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Cancer patients in the UK are being given a new immunotherapy treatment at Imperial College Healthcare NHS Trust as part of a global phase 1/2 clinical trial, which aims to evaluate its safety and potential for treating 'solid tumour' cancers such as melanoma and lung cancer. The experimental therapy, called mRNA-4359, has been designed to train patients' immune systems to recognise and fight cancer cells, according to researchers at Imperial College London. For the first time in the UK, cancer patients received the treatment at the National Institute for Health and Care Research (NIHR) Imperial Clinical Research Facility at Hammersmith Hospital. In this non-randomised trial, mRNA-4359 is administered to patients either alone or in combination with an existing cancer drug called pembrolizumab, a type of immune checkpoint inhibitor. The researchers are hopeful that this new therapeutic approach, if proven to be safe and effective in clinical trials, could lead to a new treatment option for difficult-to-treat cancers.

After receiving approval from the National Institute for Health and Care Excellence (NICE), the NHS is preparing to roll out a new combination treatment for brain tumours in children and young people in England. Dabrafenib with trametinib would be the first ever targeted treatment for children (aged 1-17) with gliomas that have a specific genetic mutation, the health service said. The treatment, which can be taken at home, has been found to slow the progression of the disease by over threefold compared to standard chemotherapy in children with low-grade gliomas that have a BRAF V600E mutation. Clinical trials have shown that it causes fewer side-effects than chemotherapy. NICE approved the combination treatment on Wednesday 24 April. It will be available on the NHS in the coming months.

Patients want to be active partners in their healthcare decisions - and eye care is no exception. Patient education is vital for understanding diagnoses, treatment options, and the importance of preventative care. When patients understand what's happening with their health, they're far more likely to follow their treatment plan and see good results. Here's a deeper look at why patient education matters. Patient-Centered Care: The Key to Success The Institute of Medicine emphasizes the importance of patient-centered care. This means involving patients in decision-making and providing them with the necessary education for informed choices. This approach is even more crucial in eye care, where conditions can lead to irreversible blindness. The Need for Patient Education Research shows that many patients crave educational materials from their eye care providers, but many don't receive them. This leaves patients searching for information on their own, potentially turning to unreliable sources. Clear, accessible patient education is vital in ensuring understanding and treatment adherence.For instance, patient education is crucial in preventing diseases like glaucoma. The more informed patients are, the more chances they will discover early signs of disease by taking OCT test for glaucoma.

The National Health Services England (NHSE) is poised to revolutionise diabetes management with the introduction of the 'artificial pancreas', also known as the Hybrid Closed Loop system, to treat type 1 diabetes. This pioneering initiative, endorsed by the National Institute of Health Care and Excellence (NICE), represents a global first in healthcare innovation. With 269,095 individuals grappling with type 1 diabetes in England, the Hybrid Closed Loop system is set to cater to tens of thousands of children and adults across the nation. This cutting-edge device operates by seamlessly monitoring blood glucose levels and autonomously adjusting insulin dosage through a pump, by eliminating the need for regular insulin injections. Furthermore, it holds the promise of averting life-threatening hypoglycaemic and hyperglycaemia episodes, mitigating significant risks associated with the condition. To facilitate the identification of beneficiaries, NHSE has allocated a substantial sum of £2.5 million, ensuring that those who could benefit from this innovative solution receive the necessary support.

Patients suffering from chronic and episodic migraine attacks are set to benefit from a groundbreaking recommendation by the National Institute for Health and Care Excellence (NICE) regarding a new medication. The atogepant, a first-of-its-kind preventive drug for migraine, offers hope for those grappling with this debilitating condition and can be taken orally. Published as part of the final guidance draft, NICE has greenlit the atogepant, also known as Aquipta and manufactured by AbbVie, as an option for preventing both chronic and episodic migraines in adults. Specifically, this recommendation is for individuals who have experienced at least four migraine days per month and have failed to find relief with at least three previous preventive treatments. With approximately 4.5 million people in the UK affected by various forms of migraine, this new recommendation marks a significant advancement in migraine management as the condition significantly impacts patients' day-to-day activities as well as places a heavy burden on the NHS and the wider economy.

