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Weiye Loh

Alzheimer's Studies Find New Genetic Links - NYTimes.com - 0 views

  • The two largest studies of Alzheimer’s disease have led to the discovery of no fewer than five genes that provide intriguing new clues to why the disease strikes and how it progresses.
  • For years, there have been unproven but persistent hints that cholesterol and inflammation are part of the disease process. People with high cholesterol are more likely to get the disease. Strokes and head injuries, which make Alzheimer’s more likely, also cause brain inflammation. Now, some of the newly discovered genes appear to bolster this line of thought, because some are involved with cholesterol and others are linked to inflammation or the transport of molecules inside cells.
  • By themselves, the genes are not nearly as important a factor as APOE, a gene discovered in 1995 that greatly increases risk for the disease: by 400 percent if a person inherits a copy from one parent, by 1,000 percent if from both parents.
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  • In contrast, each of the new genes increases risk by no more than 10 to 15 percent; for that reason, they will not be used to decide if a person is likely to develop Alzheimer’s. APOE, which is involved in metabolizing cholesterol, “is in a class of its own,” said Dr. Rudolph Tanzi, a neurology professor at Harvard Medical School and an author of one of the papers.
  • But researchers say that even a slight increase in risk helps them in understanding the disease and developing new therapies. And like APOE, some of the newly discovered genes appear to be involved with cholesterol.
  • The other paper is by researchers in Britain, France and other European countries with contributions from the United States. They confirmed the genes found by the American researchers and added one more gene.
  • The American study got started about three years ago when Gerard D. Schellenberg, a pathology professor at the University of Pennsylvania, went to the National Institutes of Health with a complaint and a proposal. Individual research groups had been doing their own genome studies but not having much success, because no one center had enough subjects. In an interview, Dr. Schellenberg said that he had told Dr. Richard J. Hodes, director of the National Institute on Aging, the small genomic studies had to stop, and that Dr. Hodes had agreed. These days, Dr. Hodes said, “the old model in which researchers jealously guarded their data is no longer applicable.”
  • So Dr. Schellenberg set out to gather all the data he could on Alzheimer’s patients and on healthy people of the same ages. The idea was to compare one million positions on each person’s genome to determine whether some genes were more common in those who had Alzheimer’s. “I spent a lot of time being nice to people on the phone,” Dr. Schellenberg said. He got what he wanted: nearly every Alzheimer’s center and Alzheimer’s geneticist in the country cooperated. Dr. Schellenberg and his colleagues used the mass of genetic data to do an analysis and find the genes and then, using two different populations, to confirm that the same genes were conferring the risk. That helped assure the investigators that they were not looking at a chance association. It was a huge effort, Dr. Mayeux said. Many medical centers had Alzheimer’s patients’ tissue sitting in freezers. They had to extract the DNA and do genome scans.
  • “One of my jobs was to make sure the Alzheimer’s cases really were cases — that they had used some reasonable criteria” for diagnosis, Dr. Mayeux said. “And I had to be sure that people who were unaffected really were unaffected.”
  • Meanwhile, the European group, led by Dr. Julie Williams of the School of Medicine at Cardiff University, was engaged in a similar effort. Dr. Schellenberg said the two groups compared their results and were reassured that they were largely finding the same genes. “If there were mistakes, we wouldn’t see the same things,” he added. Now the European and American groups are pooling their data to do an enormous study, looking for genes in the combined samples. “We are upping the sample size,” Dr. Schellenberg said. “We are pretty sure more stuff will pop out.”
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    Gene Study Yields
Weiye Loh

