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The British scientists behind one of the major therapeutic Covid-19 trials have turned their focus to treatments for monkeypox, a viral disease that has been labelled a global health emergency by the World Health Organization. The team from Oxford University behind the so-called RECOVERY trial - which honed in on four effective Covid treatments - on Tuesday unveiled a new trial, dubbed PLATINUM, to confirm whether Siga Technologies' tecovirimat is an effective treatment for monkeypox. Although there are vaccines developed for the closely related smallpox that can reduce the risk of catching monkeypox, there are currently no treatments that have been proven to help hasten recovery in those who develop the disease. The UK has over 3,000 confirmed cases of monkeypox. The virus is transmitted chiefly through close contact with an infected person. It typically causes mild symptoms including fever, rash, swollen lymph nodes and pus-filled skin lesions. Severe cases can occur, though people tend to recover within two to four weeks. Siga's drug, branded Tpoxx, has been cleared to treat diseases caused by the family of orthopoxvirus that includes smallpox, monkeypox and cowpox by the European Union and United Kingdom, but due to limited trial data it is generally only used in severe cases in Britain.

The Pharmacist' Defence Association (PDA) has welcomed the General Pharmaceutical Council (GPhC) and the Pharmaceutical Society of Northern Ireland (PSNI)'s plan to ensure a more robust, fair and positive experience for trainees, provisionally registered and potential pharmacists who will be sitting the November 2022 assessment. "Many candidates at the latest (June 2022) assessment experienced significant delays, technical issues, inadequate invigilation, and disturbances in test centres around the UK as the newly appointed company BTL ran the high-stakes pharmacist examinations for the first time. The next online exam is due in November 2022 and the PDA welcome proposed improvements to be introduced before that sitting," said the association. For some, provisional registration was the accepted response from the GPhC, but for others, such as potential pharmacists who did not want the provisional role, those unable to find a suitable provisional post, or some that did not meet the criteria for provisional registration, they found themselves in financial difficulties through no fault of their own, having reasonably expected to have joined the register in the Summer.

The National Health Service England (NHSE) aims to eliminate cervical cancer by 2040 by making the lifesaving Human Papillomavirus (HPV) vaccination easily accessible to people and increasing cervical screening uptake. In addition to the campaign, the NHS is expanding the outreach of cervical screening more than ever before. Last year, the health service invited over five million people aged 25 to 64 for the screening, out of which 3.5 million were tested. Moreover, self-sampling will be trialled to see if the service can introduced as part of national screening. England is among the first countries in the world to set this elimination ambition, which could save thousands of lives every year in the country. Amanda Pritchard, chief executive of Officer of NHS England, announced the health service's new goal and how to achieve it at the NHS Providers' annual conference today (15 November).

AstraZeneca UK has revised the expiry dates for certain batches of Fluenz Tetra nasal spray vaccines as a precautionary measure, after finding that their potency (strength) dropped faster than predicted once thawed, during routine testing. The Medicines and Healthcare products Regulatory Agency (MHRA) has been informed by the manufacturer that the printed expiry date for a limited number of batches is "incorrect." However, the MHRA has assured patients that the affected batches are safe to use and fully effective within the amended expiry date. If the vaccine is administered after the amended expiry date, it may be less effective in protecting against flu, it said. The UK regulatory authority also reiterated that it "keeps the safety of medicines, including vaccines, under review, and acts where necessary to protect patients and the public."

Thanks to the NHS primary care access recovery plan, more than 23 million people can now view test results and check their consultation notes online without needing to contact their GP practice. NHS England on Monday (4 December) announced that over 81 GP practices in England (more than four in five) are now giving patients access to their new health records online through the NHS App. In May, the NHS announced the primary care access recovery plan setting a target of 9 in 10 GP practices offering patients access to their records through the NHS App by March 2024. By making access to healthcare easier and quicker, the NHSE also aims to free up to 10 million GP appointments a year by next winter.

Diabetes affects over 537 million people worldwide; by 2045, this is estimated to increase to 783 million. [1] With the growing prevalence of diabetes, it's even more important to utilise all options to support people with diabetes (PwDs) in managing their daily life with diabetes. Where do PwDs most often access healthcare support? On average, PwDs visit the pharmacy three-to-eight times more than the general population to obtain medicines and testing supplies.[2] It is clear that pharmacists play an integral role in empowering the self-management needs of PwDs beyond the traditional role of supplying medicines. This relationship, however, may be underutilised. Research suggests there is a lack of broad recognition of pharmacists as a key source of diabetes care, and that resource constraints - particularly following the COVID-19 pandemic - can interfere with patient education provision and training.[3,4] Furthermore, the circumstances and role of the pharmacy vary, nationally and internationally. At Roche Diabetes Care we would like to shine a light on the increasing value of community pharmacists as important figures in the well-being of PwDs.

