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The Medicines and Healthcare products Regulatory Agency (MHRA) on Monday (29 January 2024) approved the medicine Rezzayo (rezafungin) to treat invasive candidiasis, an infection caused by a yeast called Candida. Invasive candidiasis can pose a serious health risk as it can affect the blood, heart, brain, eyes, bones and other parts of the body. Napp Pharmaceuticals Ltd was granted the marketing authorisation for the medicine based on phase 3 clinical trial data. In the randomised, double-blind, controlled study, more than half of the invasive candidiasis patients who were given a weekly dose of rezafungin were cured at day 14. Among 94 patients who were given a daily dose of caspofungin (another antifungal treatment), 57 of them were cured during the same time.

Pfizer said on Thursday (June 1) data from late-stage trials showed its experimental combination of antibiotics was effective in treating deadly infections caused by drug-resistant bacteria. Deaths from antibiotic-resistant bacteria, also known as superbugs, have been on the rise globally, and health regulators have called for the development of newer treatments as resistance to older antibiotics grows. The late-stage studies compared the experimental combination of the antibiotics aztreonam-avibactam (ATM-AVI) and existing generic drug metronidazole with a combination of two older antibiotics - meropenem and colistin - to treat complicated intra-abdominal infections and types of hospital-acquired pneumonia. Hospital-acquired pneumonia occurs in patients at least two to three days after being admitted, or in those who have life-threatening lung infections with high mortality rates and who are on mechanical breathing machines. Pfizer said the data from the studies shows the antibiotic combination of ATM-AVI is effective and well-tolerated in treating infections caused by gram-negative bacteria. The cure rate in patients with complicated intra-abdominal infections with Pfizer's combination therapy, along with existing generic drug metronidazole, was 76.4%, versus 74% using the other antibiotics.

If you want to start your day feeling refreshed and energized, consider creating a daily regimen of ginger shots instead! Ginger shots are like taking ginger ale straight to the source. They give you all sorts of vitamins, minerals, and antioxidants your body needs to feel its best. These shots are beverages made from concentrated doses of ginger root (Zingiber officinale), which are asserted to aid in warding off sickness and strengthen your resilience against many health conditions. However, ginger shots just became prevalent recently in the wellness society; ginger brews have been used since ancient times to cure a host of ailments. While ginger presents unique health features, you may wonder whether sipping ginger shots is healthful. This article inspects ginger shots, including their potential health benefits, side effects, and preparation at home. Ginger Shots Ginger shots are potent drinks made with fresh ginger root. The ingredients used in the shot differ depending on the recipe you want to try. Some shots include only fresh ginger juice, while others comprise lemon juice, orange juice, turmeric, cayenne pepper, and/or manuka honey. You can make it at home by squeezing fresh ginger root juice or blending fresh, grated ginger with different juices, like lemon or orange. Now you can see that these shots are available pre-made or made to take away at juicers or health food stores. You can also beat them up at home by operating a juicer machine. For this, just add freshly grated ginger to citrus juice or mix a dash of ginger with other ingredients in a high-powered blending pot. You may find ginger shots spicy and unpleasant to drink owing to their high content of ginger roots. Hence, they're made in small amounts and generally drunk in one or two swigs. Ginger Root Ginger root has been used medicinally for thousands of years. The ancient Chinese used it to treat stomach problems, colds, and inflammation. According to the National Institute of Health (NIH

