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The Medicines and Healthcare products Regulatory (MHRA) and Genomics England to launch a brand-new genetic research resource, known as a 'biobank' on Thursday (June 01) to tackle the issue of Adverse Drug Reactions (ADRs). Biobank will help to better understand how a patient's genetic makeup can impact the safety of their medicines. "The Yellow Card biobank, which will contain genetic data and patient samples, will operate alongside the MHRA's Yellow Card reporting site for suspected side effects and adverse incidents involving medicines and medical devices," said MHRA. The biobank pilot will officially begin on 1 June 2023 with participant recruitment commencing later this year, on 1 September. The sequencing of participants' genetic material will begin in Spring 2024, with initial research findings from the pilot due to be published in 2025. Genomics England will be supporting the MHRA with sequencing and storage of genetic material through use of their well-established and secure infrastructure.

Immunogenicity refers to the capacity of a vaccine to provoke an immune response in the body. An effective immune response is characterized by the production of specific antibodies, activation of immune cells, and the development of immunological memory. The goal is to elicit a durable and robust response that can prevent or control infections. Leveraging Viral Vector Technology Viral vectors serve as essential vehicles for delivering antigenic proteins or genetic material into target cells, triggering an immune response. Biotechnology companies have been exploring advanced strategies to optimize viral vector design, aiming to enhance immunogenicity and improve vaccine effectiveness. Vector Selection: The choice of viral vector plays a crucial role in determining immunogenicity. Different viruses have unique properties and characteristics that can impact immune responses. Biotechnology companies meticulously select viral vectors that possess the desired attributes, such as the ability to infect target cells efficiently and induce strong immune responses. Genetic Engineering: Advanced genetic engineering techniques are employed to modify viral vectors, tailoring them to specific vaccine requirements. By introducing specific antigenic proteins or genetic material, researchers can stimulate the immune system to mount a targeted response. This precise manipulation enhances the vaccine's ability to elicit a robust immune reaction. Immunomodulatory Elements: Biotechnology companies are incorporating immunomodulatory elements into viral vector designs. These elements can enhance the immune response by stimulating various components of the immune system, such as antigen-presenting cells and T cells. By activating and priming these immune cells, the vaccine can generate a more potent and sustained immune response. Adjuvants: Adjuvants are substances added to vaccines to enhance their immunogenicity. They stimulate and amplify the immune response, improving the va

The Health and Social Care Secretary has announced over £175 million funding to boost genomics research in the UK. Through this funding, the government aims to create the most advanced genomic healthcare system in the world. "Patients with cancer and children born with treatable rare genetic diseases are set to benefit from earlier diagnosis and faster access to treatment, following a £175 million boost to cutting-edge genomics research announced by the Health and Social Care Secretary today (Tuesday)," said DHSC. The funding will enable research which could deliver world-leading genomic healthcare to patients, which involves the study of people's DNA. "£105 million to be funded to kickstart a world-leading research study, led by Genomics England in partnership with the NHS, to explore the effectiveness of using whole genome sequencing to find and treat rare genetic diseases in newborn babies," said DHSC. "An initial £26 million to support an innovative cancer programme, led by Genomics England in partnership with the NHS, to evaluate cutting-edge genomic sequencing technology to improve the accuracy and speed of diagnosis for cancer patients and use artificial intelligence to analyse a person's DNA, alongside other information such as routine scans.

A study was carried out in which genomes of more than 1400 men were examined. Changes were found with the genes that had low levels of testosterone levels in the blood. These changes were named as "risk markers." Men having three or more of these risk markers have chances of 6.5 times low testosterone level than in men having no risk markers. Genetic markers have strong effect on testosterone levels along with some other factors that cause low testosterone levels in men; it includes smoking, age, and body weight.

A new study by The Institute of Cancer Research, London (ICR) has shown that a genetic test for faults in DNA repair could enable targeted nuclear treatments for patients with prostate cancer.

Capitalising on strong demand for its obesity therapies, Novo Nordisk's growing appetite for deals has fuelled a bet on a U.S. gene-editing company called Life Edit Therapeutics. The Danish drugmaker's collaboration with Durham, North Carolina-based Life Edit Therapeutics - owned by ElevateBio, a cell and gene therapy company in Waltham - is focused on up to seven programs for rare genetic disorders as well as cardiometabolic diseases. At the heart of the tie-up is Life Edit's technology, called base editing, which is designed to make precise changes to the human genome by tweaking one base - or letter - into a different one without affecting other letters. Single-letter mistakes, called point mutations, can give rise to genetic diseases.