Roger Pielke Jr.'s Blog: A Decrease in Floods Around the World? - 0 views

  • Bouziotas et al. presented a paper at the EGU a few weeks ago (PDF) and concluded: Analysis of trends and of aggregated time series on climatic (30-year) scale does not indicate consistent trends worldwide. Despite common perception, in general, the detected trends are more negative (less intense floods in most recent years) than positive. Similarly, Svensson et al. (2005) and Di Baldassarre et al. (2010) did not find systematical change neither in flood increasing or decreasing numbers nor change in flood magnitudes in their analysis.
  • This finding is largely consistent with Kundzewicz et al. (2005) who find: Out of more than a thousand long time series made available by the Global Runoff Data Centre (GRDC) in Koblenz, Germany, a worldwide data set consisting of 195 long series of daily mean flow records was selected, based on such criteria as length of series, currency, lack of gaps and missing values, adequate geographical distribution, and priority to smaller catchments. The analysis of annual maximum flows does not support the hypothesis of ubiquitous growth of high flows. Although 27 cases of strong, statistically significant increase were identified by the Mann-Kendall test, there are 31 decreases as well, and most (137) time series do not show any significant changes (at the 10% level). Caution is advised in interpreting these results as flooding is a complex phenomenon, caused by a number of factors that can be associated with local, regional, and hemispheric climatic processes. Moreover, river flow has strong natural variability and exhibits long-term persistence which can confound the results of trend and significance tests.
  • estructive floods observed in the last decade all over the world have led to record high material damage. The conventional belief is that the increasing cost of floods is associated with increasing human development on flood plains (Pielke & Downton, 2000). However, the question remains as to whether or not the frequency and/or magnitude of flooding is also increasing and, if so, whether it is in response to climate variability and change. Several scenarios of future climate indicate a likelihood of increased intense precipitation and flood hazard. However, observations to date provide no conclusive and general proof as to how climate change affects flood behaviour.
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  • References: Bouziotas, D., G. Deskos, N. Mastrantonas, D. Tsaknias, G. Vangelidis, S.M. Papalexiou, and D. Koutsoyiannis, Long-term properties of annual maximum daily river discharge worldwide, European Geosciences Union General Assembly 2011, Geophysical Research Abstracts, Vol. 13, Vienna, EGU2011-1439, European Geosciences Union, 2011. Kundzewicz, Z.W., D. Graczyk, T. Maurer, I. Przymusińska, M. Radziejewski, C. Svensson and M. Szwed, 2005(a):Trend detection in river flow time-series: 1. annual maximum flow. Hydrol. Sci. J., 50(5): 797-810.
Weiye Loh

Our local Animation industry | the kent ridge common - 0 views

  • While many industrial veterans here put the blame solely on the “bo chap” attitudes of the students, I wish to point out the fact that those industrial veterans in the animation industry are just too afraid to admit that it was the fault of the tertiary education systems. It is true that while some students have an attitude problem, the lecturers in the polytechnics and universities have their fair share of the blame too. I also wish to speak up for students who have the passion for the industry but they are not shown the right path. Otherwise how do you explain that it took my mentor 2 years and only half the price of the poly fees to teach me all that I needed to know to find a job in the CG industry?
Weiye Loh

Our local Animation industry | the kent ridge common - 0 views

  • What is the truth regarding our local Animation industry, you ask? The truth is… our local industry… is dying. Dying from foreign competition from giants. Dying because our locals are not supportive of our native talents. Dying before we make an animation that is truly made in Singapore.
  • our education system has failed its citizens to make sure that we are up to the mark for the various requirements of the job market in whichever industry. This made us much more vulnerable to the influx of foreign animators, who can accept lower pay and produce higher quality work than the locals; effectively starving out the local animators and animation companies.
  • To make matters worse, the government managed to woo top foreign animation companies to set up shop in Singapore, effectively killing the local companies. Many of these foreign animation companies hire lesser locals and receive government funding while local companies are left to fend for themselves. If you think about it, with the billions of dollars it makes every year, does Lucasfilm Singapore require that government funding to set up shop in Singapore? My mentor’s studio once had courses that only costed $2K with government subsidy. But now with government funding cut, the courses now costs $10K. These put a lot of financial pressure on artists with the passion for the animation industry but are financially tight. I was one of the last batches who were under the $2K scheme. Many artists like myself have already been financially drained studying in tertiary education. What they need is a job to feed themselves or in some cases repay the bank! It is not helping given the fact that our locals are being out competed due to an incompetent education system.
Weiye Loh