As the weather gets colder, we're all looking for ways to get through the winter months. One of the most popular natural remedies is ginger. It's been used for thousands of years and has been shown to relieve symptoms like sore throat and coughing as well as boost overall health. People often use ginger as a home remedy for treating colds and sore throats due to its antibacterial markers that can help handle pain and inflammation. The Ginger (Zingiber officinale) root is a perennial plant. Our forefathers have consumed ginger as a herbal therapy for decades after decades to cure many health conditions, from arthritis to abdominal pain. Today, we often use ginger when we have a cough or cold. The scientific database reveals that ginger has medicinal effects that could ease the symptoms of a cold or sore throat. This article will examine how ginger may help colds and how you can use it in teas, juices, and other home remedies. How is ginger good for treating Colds? There is no definitive proof that ginger can cure or eliminate colds from roots, but research indicates that it may help control them. Ginger can also aid in improving cold symptoms. One study review shows that there is evidence that ginger can help: prevent colds control or relieve a sore throat ease congestion decrease inflammation However, researchers need to examine ginger's additional benefits to support this evidence. Medicinal properties Ginger has blends called gingerols and shogaols. Experimenters consider that these compounds give ginger its therapeutic properties. It is a potent anti-inflammatory. It's also a natural expectorant and decongestant, which helps to clear up congestion. Ginger is high in vitamin C and manganese, both essential nutrients for boosting your immune system during the cold season. While ginger may not be a cure-all for the common cold or flu (it's always best to consult your doctor if you're sick), it can help keep you feeling better while you recover. Stu

What's valerian root used for? The ancient Greeks and Romans used valerian root to treat: Nausea Gas Heart pulsings Urinary tract infections Insomnia The German tribes believed it could tame the wildest of animals. They also hung it outside their homes to frighten witches and devils. Hertha, a Teutonic witch-goddess, rode a deer crowned with hops and used a stem of valerian as a lash. During the Middle Ages, astrological botanist Nicholas Culpeper simmered valerian root with raisins, licorice, and aniseed. He used the tonic to cure bubonic plague and chest congestion. In 1620, valerian root was carried to North America on the Mayflower. During World War I and II, it was used to reduce stress caused by air attacks. It was also mixed with hops and kava-kava to treat shell-shocked frontline troops. HOW DOES IT WORK? It is a powerful herb used since ancient times to help people relax and fall asleep. Valerian works by acting on the GABA (Gamma-Aminobutyric acid) receptors in your brain to induce relaxation, making it an ideal supplement for those with anxiety or insomnia who want to sleep better at night. The active compounds in valerian plants are called valepotriates, which act as sedatives at low doses and stimulants at higher doses. Valerian Uses & Effectiveness Consuming valerian root extract 300-600 mg by mouth daily appears to improve sleep quality. It is possibly effective for treating Insomnia symptoms. For notice effects, continue its usage for up to 4 weeks. There is welfare in consuming valerian for several other purposes, but it requires more reliable data to say whether it could help. It's generally used in various products containing other soothing herbs, such as hops, passion flowers, and lemon balms.

According to Alzheimer's Disease International, more than 55 million people worldwide will have Alzheimer's disease by 2020. This figure will nearly double every 20 years, reaching 78 million in 2030 and 139 million in 2050. The WHO Global Status Report for 2021 estimated the yearly global cost of dementia to be more than USD 1.3 trillion, with a projected increase to USD 2.8 trillion by 2030. To date most drugs developed to treat Alzheimer's disease have failed, largely because they target wrong biomarkers and individuals already exhibiting signs of the disease. Once symptoms appear, however, many brain cells responsible for memory and cognition are likely already damaged and beyond repair. Professor Shai Rahimipour in the Chemistry Department at Bar-Ilan University in Israel has pioneered a different approach utilizing theranostics to pinpoint and treat the earliest, pre-symptomatic signs of Alzheimer's disease. Showing promise in stopping progression of the disease before onset of irreversible brain cell damage, Rahimipour's groundbreaking approach has garnered significant attention in the scientific world.

