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Angina Pectoris, Heart Failure, Intermittent Claudication in Peripheral Arterial Disease, Atherosclerosis, Ischemia, Myocardial Infarction, Nutrient Interactions (Fatigue + Decreased Synthesis of L-carnitine in Vitamin C Deficiency) =============== carnitine l-carnitine cardiovascular arterial angina ischemia claudication vitaminC fatigue heartfailure heart failure pectoris pain atherosclerosis muscle tissue medicine nutrition ben chest

"According to a small German study published in the New England Journal of Medicine (NEJM), researchers found that DHEA improved sexuality and well-being in 24 women diagnosed with adrenal insufficiency. The double-blind study found that women who took 50 mg of DHEA daily reported significant increases in how often they thought about sex, how interested they were in sexual activity, and their levels of both mental and physical sexual satisfaction. These women also reported improvement in mental health issues such as obsessive-compulsive traits, depression, anxiety, and other psychological conditions. The most significant improvements were seen four months after treatment began. "

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The fact that an increasing number of medications are unable to beat sugar pills has thrown the industry into crisis. It's not that the old meds are getting weaker, drug developers say. It's as if the placebo effect is somehow getting stronger. Why are inert pills suddenly overwhelming promising new drugs and established medicines alike? Pharma doesn't know, and drugmakers are realizing they need to fully understand the mechanisms behind it so they can design trials that differentiate more clearly between the beneficial effects of their products and the body's innate ability to heal itself. special task force of the Foundation for the National Institutes of Health is seeking to stem the crisis by quietly undertaking one of the most ambitious data-sharing efforts in the history of the drug industry.

New findings in rodents and human brain shed light on the mechanisms of major depressive disorder (MDD), uncovering over-expression of MKP-1 (mitogen-activated protein kinase [MAPK] phosphatase-1)...and identifying a new therapeutic target. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival This study identifies MKP-1 as a key factor in MDD pathophysiology, and as a new target for therapeutic interventions.f Here we use whole-genome expression profiling of postmortem tissue and show significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival. We tested the role of altered MKP-1 expression in rat and mouse models of depression and found that increased hippocampal MKP-1 expression, as a result of stress or viral-mediated gene transfer, causes depressive behaviors. Conversely, chronic antidepressant treatment normalizes stress-induced MKP-1 expression and behavior, and mice lacking MKP-1 are resilient to stress. These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions.

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Daily intake of fruit and vegetables was associated with a lower risk of coronary heart disease when combined with a high dairy fat consumption...but not when combined with a low dairy fat consumption. Sara Holmberg, Anders Thelin and Eva-Lena Stiernström. Int. J. Environ. Res. Public Health 2009, 6, 2626-2638.

"Skeletal Muscle Strength as a Predictor of All-Cause Mortality in Healthy Men," "Strength, but not Muscle Mass, Is Associated With Mortality in the Health, Aging and Body Composition Study Cohort," "Decreased Muscle and Increased Central Adiposity are Independently Related to Mortality in Older Men," etc.

Multiple Clinical Data Presentations at EuroPCR 2008 Support Use of OrbusNeich's Genous(TM) Bio-engineered R stent(TM) as Safe Alternative to Drug-Eluting Stents (Randomized TRIAS HR Pilot Study)

In the world of medicine, "key opinion leader" is the somewhat Orwellian term used to describe the senior doctors who help drug companies sell drugs. : BMJ : British Medical Journal