Response to Guardian's Article on Singapore Elections | the kent ridge common - 0 views

  • Further, grumblings on Facebook accounts are hardly ‘anonymous’. Lastly, how anonymous can bloggers be, when every now and then a racist blogger gets arrested by the state? Think about it. These sorts of cases prove that the state does screen, survey and monitor the online community, and as all of us know there are many vehement anti-PAP comments and articles, much of which are outright slander and defamation.
  • Yet at the end of the day, it is the racist blogger, not the anti-government or anti-PAP blogger that gets arrested. The Singaporean model is a much more complex and sophisticated phenomenon than this Guardian writer gives it credit.
  • Why did this Guardian writer, anyway, pander to a favourite Western stereotype of that “far-off Asian undemocratic, repressive regime”? Is she really in Singapore as the Guardian claims? (“Kate Hodal in Singapore” is written at the top) Can the Guardian be anymore predictable and trite?
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  • Can any Singaporean honestly say the she/he can conceive of a fellow Singaporean setting himself or herself on fire along Orchard Road or Shenton Way, as a result of desperate economic pressures or financial constraints? Can we even fathom the social and economic pressures that mobilized a whole people to protest and overthrow a corrupt, US-backed regime? (that is, not during elections time) Singapore has real problems, the People’s Action Party has its real problems, and there is indeed much room for improvement. Yet such irresponsible reporting by one of the esteemed newspapers from the UK is utterly disappointing, not constructive in the least sense, and utterly misrepresents our political situation (and may potentially provoke more irrationality in our society, leading people to ‘believe’ their affinity with their Arab peers which leads to more radicalism).
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    Further, grumblings on Facebook accounts are hardly 'anonymous'. Lastly, how anonymous can bloggers be, when every now and then a racist blogger gets arrested by the state? Think about it. These sorts of cases prove that the state does screen, survey and monitor the online community, and as all of us know there are many vehement anti-PAP comments and articles, much of which are outright slander and defamation. Yet at the end of the day, it is the racist blogger, not the anti-government or anti-PAP blogger that gets arrested. The Singaporean model is a much more complex and sophisticated phenomenon than this Guardian writer gives it credit.
Weiye Loh

Response to Guardian's Article on Singapore Elections | the kent ridge common - 0 views

  • The first reductive move made by the writer occurs here: “Singapore is known worldwide for censorship and corporal punishment.” This is the Western media’s favourite trope of our island-nation. A whole political context and dynamic society gets reduced to these two ‘dirty’ words, at least for a ‘Western’ world that prides itself on ‘freedom’ and believes itself to be on a moral high ground because of this veritable self-image. (One could argue that censorship in the ‘West’ exists but in a different form – there, capitalist hegemons control media companies which quite effectively draw the boundaries of public debate.)
  • The writer first makes the observation that lots of people have started to speak up and speak out against the “clan” that has ruled Singapore for almost 50 years. The People’s Action Party, is for Ms Hodal, not a political party, but a “clan” – which harks back to tribal societies, to tribalism.
  • Out of all these unsuitable candidates, the writer chose the Arab Spring as the comparative situation of choice for Singapore, despite the fact that the Arab Spring movements did not occur at a time of elections, that much of the physical ‘protesting’ in Singapore was witnessed at political rallies, that there was no bottom-up movement of ‘revolt’. It is the time of the elections; it is a nationally-licensed period of political behaviour and action, for society to perform a cathartic release, for the Bakhtinian carnavalesque to unfold.
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  • The reductive move is completed in this next sentence: “Parallels with the Arab spring are striking, even if revolution is not just around the corner.”
  • She writes, “Most murmurs of discontent can be found online: fears of reprisal are diminished for anonymous bloggers. On internet forums, blogs, Facebook and Twitter, grumblings about high housing prices, the widening gap between rich and poor, immigration laws and the salaries of government ministers (among the highest in the world) are hot topics.” The most popular online newspapers, barring the Temasek Review, are The Online Citizen, mr. brown, Mr. Wang Says So, Yawningbread, etc. All these are run by people who publicly reveal their names, which increases the credibility of these sites and also instills a sense of responsibility in their writings. This is part of the reason for their enduring popularity.
Weiye Loh

