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Weiye Loh

11.01.97 - Misconceptions about the causes of cancer lead to skewed priorities and wast... - 0 views

berkeley.edu/...11_01_97a.html

Pollution Cancer Policy Science Risk

shared by Weiye Loh on 09 Apr 11 - No Cached
  • One of the big misconceptions is that artificial chemicals such as pesticides have a lot to do with human cancer, but that's just not true," says Bruce N. Ames, professor of biochemistry and molecular biology at the University of California at Berkeley and co-author of a new review of what is known about environmental pollution and cancer. "Nevertheless, it's conventional wisdom and society spends billions on this each year." "We consume more carcinogens in one cup of coffee than we get from the pesticide residues on all the fruits and vegetables we eat in a year," he adds.
  • there may be many excellent reasons for cleaning up pollution of our air, water and soil, the researchers say, prevention of cancer is not one of them.
  • "The problem is that lifestyle changes are tough," says Gold, director of the Carcinogenic Potency Project at UC Berkeley's National Institute for Environmental Health Sciences Center and a senior scientist in the cell and molecular biology division at Lawrence Berkeley National Laboratory. "But by targeting pesticide residues as a major problem, we risk making fruits and vegetables more expensive and indirectly increasing cancer risks, especially among the poor."
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  • Whereas 99.9 percent of all the chemicals we ingest are natural, 78 percent of the chemicals tested are synthetic. So when more than half of all synthetic chemicals are found to cause cancer in rodents, it's not surprising that people link cancer with synthetic chemicals. But of the natural chemicals in our diet that have been tested in animals, half also cause cancer, Gold says.
  • "We need to recognize that there are far more carcinogens in the natural world than in the synthetic world, and go after the important things, such as lifestyle change."
  • Misconception: Cancer rates are soaring. In fact, the researchers say, if lung cancer due to smoking is excluded, overall cancer deaths in the U.S. have declined 16 percent since 1950.
  • Misconception: Reducing pesticide residues is an effective way to prevent diet-related cancer. Because fruits and vegetables are of major importance in reducing cancer, the unintended effect of requiring expensive efforts to reduce the amount of pesticides remaining on fruits and vegetables will be to increase their cost. This will lead to an increase in cancer among low income people who no longer will be able to afford to eat them.
  • Misconception: Human exposures to carcinogens and other potential hazards are primarily due to synthetic chemicals. Americans actually eat about 10,000 times more natural pesticides from fruits and vegetables than synthetic pesticide residues on food. Natural pesticides are chemicals that plants produce to defend themselves against fungi, insects, and other predators. And half of all natural pesticides tested in rodents turn out to be rodent carcinogens. In addition, we consume many other carcinogens in foods because of the chemicals produced in cooking. In a single cup of roasted coffee, for example, the natural chemicals known to be rodent carcinogens are about equal in weight to an entire year's work of synthetic pesticide residues.
  • Misconception: Cancer risks to humans can be assessed by standard high-dose animal cancer tests. In cancer tests, animals are given very high, nearly toxic doses. The effect on humans at lower doses is extrapolated from these results, as if the relationship were a straight line from high dose to low dose. However, the fact that half of all chemicals tested, whether natural or synthetic, turn out to cause cancer in rodents implies that this is an artifact of using high doses. High doses of any chemical can chronically kill cells and wound tissue, a risk factor for cancer . "Our conclusion is that the scientific evidence shows that there are high-dose effects," Ames says. "But even though government regulatory agencies recognize this, they still decide which synthetic chemicals to regulate based on linear extrapolation of high dose cancer tests in animals."
  • Misconception: Synthetic chemicals pose greater carcinogenic hazards than natural chemicals. Naturally occurring carcinogens represent an enormous background compared to the low-dose exposures to residues of synthetic chemicals such as pesticides, the researchers conclude. These results call for a reevaluation of whether animal cancer tests are really useful guides for protecting the public against minor hypothetical risks.
  • Misconception: The toxicology of synthetic chemicals is different from that of natural chemicals. No evidence exists for this, but the assumption could lead to unfortunate tradeoffs between natural and synthetic pesticides. Recently, for example, when a new variety of highly insect-resistant celery was introduced on a farm, the workers handling the celery developed rashes when they were exposed to sunlight. The pest-resistant celery turned out to contain almost eight times more natural pesticide in the form of psoralens -- chemicals known to cause cancer and genetic mutations -- than common celery.
  • Misconception: Pesticides and other synthetic chemicals are disrupting human hormones. Claims that synthetic chemicals with hormonal activity contribute to cancer and reduced sperm count ignore the fact that natural chemicals have hormone-like activity millions of times greater than do traces of synthetic chemicals. Rather, lifestyle -- lack of exercise, obesity, alcohol use and reproductive history -- are known to lead to marked changes in hormone levels in the body.
  • Misconception: Regulating low, hypothetical risks advances public health. Society -- primarily the private sector -- will spend an estimated $140 billion to comply with environmental regulations this year, according to projections by the Environmental Protection Agency. Much of this is aimed at reducing low-level human exposure to chemicals solely because they are rodent carcinogens, despite the fact that this rationale is flawed. Our improved ability to detect even minuscule concentrations of chemicals makes regulation even more expensive.
  • Weiye Loh on 09 Apr 11
     
    BERKELEY -- Despite a lack of convincing evidence that pollution is an important cause of human cancer, this misconception drives government policy today and results in billions of dollars spent to clean up minuscule amounts of synthetic chemicals, say two UC Berkeley researchers.
Weiye Loh

Cancer resembles life 1 billion years ago, say astrobiologists - microbiology, genomics... - 0 views

www.lifescientist.com.au/..._years_ago_say_astrobiologists

Cancer Evolution Life

shared by Weiye Loh on 17 Feb 11 - No Cached
  • astrobiologists, working with oncologists in the US, have suggested that cancer resembles ancient forms of life that flourished between 600 million and 1 billion years ago.
  • Read more about what this discovery means for cancer research.
  • The genes that controlled the behaviour of these early multicellular organisms still reside within our own cells, managed by more recent genes that keep them in check.It's when these newer controlling genes fail that the older mechanisms take over, and the cell reverts to its earlier behaviours and grows out of control.
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  • The new theory, published in the journal Physical Biology, has been put forward by two leading figures in the world of cosmology and astrobiology: Paul Davies, director of the Beyond Center for Fundamental Concepts in Science, Arizona State University; and Charles Lineweaver, from the Australian National University.
  • According to Lineweaver, this suggests that cancer is an atavism, or an evolutionary throwback.
  • In the paper, they suggest that a close look at cancer shows similarities with early forms of multicellular life.
  • “Unlike bacteria and viruses, cancer has not developed the capacity to evolve into new forms. In fact, cancer is better understood as the reversion of cells to the way they behaved a little over one billion years ago, when humans were nothing more than loose-knit colonies of only partially differentiated cells. “We think that the tumours that develop in cancer patients today take the same form as these simple cellular structures did more than a billion years ago,” he said.
  • One piece of evidence to support this theory is that cancers appear in virtually all metazoans, with the notable exception of the bizarre naked mole rat."This quasi-ubiquity suggests that the mechanisms of cancer are deep-rooted in evolutionary history, a conjecture that receives support from both paleontology and genetics," they write.
  • the genes that controlled this early multi-cellular form of life are like a computer operating system's 'safe mode', and when there are failures or mutations in the more recent genes that manage the way cells specialise and interact to form the complex life of today, then the earlier level of programming takes over.
  • Their notion is in contrast to a prevailing theory that cancer cells are 'rogue' cells that evolve rapidly within the body, overcoming the normal slew of cellular defences.
  • However, Davies and Lineweaver point out that cancer cells are highly cooperative with each other, if competing with the host's cells. This suggests a pre-existing complexity that is reminiscent of early multicellular life.
  • cancers' manifold survival mechanisms are predictable, and unlikely to emerge spontaneously through evolution within each individual in such a consistent way.
  • The good news is that this means combating cancer is not necessarily as complex as if the cancers were rogue cells evolving new and novel defence mechanisms within the body.Instead, because cancers fall back on the same evolved mechanisms that were used by early life, we can expect them to remain predictable, thus if they're susceptible to treatment, it's unlikely they'll evolve new ways to get around it.
  • If the atavism hypothesis is correct, there are new reasons for optimism," they write.
  • Weiye Loh on 17 Feb 11
     
