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Oxford Cannabinoid Technologies Holdings plc, which specialises in developing cannabis-derived medicines with pain-relieving properties, has successfully administered the first-in-human dose of its lead pharmaceutical drug compound, OCT461201, in its phase 1 clinical trial. The company holds a portfolio of four drug candidates intended for use as licensed pain medications. The drug is a selective cannabinoid receptor type 2 agonist with the potential to treat chemotherapy-induced peripheral neuropathy and irritable bowel syndrome. The UK trial, conducted by Simbec Research Limited, part of Simbec-Orion Group Ltd., is progressing with healthy volunteers, OCTP said in a statement. Using a single ascending dose protocol, the primary objective is to demonstrate OCT461201's safety and tolerability, while providing information on its pharmacokinetic profile, to confirm its value as a potential drug. Results from the trial, funded entirely by OCTP's existing resources, are expected in the third quarter of 2023, the statement added.

Our office is located in the heart of Tulsa, Oklahoma. Regardless of your age, size, fitness level or condition, we tailor our treatment to you as an individual. We understand that patients expect the best care, an honest assessment and true concern for their health as well as an efficient means of receiving treatment. Our goal is to help you achieve your health care goals and an optimum quality of life. Our approach to your health care needs utilizes the world renowned Gonstead system. Modern chiropractic is a natural method of healthcare that does not use drugs or surgery, in contrast, the use of spinal adjustments, exercise and rehabilitation are used as a complete approach to patient care. The focus is on treating the causes, rather than just the symptoms. With a normally functioning spine, nervous system, and a healthy lifestyle, your body is better able to heal itself. We are committed to providing the Tulsa area with quality chiropractic care for the whole family. Our primary goal is your health and helping you reach your full potential. In an ideal world, we would see a majority of our patients before they began hurting or became sick. For example, a dentist finding and fixing a cavity before it becomes a crater and painful. However, it is at that very point of pain and discomfort that most of our patients first come to see us. It is then up to the patient to decide what their goals are concerning their treatment. We can offer more than just superficial relief of pain. There are three types of treatments we provide and we always respect your personal and health goals by allowing you to make decision about which you would like. 1. Relief Care Pain is often the last thing to show up and the first thing to leave. Initially, relief will come in the form of reducing inflammation and relieving pressure and irritation off of nerves. Most people that walk into our office have that goal in mind, relief. This becomes our first objecti

A Tricycle is a type of human-powered land vehicle powered by the arms rather than the legs, as on a bicycle. Most handcycles are tricycle in form, with two coasting rear wheels and one steerable powered front wheel. Despite usually having three wheels, they are also known as handbikes. Many manufacturers have designed and released hand-powered recumbent trikes, or handcycles. Handcycles are a regular sight at HPV meets and are beginning to be seen on the streets. These usually follow a delta design with front wheels driven by standard derailleur gearing powered by hand cranks. Brake levers are usually mounted on the handholds which are usually mounted in phase, unlike pedal cranks, which are usually 180° out of phase. This allows the rider to more easily use their torso to help propel the cycle. The entire crank assembly and the front wheel turn together, allowing the rider to steer and crank simultaneously. Single-Hand-Drive-Tricycle come in a variety of styles, making them accessible to people with a wide variety of disabilities. There are also hybrids between a handcycle, a recumbent bike and a tricycle. Fork steer handcycles represent the majority of handcycles sold. They work well for both low and high-level spinal injuries, and most have adjustable footrests, seat angle, and come with a variety of gearing, wheel and tire configurations depending on intended use: racing, recreation, or touring. Manufacturers of this type of handcycle include Invacare (Top End), Intrepid Equipment, Varna, Schmicking and Sunrise Medical. Lean steer handcycles are another type of handcycle. In this type of handcycle the rider leans into the turn to steer. There is a longer learning curve with lean steer handcycles, and they are significantly less stable at high speed. The lean steer system feels similar to mono skiing: using your whole body to steer the handcycle. Lean steer handcycles can work well for lower-level injuries; although, some athletes with high-level di

The truth according to Kettlebell workout 2.0 pdf is that kettlebell fat loss program must be deliberately and thoughtfully planned and it must respect the element of progression. This Kettlebell workout calorie burn has four different phases; each phase becomes more demanding on the body and is based on the previous one. You will need to follow the scientific rule of physiology stated above to produce the results that the program promises...click link for more

Denmark's Zealand Pharma and Boehringer Ingelheim said their experimental obesity treatment achieved up to 14.9% weight loss in a mid-stage trial, lining up a potential contestant in the booming obesity drug market. In a statement on Wednesday (May 10), the partners said that the Phase II dose-finding trial met its primary endpoint of weight loss after 46 weeks. Paola Casarosa, head of therapeutic areas at Germany's Boehringer Ingelheim told Reuters the partners are in discussion with regulators about the design of a planned follow-up trial in the third and last phase of testing. The enormous demand for weight-loss treatments such as Novo Nordisk's Wegovy, or potentially Eli Lilly's Mounjaro, could support as many as 10 competing products with annual sales reaching up to $100 billion within a decade, mostly in the United States, industry executives and analysts said. Lilly said about a year ago that Mounjaro was shown to reduce up to 22.5% in weight after 72 weeks of treatment in a much larger late-stage trial.