In a Brooklyn Loft, Twitter Stars Find Common Ground - NYTimes.com - 0 views

  • Five years ago, a group like Studiomates probably wouldn’t have been a group at all but rather two dozen strangers in search of a Wi-Fi signal at Starbucks. The 26 members, who each pay $500 a month for a desk, are mostly engaged in independent projects in unrelated fields, and have no practical reason to work together. But as the new media pundit Clay Shirky said at the South by Southwest conference in March, “we systematically overestimate the value of access to information and underestimate the value of access to each other.”
  • “Sure, we could all be home doing what we do, but why would we?” Tina Roth Eisenberg (a k a swissmiss) said as her studio mates clacked away at their MacBooks. “I just like being around nerdy creative people all day long. It helps make sense of all the information coming at us.” Studiomates is an especially information-oriented bunch, and an influential one, too. In addition to her swissmiss blog and Twitter following of 200,000, Ms. Eisenberg is the founder of Creative Mornings, a popular monthly speaking series that has young designers in four cities talking.
  • Much of the content for her blog and Twitter feed comes from the casual conversations at Studiomates. “The day-to-day distraction level may be slightly higher,” Ms. Popova said. “But in terms of the influx of the building blocks of productivity — ideas, story tips, the interesting people who come in — an environment like this is priceless.”
Weiye Loh

Data.gov.sg - 0 views

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    What is data.gov.sg? data.gov.sg is the first-stop portal to search and access publicly-available data published by the Singapore Government. Launched in June 2011, data.gov.sg brings together over 5000 datasets from 50 government ministries and agencies. The aims of the portal are to : Provide convenient access to publicly-available data published by the government Create value by catalysing application development Facilitate analysis and research Besides government data and metadata, data.gov.sg also offers a listing of applications developed using government data, as well as a resource page for developers. data.gov.sg was initiated by the Ministry of Finance along with the Infocomm Development Authority of Singapore . Key partners for this initiative are the Singapore Land Authority and the Singapore Department of Statistics.
Weiye Loh

FleetStreetBlues: Independent columnist Johann Hari admits copying and pasting interview quotes - 0 views

