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avivajazz  jazzaviva

Decreased free testosterone and dehydroep... [J Sex Marital Ther. 2002] - PubMed - NCBI - 0 views

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    "Decreased free testosterone and dehydroepiandrosterone-sulfate (DHEA-S) levels in women with decreased libido."
avivajazz  jazzaviva

JAMA Network | Archives of General Psychiatry | Dehydroepiandrosterone Monotherapy in M... - 0 views

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    "Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression"
avivajazz  jazzaviva

PsychiatryOnline | APA Practice Guidelines | Guideline Watch: Practice Guideline for th... - 0 views

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    "The American Psychiatric Association (APA) practice guidelines are developed by expert work groups using an explicit methodology that includes rigorous review of available evidence, broad peer review of iterative drafts, and formal approval by the APA"
avivajazz  jazzaviva

L-Carnitine + Cardiovascular Disease | Meta-Review of Studies - 0 views

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    Angina Pectoris, Heart Failure, Intermittent Claudication in Peripheral Arterial Disease, Atherosclerosis, Ischemia, Myocardial Infarction, Nutrient Interactions (Fatigue + Decreased Synthesis of L-carnitine in Vitamin C Deficiency)
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    carnitine l-carnitine cardiovascular arterial angina ischemia claudication vitaminC fatigue heartfailure heart failure pectoris pain atherosclerosis muscle tissue medicine nutrition ben chest
avivajazz  jazzaviva

A negative regulator of MAP kinase causes depressive behavior : Nature Medicine : Natur... - 0 views

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    New findings in rodents and human brain shed light on the mechanisms of major depressive disorder (MDD), uncovering over-expression of MKP-1 (mitogen-activated protein kinase [MAPK] phosphatase-1)...and identifying a new therapeutic target.

    MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival

    This study identifies MKP-1 as a key factor in MDD pathophysiology, and as a new target for therapeutic interventions.f

    Here we use whole-genome expression profiling of postmortem tissue and show significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival.

    We tested the role of altered MKP-1 expression in rat and mouse models of depression and found that increased hippocampal MKP-1 expression, as a result of stress or viral-mediated gene transfer, causes depressive behaviors. Conversely, chronic antidepressant treatment normalizes stress-induced MKP-1 expression and behavior, and mice lacking MKP-1 are resilient to stress. These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions.
avivajazz  jazzaviva

Bad practices of biomedical researchers and publishers - 0 views

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    Gaceta Sanitaria Vol.21 Núm. 06. Gaceta Sanitaria. ISSN:0213-9111 | Free full text (English)
avivajazz  jazzaviva

Clinical trials: what are the ethics of interpreting + communicating trial results? htt... - 0 views

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    Ethical Considerations in the Interpretation and Communication of Clinical Trial Results -- Coultas 4 (2): 194 -- Proceedings of the American Thoracic Society
avivajazz  jazzaviva

How many scientists fabricate and falsify research? [PLoS One. 2009] - 1 views

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    The frequency with which scientists fabricate and falsify data, or commit other forms of scientific misconduct is a matter of controversy... Misconduct was reported more frequently by medical/pharmacological researchers than others...This metareview is a conservative estimate of the true prevalence of scientific misconduct.
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