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Weiye Loh

2010 Petrol Prices: International Comparisons - 0 views

  • Petrol prices in all comparison countries were lower than British prices. The average price in the UK today is around 107-109 pence per litre. Looking abroad, petrol was cheapest in US cities (under 40 pence per litre in Dallas) and most expensive in Italy (114 pence per litre).
  • Standard Unleaded Petrol Prices Australia Price (Pence per Litre) Adelaide 68p Brisbane 69p Melbourne 70p Perth 63p Sydney 69p New Zealand Price (Pence per Litre) New Zealand 81p Canada Price (Pence per Litre) Calgary 51p Toronto 55p Vancouver 61p Montreal 59p United States Price (Pence per Litre) Las Vegas 42p Miami 42p Washington 42p Dallas 39p Los Angeles 46p Seattle 42p Europe Price (Pence per Litre) France 112p Spain 96p Italy 114p Greece 95p
  • Comment by Jason on 11 April 2010: I’m from Michigan, USA. Fuel prices here are about $3.00/gal right now. Although this is really hard to afford, because of the absence of real public transportation and the need to drive your own vehicle to work, it has recently become harder because of the downturn of the economy. If you’re planning to move to the US, be prepared for the high prices, and low wages…
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  • Comment by Mike on 4 June 2010: @ Jason, $3.00 per gallon works out at between 50 and 55 UK pence per liter. We pay around about 3 times that amount at the moment. So for us europeans $3.00 dollars a gallon would be a godsend.
kenneth yang

SD ballot measure would ease restrictions on stem cell research - 1 views

PIERRE, S.D. (AP) - A proposed ballot issue to ease restrictions on stem cell research will strike a chord with South Dakotans because nearly everyone has had a serious disease or knows someone who...

ethics rights stem cell

started by kenneth yang on 21 Oct 09 no follow-up yet
Weiye Loh

m.guardian.co.uk - 0 views

  • perhaps the reason stem cells managed to lodge themselves so deep in the public psyche was not just because of their awesome scientific potential, or their ability to turn into the treatments of the future.
  • For years, stem cells dominated all other science stories in newspaper headlines because they framed an ethical conundrum – to get to the most versatile stem cells meant destroying human embryos.
  • Research on stem cells became a political football, leading to delays in funding for scientists, particularly in the US. Not that the work itself was straightforward – the process of extracting stem cells from embryos is difficult and there is a very limited supply of material. Inevitable disappointment followed the years of headlines – where were the promised treatments? Was it all over-hyped?
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  • Key to this is the discovery, in the past few years, of a way to make stem cells that do not require the destruction of embryos. In one move, these induced pluripotent stem (iPS) cells remove the ethical roadblocks faced by embryonic stem cells and, because they are so much easier to make, give scientists an inexhaustible supply of material, bringing them ever closer to those hoped-for treatments.
  • Stem cells are the body's master cells, the raw material from which we are built. Unlike normal body cells, they can reproduce an indefinite number of times and, when prodded in the right way, can turn themselves into any type of cell in the body. The most versatile stem cells are those found in the embryo at just a few days old – this ball of a few dozen embryonic stem (ES) cells eventually goes on to form everything that makes up a person.
Weiye Loh

Cancer resembles life 1 billion years ago, say astrobiologists - microbiology, genomics... - 0 views

  • astrobiologists, working with oncologists in the US, have suggested that cancer resembles ancient forms of life that flourished between 600 million and 1 billion years ago.
  • Read more about what this discovery means for cancer research.
  • The genes that controlled the behaviour of these early multicellular organisms still reside within our own cells, managed by more recent genes that keep them in check.It's when these newer controlling genes fail that the older mechanisms take over, and the cell reverts to its earlier behaviours and grows out of control.
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  • The new theory, published in the journal Physical Biology, has been put forward by two leading figures in the world of cosmology and astrobiology: Paul Davies, director of the Beyond Center for Fundamental Concepts in Science, Arizona State University; and Charles Lineweaver, from the Australian National University.
  • According to Lineweaver, this suggests that cancer is an atavism, or an evolutionary throwback.
  • In the paper, they suggest that a close look at cancer shows similarities with early forms of multicellular life.
  • “Unlike bacteria and viruses, cancer has not developed the capacity to evolve into new forms. In fact, cancer is better understood as the reversion of cells to the way they behaved a little over one billion years ago, when humans were nothing more than loose-knit colonies of only partially differentiated cells. “We think that the tumours that develop in cancer patients today take the same form as these simple cellular structures did more than a billion years ago,” he said.
  • One piece of evidence to support this theory is that cancers appear in virtually all metazoans, with the notable exception of the bizarre naked mole rat."This quasi-ubiquity suggests that the mechanisms of cancer are deep-rooted in evolutionary history, a conjecture that receives support from both paleontology and genetics," they write.
  • the genes that controlled this early multi-cellular form of life are like a computer operating system's 'safe mode', and when there are failures or mutations in the more recent genes that manage the way cells specialise and interact to form the complex life of today, then the earlier level of programming takes over.
  • Their notion is in contrast to a prevailing theory that cancer cells are 'rogue' cells that evolve rapidly within the body, overcoming the normal slew of cellular defences.
  • However, Davies and Lineweaver point out that cancer cells are highly cooperative with each other, if competing with the host's cells. This suggests a pre-existing complexity that is reminiscent of early multicellular life.
  • cancers' manifold survival mechanisms are predictable, and unlikely to emerge spontaneously through evolution within each individual in such a consistent way.
  • The good news is that this means combating cancer is not necessarily as complex as if the cancers were rogue cells evolving new and novel defence mechanisms within the body.Instead, because cancers fall back on the same evolved mechanisms that were used by early life, we can expect them to remain predictable, thus if they're susceptible to treatment, it's unlikely they'll evolve new ways to get around it.
  • If the atavism hypothesis is correct, there are new reasons for optimism," they write.
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Weiye Loh

"Stem Cell City" To Make All Research Available To The Public | The Utopianist - Think ... - 0 views

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    A new website launched in Toronto allows the public to peruse all the current research on stem cells, as well as take a tour of a lab and stay updated on any specific disease - all in the hopes of educating us about a line of research that has huge potential to save a lot of lives. The ethical and political controversy hovering over work with stem cells, particularly embryonic cells - which have the biggest potential but pose the greatest ethical problems - has made work in the field particularly jittery; stop and go funding, as well as confusion about the concept in the public sector hasn't made for the most ideal working conditions. Stem Cell City - an online portal launched yesterday may significantly contribute to the cause, its founding scientists hope.
Weiye Loh

Analysis: Hold the panic on cell phones and cancer | Phones | iOS Central | Macworld - 0 views

