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Global demand for Pfizer's oral Covid-19 antiviral treatment Paxlovid has been unexpectedly low due to complicated eligibility requirements, reduced testing, and potential for drug interactions, according to a media report. Demand also has been hampered by the perception that Omicron infections are not that severe. Paxlovid was expected to be a major tool in the fight against Covid after it reduced hospitalizations or deaths in high-risk patients by around 90 per cent in a clinical trial. Thousands of people still die from Covid-19 every week, even as global infections are far off their peak. And there are only a few proven antiviral treatments, of which Paxlovid is the most attractive. The others are Merck & Co's far less effective rival pill molnupiravir, and Gilead Sciences' intravenous remdesivir.

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Mental health issues are very common, and one in four people will experience a mental health problem in their lifetime. Unfortunately, many people do not seek treatment because they are embarrassed or ashamed. However, there is no need to be ashamed - mental health problems are just like any other medical condition. Treatment options include therapy, medication, and lifestyle changes. In this blog post, we will discuss the top ways medications can help in treating mental health issues. We will also dispel some of the myths about mental health medications. MENTAL HEALTH MEDICATIONS CAN REDUCE ANXIETY AND DEPRESSION Mental health medications can be very effective in treating mental illness. In fact, they can be just as effective as medications for physical health conditions. Mental health medications can help to reduce symptoms, improve functioning, and prevent relapses. They are also legal psychedelic medicine that have been shown to be helpful in treating mental illness. For example, ketamine has been shown to be effective in treating depression, anxiety, and post-traumatic stress disorder. Some people worry that taking mental health medication will make them feel like a different person. However, this is not the case. Mental health medications can help you to feel like yourself again. They can also help you to function better in your everyday life.

The Medicines and Healthcare products Regulatory Agency (MHRA) has launched new guidance to highlight the latest safety advice on the steps to take during anaphylaxis. On the start of World Allergy Week (19 June), an annual initiative led by the World Allergy Organization, aiming to raise awareness of allergies, their management and prevention, the MHRA has collaborated with allergy awareness advocates to share an easy step-by-step infographic guide and video outlining the latest advice from the CHM's working group on the safe and effective use of AAIs. Steve Barclay, Secretary of State for Health and Social Care said: "A severe allergic reaction can be life-threatening. One in five people in the UK suffer with at least one allergy, so it's vital people are equipped with the knowledge to keep themselves safe. Adrenaline auto-injectors - also known as AAIs or by their brand names such as EpiPen - are highly effective and convenient for the immediate treatment of anaphylaxis. If you have been prescribed one, please carry it with you at all times and make sure you are up to date on the latest safety guidance - it could save your life."

The Department of Health and Social Care (DHSC) has issued a medicine supply notification for Temazepam 10mg and 20mg tablets. "Temazepam 10mg and 20mg tablets are in limited supply until w/c 5th December 2022. Alternative benzodiazepines and non-benzodiazepine hypnotics remain available and will be able to support increased demand," said DHSC. Temazepam 10mg/5ml oral solution remains available but cannot support an uplift in demand. DHSC suggested: "Where the above options are not suitable, unlicensed supplies of temazepam 10mg tablets may be sourced, lead times vary." The department confirmed that Target Healthcare, a specialist importers, have confirmed they can source unlicensed Temazepam 10mg tablets. "If there is currently no listing on dm+d for the imported product for prescribers to select using their prescribing systems an EPS prescription for unlicensed Temazepam 10mg tablets cannot be issued."

The UK Health Security Agency (UKHSA) has published the latest national surveillance data on antibiotic prescribing and resistance. The English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) report showed an increase in antibiotic use in all settings (apart from dental) in 2022. According to the report, antibiotic prescribing rose by 8.4 per cent in 2022 compared with 2021, although the number remains below 2019 pre-pandemic levels. "There are many reasons behind the increase in prescribing, one of which is likely related to decreased immunity and exposure to infections during the COVID-19 pandemic that may have underpinned the increased transmission in co-circulating infections, namely: influenza (flu), respiratory syncytial virus (RSV) and group A streptococcus (GAS)," the report stated.

The Medicines and Healthcare products Regulatory Agency (MHRA) has introduced a new tool to check the eligibility for marketing authorisation applicants. Applicants are now required to use the online 'Eligibility Checker' tool to determine whether their Marketing Authorisation Application (MAA) is suitable for the Agency's International Recognition procedure (IRP), which will become operational on 1 January 2024. The tool will also help applicants identify which route (A or B) to follow, before submitting their IRP application. Julian Beach, MHRA Interim Executive Director of Healthcare Quality and Access, said that the tool has been tailored to "facilitate a smooth and efficient process for marketing authorisation applicants."