    Feature: Inside DNA vaccines bioMD makes a bid for Andrew Forest's Allied Medical and Coridon Alexion acquires technology for MoCD therapy More > Most Popular Media Releases Cancer resembles life 1 billion years ago, say astrobiologists Feature: The challenge of a herpes simplex vaccine Feature: Proteomics power of pawpaw bioMD makes a bid for Andrew Forest's Allied Medical and Coridon Immune system boosting hormone might lead to HIV cure Biotechnology Directory Company Profile Check out this company's profile and more in the Biotechnology Directory! Biotechnology Directory Find company by name Find company by category Latest Jobs Senior Software Developer / Java Analyst Programm App Support Developer - Java / J2ee Solutions Consultant - VIC Technical Writer Product Manager (Fisheye/Crucible)   BUYING GUIDES Portable Multimedia Players Digital Cameras Digital Video Cameras LATEST PRODUCTS HTC Wildfire S Android phone (preview) Panasonic LUMIX DMC-GH2 digital camera HTC Desire S Android phone (preview) Qld ICT minister Robert Schwarten retires Movie piracy costs Aus economy $1.37 billion in 12 months: AFACT Wireless smartphones essential to e-health: CSIRO Aussie outsourcing CRM budgets to soar in 2011: Ovum Federal government to evaluate education revolution targets Business continuity planning - more than just disaster recovery Proving the value of IT - Part one 5 open source security projects to watch In-memory computing Information security in 2011 EFA shoots down 'unproductive' AFACT movie piracy study In Pictures: IBM hosts Galactic dinner Emerson Network Power launches new infrastructure solutions Consumers not smart enough for smartphones? Google one-ups Apple online media subscription service M2M offerings expand as more machines go online India cancels satellite spectrum deal after controversy Lenovo profit rises in Q3 on strong PC sales in China Taiwan firm to supply touch sensors to Samsung HP regains top position in India's PC market Copyright 20
Weiye Loh

Science-Based Medicine » Skepticism versus nihilism about cancer and science-... - 0 views

www.sciencebasedmedicine.org/?p=11185

Science Medicine Evidence Experiment

shared by Weiye Loh on 16 Mar 11 - No Cached
  • I’m a John Ioannidis convert, and I accept that there is a lot of medical literature that is erroneous. (Just search for Dr. Ioannidis’ last name on this blog, and you’ll find copious posts praising him and discussing his work.) In fact, as I’ve pointed out, most medical researchers instinctively know that most new scientific findings will not hold up to scrutiny, which is why we rarely accept the results of a single study, except in unusual circumstances, as being enough to change practice. I also have pointed out many times that this is not necessarily a bad thing. Replication is key to verification of scientific findings, and more often than not provocative scientific findings are not replicated. Does that mean they shouldn’t be published?
  • As for pseudoscience, I’m half tempted to agree with Dr. Spector, but just not in the way he thinks. Unfortunately, over the last 20 years or so, there has been an increasing amount of pseudoscience in the medical literature in the form of “complementary and alternative medicine” (CAM) studies of highly improbable remedies or even virtually impossible ones (i.e., homeopathy). However, that does not appear to be what Dr. Spector is talking about, which is why I looked up his references. The second reference is to an SI article from 2009 entitled Science and Pseudoscience in Adult Nutrition Research and Practice. There, and only there, did I find out just what it is that Dr. Spector apparently means by “pseudoscience”: By pseudoscience, I mean the use of inappropriate methods that frequently yield wrong or misleading answers for the type of question asked. In nutrition research, such methods also often misuse statistical evaluations.
  • Dr. Spector doesn’t really know the difference between inadequately rigorous science and pseudoscience! Now, don’t get me wrong. I know that it’s not always easy to distinguish science from pseudoscience, especially at the fringes, but in general bad science has to go a lot further than Dr. Spector thinks to merit the the term “pseudoscience.” It is clear (to me, at least) from his articles that Dr. Spector throws around the term “pseudoscience” around rather more loosely than he should, using it as a pejorative for any clinical science less rigorous than a randomized, double-blind, placebo-controlled trial that meets FDA standards for approval of a drug (his pharma background coming to the fore, no doubt). Pseudoscience, Dr. Spector. You keep using that word. I do not think it means what you think it means. Indeed, I almost get the impression from his articles that Dr. Spector views any study that doesn’t reach FDA-level standards for drug approval to be pseudoscience.
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  • Medical science, when it works well, tends to progress from basic science, to small pilot studies, to larger randomized studies, and then–only then–to those big, rigorous, insanely expensive randomized, double-blind, placebo-controlled trials. Dr. Spector mentions hierarchies of evidence, but he seems to fall into a false dichotomy, namely that if it’s not Level I evidence, it’s crap. The problem is, as Mark pointed out, in medicine we often don’t have Level I evidence for many questions. Indeed, for some questions, we will never have Level I evidence. Clinical medicine involves making decisions in the midst of uncertainty, sometimes extreme uncertainty.
  • Dr. Spector then proceeds to paint a picture of reckless physicians proceeding on crappy studies to pump women full of hormones. Actually, it was more than a bit more complicated on than that. That was the time when I was in my medical training, and I remember the discussions we had regarding the strength (or lack thereof) of the epidemiological data and the lack of good RCTs looking at HRT. I also remember that nothing works as well to relieve menopausal symptoms as HRT, an observation we have been reminded of again since 2003, which is the year when the first big study came out implicating HRT in increasing the risk of breast cancer (more later).
  • I found a rather fascinating editorial in the New England Journal of Medicine from more than 20 years ago that discussed the state of the evidence back then with regard to estrogen and breast cancer: Evidence that estrogen increases the risk of breast cancer has been surprisingly difficult to obtain. Clinical and epidemiologic studies and studies in animals strongly suggest that endogenous estrogen plays a part in causing breast cancer. If so, exogenous estrogen should be a potent promoter of breast cancer. Although more than 20 case–control and prospective studies of the relation of breast cancer and noncontraceptive estrogen use have failed to demonstrate the expected association, relatively few women in these studies used estrogen for extended periods. Studies of the use of diethylstilbestrol and oral contraceptives suggest that a long exposure or latency may be necessary to show any association between hormone use and breast cancer. In the Swedish study, only six years of follow-up was needed to demonstrate an increased risk of breast cancer with the postmenopausal use of estradiol. It should be noted, however, that half the women in the subgroup that provided detailed data on the duration of hormone use had taken estrogen for many years before their base-line prescription status was defined. The duration of estrogen exposure in these women before the diagnosis of breast cancer was probably seriously underestimated; a short latency cannot be attributed to estradiol on the basis of these data. Other recent studies of the use of noncontraceptive estrogen suggest a slightly increased risk of breast cancer after 15 to 20 years’ use.
  • even now, the evidence is conflicting regarding HRT and breast cancer, with the preponderance of evidence suggesting that mixed HRT (estrogen and progestin) significantly increases the risk of breast cancer, while estrogen-alone HRT very well might not increase the risk of breast cancer at all or (more likely) only very little. Indeed, I was just at a conference all day Saturday where data demonstrating this very point were discussed by one of the speakers. None of this stops Dr. Spector from categorically labeling estrogen as a “carcinogen that causes breast cancers that kill women.” Maybe. Maybe not. It’s actually not that clear. The problem, of course, is that, consistent with the first primary reports of WHI results, the preponderance of evidence finding health risks due to HRT have indicted the combined progestin/estrogen combinations as unsafe.
Weiye Loh