The Digital Medicines Transformation Portfolio (DMTP) was able to deliver the electronic prescription service (EPS) in Wales - just 20 months after starting the project - with support from key partners in the NHS and industry. Patients in Rhyl were the first to benefit from the new service, which allows GPs to send prescriptions electronically to the patient's choice of community pharmacy, without the need for a paper form. The new EPS service is currently in a live testing phase, with a phased roll out across Wales expected from January 2024. DMTP, which is hosted by Digital Health and Care Wales (DHCW) has worked closely with NHS England, who provided the core EPS platform that has been developed for use in Wales. NHS Wales Shared Services Partnership has also made a major contribution in the project, incorporating digital reimbursement to pharmacies and putting security measures in place.

The Department of Health (DoH) Northern Ireland is reminding the public to think Pharmacy First this winter to stay well and reduce demands on other parts of their health service. Under this new advanced service, a local pharmacy can provide treatment and advice on a range of health conditions including common colds, stomach upsets, ear aches, diarrhoea, head lice, mouth ulcers and thrush. Pharmacies will also directly provide emergency contraception and advice and treatment for uncomplicated Urinary Tract Infections (UTI) for women aged 16 to 64 years without the need for a GP appointment, the department said. Further the public are informed that 42 community pharmacies across the country will be providing a sore throat service this winter, involving advice, testing for infection and treatment, if necessary.

A total of 37 more cases of monkeypox have been detected in England and Scotland, public health officials said on Monday, taking the total to 57. Thirty-six confirmed cases were found in England, and one north of the border, the UK Health Security Agency and Public Health Scotland said. The UKHSA said it was now advising high-risk contact cases of confirmed cases who have not tested positive or developed symptoms to isolate for up to 21 days. It has also bought supplies of smallpox vaccine, which is being offered to close contacts to reduce the risk of symptomatic infection and severe illness. Chief medical adviser Susan Hopkins said contact tracing was helping to limit the close-contact spread of the virus, which causes a chickenpox-like rash. "Because the virus spreads through close contact, we are urging everyone to be aware of any unusual rashes or lesions and to contact a sexual health service if they have any symptoms," she added in a statement.

More than 5,000 vulnerable people have enrolled for the ground-breaking Platform Adaptive trial of NOvel antiviRals for eArly treatMent of Covid-19 In the Community (PANORAMIC) study on life-saving antivirals. With this the UK is now one step closer to rolling out the innovative medicines, which would help reduce the severity of symptoms and the risk of hospitalisation or death. Success of the study would eventually help to ease pressures on the NHS. Anyone over the age of 50 or between 18 to 49 with certain underlying health conditions can participate in the trial after receiving a positive PCR or lateral flow test result.

The world's first human challenge trial in which volunteers were deliberately exposed to Covid-19 to advance research into the disease was found to be safe in healthy young adults, one of the companies running the study said on Wednesday. The data supports the safety of this model which could theoretically provide a "plug and play" platform for testing therapies and vaccines using the original Covid-19 strain as well as variants of the virus, Open Orphan, which carried out the study, said in a statement. Open Orphan is running the project, launched a year ago, with Imperial College London, the UK government's vaccines task force and the clinical company  hVIVO. The trial infected 36 healthy male and female volunteers aged 18-29 years with the original SARS-CoV-2 strain of the virus and closely monitored them in a controlled quarantined setting. They will be followed up for 12 months after discharge from the quarantine facility.

Pfizer has recalled all stocks of Accupro - including 5mg, 10mg, 20mg, 40mg film-coated tablets - as a precautionary measure due to the identification of a nitrosamine above the acceptable limit. "Following testing, N-nitroso-quinapril, has been observed at a level above the acceptable limit. Nitrosamines may increase the risk of cancer if people are exposed to them above acceptable levels and over long periods of time. The recall is at pharmacy and wholesaler level," the Pharmaceutical Services Negotiating Committees (PSNC) reported. The Department of Health and Social Care (DHSC) said: "All strengths of quinapril (Accupro) tablets have been recalled with a resupply date to be confirmed. Pfizer are the sole supplier of quinapril tablets in the UK. Alternative ACE inhibitors remain available and can support an uplift in demand."