Intuit Quickbooks Remote Access takes You From the Grind to the Groove Picture this You're not stuck in a beige box on fluorescent Friday. Instead you're cruising down a vibrant boardwalk sun on your face ocean breeze in your hair and QuickBooks open on your tablet. Your fingers waltz across the screen sending invoices fluttering like colorful kites into the digital sky. No stuffy suits no soul-sucking commute just you your business and a vibrant rhythm of life. This my friend, is the sweet melody of remote QuickBooks access. Choose your soundtrack to financial freedom: Cloud Concerto: Embrace the boundless symphony of QuickBooks Online. Access your data from any device anywhere like a musical maestro conducting your finances from a rooftop café. Virtual Vault Vibe: Imagine your QuickBooks software serenading you from a secure cloud sanctuary. QuickBooks Hosting lets you access this harmonious haven remotely, like a financial alchemist unlocking the secrets of success from a sun-drenched mountaintop. Remote Bridge Rhythm: Think of these tools as trusty bongo drums connecting you to your office PC. With TeamViewer or Splashtop you're just a click away from bridging the gap opening QuickBooks from afar and drumming up some financial magic even if you're swaying to the beat by a bustling street market.

One evening whilst I was watching TV, my phone pinged with an all too familiar WhatsApp alert with a message preview saying "Can you help". I recognised the name as one of our Titan pharmacy customers who was clearly in a state of panic. I replied offering my assistance and asked him what was up. What followed over the next 24 hours was an interesting case study of how innovative technology can genuinely solve real challenges in pharmacies. Mr P (let's call him that) had booked a locum to cover in his dispensary on the next day so he could focus on his vaccination service. The problem - his locum had just called to cancel his booking (no reason given) and now he had no cover. Meanwhile, he was fully booked with back to back appointments and could not cancel them. He had phoned round his usual network of pharmacists and no one was available at short notice. He was asking if there was anything that Titan could do to reduce his workload and said he had heard about Titan's artificial intelligence module. Unfortunately, Titan. X had not been installed at this site and was not an option at this late stage. Equally, Titan's digital workflow cannot be circumvented so there was no way steps could be taken out of the process.

Kelso Pharma, the growing UK based specialty pharma business, has announced its first product launch with the release to the UK prescription medicines market of Acepiro (Acetylcysteine) 600mg effervescent tablets. Acepiro 600 mg effervescent tablets are indicated in adults only and are being made available to hospital and community prescribers in 20 and 30 day packs, with the 30 day pack consistent with monthly prescribing. The NHS List Price for the 30 day pack is £4.40, with the 20 day pack priced at £3.65. Acepiro is being launched by Stirling Anglian Pharmaceuticals (SAP), which was acquired by Kelso Pharma one year ago, providing a new UK platform and springboard for future sales growth for the business. The new product complements SAP's existing portfolio of three medicines: CosmoCol (macrogol 3350 plus electrolytes) powder for oral solution - an osmotic laxative indicated for the treatment of chronic constipation and faecal impaction. Stirlescent (naproxen) 250mg effervescent tablets - containing naproxen, which is a non-steroidal anti-inflammatory drug (NSAID).

WHAT IS PROTEINASE K MADE OF? Proteinase K is known enzyme belonging to the class of serine proteases that cleave adjacent to the carboxylic group peptide bonds of aromatic and aliphatic amino acids. It's also exhibited a very broad cleavage specificity. The enzyme was discovered in extracts of the fungus Engyodontium album. HOW DOES PROTEINASE K WORK? In molecular biology, main application of proteinase K is to digest proteins during nucleic acids purification in order to remove protein contaminants: - Proteinase K quickly inactivates nucleases (enzymes that digest nucleic acids) that degrade DNA or RNA molecules during the cleansing. - Proteinase K is activated by calcium. It does not affect the activity of the proteinase, but protects again autolysis, improves thermal stability, and regulates substrate binding capacity. To increase the stability of Proteinase K, thereby enhancing its action, Urea as well as SDS (sodium dodecyl sulfate) or elevated temperature at 37-60C is commonly used. Inactivation of Proteinase K is occurring at temperature above 65C. WHAT IS THE PURPOSE OF PROTEINASES? Proteinase K is used to break down proteins in cell lysates (tissues, cell culture cells) and to release nucleic acids due to its action described above. Proteinase K application purpose: DNA isolation from various tissues; Removal of DNAses and RNAses: Proteinase K and RNases can act together in the lysis buffer to degrades contaminating RNAs and proteins;

