Patients in Ireland with a specific type of lung cancer can now access Merck's TEPMETKO® (tepotinib) as a second-line treatment option, following its
approval for reimbursement by the Health Service Executive (HSE).
Tepotinib is the first treatment approved in Ireland specifically targeting advanced non-small cell lung cancer (NSCLC) with mesenchymal-epithelial transition
factor gene (MET) exon 14 (METex14) skipping alterations.
Previously, the oral MET inhibitor had been approved in the NHS across England, Wales, Scotland, and Northern Ireland.
Patients with advanced NSCLC with METex14 skipping alterations typically have poorer overall survival rates compared to other NSCLC patients.
According to Merck, tepotinib has shown consistent and durable antitumor activity in this group, as demonstrated in the VISION study, further cementing its role
in clinical practice.
Roisin Molloy, Managing Director of Merck Healthcare in Ireland, said: "This is an important step forward for targeted treatments in Ireland and it is fantastic
news that the HSE has reimbursed tepotinib."