"Cancer by the Numbers" by John Allen Paulos | Project Syndicate - 0 views

www.project-syndicate.org/...cancer-by-the-numbers

Data Interpretation Statistics Cost Benefits Harm Cancer Screening Health

shared by Weiye Loh on 25 Apr 12 - No Cached
  • The USPSTF recently issued an even sharper warning about the prostate-specific antigen test for prostate cancer, after concluding that the test’s harms outweigh its benefits. Chest X-rays for lung cancer and Pap tests for cervical cancer have received similar, albeit less definitive, criticism.CommentsView/Create comment on this paragraphThe next step in the reevaluation of cancer screening was taken last year, when researchers at the Dartmouth Institute for Health Policy announced that the costs of screening for breast cancer were often minimized, and that the benefits were much exaggerated. Indeed, even a mammogram (almost 40 million are given annually in the US) that detects a cancer does not necessarily save a life.CommentsView/Create comment on this paragraphThe Dartmouth researchers found that, of the estimated 138,000 breast cancers detected annually in the US, the test did not help 120,000-134,000 of the afflicted women. The cancers either were growing so slowly that they did not pose a problem, or they would have been treated successfully if discovered clinically later (or they were so aggressive that little could be done).
Weiye Loh

Analysis: Hold the panic on cell phones and cancer | Phones | iOS Central | Macworld - 0 views

www.macworld.com/...phone_cancer_who_analysis.html

Mobile Wi-Fi Radio Waves Cancer Uncertainty Causation Model

shared by Weiye Loh on 05 Jun 11 - No Cached
  • Today’s cell phones are, essentially, extremely sophisticated radios and, as such, emit electromagnetic waves. Much like the vast majority of radiation that surrounds us—from visible light to AM and FM radio waves—electromagnetic waves do not possess enough energy to interact directly with the tissues in our bodies in a way that can cause direct damage. “The radiation that cell phones emit is nowhere near the kind of radiation that x-ray machines, for example, emit,” says Perras. “X-rays […] have much, much shorter wavelengths. Consequently, [they] carry much more energy and thus have much more penetrating power, which is required to be able to image the interior of the human body.”
  • X-rays and other “hard” waves are called ionizing radiation because they can interact with the human body in a way that leads to the creation of chemical compounds called free radicals that can, in turn, be responsible for mutations and the incidence of cancer.
  • The focus of much of the currently-ongoing scientific research, then, is on whether the radiation emitted by cell phones is focused enough to be absorbed into the body and cause heating, which could, in the long run, damage human tissue and eventually lead to cancer.
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  • The issue is particularly important because most users still hold their phones close to the head; since the brain is particularly sensitive to external stimuli, even a small amount of heat could lead to medical trouble in the long term.
  • What makes it challenging to determine if a link between cell phones and cancer actually exists are the many variables involved. “The incidence of brain tumors is quite small, making it more difficult to study in large numbers,” says Dr. Eric Olyejar, a Radiation Oncologist from Ironwood Cancer and Research Centers, based in Chandler, Ariz. That means “quantifying the lifetime dose each patient received is extremely difficult.”
  • To make things more difficult, cancer often develops as a result of many different factors. “Family history, exposure to chemicals or radiation, growth defects, the amount of radiation that is actually coming from the phone, amount of time used, proximity to the brain, skull thickness, and wave frequency are only a few of the many variables,” Olyejar says.
  • cell phones have become so ubiquitous that it’s hard to compare the health of users and non-users.
  • Weiye Loh on 05 Jun 11
     
    Do cell phones cause cancer? Nobody really knows for sure, but scientists are determined to keep an eye on the ever-evolving evidence that continues to accumulate on the subject. That's the gist of a report recently released by the World Health Organization's International Agency for Research on Cancer (IARC), the United Nations body responsible for oncological studies. In the report, IARC scientists have classified cell phone usage as a possible cause of cancer, meaning that, while the data currently available is still inconclusive, the subject deserves further research before a call can be made one way or another.
Weiye Loh

Could a Vaccine for Cancer be Just a Few Years Away? | The Utopianist - Think Bigger - 0 views

utopianist.com/...ay-be-available-in-a-few-years

Cancer Vaccine

shared by Weiye Loh on 20 Jun 11 - No Cached
  • Weiye Loh on 20 Jun 11
     
    Some very exciting news from the realm of the lab rat: a vaccine has cured prostate cancer in mice, and the kind that was well-established. It may seem counter-intuitive, but with cancer, vaccines are given after infection and then teach the immune system to fight what is already there. Frustratingly, the immune system often turns a blind eye on tumors, but this kind of vaccination system will "wake it up", making it fight.
Weiye Loh