What's valerian root used for? The ancient Greeks and Romans used valerian root to treat: Nausea Gas Heart pulsings Urinary tract infections Insomnia The German tribes believed it could tame the wildest of animals. They also hung it outside their homes to frighten witches and devils. Hertha, a Teutonic witch-goddess, rode a deer crowned with hops and used a stem of valerian as a lash. During the Middle Ages, astrological botanist Nicholas Culpeper simmered valerian root with raisins, licorice, and aniseed. He used the tonic to cure bubonic plague and chest congestion. In 1620, valerian root was carried to North America on the Mayflower. During World War I and II, it was used to reduce stress caused by air attacks. It was also mixed with hops and kava-kava to treat shell-shocked frontline troops. HOW DOES IT WORK? It is a powerful herb used since ancient times to help people relax and fall asleep. Valerian works by acting on the GABA (Gamma-Aminobutyric acid) receptors in your brain to induce relaxation, making it an ideal supplement for those with anxiety or insomnia who want to sleep better at night. The active compounds in valerian plants are called valepotriates, which act as sedatives at low doses and stimulants at higher doses. Valerian Uses & Effectiveness Consuming valerian root extract 300-600 mg by mouth daily appears to improve sleep quality. It is possibly effective for treating Insomnia symptoms. For notice effects, continue its usage for up to 4 weeks. There is welfare in consuming valerian for several other purposes, but it requires more reliable data to say whether it could help. It's generally used in various products containing other soothing herbs, such as hops, passion flowers, and lemon balms.

Enterosgel is a versatile safe drug-free alternative to current anti-diarrhoeal medicines found on pharmacy shelves. Enterosgel is different from other anti-diarrhoeals within this category, as it is suitable for children aged one year and over, so can be taken by the whole family. This intestinal adsorbent can be used for both acute diarrhoea due to gastrointestinal infections and for chronic irritable bowel syndrome with diarrhoea (IBS-D). Why should community pharmacists stock this brand? Unlike anti-diarrhoeals which work by slowing gut motility, Enterosgel is an intestinal adsorbent which physically binds harmful substances from the gut, that can cause diarrhoea and other gastrointestinal symptoms and expels them naturally with the stools. Because it is a medical device not a medicine, has no pharmacological action and is not absorbed by the body, it is a safe option for children and adults and can help reduce the likelihood of side effects which can be an issue with anti-diarrhoeal medicines. Enterosgel has a unique composition of an adsorbent mineral gel based in water, it contains no additional preservatives or additives so is easy to recommend from vegetarians to people with allergies or intolerances. The gel is mixed with water and taken orally in between meals; it is tasteless so well tolerated even by children.

The Department of Health of Social Care (DHSC) has re-determined that all six Madopar (Co-beneldopa) preparations meet the special container criteria as outlined in Part II Clause 10 of the Drug Tariff. "The NHS dictionary of medicines and devices (dm+d) has now been updated with special container status applied to the complete pack sizes of all Madopar preparations," said PSNC. "The special container rules apply immediately to all branded or generically written prescriptions for Madopar dispensed from December 2022 onwards." The following products will be treated as special containers for prescriptions dispensed from December 2022 onwards:

Genomic sequencing allowed the world to track new coronavirus variants throughout the pandemic. Now British researchers plan to use it to better understand a host of other respiratory pathogens, from influenza to respiratory syncytial virus (RSV). The work is aimed at shedding more light on known threats and, potentially, emerging ones, the team at the Wellcome Sanger Institute, working with the UK Health Security Agency, said. The world has never had access to the kind of real-time information for these viruses that scientists obtained on SARS-CoV-2 through sequencing millions of genomes, Ewan Harrison, head of the new Respiratory Virus and Microbiome Initiative, told reporters on Monday. That includes granular detail on how they transmit as well as how they evolve in the face of the human immune response. "We hope that by expanding our ability to sequence these viruses routinely, we can build upon the work that's going on COVID, and hopefully supercharge research efforts to understand the transmission of these viruses, but also to help develop new treatments and vaccines," Harrison said.