  • Today’s cell phones are, essentially, extremely sophisticated radios and, as such, emit electromagnetic waves. Much like the vast majority of radiation that surrounds us—from visible light to AM and FM radio waves—electromagnetic waves do not possess enough energy to interact directly with the tissues in our bodies in a way that can cause direct damage. “The radiation that cell phones emit is nowhere near the kind of radiation that x-ray machines, for example, emit,” says Perras. “X-rays […] have much, much shorter wavelengths. Consequently, [they] carry much more energy and thus have much more penetrating power, which is required to be able to image the interior of the human body.”
  • X-rays and other “hard” waves are called ionizing radiation because they can interact with the human body in a way that leads to the creation of chemical compounds called free radicals that can, in turn, be responsible for mutations and the incidence of cancer.
  • The focus of much of the currently-ongoing scientific research, then, is on whether the radiation emitted by cell phones is focused enough to be absorbed into the body and cause heating, which could, in the long run, damage human tissue and eventually lead to cancer.
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  • The issue is particularly important because most users still hold their phones close to the head; since the brain is particularly sensitive to external stimuli, even a small amount of heat could lead to medical trouble in the long term.
  • What makes it challenging to determine if a link between cell phones and cancer actually exists are the many variables involved. “The incidence of brain tumors is quite small, making it more difficult to study in large numbers,” says Dr. Eric Olyejar, a Radiation Oncologist from Ironwood Cancer and Research Centers, based in Chandler, Ariz. That means “quantifying the lifetime dose each patient received is extremely difficult.”
  • To make things more difficult, cancer often develops as a result of many different factors. “Family history, exposure to chemicals or radiation, growth defects, the amount of radiation that is actually coming from the phone, amount of time used, proximity to the brain, skull thickness, and wave frequency are only a few of the many variables,” Olyejar says.
  • cell phones have become so ubiquitous that it’s hard to compare the health of users and non-users.
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    Do cell phones cause cancer? Nobody really knows for sure, but scientists are determined to keep an eye on the ever-evolving evidence that continues to accumulate on the subject. That's the gist of a report recently released by the World Health Organization's International Agency for Research on Cancer (IARC), the United Nations body responsible for oncological studies. In the report, IARC scientists have classified cell phone usage as a possible cause of cancer, meaning that, while the data currently available is still inconclusive, the subject deserves further research before a call can be made one way or another.
Weiye Loh

New Study Shows EMF Effect On Brain - So What? « Health « Skeptic North - 0 views

  • In the past 6 months, Skeptic North has run several articles about WiFi, cell phones and the purported health effects that radio-frequency electro-magnetic fields (RF-EMF) may or may not have on the brain and body.  Despite the overwhelming evidence to the contrary, the controversy remains to be a popular story in the media, perhaps because of the ubiquitous nature of cellular technology and the popular meme of the hidden dangers of modern life.
  • over the news this week were reports of a new study purporting to show a link between cell phone EMF radiation and increased brain metabolism.  The study was conducted by a well-respected group of NIH researchers conducting tests at the Brookhaven National Laboratory in the US.  The study is available in abstract for free here, but you have to pay to have access to the full text version.  Reporters all over network news told a simplified story of the paper by Volkow et al, published in the Journal of the American Medical Association, and drew conclusions outside the scope of the study, inflaming an already overly effulgent debate.
  •  I and others have continued to insist that there is no good evidence of any effect by the microwave radiation emitted by cell phones, cell towers and other electronics on the brain and other body systems, let alone that this radiation causes cancer or other serious illnesses.  The syndrome referred to as electro-hypersensitivity remains un-proved and unfounded, but it seems like there is new evidence that shows that the normal levels of radiation emitted by a cell phone can effect neuronal cells in the brain.
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    This study is what it is: another thread in the fine woven cloth of our knowledge of nature. It is not a panacea, nor does it refute any evidence that there is or is not a risk of health effects from cell phone use, nor does it show a mechanism of how EMF could alter biological systems. Anybody who purports that it does is basing this conclusion on ideology, not science.
Weiye Loh

Paul Crowley's Blog - A survey of anti-cryonics writing - 0 views

  • cryonics offers almost eternal life. To its critics, cryonics is pseudoscience; the idea that we could freeze someone today in such a way that future technology might be able to re-animate them is nothing more than wishful thinking on the desire to avoid death. Many who battle nonsense dressed as science have spoken out against it: see for example Nano Nonsense and Cryonics, a 2001 article by celebrated skeptic Michael Shermer; or check the Skeptic’s Dictionary or Quackwatch entries on the subject, or for more detail read the essay Cryonics–A futile desire for everlasting life by “Invisible Flan”.
  • And of course the pro-cryonics people have written reams and reams of material such as Ben Best’s Scientific Justification of Cryonics Practice on why they think this is exactly as plausible as I might think, and going into tremendous technical detail setting out arguments for its plausibility and addressing particular difficulties. It’s almost enough to make you want to sign up on the spot. Except, of course, that plenty of totally unscientific ideas are backed by reams of scientific-sounding documents good enough to fool non-experts like me. Backed by the deep pockets of the oil industry, global warming denialism has produced thousands of convincing-sounding arguments against the scientific consensus on CO2 and AGW. T
  • Nano Nonsense and Cryonics goes for the nitty-gritty right away in the opening paragraph:To see the flaw in this system, thaw out a can of frozen strawberries. During freezing, the water within each cell expands, crystallizes, and ruptures the cell membranes. When defrosted, all the intracellular goo oozes out, turning your strawberries into runny mush. This is your brain on cryonics.This sounds convincing, but doesn’t address what cryonicists actually claim. Ben Best, President and CEO of the Cryonics Institute, replies in the comments:Strawberries (and mammalian tissues) are not turned to mush by freezing because water expands and crystallizes inside the cells. Water crystallizes in the extracellular space because more nucleators are found extracellularly. As water crystallizes in the extracellular space, the extracellular salt concentration increases causing cells to lose water osmotically and shrink. Ultimately the cell membranes are broken by crushing from extracellular ice and/or high extracellular salt concentration. […] Cryonics organizations use vitrification perfusion before cooling to cryogenic temperatures. With good brain perfusion, vitrification can reduce ice formation to negligible amounts.
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  • The Skeptic’s Dictionary entry is no advance. Again, it refers erroneously to a “mushy brain”. It points out that the technology to reanimate those in storage does not already exist, but provides no help for us non-experts in assessing whether it is a plausible future technology, like super-fast computers or fusion power, or whether it is as crazy as the sand-powered tank; it simply asserts baldly and to me counterintuitively that it is the latter. Again, perhaps cryonic reanimation is a sand-powered tank, but I can explain to you why a sand-powered tank is implausible if you don’t already know, and if cryonics is in the same league I’d appreciate hearing the explanation.
  • Another part of the article points out the well-known difficulties with whole-body freezing — because the focus is on achieving the best possible preservation of the brain, other parts suffer more. But the reason why the brain is the focus is that you can afford to be a lot bolder in repairing other parts of the body — unlike the brain, if my liver doesn’t survive the freezing, it can be replaced altogether.
  • Further, the article ignores one of the most promising possibilities for reanimation, that of scanning and whole-brain emulation, a route that requires some big advances in computer and scanning technology as well as our understanding of the lowest levels of the brain’s function, but which completely sidesteps any problems with repairing either damage from the freezing process or whatever it was that led to legal death.
  • Sixteen years later, it seems that hasn’t changed; in fact, as far as the issue of technical feasability goes it is starting to look as if on all the Earth, or at least all the Internet, there is not one person who has ever taken the time to read and understand cryonics claims in any detail, still considers it pseudoscience, and has written a paper, article or even a blog post to rebut anything that cryonics advocates actually say. In fact, the best of the comments on my first blog post on the subject are already a higher standard than anything my searches have turned up.
  • I don’t have anything useful to add, I just wanted to say that I feel exactly as you do about cryonics and living forever. And I thought that this statement: I know that I don’t know enough to judge. shows extreme wisdom. If only people wishing to comment on global warming would apply the same test.
  • WRT global warming, the mistake people make is trying to go direct to the first-order evidence, which is much too complicated and too easy to misrepresent to hope to directly interpret unless you make it your life’s work, and even then only in a particular area. The correct thing to do is to collect second-order evidence, such as that every major scientific academy has backed the IPCC.
    • Weiye Loh
       