gladwell dot com - something borrowed - 0 views

gladwell.com/...2004_11_25_a_borrowed.html

Copyright

shared by Weiye Loh on 19 May 11 - Cached
  • Intellectual-property doctrine isn't a straightforward application of the ethical principle "Thou shalt not steal." At its core is the notion that there are certain situations where you can steal. The protections of copyright, for instance, are time-limited; once something passes into the public domain, anyone can copy it without restriction. Or suppose that you invented a cure for breast cancer in your basement lab. Any patent you received would protect your intellectual property for twenty years, but after that anyone could take your invention.
  • You get an initial monopoly on your creation because we want to provide economic incentives for people to invent things like cancer drugs. But everyone gets to steal your breast-cancer cure—after a decent interval—because it is also in society's interest to let as many people as possible copy your invention; only then can others learn from it, and build on it, and come up with better and cheaper alternatives. This balance between the protecting and the limiting of intellectual property
  • Stanford law professor Lawrence Lessig argues in his new book "Free Culture": In ordinary language, to call a copyright a "property" right is a bit misleading, for the property of copyright is an odd kind of property. . . . I understand what I am taking when I take the picnic table you put in your backyard. I am taking a thing, the picnic table, and after I take it, you don't have it. But what am I taking when I take the good idea you had to put a picnic table in the backyard—by, for example, going to Sears, buying a table, and putting it in my backyard? What is the thing that I am taking then? The point is not just about the thingness of picnic tables versus ideas, though that is an important difference. The point instead is that in the ordinary case—indeed, in practically every case except for a narrow range of exceptions—ideas released to the world are free. I don't take anything from you when I copy the way you dress—though I might seem weird if I do it every day. . . . Instead, as Thomas Jefferson said (and this is especially true when I copy the way someone dresses), "He who receives an idea from me, receives instruction himself without lessening mine; as he who lights his taper at mine, receives light without darkening me."
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  • Lessig argues that, when it comes to drawing this line between private interests and public interests in intellectual property, the courts and Congress have, in recent years, swung much too far in the direction of private interests.
  • We could have sat in his living room playing at musical genealogy for hours. Did the examples upset him? Of course not, because he knew enough about music to know that these patterns of influence—cribbing, tweaking, transforming—were at the very heart of the creative process.
  • True, copying could go too far. There were times when one artist was simply replicating the work of another, and to let that pass inhibited true creativity. But it was equally dangerous to be overly vigilant in policing creative expression, because if Led Zeppelin hadn't been free to mine the blues for inspiration we wouldn't have got "Whole Lotta Love," and if Kurt Cobain couldn't listen to "More Than a Feeling" and pick out and transform the part he really liked we wouldn't have "Smells Like Teen Spirit"—and, in the evolution of rock, "Smells Like Teen Spirit" was a real step forward from "More Than a Feeling." A successful music executive has to understand the distinction between borrowing that is transformative and borrowing that is merely derivative, and that distinction, I realized, was what was missing from the discussion of Bryony Lavery's borrowings. Yes, she had copied my work. But no one was asking why she had copied it, or what she had copied, or whether her copying served some larger purpose.
  • It also matters how Lavery chose to use my words. Borrowing crosses the line when it is used for a derivative work. It's one thing if you're writing a history of the Kennedys, like Doris Kearns Goodwin, and borrow, without attribution, from another history of the Kennedys. But Lavery wasn't writing another profile of Dorothy Lewis. She was writing a play about something entirely new—about what would happen if a mother met the man who killed her daughter. And she used my descriptions of Lewis's work and the outline of Lewis's life as a building block in making that confrontation plausible.
  • this is the second problem with plagiarism. It is not merely extremist. It has also become disconnected from the broader question of what does and does not inhibit creativity. We accept the right of one writer to engage in a full-scale knockoff of another—think how many serial-killer novels have been cloned from "The Silence of the Lambs." Yet, when Kathy Acker incorporated parts of a Harold Robbins sex scene verbatim in a satiric novel, she was denounced as a plagiarist (and threatened with a lawsuit)
  • Weiye Loh on 19 May 11
     
    Under copyright law, what matters is not that you copied someone else's work. What matters is what you copied, and how much you copied.
kenneth yang

SD ballot measure would ease restrictions on stem cell research - 1 views

PIERRE, S.D. (AP) - A proposed ballot issue to ease restrictions on stem cell research will strike a chord with South Dakotans because nearly everyone has had a serious disease or knows someone who...

ethics rights stem cell

started by kenneth yang on 21 Oct 09 no follow-up yet
Weiye Loh

Hermits and Cranks: Lessons from Martin Gardner on Recognizing Pseudoscientists: Scient... - 0 views

www.scientificamerican.com/article.cfm

Science Pseudo-Science

shared by Weiye Loh on 09 Jul 10 - Cached
  • In 1950 Martin Gardner published an article in the Antioch Review entitled "The Hermit Scientist," about what we would today call pseudoscientists.
  • there has been some progress since Gardner offered his first criticisms of pseudoscience. Now largely antiquated are his chapters on believers in a flat Earth, a hollow Earth, Atlantis and Lemuria, Alfred William Lawson, Roger Babson, Trofim Lysenko, Wilhelm Reich and Alfred Korzybski. But disturbingly, a good two thirds of the book's contents are relevant today, including Gardner's discussions of homeopathy, naturopathy, osteopathy, iridiagnosis (reading the iris of the eye to deter- mine bodily malfunctions), food faddists, cancer cures and other forms of medical quackery, Edgar Cayce, the Great Pyramid's alleged mystical powers, handwriting analysis, ESP and PK (psychokinesis), reincarnation, dowsing rods, eccentric sexual theories, and theories of group racial differences.
  • The "hermit scientist," a youthful Gardner wrote, works alone and is ignored by mainstream scientists. "Such neglect, of course, only strengthens the convictions of the self-declared genius."
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  • Even then Gardner was bemoaning that some beliefs never seem to go out of vogue, as he recalled an H. L. Mencken quip from the 1920s: "Heave an egg out of a Pullman window, and you will hit a Fundamentalist almost anywhere in the U.S. today." Gardner cautions that when religious superstition should be on the wane, it is easy "to forget that thousands of high school teachers of biology, in many of our southern states, are still afraid to teach the theory of evolution for fear of losing their jobs." Today creationism has spread northward and mutated into the oxymoronic form of "creation science."
  • the differences between science and pseudoscience. On the one extreme we have ideas that are most certainly false, "such as the dianetic view that a one-day-old embryo can make sound recordings of its mother's conversation." In the borderlands between the two "are theories advanced as working hypotheses, but highly debatable because of the lack of sufficient data." Of these Gardner selects a most propitious propitious example: "the theory that the universe is expanding." That theory would now fall at the other extreme end of the spectrum, where lie "theories al- most certainly true, such as the belief that the Earth is round or that men and beasts are distant cousins."
  • How can we tell if someone is a scientific crank? Gardner offers this advice: (1) "First and most important of these traits is that cranks work in almost total isolation from their colleagues." Cranks typically do not understand how the scientific process operates—that they need to try out their ideas on colleagues, attend conferences and publish their hypotheses in peer-reviewed journals before announcing to the world their startling discovery. Of course, when you explain this to them they say that their ideas are too radical for the conservative scientific establishment to accept.
  • (2) "A second characteristic of the pseudo-scientist, which greatly strengthens his isolation, is a tendency toward paranoia," which manifests itself in several ways: (1) He considers himself a genius. (2) He regards his colleagues, without exception, as ignorant blockheads....(3) He believes himself unjustly persecuted and discriminated against. The recognized societies refuse to let him lecture. The journals reject his papers and either ignore his books or assign them to "enemies" for review. It is all part of a dastardly plot. It never occurs to the crank that this opposition may be due to error in his work....(4) He has strong compulsions to focus his attacks on the greatest scientists and the best-established theories. When Newton was the outstanding name in physics, eccentric works in that science were violently anti-Newton. Today, with Einstein the father-symbol of authority, a crank theory of physics is likely to attack Einstein....(5) He often has a tendency to write in a complex jargon, in many cases making use of terms and phrases he himself has coined.
  • "If the present trend continues," Gardner concludes, "we can expect a wide variety of these men, with theories yet unimaginable, to put in their appearance in the years immediately ahead. They will write impressive books, give inspiring lectures, organize exciting cults. They may achieve a following of one—or one million. In any case, it will be well for ourselves and for society if we are on our guard against them."
  • Weiye Loh on 09 Jul 10
     
    May 23, 2010 | 31 comments Hermits and Cranks: Lessons from Martin Gardner on Recognizing Pseudoscientists Fifty years ago Gardner launched the modern skeptical movement. Unfortunately, much of what he wrote about is still current today By Michael Shermer   
Weiye Loh