Suffering a brain injury is no easy thing. The plurality of potential symptoms meets with the potential long-term effects to create a poor prognosis for many unfortunate enough to experience them. But new technological leaps could pave the way to a better quality of life. What is a Brain Injury? The above question might seem a simple one, with a simple answer. But brain injuries are by no means simple, and by no means simply defined. There are two major categories under which a brain injury can fall: hypoxic and traumatic. Of civil brain injury claims in the UK, traumatic brain injuries (TBIs) are the most common - with 95% of claims revolving around some form of traumatic injury or incident. TBIs are brain injuries suffered as a result of a specific or direct injury. The brain is damaged through direct contact or the transfer of force. A direct strike to the head is in an assault or a serious fall might compromise the cranium, sending shockwaves of energy through the brain and potentially crushing the skull into the cranial cavity. Alternatively, a car accident or sudden stop might see the brain bashed against the occipital bone, causing internal trauma and intracranial hypertension. Hypoxic brain injuries refer specifically to injuries caused as a result of loss of blood or oxygen to the head. These injuries reflect birth injuries that might lead to cerebral palsy, or serious medical events that might alter the brain's response to stimuli. How are Brain Injuries Diagnosed and Treated? While the potential causes of a brain injury are plain to see, diagnosing a brain injury is not as straightforward. There are immediate symptoms that can indicate brain injury, such as the 'fencing response' which can indicate a severe rotational brain injury. Conscious patients might also exhibit difficulty speaking, remembering key pieces of information or responding to any stimuli.

Diaphragm pumps are positive displacement pumps that use a flexible diaphragm to displace a fluid volume. They're used to move fluids with viscous materials or solid particles because they can move the fluids without causing damage to the pump. Almost all major industries use diaphragm pumps to move concrete, acid, and abrasive fluids. Diaphragm pumps use power sources like air pressure, mechanical means, and electricity. One industry that relies heavily on diaphragm pump operation is the pharmaceutical industry. The diaphragm pump is suitable for the pharmaceutical industry because it can handle a variety of fluids and provide a gentle flow. This article discusses the various uses of diaphragm pumps in the pharmaceutical industry and how they have revolutionized it. 1. Filling Vials Filling vials with liquid medication is a task that has to be accurate and concise. Diaphragm pumps can dispense a precise amount of drugs into a vial. The pump provides an exact flow rate, ensuring each vial has the correct medication dosage. Diaphragm pumps reduce the risk of medication errors.

The Medicines and Healthcare products Regulatory Agency (MHRA) has advised the public to exercise caution when buying anti-choking devices online, ensuring these products are purchased from reputable sellers. As estimated by the regulator, more than 10,000 counterfeit or unbranded anti-choking devices have been purchased by the public within the last two years through listings on online marketplaces such as Amazon and eBay, as well as drop-shipping websites. People are cautioned that the use of such products poses a substantial risk of failure in clearing blockages and could exacerbate the situation by pushing obstructions further down into the airway passage. Dr Alison Cave, MHRA Chief Safety Officer, said: "Buying anti-choking devices that do not have a valid UKCA or CE mark increases the risk of receiving a product which does not include appropriate instructions and is either fake or does not meet the UK's regulatory requirements. "These products do not meet our strict quality standards and may put your health and safety at significant risk by failing to resolve or even worsening choking incidents."

Covid-19 vaccine maker Novavax on Wednesday said it expects revenue this year to be flat or lower as it works to improve its commercial performance and pick up market share from much larger rivals, Pfizer and Moderna. The company posted a larger-than-expected fourth-quarter loss as revenue lagged analysts' estimates. Chief executive John Jacobs said Novavax claimed just a low-single-digit percentage market share in the US during the most recent vaccination campaign, as demand for Covid vaccines was smaller than hoped and the company got its protein-based shot to market later than its messenger RNA-based rivals. "We were disappointed with that US performance," Jacobs said in an interview. He said the company's sales force was not targeted enough toward retail pharmacy chains, and that its 5-dose vials were not as convenient for use as rivals' pre-filled syringes.

NHS England on Monday (19 February) unveiled a new multichannel campaign to inform the public about the additional services offered at their local pharmacy under the recently launched Pharmacy First service. The extended service allows patients to get treatment and medicines from their local pharmacy for seven common conditions, including sinusitis, sore throat, earache, infected insect bite, impetigo, shingles, and uncomplicated urinary tract infections in women, without needing to see a GP. As part of its 'Help Us, Help You' campaign, NHS England has started running adverts across on-demand TV services, radio, bus stops and billboards as well as social media, encouraging people to use their high street pharmacies for treatment of these common illnesses.