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Matti Narkia

Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disea... - 0 views

    Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.
    Kidd P.
    Altern Med Rev. 2003 Aug;8(3):223-46. Review.
    PMID: 12946237

    Th1 pathways typically produce activation of cytotoxic T
    lymphocytes (Tc), NK cells, macrophages, and monocytes, all of
    which can attack cancer cells and generally defend against tumors.
    55 IFN-gamma and other Th1 cytokines are typically lower in
    advanced cancer patients, while the Th2 marker IL-4 can be higher
    or unchanged.56 Nodules of non-small cell lung cancer freshly
    removed from patients expressed a marked imbalance toward Th2, as
    did biopsy samples from basal cell carcinoma.57 In prostate cancer
    patients IL-2 was low (Th1) and IL-10 high.58 IL-10 is a confirmed
    Th1-suppressive cytokine, and heightened IL-10 is a common factor
    in cancer.55

    IL-10 has a variety of suppressive effects that include inhibiting
    Th1 cytokine production, down-regulating APC and NK cell function,
    and lowering overall T-cell proliferation.57 Especially under the
    influence of IL-4 (Th2), tumor cells apparently up-regulate IL-10
    that suppresses nearby killer cells. Tumor-derived IL-10 has been
    documented in lymphoma, ovarian carcinoma, melanoma, neuroblastoma,
    and renal cell and colon carcinoma.57 IL-12 is another cytokine
    that can be up-regulated by Th1 activity and inhibited by Th2.59 A
    low IL-12/IL-10 ratio was found in cervical cancer patients.55
    Recent clinical studies suggest elevated IL-10 is predictive of a
    poor prognosis. 57 With both IL-4 and IL-10 being proven inhibitors
    of Th1 and promoters of Th2 activity, the recognized capability of
    cancerous tissue to suppress immunity is readily rationalized.
Matti Narkia

Stress and Sleep, melatonin and cortisol - Honest Nutrition: - 0 views

    Sleep allows an overactive adrenal to rest overnight, also allowing your melatonin to give you a good night's sleep. Cortisol and melatonin are agonists, and fight for dominance. Cortisol is a stress hormone made by the adrenal gland and melatonin is an antioxidant sleep hormone produced by the pineal gland at night, in darkness.
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