  • this isn't just a case of referencing something the interviewee has written previously - 'As XXX has written before...', or such like. No, Hari adds dramatic context to quotes which were never said - the following paragraph, for instance, is one of the quotes from the Levy interview which seems to have appeared elsewhere before. After saying this, he falls silent, and we stare at each other for a while. Then he says, in a quieter voice: “The facts are clear. Israel has no real intention of quitting the territories or allowing the Palestinian people to exercise their rights. No change will come to pass in the complacent, belligerent, and condescending Israel of today. This is the time to come up with a rehabilitation programme for Israel.”
  • So how does Hari justify it? Well, his post on 'Interview etiquette', as he calls it, is so stunningly brazen about playing fast-and-loose with quotes
  • When I’ve interviewed a writer, it’s quite common that they will express an idea or sentiment to me that they have expressed before in their writing – and, almost always, they’ve said it more clearly in writing than in speech. (I know I write much more clearly than I speak – whenever I read a transcript of what I’ve said, or it always seems less clear and more clotted. I think we’ve all had that sensation in one form or another). So occasionally, at the point in the interview where the subject has expressed an idea, I’ve quoted the idea as they expressed it in writing, rather than how they expressed it in speech. It’s a way of making sure the reader understands the point that (say) Gideon Levy wants to make as clearly as possible, while retaining the directness of the interview. Since my interviews are intellectual portraits that I hope explain how a person thinks, it seemed the most thorough way of doing it...
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  • ...I’m a bit bemused to find one blogger considers this “plagiarism”. Who’s being plagiarized? Plagiarism is passing off somebody else’s intellectual work as your own – whereas I’m always making it clear that (say) Gideon Levy’s thought is Gideon Levy’s thought. I’m also a bit bemused to find that some people consider this “churnalism”. Churnalism is a journalist taking a press release and mindlessly recycling it – not a journalist carefully reading over all a writer’s books and selecting parts of it to accurately quote at certain key moments to best reflect how they think.
  • I called round a few other interviewers for British newspapers and they said what I did was normal practice and they had done it themselves from time to time. My test for journalism is always – would the readers mind you did this, or prefer it? Would they rather I quoted an unclear sentence expressing a thought, or a clear sentence expressing the same thought by the same person very recently? Both give an accurate sense of what a person is like, but one makes their ideas as accessible as possible for the reader while also being an accurate portrait of the person.
  • The Independent's top columnist and interviewer has just admitted that he routinely adds things his interviewees have written at some point in the past to their quotes, and then deliberately passes these statements off as though they were said to him in the course of an interview. The main art of being an interviewer is to be skilled at eliciting the right quotes from your subject. If Johann Hari wants to write 'intellectual portraits', he should go and write fiction. Do his editors really know that the copy they're printing ('we stare at each other for a while. Then he says in a quieter voice...') is essentially made up? What would Jayson Blair make of it all? Astonishing.
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    In the last few days, a couple of blogs have been scrutinising the work of Johann Hari, the multiple award-winning Independent columnist and interviewer. A week ago on Friday the political DSG blog pointed out an eerie series of similarities between the quotes in Hari's interview with Toni Negri in 2004, and quotes in the book Negri on Negri, published in 2003. Brian Whelan, an editor with Yahoo! Ireland and a regular FleetStreetBlues contributor, spotted this and got in touch to suggest perhaps this wasn't the only time quotes in Hari's interviews had appeared elsewhere before. We ummed and ahhed slightly about running the piece based on one analysis from a self-proclaimed leftist blog - so Brian went away and did some analysis of his own. And found that a number of quotes in Hari's interview with Gideon Levy in the Independent last year had also been copied from elsewhere. So far, so scurrilous. But what's really astonishing is that Johann Hari has now responded to the blog accusations. And cheerfully admitted that he regularly includes in interviews quotes which the interviewee never actually said to him.
Weiye Loh

Interview etiquette : Johann Hari - 0 views

  • occasionally, at the point in the interview where the subject has expressed an idea, I’ve quoted the idea as they expressed it in writing, rather than how they expressed it in speech. It’s a way of making sure the reader understands the point that (say) Gideon Levy wants to make as clearly as possible, while retaining the directness of the interview.
  • if somebody interviewed me and asked my views of Martin Amis, instead of quoting me as saying “Um, I think, you know, he got the figures for, uh, how many Muslims there are in Europe upside down”, they could quote instead what I’d written more cogently about him a month before, as a more accurate representation of my thoughts. I stress: I have only ever done this where the interviewee was making the same or very similar point to me in the interview that they had already made more clearly in print.
  • after doing what must be over fifty interviews, none of my interviewees have ever said they had been misquoted, even when they feel I’ve been very harsh on them in other ways.
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  • Gideon Levy said, after my interview with him was published, that it was “the most accurate take on me anyone has written” and “profoundly moved him” – which hardly fits with the idea it was an inaccurate or misleading picture.
  • one blogger considers this “plagiarism”. Who’s being plagiarized? Plagiarism is passing off somebody else’s intellectual work as your own – whereas I’m always making it clear that (say) Gideon Levy’s thought is Gideon Levy’s thought. I’m also a bit bemused to find that some people consider this “churnalism”. Churnalism is a journalist taking a press release and mindlessly recycling it – not a journalist carefully reading over all a writer’s books and selecting parts of it to accurately quote at certain key moments to best reflect how they think.
  • I called round a few other interviewers for British newspapers and they said what I did was normal practice and they had done it themselves from time to time. My test for journalism is always – would the readers mind you did this, or prefer it? Would they rather I quoted an unclear sentence expressing a thought, or a clear sentence expressing the same thought by the same person very recently? Both give an accurate sense of what a person is like, but one makes their ideas as accessible as possible for the reader while also being an accurate portrait of the person.
Weiye Loh