The UK's National Health Service (NHS) has become the first healthcare system in the world to provide a new blood group genotyping test for people with rare inherited blood disorders. From Monday (22 January), thousands of patients suffering from sickle cell disorder and thalassaemia will get access to the world-first 'blood matching' genetic test, which will help reduce their risk of transfusion side effects while offering more personalised care. In England, it is estimated that around 17,000 people are living with sickle cell disorder, with 250 new cases reported each year, and there are about 800 thalassaemia patients, with less than 50 new cases a year. Health Minister Andrea Leadsom said: "Thousands of people living with sickle cell disease and thalassaemia will be eligible for this new world-first blood test which is set to transform their care.

A revolutionary discovery by the researchers have proved that the most severe form of malaria, caused by the parasite Plasmodium falciparum,is linked with natural variation in human red blood cell genes.

A revolutionary discovery by the researchers have proved that the most severe form of malaria, caused by the parasite Plasmodium falciparum,is linked with natural variation in human red blood cell genes.

Stroke is a cerebrovascular syndrome that involves the blockage and bursting of blood vessels in the brain. It shows a multifactorial pattern of inheritance. High cholesterol levels, high blood pressure, hypertension and obesity are the key causes of stroke besides inherited genes.

Psoriasis vs Eczema, while both causing itchy, inflamed skin, are distinct conditions with different underlying causes and treatments. Understanding these differences is crucial for proper diagnosis and management. Symptoms: Psoriasis: Thick, red, scaly patches: Often on elbows, knees, scalp, but can affect any area. Silvery scales: Easily removed, revealing inflamed skin beneath. Eczema: Dry, itchy, red patches: Often on inner elbows, knees, hands, face, but can be widespread. Fine, scaling: Less prominent compared to psoriasis. Causes: Psoriasis: Autoimmune condition: Immune system mistakenly attacks healthy skin cells, causing rapid growth and buildup. Genetic predisposition: Family history increases risk. Eczema: Atopic dermatitis: Combination of genetic and environmental factors. Dry skin: Major contributing factor. Treatments: Psoriasis: Topical medications: Steroids, retinoids, vitamin D analogues to reduce inflammation and cell growth. Light therapy: Ultraviolet light exposure to slow skin cell production. Eczema: Moisturizers: Regular use hydrates and protects the skin barrier. Emollients: Oil-based creams to soothe dryness and itching. Key Differences: Cause: Psoriasis is autoimmune, while eczema is complex and involves both genetics and environment. Symptoms: Psoriasis typically has thicker scales and less itching, while eczema is drier and itchier.

If your family members are not slim and it is your genetic hereditary to be on the plus side, then also it will be a little difficult. In both the cases you will require help of the physician and fast weight loss pills.

The body size differences are paralleled by maturational changes. The smaller body of an infant or neonate is substantially different physiologically from that of an adult. Congenital defects, genetic variance, and developmental issues are of greater concern to pediatricians than they often are to adult physicians. A major difference between pediatrics and adult medicine is that children are minors and, in most jurisdictions, cannot make decisions for themselves. The issues of guardianship, privacy, legal responsibility and informed consent must always be considered in every pediatric procedure. In a sense, pediatricians often have to treat the parents and sometimes, the family, rather than just the child. Adolescents are in their own legal class, having rights to their own health care decisions in certain circumstances. In basic terms, pediatricians take care of all of the children's needs from emotional support to medical support. Wheelchair india as Pediatric Wheelchair Manufacturers and Pediatric Wheelchair supplier sale at low cost - price, We Sale online Pediatric Powered Wheelchair and Pediatric Electric Wheelchair at wholesale prices...

For many thin guys around the world, gaining weight without using illegal steroids has been a challenge. For thousands of lean young men, the dream is to gain weight, but no matter how much they eat they remain thin. Some people are naturally thin; that means their genetic makeup is in such a way that the body burns more calories than others. The very basic method of weight gain is to eat more calories than your body burns off. By providing the body with more calories, this balance can be altered and body mass can be increased. Weight training is of great importance in this context, which enables the body to absorb more nutrients from the food by increasing the level of certain hormones and increasing the muscle mass.