Book Review: "Merchants of Doubt: How a Handful of Scientists Obscured the Tr... - 0 views

www.skepticnorth.com/...aomi-oreskes-and-erik-m-conway

Science Uncertainty Political Economy

shared by Weiye Loh on 19 Nov 10 - No Cached
  • Merchant of Doubt is exactly what its subtitle says: a historical view of how a handful of scientists have obscured the truth on matters of scientific fact.
  • it was a very small group who were responsible for creating a great deal of doubt on a variety of issues. The book opens in 1953, where the tobacco industry began to take action to obscure the truth about smoking’s harmful effects, when its relationship to cancer first received widespread media attention.
  • The tobacco industry exploited scientific tendency to be conservative in drawing conclusions, to throw up a handful of cherry-picked data and misleading statistics and to “spin unreasonable doubt.” This tactic, combined with the media’s adherence to the “fairness doctrine” which was interpreted as giving equal time “to both sides [of an issue], rather than giving accurate weight to both sides” allowed the tobacco industry to delay regulation for decades.
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  • The natural scientific doubt was this: scientists could not say with absolute certainty that smoking caused cancer, because there wasn’t an invariable effect. “Smoking does not kill everyone who smokes, it only kills about half of them.” All scientists could say was that there was an extremely strong association between smoking and serious health risks
  • the “Tobacco Strategy” was created, and had two tactics: To “use normal scientific doubt to undermine the status of actual scientific knowledge” and To exploit the media’s adherence to the fairness doctrine, which would give equal weight to each side of a debate, regardless of any disparity in the supporting scientific evidence
  • Fred Seitz was a scientist who learned the Tobacco Strategy first-hand. He had an impressive resume. An actual rocket scientist, he helped build the atomic bomb in the 1940s, worked for NATO in the 1950s, was president of the U.S. National Academy of Sciences in the 1960s, and of Rockefeller University in the 1970s.
  • After his retirement in 1979, Seitz took on a job for the tobacco industry. Over the next 6 years, he doled out $45 million of R.J. Reynolds’ money to fund biomedical research to create “an extensive body of scientifically well-grounded data useful in defending the industry against attacks” by such means as focussing on alternative “causes or development mechanisms of chronic degenerative diseases imputed to cigarettes.” He was joined by, most notably, two other physicists: William Nierenberg, who also worked on the atom bomb in the 1940s, submarine warfare, NATO, and was appointed director or the Scripps Institution of Oceanography in 1965; and Robert Jastrow, who founded NASA’s Goddard Institute for Space Studies, which he directed until he retired in 1981 to teach at Dartmouth College.
  • In 1984, these three founded the think tank, the George C. Marshall Institute
  • None of these men were experts in environmental and health issues, but they all “used their scientific credentials to present themselves as authorities, and they used their authority to discredit any science they didn’t like.” They turned out to be wrong, in terms of the science, on every issue they weighed in on. But they turned out to be highly successful in preventing or limiting regulation that the scientific evidence would warrant.
  • The bulk of the book details at how these men and others applied the Tobacco Strategy to create doubt on the following issues: the unfeasibility of the Strategic Defense Initiative (Ronald Reagan’s “Star Wars”), and the resultant threat of nuclear winter that Carl Sagan, among others, pointed out acid rain depletion of the ozone layer second-hand smoke, and most recently, and significantly, global warming.
  • Having pointed out the dangers the doubt-mongers pose, Oreskes and Conway propose a remedy: an emphasis on scientific literacy, not in the sense of memorizing scientific facts, but in being able to assess which scientists to trust.
Weiye Loh

Arsenic bacteria - a post-mortem, a review, and some navel-gazing | Not Exactly Rocket ... - 0 views

blogs.discovermagazine.com/...a-review-and-some-navel-gazing

Journalism Ethics Science Biology

shared by Weiye Loh on 11 Dec 10 - No Cached
  • t was the big news that wasn’t. Hyperbolic claims about the possible discovery of alien life, or a second branch of life on Earth, turned out to be nothing more than bacteria that can thrive on arsenic, using it in place of phosphorus in their DNA and other molecules. But after the initial layers of hype were peeled away, even this extraordinar
  • This is a chronological roundup of the criticism against the science in the paper itself, ending with some personal reflections on my own handling of the story (skip to Friday, December 10th for that bit).
  • Thursday, December 2nd: Felisa Wolfe-Simon published a paper in Science, claiming to have found bacteria in California’s Mono Lake that can grow using arsenic instead of phosphorus. Given that phosphorus is meant to be one of six irreplaceable elements, this would have been a big deal, not least because the bacteria apparently used arsenic to build the backbones of their DNA molecules.
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  • In my post, I mentioned some caveats. Wolfe-Simon isolated the arsenic-loving strain, known as GFAJ-1, by growing Mono Lake bacteria in ever-increasing concentrations of arsenic while diluting out the phosphorus. It is possible that the bacteria’s arsenic molecules were an adaptation to the harsh environments within the experiment, rather than Mono Lake itself. More importantly, there were still detectable levels of phosphorus left in the cells at the end of the experiment, although Wolfe-Simon claimed that the bacteria shouldn’t have been able to grow on such small amounts.
  • signs emerged that NASA weren’t going to engage with the criticisms. Dwayne Brown, their senior public affairs officer, highlighted the fact that the paper was published in one of the “most prestigious scientific journals” and deemed it inappropriate to debate the science using the same media and bloggers who they relied on for press coverage of the science. Wolfe-Simon herself tweeted that “discussion about scientific details MUST be within a scientific venue so that we can come back to the public with a unified understanding.”
  • Jonathan Eisen says that “they carried out science by press release and press conference” and “are now hypocritical if they say that the only response should be in the scientific literature.” David Dobbs calls the attitude “a return to pre-Enlightenment thinking”, and rightly noted that “Rosie Redfield is a peer, and her blog is peer review”.
  • Chris Rowan agreed, saying that what happens after publication is what he considers to be “real peer review”. Rowan said, “The pre-publication stuff is just a quality filter, a check that the paper is not obviously wrong – and an imperfect filter at that. The real test is what happens in the months and years after publication.”Grant Jacobs and others post similar thoughts, while Nature and the Columbia Journalism Review both cover the fracas.
  • Jack Gilbert at the University of Chicago said that impatient though he is, peer-reviewed journals are the proper forum for criticism. Others were not so kind. At the Guardian, Martin Robbins says that “at almost every stage of this story the actors involved were collapsing under the weight of their own slavish obedience to a fundamentally broken… well… ’system’” And Ivan Oransky noted that NASA failed to follow its own code of conduct when announcing the study.
  • Dr Isis said, “If question remains about the voracity of these authors findings, then the only thing that is going to answer that doubt is data.  Data cannot be generated by blog discussion… Talking about digging a ditch never got it dug.”
  • it is astonishing how quickly these events unfolded and the sheer number of bloggers and media outlets that became involved in the criticism. This is indeed a brave new world, and one in which we are all the infamous Third Reviewer.
  • I tried to quell the hype around the study as best I could. I had the paper and I think that what I wrote was a fair representation of it. But, of course, that’s not necessarily enough. I’ve argued before that journalists should not be merely messengers – we should make the best possible efforts to cut through what’s being said in an attempt to uncover what’s actually true. Arguably, that didn’t happen although to clarify, I am not saying that the paper is rubbish or untrue. Despite the criticisms, I want to see the authors respond in a thorough way or to see another lab attempt replicate the experiments before jumping to conclusions.
  • the sheer amount of negative comment indicates that I could have been more critical of the paper in my piece. Others have been supportive in suggesting that this was more egg on the face of the peer reviewers and indeed, several practicing scientists took the findings on face value, speculating about everything from the implications for chemotherapy to whether the bacteria have special viruses. The counter-argument, which I have no good retort to, is that peer review is no guarantee of quality, and that writers should be able to see through the fog of whatever topic they write about.
  • my response was that we should expect people to make reasonable efforts to uncover truth and be skeptical, while appreciating that people can and will make mistakes.
  • it comes down to this: did I do enough? I was certainly cautious. I said that “there is room for doubt” and I brought up the fact that the arsenic-loving bacteria still contain measurable levels of phosphorus. But I didn’t run the paper past other sources for comment, which I typically do it for stories that contain extraordinary claims. There was certainly plenty of time to do so here and while there were various reasons that I didn’t, the bottom line is that I could have done more. That doesn’t always help, of course, but it was an important missed step. A lesson for next time.
  • I do believe that it you’re going to try to hold your profession to a higher standard, you have to be honest and open when you’ve made mistakes yourself. I also think that if you cover a story that turns out to be a bit dodgy, you have a certain responsibility in covering the follow-up
  • A basic problem with is the embargo. Specifically that journalists get early access, while peers – other specialists in the field – do not. It means that the journalist, like yourself, can rely only on the original authors, with no way of getting other views on the findings. And it means that peers can’t write about the paper when the journalists (who, inevitably, do a positive-only coverage due to the lack of other viewpoints) do, but will be able to voice only after they’ve been able to digest the paper and formulate a response.
  • No, that’s not true. The embargo doens’t preclude journalists from sending papers out to other authors for review and comment. I do this a lot and I have been critical about new papers as a result, but that’s the step that I missed for this story.
Weiye Loh