Clinical trials for BioNTech's cancer vaccines should start this year in Britain, marking an important step towards their possible sale on the open market, the German company's top executive Ugur Sahin told magazine Der Spiegel. BioNTech, known for its COVID vaccine with U.S. partner Pfizer, is currently deciding which types of cancer it wants to test its personalized cancer immunotherapies on and the locations where it will conduct the trials, Sahin said. The company wants these therapies, which are based on messenger RNA (mRNA) technology similar to the one that underpins its COVID-19 vaccine, to soon become a regular treatment for cancer patients. "We believe that this should be possible for large amounts of patients before 2030," Sahin said.

An Indian court has sentenced two pharmaceutical company executives to two-and-half years in jail for exporting substandard drugs to Vietnam a decade ago, months after the WHO linked their cough syrups to the deaths of children in Gambia. India suspended production at Maiden Pharmaceuticals in October last year for violations of manufacturing standards after the World Health Organization said four of its cough syrups may have killed dozens of children in Gambia. The company has denied its drugs were at fault for the deaths in Gambia and tests by an Indian government laboratory found there were no toxins in them. The company had been facing legal difficulties for years over suspected shoddy products. A court in Sonipat, near New Delhi, where Maiden has its main production facility, ordered jail for company founder Naresh Kumar Goel and technical director M.K. Sharma for exporting heartburn medicine "not of standard quality" to Vietnam.

After you've had surgery, it's normal to feel a little anxious about the recovery process. But there are some things you can do to help make sure everything goes smoothly. Here are four important pieces of postoperative advice that will help you heal quickly and avoid any complications. Follow these tips and you'll be on your way to a full recovery in no time. FOLLOW YOUR DOCTOR'S ORDERS No matter how minor the operation, following your doctor's orders after surgery is essential to a speedy and successful recovery. Doing the right things like following a balanced diet, taking the recommended amount of medications, and avoiding strenuous activity can help minimize complications, reduce pain, and speed up healing. Furthermore, consistent follow-up visits with your doctor and timely scheduling of any necessary tests ensure that any post-operative problems are addressed in their early stages when they are easiest to treat. The people behind www.alamoplasticsurgery.com note that failing to take your doctor's instructions seriously can have a significant impact on your overall recovery time, jeopardize the long-term outcome of your treatment, or even lead to additional procedures. To ensure you make the most out of your surgery experience - listen to what your doctor has to say! GET PLENTY OF REST Getting a full night's rest after the surgery is key to a successful recovery. During recovery, your body is working overtime to heal and repair itself, so by getting plenty of rest, you'll give it the best opportunity to do this. Not only that - research has shown that getting lots of sleep may help support important bodily functions related to healing such as immune response and inflammation control. Listen to your doctor's advice post-surgery and make sure you get enough sleep - providing your body with the downtime it needs will ultimately speed up the healing process and help ensure you get back on your feet soon. When it comes to recovering from surgery,

Community pharmacies must be involved in future planning for public health emergencies, especially in cases where a quick response is needed such as the Covid-19 pandemic, a European-wide research has recommended. The project, co-led by the University of Huddersfield professor Zaheer-Ud-Din Babar in medicines and healthcare, focuses on how community pharmacies dealt with the pandemic, covering 31 pharmacy interventions on Covid-19 in 32 countries in Europe. The interventions include prevention, response, and recovery measures. It also covers improved access to medicines, expanded powers granted to pharmacies, rapid antigen testing, along with Covid-19 vaccination. Community pharmacists in the US, Canada, and Australia have been engaged in pandemic prevention, preparedness, and response strategic guidance after the 2009 flu pandemic. The aim of the research is to map the current reported practice and trends and review the pharmacies' intervention in Europe.

Deaths caused by hepatitis C has declined by 35 per cent in England between 2015 and 2020, latest data from the UK Health Security Agency (UKHSA) revealed. It showed that estimated prevalence of chronic hepatitis C in England has continued to fall to around 81,000 in 2020 from 129,000 in 2015, showing a considerable progress has been made towards eliminating the virus as a public health problem by 2030 in England. Commenting on the data release, health and social care secretary Sajid Javid, said: "It is fantastic to see the significant progress that has been made in eliminating hepatitis C in England. Deaths and prevalence of the virus have fallen consistently thanks to improvements in diagnosis, access to treatments and the hard work of the NHS. "This is another example of the UK being at the forefront of tackling serious diseases. We are on track to eliminate this virus by 2030 and I urge anyone who may be at risk to get tested as soon as possible."