Too Much Information - Gareth Evans - Project Syndicate - 0 views

  • But some lines do have to be drawn if good government is to be possible, just as a zone of privacy in our personal and family lives is crucial to sustaining the relationships that matter most to us.
  • Some of WikiLeaks’ releases of sensitive material have been perfectly defensible on classic freedom-of-information grounds, exposing abuses that might otherwise have remained concealed. The helicopter gunship killings in Iraq, the corruption of former Tunisian President Zine el-Abidine Ben Ali’s family, and the paucity of progress in Afghanistan are, by this standard, fair game. None of this makes Julian Assange a Daniel Ellsberg (who 40 years ago leaked the Pentagon Papers, exposing US-government thinking on Vietnam). Nor does it put him in the same league with Anna Politkovskaya, the crusading journalist who was murdered after refusing to stop investigating Russian human rights abuses. His stated motives seem too anarchic for that. Sometimes, however, whistles do need to be blown.
  • But some leaks are indefensible, and at least the sources must expect some punitive reckoning. This category includes leaks that put intelligence sources or other individuals at physical risk (as did some of WikiLeaks’ early releases on Afghanistan and Zimbabwe). It also includes leaks that genuinely prejudice intelligence methods and military operational effectiveness; expose exploratory positions in peace negotiations (invariably helping only spoilers); or disclose bottom lines in trade talks. What is clear in all of these cases is that the stakes are so high that it simply cannot be left to the judgment of WikiLeaks and media outlets to make the necessary calls without consulting relevant officials. Sensibly, US officials facilitated such consultations, on a “without prejudice” basis, in some of the early WikiLeaks cases.
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  • The trickiest cases are in a third category: private conversations whose disclosure is bound to cause offense, embarrassment, or tension, but has no obvious redeeming public-policy justification. The problem is not that negative things are said behind closed doors – as one leader famously responded to an apologizing Hillary Clinton, “You should hear what we say about you” – but that they become public knowledge. Particularly in Asia, loss of face means much more than most Westerners will ever understand.
  • these kinds of leaks should not be naively applauded as somehow contributing to better government. They don’t, and won’t, because they will strongly influence at least what is written down and circulated, thereby inhibiting the free exchange of information within government. Leaks of this kind will reinforce the bureaucratic barriers that must be removed if policymaking and implementation are to be effective in all areas that require input, coordination, and common information and analysis across departments and agencies.
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    In government, any leak is, by definition, embarrassing to someone, somewhere in the system. Most leaks are likely to involve some breach of law by the original source, if not by the publisher. But that doesn't mean that all leaks should be condemned. One of the hardest lessons for senior government officials to learn -­ including for me, when I was Australian Attorney General and Foreign Minister - is the futility, in all but a tiny minority of cases, of trying to prosecute and punish those responsible for leaks. It doesn't undo the original damage, and usually compounds it with further publicity. The media are never more enthusiastic about free speech than when they see it reddening the faces, with rage or humiliation, of those in power. Prosecution usually boosts leakers' stature, making it useless as a deterrent.
Weiye Loh

American Medical Association Officially Condemns Photoshopping - Health - GOOD - 0 views

  • The AMA this week formally denounced retouching pictures and asked ad agencies to consider setting stricter guidelines for how photos are manipulated before becoming advertisements.
  • Last year in France, members of parliament advocated attaching warning labels to imagery that had been digitally enhanced; lawmakers in England have also dabbled with the idea. Perhaps the AMA's new stance will be the nudge America needs to follow our European friends' lead. Unfortunately, our staggering eating disorder statistics seem to not be enough.
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