      First-order evidence vs second-order evidence...
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    Cryonics
Weiye Loh

Evaluating The Evidence for Cell Phones and WiFi « Critical Thinking « Skepti... - 0 views

  • he “weight of evidence” approach to evaluation of causality is often vilified by cell phone and WiFi scare mongers as being an inadequate way to judge the evidence – often because it disagrees with their own sentiments about the science.  If you can’t disqualify the evidence, then you can go after the method of evaluation and disqualify that, right?  Of course, the weight of evidence approach is often portrayed as a dumbshow of putting all the “positive” trials on one side of the scale and all of the “negative” trials on the other and taking the difference in mass as the evidence.  This is how Dr. Phillips characterised it in his paper on electromagnetic fields and DNA damage, as well as his appearance on CBC Radio.  Of course, the procedure is much more like a systematic review, where all of the papers, regardless of their outcomes, are weighed for their quality. (The higher quality studies will have good internal and external validity, proper blinding and randomisation, large enough sample size, proper controls and good statistical analysis; as well as being reproduced by independent investigators.) Then they are tallied and a rational conclusion is offered as to the most likely state of the evidence (of course, it is much more involved than I am stating, but suffice it to say, it does not involve a scale.)   This is standard operating procedure and, in fact, is what we all do when we are evaluating evidence: we decide which studies are good and we pool the evidence before we make a decision.
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    n many discussions of the "dangers" of WiFi and cell phones, the precautionary principle is evoked. It is the idea that we have "an obligation, if the level of harm may be high, for action to prevent or minimise such harm even when the absence of scientific certainty makes it difficult to predict the likelihood of harm occurring, or the level of harm should it occur."  It is important to note that the precautionary principle or approach is required when we do not have a scientific consensus or if we have a lack of scientific certainty.  It is used often in European regulation of potential health and environmental hazards.  "Scientific certainty" is an important clause here, because it does not mean 100% certainty. Science can never give that absolute a result and if we required 100% certainty of no risk, we would not walk out our front doors or even get out of bed, lest we have a mishap.
Weiye Loh

How wise are crowds? - 0 views

  • n the past, economists trying to model the propagation of information through a population would allow any given member of the population to observe the decisions of all the other members, or of a random sampling of them. That made the models easier to deal with mathematically, but it also made them less representative of the real world.
    • Weiye Loh
       
      Random sampling is not representative
  • this paper does is add the important component that this process is typically happening in a social network where you can’t observe what everyone has done, nor can you randomly sample the population to find out what a random sample has done, but rather you see what your particular friends in the network have done,” says Jon Kleinberg, Tisch University Professor in the Cornell University Department of Computer Science, who was not involved in the research. “That introduces a much more complex structure to the problem, but arguably one that’s representative of what typically happens in real settings.”
    • Weiye Loh
       
      So random sampling is actually more accurate?
  • Earlier models, Kleinberg explains, indicated the danger of what economists call information cascades. “If you have a few crucial ingredients — namely, that people are making decisions in order, that they can observe the past actions of other people but they can’t know what those people actually knew — then you have the potential for information cascades to occur, in which large groups of people abandon whatever private information they have and actually, for perfectly rational reasons, follow the crowd,”
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  • The MIT researchers’ paper, however, suggests that the danger of information cascades may not be as dire as it previously seemed.
  • a mathematical model that describes attempts by members of a social network to make binary decisions — such as which of two brands of cell phone to buy — on the basis of decisions made by their neighbors. The model assumes that for all members of the population, there is a single right decision: one of the cell phones is intrinsically better than the other. But some members of the network have bad information about which is which.
  • The MIT researchers analyzed the propagation of information under two different conditions. In one case, there’s a cap on how much any one person can know about the state of the world: even if one cell phone is intrinsically better than the other, no one can determine that with 100 percent certainty. In the other case, there’s no such cap. There’s debate among economists and information theorists about which of these two conditions better reflects reality, and Kleinberg suggests that the answer may vary depending on the type of information propagating through the network. But previous models had suggested that, if there is a cap, information cascades are almost inevitable.
  • if there’s no cap on certainty, an expanding social network will eventually converge on an accurate representation of the state of the world; that wasn’t a big surprise. But they also showed that in many common types of networks, even if there is a cap on certainty, convergence will still occur.
  • people in the past have looked at it using more myopic models,” says Acemoglu. “They would be averaging type of models: so my opinion is an average of the opinions of my neighbors’.” In such a model, Acemoglu says, the views of people who are “oversampled” — who are connected with a large enough number of other people — will end up distorting the conclusions of the group as a whole.
  • What we’re doing is looking at it in a much more game-theoretic manner, where individuals are realizing where the information comes from. So there will be some correction factor,” Acemoglu says. “If I’m seeing you, your action, and I’m seeing Munzer’s action, and I also know that there is some probability that you might have observed Munzer, then I discount his opinion appropriately, because I know that I don’t want to overweight it. And that’s the reason why, even though you have these influential agents — it might be that Munzer is everywhere, and everybody observes him — that still doesn’t create a herd on his opinion.”
  • the new paper leaves a few salient questions unanswered, such as how quickly the network will converge on the correct answer, and what happens when the model of agents’ knowledge becomes more complex.
  • the MIT researchers begin to address both questions. One paper examines rate of convergence, although Dahleh and Acemoglu note that that its results are “somewhat weaker” than those about the conditions for convergence. Another paper examines cases in which different agents make different decisions given the same information: some people might prefer one type of cell phone, others another. In such cases, “if you know the percentage of people that are of one type, it’s enough — at least in certain networks — to guarantee learning,” Dahleh says. “I don’t need to know, for every individual, whether they’re for it or against it; I just need to know that one-third of the people are for it, and two-thirds are against it.” For instance, he says, if you notice that a Chinese restaurant in your neighborhood is always half-empty, and a nearby Indian restaurant is always crowded, then information about what percentages of people prefer Chinese or Indian food will tell you which restaurant, if either, is of above-average or below-average quality.
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    By melding economics and engineering, researchers show that as social networks get larger, they usually get better at sorting fact from fiction.
Weiye Loh

Biomimicry: How Scientists Emulate Nature to Create Sustainable Designs | The Utopianis... - 0 views

  • “The core idea is that nature, imaginative by necessity, has already solved many of the problems we are grappling with. Animals, plants, and microbes are the consummate engineers. They have found what works, what is appropriate, and most important, what lasts here on Earth. This is the real news of biomimicry: After 3.8 billion years of research and development, failures are fossils, and what surrounds us is the secret to survival. Like the viceroy butterfly imitating the monarch, we humans are imitating the best adapted organisms in our habitat. We are learning, for instance, how to harness energy like a leaf, grow food like a prairie, build ceramics like an abalone, self-medicate like a chimp, create color like a peacock, compute like a cell, and run a business like a hickory forest.”
  • A more recent example of biomimetics in action is a biological laser created by two physicists at Harvard Medical School. Malte Gather and Seok Hyun Yun placed a single cell, genetically engineered to produce green fluorescent proteins originally found in jellyfish, into a cavity with two parallel mirrors on either side. When they exposed the cell to pulses of light, it emitted green fluorescent light that focused into a laser beam with the aid of the parallel mirrors. As Gather and Yun pointed out in their paper, the single-cell biological laser avoids the use of “artificial or engineered optical gain materials, such as doped crystals, semiconductors, synthetic dyes and purified gases.”
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    if one of our goals as a species is longevity, we may want to humble ourselves and take a look at how other species manage to live symbiotically with the earth instead of just on it. Biomimetics, or biomimicry, does just that.
Satveer