The Digital Medicines Transformation Portfolio (DMTP) was able to deliver the electronic prescription service (EPS) in Wales - just 20 months after starting the project - with support from key partners in the NHS and industry. Patients in Rhyl were the first to benefit from the new service, which allows GPs to send prescriptions electronically to the patient's choice of community pharmacy, without the need for a paper form. The new EPS service is currently in a live testing phase, with a phased roll out across Wales expected from January 2024. DMTP, which is hosted by Digital Health and Care Wales (DHCW) has worked closely with NHS England, who provided the core EPS platform that has been developed for use in Wales. NHS Wales Shared Services Partnership has also made a major contribution in the project, incorporating digital reimbursement to pharmacies and putting security measures in place.

The National AIDS Control Programme (NACP) has entered its third phase with a three-pronged strategy, as per the Union Minister of State for Health and Family Welfare (India).

Initial weeks are very hectic for the newborns and their mothers, because in this phase, infants are trying to adapt the new things from the surrounding.

Initial weeks are very hectic for the newborns and their mothers, because in this phase, infants are trying to adapt the new things from the surrounding.

The Scottish Medicines Consortium (SMC) has accepted AbbVie's RINVOQ (upadacitinib) for use within NHS Scotland for the treatment of adult patients with moderately to severely active ulcerative colitis (UC). Upadacitinib offers an additional treatment choice in the therapeutic class of janus kinase inhibitors. "Daily life with ulcerative colitis is difficult due to the debilitating and unpredictable nature of its symptoms", said Dr Jonathan Macdonald, Consultant Gastroenterologist at NHS Greater Glasgow and Clyde. "Clinical trials have shown that upadacitinib as a once daily pill controls symptoms in eight weeks for many patients and provided sustained responses at one year. The SMC's decision is good news for people with ulcerative colitis in Scotland as it provides an additional treatment option to help them gain control of their condition." The SMC decision is based on data from the induction studies U-ACHIEVE and U-ACCOMPLISH, as well as the Phase 3 U-ACHIEVE maintenance study, which demonstrated the efficacy of upadacitinib versus placebo in its ability to achieve clinical remission. The SMC's decision follows the granting of Marketing Authorisation for upadacitinib in UC in July 2022.

The US Food and Drug Administration (FDA) has approved the Novartis drug, Cosentyx, (secukinumab) to treat moderate to severe hidradenitis suppurativa (HS) in adults. HS is a chronic, progressive and painful disease which affects one in 100 people worldwide, and has limited treatment options. "Cosentyx is the only FDA-approved fully human biologic that directly inhibits interleukin-17A (IL-17A), a cytokine believed to be involved in the inflammation of HS," said the Swiss company. The FDA approval was based on robust Phase III data (SUNSHINE and SUNRISE studies) in which Cosentyx showed rapid relief from HS symptoms as early as Week 21.

The Medicines and Healthcare products Regulatory Agency (MHRA) on Monday (29 January 2024) approved the medicine Rezzayo (rezafungin) to treat invasive candidiasis, an infection caused by a yeast called Candida. Invasive candidiasis can pose a serious health risk as it can affect the blood, heart, brain, eyes, bones and other parts of the body. Napp Pharmaceuticals Ltd was granted the marketing authorisation for the medicine based on phase 3 clinical trial data. In the randomised, double-blind, controlled study, more than half of the invasive candidiasis patients who were given a weekly dose of rezafungin were cured at day 14. Among 94 patients who were given a daily dose of caspofungin (another antifungal treatment), 57 of them were cured during the same time.

If travel by wheelchair or travel by scooter, make sure your wheelchair or scooter is in good working order before leave house. If chair has not been serviced recently, send it to a repair shop for a general check over. This extra effort can save the heartache of suffering a breakdown overseas; save the time wasted trying to locate a repair shop and save the time wasted waiting for the repair. Transport considerations should be factored into the initial phase of the wheelchair and seating assessment process. Manufacturers of Soma SM 150.3 wheelchairs and seating systems should make information relating to the safe transportation of their products readily available and easy to understand.

In the past, women did not use to talk about their sex life, but now they are coming out of the shadows and expressing concerns about their sexual desires and looking for ways to boost up their libido. Many women have also made confessions that they do need sexual boost occasionally in the bedroom. During the phase of menopause, body of a woman goes through lots of psychological, physical and hormonal changes

Higher levels of testosterone are associated with depression in the menopausal women. It is observed that women who have high levels of testosterone hormone during the phase of menopause are more likely to develop depression. Testosterone is found in high quantity in men than in women, as it is a male sex hormone. It also plays a vital role in the biology of women. In men, low testosterone levels result in depression. Men who have testosterone deficiency, testosterone replacement therapy can be a good mode of treatment for relieving some depressive symptoms.

As men becomeold, they face the problem of weak erection, decreased libido and low level oftestosterone. Along with the advancement of age, erection becomes slower anddelayed orgasm occurs. Each phase in sexual response changes its rate.Initially the intensity of orgasm weakens and if a person lives long, then itfades away completely at the later stages of life. The ability of erectile alsodecreases.

Most of the healthcare providers believe that HRT plays an important role in making a woman look younger. However, it responds differently in various conditions. Similarly HRT which is taken by women with POF is quite different from the hormone therapy that women adopt who have passed through the menopause phase.

People want to know whether the Human Growth Hormone (HGH) can help them in growing taller, or not. The fact is that increase in the rate of your growth occurs only during the phase when you are a child and growing. HGH is manufactured by the pituitary gland in the brain and is responsible for the development and growth of human body. However, the pituitary gland does not produce HGH at its peak level all the time. Many factors such as abnormal pituitary gland, or imbalance of hormones can cause decreased levels of HGH in the body.