Adventures in Flay-land: James Delingpole and the "Science" of Denialism - 0 views

flay.jellybee.co.uk/...delingpole-and-science-of.html

Climate Science AGW Skepticism Denial

shared by Weiye Loh on 30 Jan 11 - No Cached
  • Perhaps like me, you watched the BBC Two Horizons program Monday night presented by Sir Paul Nurse, president of the Royal Society and Nobel Prize winning geneticist for his discovery of the genes of cell division.
  • James. He really believes there's some kind of mainstream science "warmist" conspiracy against the brave outliers who dare to challenge the consensus. He really believes that "climategate" is a real scandal. He fails to understand that it is a common practice in statistics to splice together two or more datasets where you know that the quality of data is patchy. In the case of "climategate", researchers found that indirect temperature measurements based on tree ring widths (the tree ring temperature proxy) is consistent with other proxy methods of recording temperature from before the start of the instrumental temperature record (around 1950) but begins to show a decline in temperature after that for reasons which are unclear. Actual temperature measurements however show the opposite. The researcher at the head of the climategate affair, Phil Jones, created a graph of the temperature record to include on the cover of a report for policy makers and journalists. For this graph he simply spliced together the tree ring proxy data up until 1950 with the recorded data after that using statistical techniques to bring them into agreement. What made this seem particularly dodgy was an email intercepted by a hacker in which Jones referred to this practice as a "Mike's Nature trick", referring to a paper published by his colleague Mike Hulme Michael Mann in the journal Nature. It is however nothing out of the ordinary. Delingpole and others have talked about how this "trick" was used here to "hide the decline" revealed by the other dataset, as though this was some sort of deception. The fact that all parties were found to have behaved ethically is simply further evidence of the global warmist conspiracy. Delingpole takes it further and casts aspersions on scientific consensus and the entire peer review process.
  • When Nurse asked Delingpole the very straightforward question of whether he would be willing to trust a scientific consensus if he required treatment for cancer, he could have said "Gee, that's an interesting question. Let me think about that and why it's different."
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  • Instead, he became defensive and lost his focus. Eventually he would make such regrettable statements as this one: "It is not my job to sit down and read peer-reviewed papers because I simply haven’t got the time, I haven’t got the scientific expertise… I am an interpreter of interpretation."
  • In a parallel universe where James Delingpole is not the "penis" that Ben Goldacre describes him to be, he might have said the following: Gee, that's an interesting question. Let me think about why it's different. (Thinks) Well, it seems to me that when evaluating a scientifically agreed treatment for a disease such as cancer, we have not only all the theory to peruse and the randomized and blinded trials, but also thousands if not millions of case studies where people have undergone the intervention. We have enough data to estimate a person's chances of recovery and know that on average they will do better. When discussing climate change, we really only have the one case study. Just the one earth. And it's a patient that has not undergone any intervention. The scientific consensus is therfore entirely theoretical and intangible. This makes it more difficult for the lay person such as myself to trust it.
  • Sir Paul ended the program saying "Scientists have got to get out there… if we do not do that it will be filled by others who don’t understand the science, and who may be driven by politics and ideology."
  • f proxy tracks instrumental from 1850 to 1960 but then diverges for unknown reasons, how do we know that the proxy is valid for reconstructing temperatures in periods prior to 1850?
  • This is a good question and one I'm not sure I can answer it to anyone's satisfaction. We seem to have good agreement among several forms of temperature proxy going back centuries and with direct measurements back to 1880. There is divergence in more recent years and there are several theories as to why that might be. Some possible explanations here:http://www.skepticalscience.com/Tree-ring-proxies-divergence-problem.htm
  • In the physical world we can never be absolutely certain of anything. Rene Des Cartes showed it was impossible to prove that everything he sensed wasn't manipulated by some invisible demon.
  • It is necessary to first make certain assumptions about the universe that we observe. After that, we can only go with the best theories available that allow us to make scientific progress.
lee weiting

should we develop nanotechnology? - 1 views

http://www.sciencedaily.com/releases/2009/06/090610192431.htm This articles discuss about the possible health risk of nanotechnology. on one hand, the use of nanoparticles may be promising for di...

nanotechnology

started by lee weiting on 28 Oct 09 no follow-up yet
Weiye Loh

The Great Organ Bazaar - Susanne Lundin - Project Syndicate - 0 views

www.project-syndicate.org/...English

Organ Transplant Trade Internet Bioethics

shared by Weiye Loh on 23 Jun 11 - No Cached
  • All of this Internet activity is but the tip of the iceberg of a new and growing global human-tissue economy. Indeed, the World Health Organization (WHO) has estimated that about 10% of organ transplants around the world stem from purely commercial transactions.
  • Trade in organs follows a clear, geographically linked pattern: people from rich countries buy the organs, and people in poor countries sell them. In my research on organ trafficking, I have entered some of these shadow markets, where body parts from the poor, war victims, and prisoners are commodities, bought or stolen for transplant into affluent ill people.
  • Organ trafficking depends on several factors. One is people in distress. They are economically or socially disadvantaged, or live in war-torn societies with prevalent crime and a thriving black market. On the demand side are people who are in danger of dying unless they receive an organ transplant. Additionally, there are organ brokers who arrange the deals between sellers and buyers.
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  • Trade in humans and their bodies is not a new phenomenon, but today’s businesses are historically unique, because they require advanced biomedicine, as well as ideas and values that enhance the trade in organs. Western medicine starts from the view that human illness and death are failures to be combated. It is within this conceptual climate – the dream of the regenerative body – that transplantation technology develops and demand for biological replacement parts grows.
  • In an era of transplants on demand, there is no way around this dilemma. The biological imperatives that guide the priority system of transplant waiting lists are easily transformed into economic values. As always where demand exceeds supply, people may not accept waiting their turn – and other countries and other peoples’ bodies give them the alternative they seek.
  • Weiye Loh on 23 Jun 11
     