Why I hate stem-cell technologies & Regenerative Therapies - 5 views

http://news.bbc.co.uk/2/hi/health/8314442.stm This article is another one of those regenerative therapies article that use of stem-cell technology to reverse aging because first world countries ar...

stem cell regenerative first world third

started by Satveer on 21 Oct 09 no follow-up yet
Weiye Loh

Science, Strong Inference -- Proper Scientific Method - 0 views

  • Scientists these days tend to keep up a polite fiction that all science is equal. Except for the work of the misguided opponent whose arguments we happen to be refuting at the time, we speak as though every scientist's field and methods of study are as good as every other scientist's and perhaps a little better. This keeps us all cordial when it comes to recommending each other for government grants.
  • Why should there be such rapid advances in some fields and not in others? I think the usual explanations that we tend to think of - such as the tractability of the subject, or the quality or education of the men drawn into it, or the size of research contracts - are important but inadequate. I have begun to believe that the primary factor in scientific advance is an intellectual one. These rapidly moving fields are fields where a particular method of doing scientific research is systematically used and taught, an accumulative method of inductive inference that is so effective that I think it should be given the name of "strong inference." I believe it is important to examine this method, its use and history and rationale, and to see whether other groups and individuals might learn to adopt it profitably in their own scientific and intellectual work. In its separate elements, strong inference is just the simple and old-fashioned method of inductive inference that goes back to Francis Bacon. The steps are familiar to every college student and are practiced, off and on, by every scientist. The difference comes in their systematic application. Strong inference consists of applying the following steps to every problem in science, formally and explicitly and regularly: Devising alternative hypotheses; Devising a crucial experiment (or several of them), with alternative possible outcomes, each of which will, as nearly is possible, exclude one or more of the hypotheses; Carrying out the experiment so as to get a clean result; Recycling the procedure, making subhypotheses or sequential hypotheses to refine the possibilities that remain, and so on.
  • On any new problem, of course, inductive inference is not as simple and certain as deduction, because it involves reaching out into the unknown. Steps 1 and 2 require intellectual inventions, which must be cleverly chosen so that hypothesis, experiment, outcome, and exclusion will be related in a rigorous syllogism; and the question of how to generate such inventions is one which has been extensively discussed elsewhere (2, 3). What the formal schema reminds us to do is to try to make these inventions, to take the next step, to proceed to the next fork, without dawdling or getting tied up in irrelevancies.
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  • It is clear why this makes for rapid and powerful progress. For exploring the unknown, there is no faster method; this is the minimum sequence of steps. Any conclusion that is not an exclusion is insecure and must be rechecked. Any delay in recycling to the next set of hypotheses is only a delay. Strong inference, and the logical tree it generates, are to inductive reasoning what the syllogism is to deductive reasoning in that it offers a regular method for reaching firm inductive conclusions one after the other as rapidly as possible.
  • "But what is so novel about this?" someone will say. This is the method of science and always has been, why give it a special name? The reason is that many of us have almost forgotten it. Science is now an everyday business. Equipment, calculations, lectures become ends in themselves. How many of us write down our alternatives and crucial experiments every day, focusing on the exclusion of a hypothesis? We may write our scientific papers so that it looks as if we had steps 1, 2, and 3 in mind all along. But in between, we do busywork. We become "method- oriented" rather than "problem-oriented." We say we prefer to "feel our way" toward generalizations. We fail to teach our students how to sharpen up their inductive inferences. And we do not realize the added power that the regular and explicit use of alternative hypothesis and sharp exclusion could give us at every step of our research.
  • A distinguished cell biologist rose and said, "No two cells give the same properties. Biology is the science of heterogeneous systems." And he added privately. "You know there are scientists, and there are people in science who are just working with these over-simplified model systems - DNA chains and in vitro systems - who are not doing science at all. We need their auxiliary work: they build apparatus, they make minor studies, but they are not scientists." To which Cy Levinthal replied: "Well, there are two kinds of biologists, those who are looking to see if there is one thing that can be understood and those who keep saying it is very complicated and that nothing can be understood. . . . You must study the simplest system you think has the properties you are interested in."
  • At the 1958 Conference on Biophysics, at Boulder, there was a dramatic confrontation between the two points of view. Leo Szilard said: "The problems of how enzymes are induced, of how proteins are synthesized, of how antibodies are formed, are closer to solution than is generally believed. If you do stupid experiments, and finish one a year, it can take 50 years. But if you stop doing experiments for a little while and think how proteins can possibly be synthesized, there are only about 5 different ways, not 50! And it will take only a few experiments to distinguish these." One of the young men added: "It is essentially the old question: How small and elegant an experiment can you perform?" These comments upset a number of those present. An electron microscopist said. "Gentlemen, this is off the track. This is philosophy of science." Szilard retorted. "I was not quarreling with third-rate scientists: I was quarreling with first-rate scientists."
  • Any criticism or challenge to consider changing our methods strikes of course at all our ego-defenses. But in this case the analytical method offers the possibility of such great increases in effectiveness that it is unfortunate that it cannot be regarded more often as a challenge to learning rather than as challenge to combat. Many of the recent triumphs in molecular biology have in fact been achieved on just such "oversimplified model systems," very much along the analytical lines laid down in the 1958 discussion. They have not fallen to the kind of men who justify themselves by saying "No two cells are alike," regardless of how true that may ultimately be. The triumphs are in fact triumphs of a new way of thinking.
  • the emphasis on strong inference
  • is also partly due to the nature of the fields themselves. Biology, with its vast informational detail and complexity, is a "high-information" field, where years and decades can easily be wasted on the usual type of "low-information" observations or experiments if one does not think carefully in advance about what the most important and conclusive experiments would be. And in high-energy physics, both the "information flux" of particles from the new accelerators and the million-dollar costs of operation have forced a similar analytical approach. It pays to have a top-notch group debate every experiment ahead of time; and the habit spreads throughout the field.
  • Historically, I think, there have been two main contributions to the development of a satisfactory strong-inference method. The first is that of Francis Bacon (13). He wanted a "surer method" of "finding out nature" than either the logic-chopping or all-inclusive theories of the time or the laudable but crude attempts to make inductions "by simple enumeration." He did not merely urge experiments as some suppose, he showed the fruitfulness of interconnecting theory and experiment so that the one checked the other. Of the many inductive procedures he suggested, the most important, I think, was the conditional inductive tree, which proceeded from alternative hypothesis (possible "causes," as he calls them), through crucial experiments ("Instances of the Fingerpost"), to exclusion of some alternatives and adoption of what is left ("establishing axioms"). His Instances of the Fingerpost are explicitly at the forks in the logical tree, the term being borrowed "from the fingerposts which are set up where roads part, to indicate the several directions."
  • ere was a method that could separate off the empty theories! Bacon, said the inductive method could be learned by anybody, just like learning to "draw a straighter line or more perfect circle . . . with the help of a ruler or a pair of compasses." "My way of discovering sciences goes far to level men's wit and leaves but little to individual excellence, because it performs everything by the surest rules and demonstrations." Even occasional mistakes would not be fatal. "Truth will sooner come out from error than from confusion."
  • Nevertheless there is a difficulty with this method. As Bacon emphasizes, it is necessary to make "exclusions." He says, "The induction which is to be available for the discovery and demonstration of sciences and arts, must analyze nature by proper rejections and exclusions, and then, after a sufficient number of negatives come to a conclusion on the affirmative instances." "[To man] it is granted only to proceed at first by negatives, and at last to end in affirmatives after exclusion has been exhausted." Or, as the philosopher Karl Popper says today there is no such thing as proof in science - because some later alternative explanation may be as good or better - so that science advances only by disproofs. There is no point in making hypotheses that are not falsifiable because such hypotheses do not say anything, "it must be possible for all empirical scientific system to be refuted by experience" (14).
