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Tero Toivanen

The five ages of the brain: Adolescence - life - 04 April 2009 - New Scientist - 0 views

  • Jay Giedd at the National Institute of Mental Health in Bethesda, Maryland, and his colleagues have followed the progress of nearly 400 children, scanning many of them every two years as they grew up. They found that adolescence brings waves of grey-matter pruning, with teens losing about 1 per cent of their grey matter every year until their early 20s (Nature Neuroscience, vol 2, p 861).
  • This cerebral pruning trims unused neural connections that were overproduced in the childhood growth spurt, starting with the more basic sensory and motor areas.
  • Among the last to mature is the dorsolateral prefrontal cortex at the very front of the frontal lobe. This area is involved in control of impulses, judgement and decision-making, which might explain some of the less-than-stellar decisions made by your average teen. This area also acts to control and process emotional information sent from the amygdala - the fight or flight centre of gut reactions - which may account for the mercurial tempers of adolescents.
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  • These changes have both benefits and pitfalls. At this stage of life the brain is still childishly flexible, so we are still sponges for learning. On the other hand, the lack of impulse control may lead to risky behaviours such as drug and alcohol abuse, smoking and unprotected sex.
  • As grey matter is lost, though, the brain gains white matter
  • Substance abuse is particularly concerning, as brain imaging studies suggest that the motivation and reward circuitry in teen brains makes them almost hard-wired for addiction.
  • since drug abuse and stressful events - even a broken heart - have been linked to mood disorders later in life, this is the time when both are best avoided.
  • Making the most of this time is a matter of throwing all that teen energy into learning and new experiences - whether that means hitting the books, learning to express themselves through music or art, or exploring life by travelling the world.
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    Jay Giedd at the National Institute of Mental Health in Bethesda, Maryland, and his colleagues have followed the progress of nearly 400 children, scanning many of them every two years as they grew up. They found that adolescence brings waves of grey-matter pruning, with teens losing about 1 per cent of their grey matter every year until their early 20s (Nature Neuroscience, vol 2, p 861).
Tero Toivanen

Jellinek - Drugs in de hersenen - 0 views

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    Really interesting resource about Drugs and the brain.
Michael Manning

The Neuroscience of Addiction: A Conversation with Dr. Nora Volkow - 0 views

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    For many years, drug addictions were deemed to be largely behavioral disorders once the abuser went through a period of detoxification.  But advanced imaging technologies have now indicated that addiction is a physical process that occurs in addition to physical dependency. 
Tero Toivanen

Growing evidence of the brain's plasticity could benefit stroke victims or those suffer... - 0 views

  • With the right training, scientists now know the brain can reshape itself to work around dead and damaged areas, often with dramatic benefits.
  • Therapies that exploit the brain's power to adapt have helped people overcome damage caused by strokes, depression, anxiety and learning disabilities, and may one day replace drugs for some of these conditions.
  • Children with language difficulties have been shown to make significant progress using computer training tools that are the equivalent of cerebral cross-training.
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  • Neuroplasticity does not see the different regions of the brain as completely versatile and certainly not interchangeable. But it recognises that if part of the brain is damaged, it can be possible to train other areas to take on, at least to some extent, the job of the lost brain matter.
  • Doidge says he is not anti-medication, but wonders if therapies that tap into neuro-plasticity will soon replace drug treatments for certain conditions. "We can change our brains by sensing, imagining and acting in the world. It's economical and mostly low-tech, and I'm very, very hopeful"
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    With the right training, scientists now know the brain can reshape itself to work around dead and damaged areas, often with dramatic benefits.
Tero Toivanen

http://www.sciencedaily.com/releases/2009/12/091223125125.htm - 1 views

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    Scientists at UC Santa Barbara have made a major discovery in how the brain encodes memories. The finding, published in the December 24 issue of the journal Neuron, could eventually lead to the development of new drugs to aid memory.
Tero Toivanen

'Noisiest' neurons persist in the adult brain - 0 views

  • In addition, the observation that the "noisiest" neurons have a survival advantage helps explain the prevalence of epilepsy, in which some neurons become hyperactive and fire in an uncontrollable fashion.
  • during childhood, when many neurons are still being added to the brain, it is likely that neurons that become pathologically hyperactive will be preferentially selected for survival, and these abnormal neurons will be the trigger for epilepsy,
  • Investigating the molecular signals launched by neuronal activity will potentially lead to new drugs that bolster the survival of new neurons. These drugs could be used to increase the efficacy of treatments that depend on grafting stem cell-derived neurons into the adult brain to treat neurological diseases such as Parkinson's and Alzheimer's.
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    'Noisiest' neurons persist in the adult brain
Tero Toivanen

Brain Foundation - Healthy Brain - 0 views

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    The Healthy Brain Program, an initiative of the Brain Foundation, aims to assist Australians to keep their brains healthy into old age, through the provision of community education and research. The program aims to address issues such as: People are living longer, and the prevalence of degenerative brain disorders is increasing. There is little information available about how to keep the brain healthy compared to the wealth of information about a healthy body and heart. There is a need for a coordinated approach to education on key indicators and risk reduction strategies.
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