    The Web site 88DB.com Philippines is an active online portal that allows service providers and consumers to find and interact with each other. Naoval, an Indonesian man with "AB blood type, no drugs and no alcohol," wants to sell his kidney. Another man says, "I am a Filipino. I am willing to sell my kidney for my wife. She has breast cancer and I can't afford her medications." Then there is Enrique, who is "willing to donate my kidney for an exchange. 21 years old and healthy." Other offers of this type could, just a few years ago, be found at www.liver4you.org, which promised kidneys for $80,000-$110,000. The costs of the operation, including the fees of the surgeons - licensed in the United States, Great Britain, or the Philippines - would be included in the price.
Weiye Loh

Roger Pielke Jr.'s Blog: Mike Daisey and Higher Truths - 0 views

rogerpielkejr.blogspot.com/...-daisey-and-higher-truths.html

Politics Truth Journalism Objectivity News Climate Climate Change Climate Science Balance

shared by Weiye Loh on 19 Mar 12 - No Cached
  • Real life is messy. And as a general rule, the more theatrical the story you hear, and the more it divides the world into goodies vs baddies, the less reliable that story is going to be.
  • some people do feel that certain issues are so important that there should be cause in political debates to overlook lies or misrepresentations in service of a "larger truth" (Yellow cake, anyone?). I have seen this attitude for years in the climate change debate (hey look, just today), and often condoned by scientists and journalists alike.
  • the "global warming: yes or no?" debate has become an obstacle to effective policy action related to climate. Several of these colleagues suggested that I should downplay the policy implications of my work showing that for a range of phenomena and places, future climate impacts depend much more on growing human vulnerability to climate than on projected changes in climate itself (under the assumptions of the Intergovernmental Panel on Climate Change). One colleague wrote, "I think we have a professional (or moral?) obligation to be very careful what we say and how we say it when the stakes are so high." In effect, some of these colleagues were intimating that ends justify means or, in other words, doing the "right thing" for the wrong reasons is OK.
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  • When science is used (and misused) in political advocacy, there are frequent opportunities for such situations to arise.
  • I don't think you're being fair to Mike Lemonick. In the article by him that you cite, MIke's provocative question was framed in the context of an analogy he was making to the risks of smoking. For example, in that article, he also says: "So should the overall message be that nobody knows anything? I don’t think so. We would never want to pretend the uncertainty isn’t there, since that would be dishonest. But featuring it prominently is dishonest ,too, just as trumpeting uncertainty in the smoking-cancer connection would have been."Thus, I think you're reading way too much into Mike's piece. That said, I do agree with you that there are implications of the Daisey case for climate communicators and climate journalism. My own related post is here: http://www.collide-a-scape.com/2012/03/19/the-seduction-of-narrative/"
  • I don't want journalists shading the truth in a desire to be "effective" in some way. That is Daisey's tradeoff too.
  • Weiye Loh on 19 Mar 12
     
    Recall that in the aftermath of initial revelations about Peter Gleick's phishing of the Heartland Institute, we heard defenses of his action that included claims that he was only doing the same thing that journalists do to the importance of looking beyond Gleick's misdeeds at the "larger truth." Consider also what was described in the UEA emails as "pressure to present a nice tidy story" related to climate science as well as the IPCC's outright falsification related to disasters and climate change. Such shenanigans so endemic in the climate change debate that when a journalist openly asks whether the media should tell the whole truth about climate change, no one even bats an eye. 
Jude John

What's so Original in Academic Research? - 26 views

Thanks for your comments. I may have appeared to be contradictory, but what I really meant was that ownership of IP should not be a motivating factor to innovate. I realise that in our capitalistic...

started by Weiye Loh on 21 Aug 09 4 follow-ups, last by Jude John on 25 Aug 09
Weiye Loh

CancerGuide: The Median Isn't the Message - 0 views

cancerguide.org/median_not_msg.html

Statistics Science Cancer

shared by Weiye Loh on 08 Aug 10 - Cached
  • Statistics recognizes different measures of an "average," or central tendency. The mean is our usual concept of an overall average - add up the items and divide them by the number of sharers
  • The median, a different measure of central tendency, is the half-way point.
  • A politician in power might say with pride, "The mean income of our citizens is $15,000 per year." The leader of the opposition might retort, "But half our citizens make less than $10,000 per year." Both are right, but neither cites a statistic with impassive objectivity. The first invokes a mean, the second a median. (Means are higher than medians in such cases because one millionaire may outweigh hundreds of poor people in setting a mean; but he can balance only one mendicant in calculating a median).
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  • The larger issue that creates a common distrust or contempt for statistics is more troubling. Many people make an unfortunate and invalid separation between heart and mind, or feeling and intellect. In some contemporary traditions, abetted by attitudes stereotypically centered on Southern California, feelings are exalted as more "real" and the only proper basis for action - if it feels good, do it - while intellect gets short shrift as a hang-up of outmoded elitism. Statistics, in this absurd dichotomy, often become the symbol of the enemy. As Hilaire Belloc wrote, "Statistics are the triumph of the quantitative method, and the quantitative method is the victory of sterility and death."
  • This is a personal story of statistics, properly interpreted, as profoundly nurturant and life-giving. It declares holy war on the downgrading of intellect by telling a small story about the utility of dry, academic knowledge about science. Heart and head are focal points of one body, one personality.
  • We still carry the historical baggage of a Platonic heritage that seeks sharp essences and definite boundaries. (Thus we hope to find an unambiguous "beginning of life" or "definition of death," although nature often comes to us as irreducible continua.) This Platonic heritage, with its emphasis in clear distinctions and separated immutable entities, leads us to view statistical measures of central tendency wrongly, indeed opposite to the appropriate interpretation in our actual world of variation, shadings, and continua. In short, we view means and medians as the hard "realities," and the variation that permits their calculation as a set of transient and imperfect measurements of this hidden essence. If the median is the reality and variation around the median just a device for its calculation, the "I will probably be dead in eight months" may pass as a reasonable interpretation.
  • But all evolutionary biologists know that variation itself is nature's only irreducible essence. Variation is the hard reality, not a set of imperfect measures for a central tendency. Means and medians are the abstractions. Therefore, I looked at the mesothelioma statistics quite differently - and not only because I am an optimist who tends to see the doughnut instead of the hole, but primarily because I know that variation itself is the reality. I had to place myself amidst the variation. When I learned about the eight-month median, my first intellectual reaction was: fine, half the people will live longer; now what are my chances of being in that half. I read for a furious and nervous hour and concluded, with relief: damned good. I possessed every one of the characteristics conferring a probability of longer life: I was young; my disease had been recognized in a relatively early stage; I would receive the nation's best medical treatment; I had the world to live for; I knew how to read the data properly and not despair.
  • Another technical point then added even more solace. I immediately recognized that the distribution of variation about the eight-month median would almost surely be what statisticians call "right skewed." (In a symmetrical distribution, the profile of variation to the left of the central tendency is a mirror image of variation to the right. In skewed distributions, variation to one side of the central tendency is more stretched out - left skewed if extended to the left, right skewed if stretched out to the right.) The distribution of variation had to be right skewed, I reasoned. After all, the left of the distribution contains an irrevocable lower boundary of zero (since mesothelioma can only be identified at death or before). Thus, there isn't much room for the distribution's lower (or left) half - it must be scrunched up between zero and eight months. But the upper (or right) half can extend out for years and years, even if nobody ultimately survives. The distribution must be right skewed, and I needed to know how long the extended tail ran - for I had already concluded that my favorable profile made me a good candidate for that part of the curve.
  • The distribution was indeed, strongly right skewed, with a long tail (however small) that extended for several years above the eight month median. I saw no reason why I shouldn't be in that small tail, and I breathed a very long sigh of relief. My technical knowledge had helped. I had read the graph correctly. I had asked the right question and found the answers. I had obtained, in all probability, the most precious of all possible gifts in the circumstances - substantial time.
  • One final point about statistical distributions. They apply only to a prescribed set of circumstances - in this case to survival with mesothelioma under conventional modes of treatment. If circumstances change, the distribution may alter. I was placed on an experimental protocol of treatment and, if fortune holds, will be in the first cohort of a new distribution with high median and a right tail extending to death by natural causes at advanced old age.
  • Weiye Loh on 08 Aug 10
     