  • The difficulty is that disproof is a hard doctrine. If you have a hypothesis and I have another hypothesis, evidently one of them must be eliminated. The scientist seems to have no choice but to be either soft-headed or disputatious. Perhaps this is why so many tend to resist the strong analytical approach and why some great scientists are so disputatious.
  • Fortunately, it seems to me, this difficulty can be removed by the use of a second great intellectual invention, the "method of multiple hypotheses," which is what was needed to round out the Baconian scheme. This is a method that was put forward by T.C. Chamberlin (15), a geologist at Chicago at the turn of the century, who is best known for his contribution to the Chamberlain-Moulton hypothesis of the origin of the solar system.
  • Chamberlin says our trouble is that when we make a single hypothesis, we become attached to it. "The moment one has offered an original explanation for a phenomenon which seems satisfactory, that moment affection for his intellectual child springs into existence, and as the explanation grows into a definite theory his parental affections cluster about his offspring and it grows more and more dear to him. . . . There springs up also unwittingly a pressing of the theory to make it fit the facts and a pressing of the facts to make them fit the theory..." "To avoid this grave danger, the method of multiple working hypotheses is urged. It differs from the simple working hypothesis in that it distributes the effort and divides the affections. . . . Each hypothesis suggests its own criteria, its own method of proof, its own method of developing the truth, and if a group of hypotheses encompass the subject on all sides, the total outcome of means and of methods is full and rich."
  • The conflict and exclusion of alternatives that is necessary to sharp inductive inference has been all too often a conflict between men, each with his single Ruling Theory. But whenever each man begins to have multiple working hypotheses, it becomes purely a conflict between ideas. It becomes much easier then for each of us to aim every day at conclusive disproofs - at strong inference - without either reluctance or combativeness. In fact, when there are multiple hypotheses, which are not anyone's "personal property," and when there are crucial experiments to test them, the daily life in the laboratory takes on an interest and excitement it never had, and the students can hardly wait to get to work to see how the detective story will come out. It seems to me that this is the reason for the development of those distinctive habits of mind and the "complex thought" that Chamberlin described, the reason for the sharpness, the excitement, the zeal, the teamwork - yes, even international teamwork - in molecular biology and high- energy physics today. What else could be so effective?
  • Unfortunately, I think, there are other other areas of science today that are sick by comparison, because they have forgotten the necessity for alternative hypotheses and disproof. Each man has only one branch - or none - on the logical tree, and it twists at random without ever coming to the need for a crucial decision at any point. We can see from the external symptoms that there is something scientifically wrong. The Frozen Method, The Eternal Surveyor, The Never Finished, The Great Man With a Single Hypothcsis, The Little Club of Dependents, The Vendetta, The All-Encompassing Theory Which Can Never Be Falsified.
  • a "theory" of this sort is not a theory at all, because it does not exclude anything. It predicts everything, and therefore does not predict anything. It becomes simply a verbal formula which the graduate student repeats and believes because the professor has said it so often. This is not science, but faith; not theory, but theology. Whether it is hand-waving or number-waving, or equation-waving, a theory is not a theory unless it can be disproved. That is, unless it can be falsified by some possible experimental outcome.
  • the work methods of a number of scientists have been testimony to the power of strong inference. Is success not due in many cases to systematic use of Bacon's "surest rules and demonstrations" as much as to rare and unattainable intellectual power? Faraday's famous diary (16), or Fermi's notebooks (3, 17), show how these men believed in the effectiveness of daily steps in applying formal inductive methods to one problem after another.
  • Surveys, taxonomy, design of equipment, systematic measurements and tables, theoretical computations - all have their proper and honored place, provided they are parts of a chain of precise induction of how nature works. Unfortunately, all too often they become ends in themselves, mere time-serving from the point of view of real scientific advance, a hypertrophied methodology that justifies itself as a lore of respectability.
  • We speak piously of taking measurements and making small studies that will "add another brick to the temple of science." Most such bricks just lie around the brickyard (20). Tables of constraints have their place and value, but the study of one spectrum after another, if not frequently re-evaluated, may become a substitute for thinking, a sad waste of intelligence in a research laboratory, and a mistraining whose crippling effects may last a lifetime.
  • Beware of the man of one method or one instrument, either experimental or theoretical. He tends to become method-oriented rather than problem-oriented. The method-oriented man is shackled; the problem-oriented man is at least reaching freely toward that is most important. Strong inference redirects a man to problem-orientation, but it requires him to be willing repeatedly to put aside his last methods and teach himself new ones.
  • anyone who asks the question about scientific effectiveness will also conclude that much of the mathematizing in physics and chemistry today is irrelevant if not misleading. The great value of mathematical formulation is that when an experiment agrees with a calculation to five decimal places, a great many alternative hypotheses are pretty well excluded (though the Bohr theory and the Schrödinger theory both predict exactly the same Rydberg constant!). But when the fit is only to two decimal places, or one, it may be a trap for the unwary; it may be no better than any rule-of-thumb extrapolation, and some other kind of qualitative exclusion might be more rigorous for testing the assumptions and more important to scientific understanding than the quantitative fit.
  • Today we preach that science is not science unless it is quantitative. We substitute correlations for causal studies, and physical equations for organic reasoning. Measurements and equations are supposed to sharpen thinking, but, in my observation, they more often tend to make the thinking noncausal and fuzzy. They tend to become the object of scientific manipulation instead of auxiliary tests of crucial inferences.
  • Many - perhaps most - of the great issues of science are qualitative, not quantitative, even in physics and chemistry. Equations and measurements are useful when and only when they are related to proof; but proof or disproof comes first and is in fact strongest when it is absolutely convincing without any quantitative measurement.
  • you can catch phenomena in a logical box or in a mathematical box. The logical box is coarse but strong. The mathematical box is fine-grained but flimsy. The mathematical box is a beautiful way of wrapping up a problem, but it will not hold the phenomena unless they have been caught in a logical box to begin with.
  • Of course it is easy - and all too common - for one scientist to call the others unscientific. My point is not that my particular conclusions here are necessarily correct, but that we have long needed some absolute standard of possible scientific effectiveness by which to measure how well we are succeeding in various areas - a standard that many could agree on and one that would be undistorted by the scientific pressures and fashions of the times and the vested interests and busywork that they develop. It is not public evaluation I am interested in so much as a private measure by which to compare one's own scientific performance with what it might be. I believe that strong inference provides this kind of standard of what the maximum possible scientific effectiveness could be - as well as a recipe for reaching it.
  • The strong-inference point of view is so resolutely critical of methods of work and values in science that any attempt to compare specific cases is likely to sound but smug and destructive. Mainly one should try to teach it by example and by exhorting to self-analysis and self-improvement only in general terms
  • one severe but useful private test - a touchstone of strong inference - that removes the necessity for third-person criticism, because it is a test that anyone can learn to carry with him for use as needed. It is our old friend the Baconian "exclusion," but I call it "The Question." Obviously it should be applied as much to one's own thinking as to others'. It consists of asking in your own mind, on hearing any scientific explanation or theory put forward, "But sir, what experiment could disprove your hypothesis?"; or, on hearing a scientific experiment described, "But sir, what hypothesis does your experiment disprove?"
  • It is not true that all science is equal; or that we cannot justly compare the effectiveness of scientists by any method other than a mutual-recommendation system. The man to watch, the man to put your money on, is not the man who wants to make "a survey" or a "more detailed study" but the man with the notebook, the man with the alternative hypotheses and the crucial experiments, the man who knows how to answer your Question of disproof and is already working on it.
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    There is so much bad science and bad statistics information in media reports, publications, and shared between conversants that I think it is important to understand about facts and proofs and the associated pitfalls.
Weiye Loh