For many thin guys around the world, gaining weight without using illegal steroids has been a challenge. For thousands of lean young men, the dream is to gain weight, but no matter how much they eat they remain thin. Some people are naturally thin; that means their genetic makeup is in such a way that the body burns more calories than others. The very basic method of weight gain is to eat more calories than your body burns off. By providing the body with more calories, this balance can be altered and body mass can be increased. Weight training is of great importance in this context, which enables the body to absorb more nutrients from the food by increasing the level of certain hormones and increasing the muscle mass.

Though there may be many reasons why you may be thin, the most apparent reason is because of your genetics. If your parents are naturally thin or have a small body frame, then you will most likely have the same small body type.

In old age, your skin start to develop fine lines and your skin starts losing tones. However, it varies depending upon your dietary habits, genetics, and physical activity. Aging signs become prominent when Human Growth Hormone level within your pituitary gland starts declining. This decline in HGH level make your skin to hang down as a result lines develop, decreased level of HGH drops down your metabolic rate and loses your muscles toning.

Prader-Willi Syndrome or PWS is a genetic disorder. In this disease, individual experiences extreme hunger and require excessive food that make it fatty and causes other problems that are associated with overeating. Such individuals also have difficulties in learning throughout their life and usually have short stature. Although this disease is not common, the rate of having PWS is 1 in every 15,000 live births. However, this number is rising.

Cerebral palsy (CP) is a general term for a group of permanent movement problems that do not get worse over time. They cause physical disability,mainly in the areas of body movement.There may also be problems with sensation, depth perception,so you use Cerebral palsy wheelchair and communication ability. Difficulty with cognition and epilepsy are found in about one-third of cases. There are subtypes including a type characterized by spasticity, a type characterized by poor coordination, and types which feature both symptoms or neither. Cerebral palsy is caused by damage to the motor control centers of the developing brain and can occur during pregnancy, during childbirth, or after birth up to about age three.About 2% of all cerebral palsy cases are believed to be due to a genetic cause.Cerebral palsy is not an infectious disease and is not contagious. Most cases are diagnosed at a young age rather than during adolescence or adulthood.CP 2 Pediatric Wheelchair is very useful for cerebral palsy person. Improvements in the care of newborns has helped reduce the number of babies who develop cerebral palsy and increased the survival of those with very low birth weights.There is no cure, with efforts attempting to treat and prevent complications. It occurs in about 2.1 per 1,000 live births.Physical therapy may help. Cerebral refers to the cerebrum, which is the affected area of the brain. The disorder may often involve connections between the cortex and other parts of the brain such as the cerebellum. The root word "palsy" means "paralysis". In medicine, this is often used in reference to the paralysis or weakness that often accompanies nerve damage, loss of sensation or muscle disorders involving uncontrollable movements such as trembling or shaking.

Pediatric Wheelchair are fabricated using finest grade raw materials such as aluminum, ms steel pipe, stainless steel pipe.Pediatric Wheelchairs specially designed wheelchairs are suitable for children up to 15 years of age and are capable for 50 kgs. Our range of pediatric wheelchairs are easy to handle and can be used for indoor as well as outdoor purposes.Cerebral palsy is a very common childhood condition, with a consistent prevalence rate estimated at 2/ 1000 children in developed countries. Cerebral palsy occurs when parts of the brain that control muscles are damaged, causing varying degrees of lifelong disability. There is a wide spectrum disability within CP, ranging from mild physical disabilities to more severe cognitive and physical disabilities both. Types of Cerebral Palsy: Spastic CP Ataxic CP Mixed CP Monoplegic CP Spastic Cerebral Palsy: This is the most common type of CP. Spastic is a condition of muscular rigidity or spasm that children with CP have. Muscle stiffness causes the body to adopt abnormal positions that the child cannot easily move out from. Movements are awkward and limited or restricted. Ataxic Cerebral Palsy: Ataxic means unsteady or shaky movements that are less pronounced than in athetosis. These unsteady movements are observed when a child tries to carry out an activity. For example, when he/she reaches for an object or a toy, he/she may miss the target in the first attempt. Due to poor balance, standing and walking may take longer to learn. Mixed Cerebral Palsy: Children with mixed CP show features of more than one type of cerebral palsy. For example, some children have spastic CP with athetosis. Monoplegic: Occasionally a child has monoplegic CP, in which only one limb is affected. Monoplegic cases are few. CP Child Chair CP is usually caused by factors prior to birth: lack of oxygen passed to the child before birth, via infection spreading from mother to baby or by genetic disorder.