The number of people suffering from addiction is at an all time high, with more people seeking treatment across the USA due to the fentanyl crisis, but new studies have shown that addiction drugs may not only be able to aid those suffering from the deadly disease, but also aid people suffering from long COVID. While there has long been research underway to find a cure for the likes of alcoholism and drug addiction, it turns out naltrexone, a drug used in the addiction treatment space, is helping people who have been suffering from headaches, seizures and fatigue as a result of long COVID. According to Dr. Paul Valbuena at The River Source, an Arizona drug rehab, naltrexone is typically used by rehab centers and prescribed to patients suffering from addiction to reduce cravings and the feeling of euphoria associated with substance use disorder, giving patients clarity and focus to concentrate on recovery. Thanks to a recent report, that has also been revealed to be the case for those suffering with long COVID too, with Lauren Nichols, a long COVID sufferer from Chicago being prescribed the drug by her doctor. She found that the drug helped quell her seizures and headaches, alowing her to think clearly and get on with her life as normal. It's been a similar story for other patients too, and has marked a major breakthrough in the bid to help those who are still suffering in the aftermath of the pandemic.

Researchers are curious about curcumin to create an effective anti-infection therapeutic effect and control fungal infections in cancer patients. Curcumin could grow the fungal infection sustainability among cancer patients with candida. Thus, turmeric curcumin supplements offer a reasonably 'secure cure' against candida with minimal or no adverse effects, even when using a higher curcumin dose.

Erectile dysfunction is a very common form of medical condition that occurs in males over time. Usually, this problem is found in people who take too much medication, and ED is probably a side effect of any one of them. However, in seventy-five percent of males, the cause of erectile dysfunction is unknown, and finding the accurate reason for it is very complex. It can be a result of any neural complications, diabetes, or any surgeries that include the prostate of our body. ED can also be treated by using a vacuum device and surgeries on the private parts. However, it can be eradicated completely without any surgeries, and here are some tips that will help you in overcoming erectile dysfunction without surgery and lead a happy life. DO EXERCISE Exercise is a great way to overcome any health issues, and also to safeguard yourself from health issues in the future. Physical activity also helps you in controlling obesity, which is one of the reasons behind ED. By not doing regular exercises, you expose yourself to various cardiovascular problems, which contribute to ED. Studies show that light aerobic exercise for 30-40 minutes a day for at least four times a week for at least 6 months has considerably reduced ED in people. STAY SLIM Studies have shown that a person who has a waist near 42 inches is more likely to suffer from ED than a person with a waistline of 32 inches. Therefore, if you are obese it's time that you lose some weight. Excessive fat in the body is the birthplace of various diseases. Obesity is also responsible for vascular problems and diabetes which are two primary causes of ED.

The National Institute for Health and Care Excellence (NICE) has recommended Enhertu for people with advance breast cancer. "There is not enough evidence yet to show how much longer people live with Enhertu compared with trastuzumab emtansine because the clinical trial is still ongoing. This means the cost-effectiveness estimates are highly uncertain and Enhertu cannot be recommended for routine use in the NHS," said NICE. The independent appraisal committee concluded that Enhertu could be cost-effective if further evidence from the ongoing trial and from NHS practice can show how much longer people live with treatment. Helen Knight, director of medicines evaluation at NICE, said: "Today's draft guidance is good news for people with this type of advanced breast cancer, who often experience severe and debilitating symptoms.

The European Union's health regulator on Friday said it had recommended granting a conditional marketing authorisation for a gene therapy by Australian drugmaker CSL Ltd and partner uniQure N.V. , to treat haemophilia B, a rare bleeding disorder which is caused by genetic anomalies. About one in 40,000 people are affected by the inherited disorder, caused by a gene mutation that hampers the body's ability to make clotting protein factor IX. If approved, the treatment, branded Hemgenix, will be the first gene therapy in the European Union for the condition that is usually treated by regular injections of factor IX, the European Medicines Agency said. CSL had acquired exclusive global rights to Hemgenix in May last year from uniQure N.V.