TODAYonline | World | Off-the-shelf body parts? - 0 views

  • LONDON - Scientific advances including techniques allowing patients to grow new joints inside their own bodies will allow the elderly to remain active well beyond their 100th birthdays, researchers claim. British scientists are working on a system which should allow the elderly to buy body parts "off the shelf" and even regenerate their own damaged joints and hearts. Their ultimate aim is to fix up the body with customised replacement parts grown to order. They have already carried out human trials on heart valves which are still working four years after they were transplanted. At the University of Leeds, Britain's biggest bioengineering unit and the world leader in artificial joint replacement research is coordinating a project that aims to give people 50 active years after the age of 50."It is the rise of the bionic pensioner," said Professor Christina Doyle, whose company is working with the university to develop the new technologies. "The idea is when something wears out, your surgeon can buy a replacement off the shelf or, more accurately, in a bag."The university is spending £50 million ($114 million) over the next five years on the new project. The main thrust of the research centres on a method of tissue and medical engineering which the university is at the forefront of developing. Led by the immunologist Professor Eileen Ingham, they are pioneering a technique of stripping the living cells from donor human and animal parts, leaving just the collagen or elastin "scaffold" of the tissue. These "biological shells", which could be for knee, ankle or hip ligaments, as well as blood vessels and heart valves, are then transplanted into the patient whose own body then invades them replacing the removed cells with their own. The technique, which could be available within five years, effectively removes the need for anti-rejection drugs. It is similar to the recently developed system of using stem cells to regrow organs outside the body, but costs about a tenth of the price.
Wing Yan Wong

Are the Feds Stalking Your Cell Phone? Lawsuit Seeks Answers - 1 views

http://www.technewsworld.com/story/63668.html?wlc=1252493244 Two legal groups have filed a lawsuit to get more information on whether the Federal Government may be using Americans' handphones to l...

privacy

started by Wing Yan Wong on 09 Sep 09 no follow-up yet
Weiye Loh

Science scorned : Nature : Nature Publishing Group - 0 views

  • There is a growing anti-science streak on the American right that could have tangible societal and political impacts on many fronts — including regulation of environmental and other issues and stem-cell research.
  • The right-wing populism that is flourishing in the current climate of economic insecurity echoes many traditional conservative themes, such as opposition to taxes, regulation and immigration. But the Tea Party and its cheerleaders, who include Limbaugh, Fox News television host Glenn Beck and Sarah Palin (who famously decried fruitfly research as a waste of public money), are also tapping an age-old US political impulse — a suspicion of elites and expertise.
  • Denialism over global warming has become a scientific cause célèbre within the movement. Limbaugh, for instance, who has told his listeners that “science has become a home for displaced socialists and communists”, has called climate-change science “the biggest scam in the history of the world”. The Tea Party's leanings encompass religious opposition to Darwinian evolution and to stem-cell and embryo research — which Beck has equated with eugenics. The movement is also averse to science-based regulation, which it sees as an excuse for intrusive government. Under the administration of George W. Bush, science in policy had already taken knocks from both neglect and ideology. Yet President Barack Obama's promise to “restore science to its rightful place” seems to have linked science to liberal politics, making it even more of a target of the right.
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  • US citizens face economic problems that are all too real, and the country's future crucially depends on education, science and technology as it faces increasing competition from China and other emerging science powers.
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    Science Scorned  The anti-science strain pervading the right wing in the United States is the last thing the country needs in a time of economic challenge.
Weiye Loh