Pfizer's oral Covid-19 therapy will be evaluated as a potential treatment for patients hospitalised with the illness in a major British trial, scientists said on Monday, as cases rise in some parts of the world. The world's largest randomised study of potential medicines for Covid-19, dubbed the RECOVERY trial, will assess Paxlovid across hospitals in Britain, which has already approved the drug for early-stage treatment. "Paxlovid is a promising oral antiviral drug but we don't know if it can improve survival of patients with severe Covid-19," said Peter Horby, a professor at the University of Oxford and joint chief investigator of the RECOVERY trial. The scientists said they aim to mainly find whether Pfizer's Paxlovid reduces the risk of death among patients admitted to hospitals with Covid-19.

Ginger for Anxiety: How Does it Work? If you suffer from anxiety, you've probably tried countless methods to help yourself feel better. Some people swear by medications like Xanax or Prozac, while others prefer to take a more holistic approach. If you're on the latter side of the spectrum, you may want to consider adding ginger to your diet. Read on for everything you should know about how this powerful root can help with anxiety! Especially, gingerol is what ginger owns its intrinsic antioxidant effects, which reduce oxidative stress markers. This is the effect that is equally responsible for the anti-inflammatory abilities described in ginger intake. Although, none of this supports the answer to our question: does ginger help with anxiety? To understand the effects of ginger on stress, we need to find out what it does to the brain to reduce anxiety. STUDIES ON THE EFFECTIVENESS OF GINGER IN TREATING ANXIETY: Miscellaneous studies have revealed that ginger profoundly affects human cognition and brain function. For example, one double-blind, placebo-controlled study of 70 middle-aged Thai women found that ginger root extract improved cognitive function and memory. Other studies performed in rat brains saw ginger improved mental capacity "somewhat through the antioxidant action of the extract." How Does it Work? Some of the most optimistic studies concerning whether or not ginger does help with anxiety implicate serotonin. Mainly one of these underlying studies, served on rats, primarily studied the cellular action to decide why ginger does help with anxiety in introductory studies. An animal study analysis found that ginger relieves anxiety by affixing serotonin receptors. The researchers found nine components of ginger that partially bandage the brain's 5-HT(1A) receptor. In turn, this stimulated reduced symptoms of anxiety in the tested subjects.

Body Luxuries Enchanting Perfume for Women When it comes to selecting a fragrance, women look for something that embodies their personality and makes them feel confident. Body Luxuries Enchanting Perfume is a fragrance that offers just that. This perfume for women is an affordable yet luxurious scent that captures the essence of femininity and elegance. Enchanting Perfume Designed The best fragrance is designed to evoke the feeling of enchantment, with top notes of peach, apricot, and bergamot, giving a fruity and fresh scent. The heart notes are floral, featuring jasmine, rose, and ylang-ylang, which gives a sweet, romantic, and sensual vibe. Finally, the base notes of musk, vanilla, and sandalwood, provide a warm and cozy aroma that lingers throughout the day. One of the best things about Body Luxuries Enchanting Perfume in Pakistan is that it is suitable for any occasion, whether it be for a special event or everyday wear. The scent is not too overpowering, making it perfect for the workplace or a casual outing. It also has good longevity, allowing the fragrance to last for hours without the need for reapplication. Body Luxuries Enchanting Perfume Packaging The packaging of the perfume is also a standout feature. It comes in an elegant, sleek bottle with a beautiful design that is sure to catch the eye of anyone who sees it. The perfume bottle is also compact, making it easy to carry in a purse or handbag for those on-the-go touch-ups. Body Luxuries Enchanting Perfume for ladies is an excellent option for those looking for a high-quality fragrance that is both affordable and long-lasting. It is also cruelty-free, making it an ethical choice for those who prefer to use products that are not tested on animals. In conclusion, Body Luxuries Enchanting Perfume for Women is a fragrance that truly captivates the senses. Its unique blend of fruity and floral scents with a warm and cozy undertone makes it a must-have for any woman looking to add a touch of elegance and