    The Median Isn't the Message by Stephen Jay Gould
Weiye Loh

nanopolitan: Medicine, Trials, Conflict of Interest, Disclosures - 0 views

nanopolitan.blogspot.com/...ials-conflict-of-interest.html

Medicine Academic Journal Political Economy

shared by Weiye Loh on 27 Sep 10 - No Cached
  • Some 1500 documents revealed in litigation provide unprecedented insights into how pharmaceutical companies promote drugs, including the use of vendors to produce ghostwritten manuscripts and place them into medical journals.
  • Dozens of ghostwritten reviews and commentaries published in medical journals and supplements were used to promote unproven benefits and downplay harms of menopausal hormone therapy (HT), and to cast raloxifene and other competing therapies in a negative light.
  • the pharmaceutical company Wyeth used ghostwritten articles to mitigate the perceived risks of breast cancer associated with HT, to defend the unsupported cardiovascular “benefits” of HT, and to promote off-label, unproven uses of HT such as the prevention of dementia, Parkinson's disease, vision problems, and wrinkles.
  • ...7 more annotations...
  • Given the growing evidence that ghostwriting has been used to promote HT and other highly promoted drugs, the medical profession must take steps to ensure that prescribers renounce participation in ghostwriting, and to ensure that unscrupulous relationships between industry and academia are avoided rather than courted.
  • Twenty-five out of 32 highly paid consultants to medical device companies in 2007, or their publishers, failed to reveal the financial connections in journal articles the following year, according to a [recent] study.
  • The study compared major payments to consultants by orthopedic device companies with financial disclosures the consultants later made in medical journal articles, and found them lacking in public transparency. “We found a massive, dramatic system failure,” said David J. Rothman, a professor and president of the Institute on Medicine as a Profession at Columbia University, who wrote the study with two other Columbia researchers, Susan Chimonas and Zachary Frosch.
  • Carl Elliot in The Chronicle of Higher Educations: The Secret Lives of Big Pharma's 'Thought Leaders':
  • See also a related NYTimes report -- Menopause, as Brought to You by Big Pharma by Natasha Singer and Duff Wilson -- from December 2009. Duff Wilson reports in the NYTimes: Medical Industry Ties Often Undisclosed in Journals:
  • Pharmaceutical companies hire KOL's [Key Opinion Leaders] to consult for them, to give lectures, to conduct clinical trials, and occasionally to make presentations on their behalf at regulatory meetings or hearings.
  • KOL's do not exactly endorse drugs, at least not in ways that are too obvious, but their opinions can be used to market them—sometimes by word of mouth, but more often by quasi-academic activities, such as grand-rounds lectures, sponsored symposia, or articles in medical journals (which may be ghostwritten by hired medical writers). While pharmaceutical companies seek out high-status KOL's with impressive academic appointments, status is only one determinant of a KOL's influence. Just as important is the fact that a KOL is, at least in theory, independent. [...]
  • Weiye Loh on 27 Sep 10
     
    Medicine, Trials, Conflict of Interest, Disclosures Just a bunch of links -- mostly from the US -- that paint give us a troubling picture of the state of ethics in biomedical fields:
Weiye Loh

Titans of science: David Attenborough meets Richard Dawkins | Science | The Guardian - 0 views

www.guardian.co.uk/...d-attenborough-richard-dawkins

Science

shared by Weiye Loh on 11 Sep 10 - No Cached
  • What is the one bit of science from your field that you think everyone should know?David Attenborough: The unity of life.Richard Dawkins: The unity of life that comes about through evolution, since we're all descended from a single common ancestor. It's almost too good to be true, that on one planet this extraordinary complexity of life should have come about by what is pretty much an intelligible process. And we're the only species capable of understanding it.
  • RD: I know you're working on a programme about Cambrian and pre-Cambrian fossils, David. A lot of people might think, "These are very old animals, at the beginning of evolution; they weren't very good at what they did." I suspect that isn't the case?DA: They were just as good, but as generalists, most were ousted from the competition.RD: So it probably is true there's a progressive element to evolution in the short term but not in the long term – that when a lineage branches out, it gets better for about five million years but not 500 million years. You wouldn't see progressive improvement over that kind of time scale.DA: No, things get more and more specialised. Not necessarily better.RD: The "camera" eyes of any modern animal would be better than what had come before.DA: Certainly... but they don't elaborate beyond function. When I listen to a soprano sing a Handel aria with an astonishing coloratura from that particular larynx, I say to myself, there has to be a biological reason that was useful at some stage. The larynx of a human being did not evolve without having some function. And the only function I can see is sexual attraction.RD: Sexual selection is important and probably underrated.DA: What I like to think is that if I think the male bird of paradise is beautiful, my appreciation of it is precisely the same as a female bird of paradise.
    • Weiye Loh
      Weiye Loh on 11 Sep 10
       
      Is survivability really all about sex and reproduction of future generation? 
  • People say Richard Feynman had one of these extraordinary minds that could grapple with ideas of which I have no concept. And you hear all the ancillary bits – like he was a good bongo player – that make him human. So I admire this man who could not only deal with string theory but also play the bongos. But he is beyond me. I have no idea what he was talking of.
  • ...6 more annotations...
  • RD: There does seem to be a sense in which physics has gone beyond what human intuition can understand. We shouldn't be too surprised about that because we're evolved to understand things that move at a medium pace at a medium scale. We can't cope with the very tiny scale of quantum physics or the very large scale of relativity.
  • DA: A physicist will tell me that this armchair is made of vibrations and that it's not really here at all. But when Samuel Johnson was asked to prove the material existence of reality, he just went up to a big stone and kicked it. I'm with him.
  • RD: It's intriguing that the chair is mostly empty space and the thing that stops you going through it is vibrations or energy fields. But it's also fascinating that, because we're animals that evolved to survive, what solidity is to most of us is something you can't walk through.
  • the science of the future may be vastly different from the science of today, and you have to have the humility to admit when you don't know. But instead of filling that vacuum with goblins or spirits, I think you should say, "Science is working on it."
  • DA: Yes, there was a letter in the paper [about Stephen Hawking's comments on the nonexistence of God] saying, "It's absolutely clear that the function of the world is to declare the glory of God." I thought, what does that sentence mean?!
  • What is the most difficult ethical dilemma facing science today?DA: How far do you go to preserve individual human life?RD: That's a good one, yes.DA: I mean, what are we to do with the NHS? How can you put a value in pounds, shillings and pence on an individual's life? There was a case with a bowel cancer drug – if you gave that drug, which costs several thousand pounds, it continued life for six weeks on. How can you make that decision?
  • Weiye Loh on 11 Sep 10
     
    Of mind and matter: David Attenborough meets Richard Dawkins We paired up Britain's most celebrated scientists to chat about the big issues: the unity of life, ethics, energy, Handel - and the joy of riding a snowmobile
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