Research integrity: Sabotage! : Nature News - 0 views

  • University of Michigan in Ann Arbor
  • Vipul Bhrigu, a former postdoc at the university's Comprehensive Cancer Center, wears a dark-blue three-buttoned suit and a pinched expression as he cups his pregnant wife's hand in both of his. When Pollard Hines calls Bhrigu's case to order, she has stern words for him: "I was inclined to send you to jail when I came out here this morning."
  • Bhrigu, over the course of several months at Michigan, had meticulously and systematically sabotaged the work of Heather Ames, a graduate student in his lab, by tampering with her experiments and poisoning her cell-culture media. Captured on hidden camera, Bhrigu confessed to university police in April and pleaded guilty to malicious destruction of personal property, a misdemeanour that apparently usually involves cars: in the spaces for make and model on the police report, the arresting officer wrote "lab research" and "cells". Bhrigu has said on multiple occasions that he was compelled by "internal pressure" and had hoped to slow down Ames's work. Speaking earlier this month, he was contrite. "It was a complete lack of moral judgement on my part," he said.
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  • Bhrigu's actions are surprising, but probably not unique. There are few firm numbers showing the prevalence of research sabotage, but conversations with graduate students, postdocs and research-misconduct experts suggest that such misdeeds occur elsewhere, and that most go unreported or unpoliced. In this case, the episode set back research, wasted potentially tens of thousands of dollars and terrorized a young student. More broadly, acts such as Bhrigu's — along with more subtle actions to hold back or derail colleagues' work — have a toxic effect on science and scientists. They are an affront to the implicit trust between scientists that is necessary for research endeavours to exist and thrive.
  • Despite all this, there is little to prevent perpetrators re-entering science.
  • federal bodies that provide research funding have limited ability and inclination to take action in sabotage cases because they aren't interpreted as fitting the federal definition of research misconduct, which is limited to plagiarism, fabrication and falsification of research data.
  • In Bhrigu's case, administrators at the University of Michigan worked with police to investigate, thanks in part to the persistence of Ames and her supervisor, Theo Ross. "The question is, how many universities have such procedures in place that scientists can go and get that kind of support?" says Christine Boesz, former inspector-general for the US National Science Foundation in Arlington, Virginia, and now a consultant on scientific accountability. "Most universities I was familiar with would not necessarily be so responsive."
  • Some labs are known to be hyper-competitive, with principal investigators pitting postdocs against each other. But Ross's lab is a small, collegial place. At the time that Ames was noticing problems, it housed just one other graduate student, a few undergraduates doing projects, and the lab manager, Katherine Oravecz-Wilson, a nine-year veteran of the lab whom Ross calls her "eyes and ears". And then there was Bhrigu, an amiable postdoc who had joined the lab in April 2009.
  • Some people whom Ross consulted with tried to convince her that Ames was hitting a rough patch in her work and looking for someone else to blame. But Ames was persistent, so Ross took the matter to the university's office of regulatory affairs, which advises on a wide variety of rules and regulations pertaining to research and clinical care. Ray Hutchinson, associate dean of the office, and Patricia Ward, its director, had never dealt with anything like it before. After several meetings and two more instances of alcohol in the media, Ward contacted the department of public safety — the university's police force — on 9 March. They immediately launched an investigation — into Ames herself. She endured two interrogations and a lie-detector test before investigators decided to look elsewhere.
  • At 4:00 a.m. on Sunday 18 April, officers installed two cameras in the lab: one in the cold room where Ames's blots had been contaminated, and one above the refrigerator where she stored her media. Ames came in that day and worked until 5:00 p.m. On Monday morning at around 10:15, she found that her medium had been spiked again. When Ross reviewed the tapes of the intervening hours with Richard Zavala, the officer assigned to the case, she says that her heart sank. Bhrigu entered the lab at 9:00 a.m. on Monday and pulled out the culture media that he would use for the day. He then returned to the fridge with a spray bottle of ethanol, usually used to sterilize lab benches. With his back to the camera, he rummaged through the fridge for 46 seconds. Ross couldn't be sure what he was doing, but it didn't look good. Zavala escorted Bhrigu to the campus police department for questioning. When he told Bhrigu about the cameras in the lab, the postdoc asked for a drink of water and then confessed. He said that he had been sabotaging Ames's work since February. (He denies involvement in the December and January incidents.)
  • Misbehaviour in science is nothing new — but its frequency is difficult to measure. Daniele Fanelli at the University of Edinburgh, UK, who studies research misconduct, says that overtly malicious offences such as Bhrigu's are probably infrequent, but other forms of indecency and sabotage are likely to be more common. "A lot more would be the kind of thing you couldn't capture on camera," he says. Vindictive peer review, dishonest reference letters and withholding key aspects of protocols from colleagues or competitors can do just as much to derail a career or a research project as vandalizing experiments. These are just a few of the questionable practices that seem quite widespread in science, but are not technically considered misconduct. In a meta-analysis of misconduct surveys, published last year (D. Fanelli PLoS ONE 4, e5738; 2009), Fanelli found that up to one-third of scientists admit to offences that fall into this grey area, and up to 70% say that they have observed them.
  • Some say that the structure of the scientific enterprise is to blame. The big rewards — tenured positions, grants, papers in stellar journals — are won through competition. To get ahead, researchers need only be better than those they are competing with. That ethos, says Brian Martinson, a sociologist at HealthPartners Research Foundation in Minneapolis, Minnesota, can lead to sabotage. He and others have suggested that universities and funders need to acknowledge the pressures in the research system and try to ease them by means of education and rehabilitation, rather than simply punishing perpetrators after the fact.
  • Bhrigu says that he felt pressure in moving from the small college at Toledo to the much bigger one in Michigan. He says that some criticisms he received from Ross about his incomplete training and his work habits frustrated him, but he doesn't blame his actions on that. "In any kind of workplace there is bound to be some pressure," he says. "I just got jealous of others moving ahead and I wanted to slow them down."
  • At Washtenaw County Courthouse in July, having reviewed the case files, Pollard Hines delivered Bhrigu's sentence. She ordered him to pay around US$8,800 for reagents and experimental materials, plus $600 in court fees and fines — and to serve six months' probation, perform 40 hours of community service and undergo a psychiatric evaluation.
  • But the threat of a worse sentence hung over Bhrigu's head. At the request of the prosecutor, Ross had prepared a more detailed list of damages, including Bhrigu's entire salary, half of Ames's, six months' salary for a technician to help Ames get back up to speed, and a quarter of the lab's reagents. The court arrived at a possible figure of $72,000, with the final amount to be decided upon at a restitution hearing in September.
  • Ross, though, is happy that the ordeal is largely over. For the month-and-a-half of the investigation, she became reluctant to take on new students or to hire personnel. She says she considered packing up her research programme. She even questioned her own sanity, worrying that she was the one sabotaging Ames's work via "an alternate personality". Ross now wonders if she was too trusting, and urges other lab heads to "realize that the whole spectrum of humanity is in your lab. So, when someone complains to you, take it seriously."
  • She also urges others to speak up when wrongdoing is discovered. After Bhrigu pleaded guilty in June, Ross called Trempe at the University of Toledo. He was shocked, of course, and for more than one reason. His department at Toledo had actually re-hired Bhrigu. Bhrigu says that he lied about the reason he left Michigan, blaming it on disagreements with Ross. Toledo let Bhrigu go in July, not long after Ross's call.
  • Now that Bhrigu is in India, there is little to prevent him from getting back into science. And even if he were in the United States, there wouldn't be much to stop him. The National Institutes of Health in Bethesda, Maryland, through its Office of Research Integrity, will sometimes bar an individual from receiving federal research funds for a time if they are found guilty of misconduct. But Bhigru probably won't face that prospect because his actions don't fit the federal definition of misconduct, a situation Ross finds strange. "All scientists will tell you that it's scientific misconduct because it's tampering with data," she says.
  • Ames says that the experience shook her trust in her chosen profession. "I did have doubts about continuing with science. It hurt my idea of science as a community that works together, builds upon each other's work and collaborates."
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    Research integrity: Sabotage! Postdoc Vipul Bhrigu destroyed the experiments of a colleague in order to get ahead.
Weiye Loh

Skepticblog » Investing in Basic Science - 0 views

  • A recent editorial in the New York Times by Nicholas Wade raises some interesting points about the nature of basic science research – primarily that its’ risky.
  • As I have pointed out about the medical literature, researcher John Ioaniddis has explained why most published studies turn out in retrospect to be wrong. The same is true of most basic science research – and the underlying reason is the same. The world is complex, and most of our guesses about how it might work turn out to be either flat-out wrong, incomplete, or superficial. And so most of our probing and prodding of the natural world, looking for the path to the actual answer, turn out to miss the target.
  • research costs considerable resources of time, space, money, opportunity, and people-hours. There may also be some risk involved (such as to subjects in the clinical trial). Further, negative studies are actually valuable (more so than terrible pictures). They still teach us something about the world – they teach us what is not true. At the very least this narrows the field of possibilities. But the analogy holds in so far as the goal of scientific research is to improve our understanding of the world and to provide practical applications that make our lives better. Wade writes mostly about how we fund research, and this relates to our objectives. Most of the corporate research money is interested in the latter – practical (and profitable) applications. If this is your goal, than basic science research is a bad bet. Most investments will be losers, and for most companies this will not be offset by the big payoffs of the rare winners. So many companies will allow others to do the basic science (government, universities, start up companies) then raid the winners by using their resources to buy them out, and then bring them the final steps to a marketable application. There is nothing wrong or unethical about this. It’s a good business model.
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  • What, then, is the role of public (government) funding of research? Primarily, Wade argues (and I agree), to provide infrastructure for expensive research programs, such as building large colliders.
  • the more the government invests in basic science and infrastructure, the more winners will emerge that private industry can then capitalize on. This is a good way to build a competitive dynamic economy.
  • But there is a pitfall – prematurely picking winners and losers. Wade give the example of California investing specifically into developing stem cell treatments. He argues that stem cells, while promising, do not hold a guarantee of eventual success, and perhaps there are other technologies that will work and are being neglected. The history of science and technology has clearly demonstrated that it is wickedly difficult to predict the future (and all those who try are destined to be mocked by future generations with the benefit of perfect hindsight). Prematurely committing to one technology therefore contains a high risk of wasting a great deal of limited resources, and missing other perhaps more fruitful opportunities.
  • The underlying concept is that science research is a long-term game. Many avenues of research will not pan out, and those that do will take time to inspire specific applications. The media, however, likes catchy headlines. That means when they are reporting on basic science research journalists ask themselves – why should people care? What is the application of this that the average person can relate to? This seems reasonable from a journalistic point of view, but with basic science reporting it leads to wild speculation about a distant possible future application. The public is then left with the impression that we are on the verge of curing the common cold or cancer, or developing invisibility cloaks or flying cars, or replacing organs and having household robot servants. When a few years go by and we don’t have our personal android butlers, the public then thinks that the basic science was a bust, when in fact there was never a reasonable expectation that it would lead to a specific application anytime soon. But it still may be on track for interesting applications in a decade or two.
  • this also means that the government, generally, should not be in the game of picking winners an losers – putting their thumb on the scale, as it were. Rather, they will get the most bang for the research buck if they simply invest in science infrastructure, and also fund scientists in broad areas.
  • The same is true of technology – don’t pick winners and losers. The much-hyped “hydrogen economy” comes to mind. Let industry and the free market sort out what will work. If you have to invest in infrastructure before a technology is mature, then at least hedge your bets and keep funding flexible. Fund “alternative fuel” as a general category, and reassess on a regular basis how funds should be allocated. But don’t get too specific.
  • Funding research but leaving the details to scientists may be optimal
  • The scientific community can do their part by getting better at communicating with the media and the public. Try to avoid the temptation to overhype your own research, just because it is the most interesting thing in the world to you personally and you feel hype will help your funding. Don’t make it easy for the media to sensationalize your research – you should be the ones trying to hold back the reigns. Perhaps this is too much to hope for – market forces conspire too much to promote sensationalism.
Weiye Loh