A bout 15 to 30 per cent of the UK population suffers from hay fever and there has been a definite increase in the number of moderate to severe hay fever sufferers, with sufferers experiencing more frequent and longer seasons. And now that the government has announced its plans for the easing of lockdown, community pharmacists can expect to see many more of their patients presenting with more severe symptoms than usual, as there will be more opportunities to spend time outside and be exposed to higher levels of pollen. Symptoms Common symptoms include sneezing, a runny stuffed up nose, itchy, watery eyes, nasal congestion and a general stuffed up feeling in the nose and throat. Some experience itching around the face and mouth, with an itchy palette, and burning sensation in the throat. Headaches and wheezing can also occur, as well as an overall achy feeling, or build-up of pressure in the facial area. The sinus area can become painful and constant nose blowing can leave sufferers with skin irritation. This can lead to tiredness and affect sleep, which in turn reduces energy.

Dry eye syndrome is incredibly common and prevalence is increasing globally. Studies show that prevalence rates vary from five to 50 per cent but can be as high as 75 per cent in people over the age of 40, in people who wear contact lenses and those who work with computers. It is more common in women than in men, particularly during and after the menopause. According to a new real-world research commissioned by world experts in eye-care, Rohto, more than eight in ten women (83 per cent) indicate that they suffer from the condition, but only once they have had the symptoms of dry eye syndrome described to them. Without detailed explanation, 56 per cent of people say they have never even heard of dry eye syndrome, showing just how under diagnosed it may be. Causes of dry eye Dry eyes are a clinical cause of eye irritation, fatigue, and discomfort, often causing feelings of itchiness, grittiness, and excess watering. If left untreated, dry eyes can even lead to long-term damage and sight problems. Dry eyes may occur if enough tears aren't produced if poor-quality tears are generated or if the tears evaporate from the surface of the eye too quickly. This leads to poor lubrication of the tear film. In a normal eye, the tear film4- the multilayer moist protective film - covers the cornea and lubricates the eye. However, if the lubricative process is faulty dry spots appear on the surface of the eye and this causes irritation and discomfort. The tear film has several layers: fatty oils, aqueous fluid, and mucus. This combination normally keeps the surface of your eyes lubricated, smooth and clear. But problems with any of these layers can cause dry eyes.

Community pharmacists are readily accessible healthcare providers and medicine experts in the community setting and their counsel is often sought by patients and consumers on a number of subjects including the use of dietary supplements. Their role in the sale of and advice regarding natural health and drug alternatives has never been more relevant. The recent National Health Service (NHS) Interim People Plan calls for the NHS to put all staff front and centre of the way it operates and identifies pharmacists as a critical part of multidisciplinary teams, providing care across a wide range of increasingly complex patient needs. Despite existing demand to counsel patients on a vast range of medicines, more and more consumers are looking to their pharmacist to support and enhance their knowledge regarding the relevance of a growing range of supplementary nutrients now available. Nutritional supplementation is increasingly becoming the consumer's first choice for 'drug free' treatment or natural prevention that provides a true sense of taking control, which the prescription process often denies them. Historically the immense benefits provided by the NHS have instilled a general abdication of our personal health control, leaving us to rely on the health service to treat and cure as necessary. As our NHS has become visibly over-stretched we begin to realise what the rest of the world has known for centuries - good health is based primarily upon nutritional robustness. It may be stating the obvious but there is an excellent source of incremental revenue for the pharmacist who is willing to provide space to and advice for nutritional supplements.

An autism spectrum disorder is a neurological and developmental disorder that affects a person's ability to communicate, interact with others, and process information. There is no one-size-fits-all for people with ASD, as each experiences symptoms differently. While some people with ASD may be nonverbal, others may speak fluently but have difficulty with social interaction. Most people with ASD need specialized educational and behavioral intervention early. There is no medical cure for ASD, but treatments and therapies can improve symptoms and help people with ASD lead fulfilling lives. If you or your child has just been diagnosed with autism spectrum disorder (ASD), it's normal to feel a range of emotions. You may feel relieved to finally have a diagnosis and explanation for your or your child's symptoms. Or you may feel overwhelmed, worried, or even angry about the diagnosis.

