enough to achieve 25(OH)D concentration, considered optimal for bone health.
Matti Narkia

Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-... - 0 views

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    Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study.
    Kim J, Lim SY, Shin A, Sung MK, Ro J, Kang HS, Lee KS, Kim SW, Lee ES.
    BMC Cancer. 2009 Jun 30;9:216.
    PMID: 19566923
    doi: 10.1186/1471-2407-9-216

    Conclusion
    These results suggest that high consumption of fatty fish is associated with a reduced risk for breast cancer, and that the intake of omega-3 fatty acids from fish is inversely associated with postmenopausal breast cancer risk
Matti Narkia

Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal J... - 0 views

  •  
    Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women.
    Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, Miyachi M, Sasaki S, Ishimi Y.
    J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):15-21.
    PMID: 19352059

    These results suggest that supplementation with 1.5 mg/d MK-4 accelerated the degree of OC gamma-carboxylation. The concentrations of serum lipids and other indices were not different between the groups at either intervention period. Thus, the additional intake of MK-4 might be beneficial in the maintenance of bone health in postmenopausal Japanese women.
Matti Narkia

A high menaquinone reduces the incidence of coronary heart disease in women - 0 views

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    A high menaquinone reduces the incidence of coronary heart disease in women.\nGast GC, de Roos NM, Sluijs I, Bots ML, Beulens JW, Geleijnse JM, Witteman JC, Grobbee DE, Peeters PH, van der Schouw YT.\nNutr Metab Cardiovasc Dis. 2009 Jan 27. [Epub ahead of print]\nPMID: 19179058 \ndoi: 10.1016/j.numecd.2008.10.004\n
Matti Narkia

Vitamin K2, but not K1, effective for heart health benefits: Study - 0 views

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    Increased intakes of vitamin K2, but not vitamin K1, may decrease the risk of coronary heart disease in postmenopausal women, says a new study.\nFor every 10 microgram increase in the amount of vitamin K2 consumed, researchers from the Netherlands report a 9 per cent reduction in the risk of developing coronary heart disease (CHD).
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