homunculus: I can see clearly now - 0 views

  • Here’s a little piece I wrote for Nature news. To truly appreciate this stuff you need to take a look at the slideshow. There will be a great deal more on early microscopy in my next book, probably called Curiosity and scheduled for next year.
  • The first microscopes were a lot better than they are given credit for. That’s the claim of microscopist Brian Ford, based at Cambridge University and a specialist in the history and development of these instruments.
  • Ford says it is often suggested that the microscopes used by the earliest pioneers in the seventeenth century, such as Robert Hooke and Antony van Leeuwenhoek, gave only very blurred images of structures such as cells and micro-organisms. Hooke was the first to record cells, seen in thin slices of cork, while Leeuwenhoek described tiny ‘animalcules’, invisible to the naked eye, in rain water in 1676. The implication is that these breakthroughs in microscopic biology involved more than a little guesswork and invention. But Ford has looked again at the capabilities of some of Leeuwenhoek’s microscopes, and says ‘the results were breathtaking’. ‘The images were comparable with those you would obtain from a modern light microscope’, he adds in an account of his experiments in Microscopy and Analysis [1].
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  • The poor impression of the seventeenth-century instruments, says Ford, is due to bad technique in modern reconstructions. In contrast to the hazy images shown in some museums and television documentaries, careful attention to such factors as lighting can produce micrographs of startling clarity using original microscopes or modern replicas.
  • Ford was able to make some of these improvements when he was granted access to one of Leeuwenhoek’s original microscopes owned by the Utrecht University Museum in the Netherlands. Leeuwenhoek made his own instruments, which had only a single lens made from a tiny bead of glass mounted in a metal frame. These simple microscopes were harder to make and to use than the more familiar two-lens compound microscope, but offered greater resolution.
  • Hooke popularized microscopy in his 1665 masterpiece Micrographia, which included stunning engravings of fleas, mites and the compound eyes of flies. The diarist Samuel Pepys judged it ‘the most ingenious book that I ever read in my life’. Ford’s findings show that Hooke was not, as some have imagined, embellishing his drawings from imagination, but should genuinely have been able to see such things as the tiny hairs on the flea’s legs.
  • Even Hooke was temporarily foxed, however, when he was given the duty of reproducing the results described by Leeuwenhoek, a linen merchant of Delft, in a letter to the Royal Society. It took him over a year before he could see these animalcules, whereupon he wrote that ‘I was very much surprised at this so wonderful a spectacle, having never seen any living creature comparable to these for smallness.’ ‘The abilities of those pioneer microscopists were so much greater than has been recognized’ says Ford. He attributes this misconception to the fact that ‘no longer is microscopy properly taught.’
  • Reference1. Ford, B. J. Microsc. Anal. March 2011 (in press).
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    The first microscopes were a lot better than they are given credit for.
Weiye Loh

How the net traps us all in our own little bubbles | Technology | The Observer - 0 views

  • Google would use 57 signals – everything from where you were logging in from to what browser you were using to what you had searched for before – to make guesses about who you were and what kinds of sites you'd like. Even if you were logged out, it would customise its results, showing you the pages it predicted you were most likely to click on.
  • Most of us assume that when we google a term, we all see the same results – the ones that the company's famous Page Rank algorithm suggests are the most authoritative based on other pages' links. But since December 2009, this is no longer true. Now you get the result that Google's algorithm suggests is best for you in particular – and someone else may see something entirely different. In other words, there is no standard Google any more.
  • In the spring of 2010, while the remains of the Deepwater Horizon oil rig were spewing oil into the Gulf of Mexico, I asked two friends to search for the term "BP". They're pretty similar – educated white left-leaning women who live in the north-east. But the results they saw were quite different. One saw investment information about BP. The other saw news.
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  • the query "stem cells" might produce diametrically opposed results for scientists who support stem-cell research and activists who oppose it.
  • "Proof of climate change" might turn up different results for an environmental activist and an oil-company executive.
  • majority of us assume search engines are unbiased. But that may be just because they're increasingly biased to share our own views. More and more, your computer monitor is a kind of one-way mirror, reflecting your own interests while algorithmic observers watch what you click. Google's announcement marked the turning point of an important but nearly invisible revolution in how we consume information. You could say that on 4 December 2009 the era of personalisation began.
  • We are predisposed to respond to a pretty narrow set of stimuli – if a piece of news is about sex, power, gossip, violence, celebrity or humour, we are likely to read it first. This is the content that most easily makes it into the filter bubble. It's easy to push "Like" and increase the visibility of a friend's post about finishing a marathon or an instructional article about how to make onion soup. It's harder to push the "Like" button on an article titled "Darfur sees bloodiest month in two years". In a personalised world, important but complex or unpleasant issues – the rising prison population, for example, or homelessness – are less likely to come to our attention at all.
  • As a consumer, it's hard to argue with blotting out the irrelevant and unlikable. But what is good for consumers is not necessarily good for citizens. What I seem to like may not be what I actually want, let alone what I need to know to be an informed member of my community or country. "It's a civic virtue to be exposed to things that appear to be outside your interest," technology journalist Clive Thompson told me. Cultural critic Lee Siegel puts it a different way: "Customers are always right, but people aren't."
  • Personalisation is based on a bargain. In exchange for the service of filtering, you hand large companies an enormous amount of data about your daily life – much of which you might not trust friends with.
  • To be the author of your life, professor Yochai Benkler argues, you have to be aware of a diverse array of options and lifestyles. When you enter a filter bubble, you're letting the companies that construct it choose which options you're aware of. You may think you're the captain of your own destiny, but personalisation can lead you down a road to a kind of informational determinism in which what you've clicked on in the past determines what you see next – a web history you're doomed to repeat. You can get stuck in a static, ever- narrowing version of yourself – an endless you-loop.
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    An invisible revolution has taken place is the way we use the net, but the increasing personalisation of information by search engines such as Google threatens to limit our access to information and enclose us in a self-reinforcing world view, writes Eli Pariser in an extract from The Filter Bubble
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