Polio has been detected in sewage samples in London, the first sign since the 1980s that the virus could be spreading in the UK, but no cases have been found, authorities said. The risk of infection from the disease, which causes paralysis in children in under one per cent of cases, was also low because of high vaccination rates, the UK Health Security Agency (UKHSA) said. The agency nevertheless encouraged parents to make sure their children were vaccinated after the discovery of the virus during routine wastewater surveillance - particularly those who may have missed shots during the Covid-19 pandemic. Nationwide vaccination levels are above the 90 per cent needed to prevent outbreaks, but London's coverage rates among the under-twos has dipped below that in recent years. NHS England will begin contacting parents of children under five who are not immunised. Polio, spread mainly through contamination by faecal matter, used to kill and paralyse thousands of children annually worldwide. There is no cure, but vaccination brought the world close to ending the wild, or naturally occurring, form of the disease.

The National Institute for Health and Care Excellence (NICE) has recommended abemaciclib also called Verzenios, made by Eli Lilly, for people with hormone receptor-positive, HER2-negative, node-positive early breast cancer at high risk of recurrence who have had surgery to remove their tumour. The clinical trial result showed that people having abemaciclib with hormone therapy had a more than 30 per cent better chance of their cancer not coming back following surgery compared with people having hormone therapy alone. Helen Knight, interim director of medicines evaluation at NICE, said: "Today's positive draft recommendation, which comes less than a month after abemaciclib received its licence, is fantastic news. The fact that we have been able to produce draft recommendations so quickly is testament to the success of our ambition to support patient access to clinically and cost effective treatments as early as possible. "Until now there have been no targeted treatments for people with this type of breast cancer. Abemaciclib with hormone therapy represents a significant improvement in how it is treated because being able to have a targeted treatment earlier after surgery will increase the chance of curing the disease and reduce the likelihood of developing incurable advanced disease."

Eczema (atopic dermatitis), which affects up to 20 per cent of children, is one of the most common conditions pharmacists encounter, but don't underestimate eczema. Generalised eczema may compromise health-related quality of life (HRQoL) more than several other chronic diseases, including asthma, epilepsy and diabetes. Despite the impact on HRQoL, underuse of moisturisers and topical corticosteroids often leaves childhood eczema poorly controlled. UK researchers recently reported that several factors contribute to the underuse of moisturisers and topical corticosteroids in children with eczema. For instance, most of the 30 parents and carers interviewed felt that they had received little information about eczema. The lack of understanding may help explain why some parents and carers expressed concerns, such as the risk of skin thinning, about topical corticosteroids. Some were not convinced that moisturisers (strictly, an emollient is an ingredient of a moisturiser) reduced itch and maintained control of eczema. Some felt that moisturisers' efficacy declined over time. Parents and carers also admitted to "incomplete knowledge and skills" about managing eczema (such as whether they should apply moisturisers regularly) and reluctance to manage eczema in collaboration with their child. Parents and carers wanted advice about using treatments and explanations of moisturisers' and topical corticosteroids' mechanisms of action. The authors note that healthcare professionals could help identify and address gaps in knowledge.

Dry eye disease, also known as dry eye syndrome, occurs when the eye stops producing enough tears, the tears that are made are of poor quality or the tears evaporate faster than they should. This causes dryness and irritation of the surface of the eye and results in inflammation, discomfort, and damage.[i] Symptoms include dry, red, itchy or tired eyes, blurred vision and foreign body sensation. From over-the-counter eye drops and heated eye masks, to eyelid-cleansing wipes, there are a multitude of options that can be offered to sufferers to provide relief. As a result of the pandemic and new living and working patterns, the World Health Organization has indicated dry eye disease is on the rise. This can be attributed to various lifestyle factors including increased screen use and wearing of face masks. An increase in sufferers seeking advice on the condition in pharmacies has also been reported. It is no surprise that sufferers will turn to their pharmacists for help, support and information on the condition and how it can be managed by treatment options available over-the-counter.