Artificial spleen cleans up blood : Nature News & Comment - 0 views
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A device inspired by the spleen can quickly clean blood of everything from Escherichia coli to Ebola, researchers report on 14 September in Nature Medicine1.
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Blood infections can be very difficult to treat, and can lead to sepsis, an often-fatal immune response. More than 50% of the time, physicians cannot diagnose the cause of an infection that has prompted sepsis, and so they resort to antibiotics that attack a broad range of bacteria2. This approach is not always effective, and can lead to antibiotic resistance in bacteria.
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To test the device, Ingber and his team infected rats with either E. coli or Staphylococcus aureus and filtered blood from some of the animals through the biospleen. Five hours after infection, 89% of the rats whose blood had been filtered were still alive, compared with only 14% of those that were infected but not treated.
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