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The NHS England last week released a survey report on the involvement of pharmacy professionals in research, and proposed the implementation of a clinical academic training pathway for pharmacy professionals by 2030. Recommendations were made to support the embedding of research at all stages of a pharmacy professional's career. The report presented the findings of two surveys that NHS England launched in May 2022, one for individual pharmacy professionals and one for organisations, calling for evidence on clinical academic careers in pharmacy. The survey found that only a minority of the pharmacy workforce take up clinical research training opportunities. "Just under a quarter of individual respondents had applied for the National Institute of Health and Care Research (NIHR) or other research project grants, and just under half of the organisational survey respondents had supported individuals to apply for such a grant," it said.

The only way to overcome the challenges facing the medicines supply chain in the UK is through close cooperation - the government, pharmacies, and the industry all working together in tandem - said Andrew Stephenson, Minister for Health and Social Care. The MP for Pendle, Lancashire made the statement while addressing the Healthcare Distribution Association's (HDA) Annual Conference at the Institute of Directors in Pall Mall, London on Thursday (25 January), where over 130 leaders from the pharma industry gathered. As the keynote speaker, Stephenson acknowledged the crucial role wholesalers, manufacturers, and retail pharmacy chains, play in the wellbeing of the nation. He said: "In the first few months that I've been in this job, it's become immediately obvious to me just how important this sector is and just how important the work that all of you do is for our country."

Researchers from the London School of Hygiene & Tropical Medicine (LSHTM) have been tasked to evaluate the impact, safety and effectiveness of the Pharmacy First service, which was launched across England in January 2024. They have been awarded £2.4million by the National Institute for Health and Care Research (NIHR) to generate evidence on the new service that allows pharmacies to provide advice and treatment for seven common conditions without the need for a GP appointment. After consultation, if necessary, a community pharmacist can supply some prescription-only medicines to treat earache, sore throat, sinusitis, impetigo, shingles, infected insect bites or uncomplicated urinary tract infections in women. The LSHTM researcher team will be working together with experts at the UK Health Security Agency (UKHSA) and the Universities of Oxford, Manchester and Nottingham on the project. Dr Rebecca Glover, assistant professor in Antimicrobial Resistance at LSHTM, who will lead the three-year project, said they will evaluate "Pharmacy First's impact on GPs and the wider NHS, pharmacy services and patients."

Staveley Pharmacy, a well-established community pharmacy located in the picturesque village of Kendal within the Lake District, has undergone a change in ownership. The family-run business led by a husband-and-wife team has been acquired by brothers Mohammad Waqas and Khuram Shazad, taking the helm as first-time buyers, according to Hutchings Consultants. Known for its strong counter trade and deep community ties, the pharmacy has been nurtured and managed by the previous owners with a profound dedication to the local community. Over the years, they have developed the business into a trusted local institution. Paul Steet, Associate Director of Hutchings who managed the sale, reflected on the transition, noting the longstanding relationship with the sellers. "Having worked with the previous owners since 2015 when they initially contacted Hutchings Consultants to discuss a valuation of the business, I feel personally connected to this pharmacy. I am delighted that Mohammad and Khuram will be taking over the reins," he said.

At the Future of Britain Conference 2024, the newly appointed Secretary of Health and Social Care, (DHSC) Wes Streeting, stated that "Labour's DNA is in the NHS". He also called for a long-term approach to reform the broken health sector and the integration of artificial intelligence (AI) to steer the healthcare system towards sustainability and growth. Hosted by Tony Blair Institute for Global Change and My Life My Say today, Tuesday, 9, Streeting discussed the plans to fix the healthcare system and role of Artificial Intelligence (AI) in "making the right choices" by bringing in three essential shifts in the healthcare. Criticising the previous Conservative administration for leaving "massive burning deck issues" due to constant reshuffling within the Department of Health and Social Care (DHSC), Streeting lamented that this "instability" and "indecisions" have made comprehensive reform even more pressing. Drawing inspiration from Chancellor Rachel Reeves' speech on economic growth, Streeting stressed the interconnectedness of health and economic prosperity.

"The UK remains genuinely world-leading for life sciences in numerous areas - yet we continue to underperform on our potential," said Richard Torbett, Chief Executive of the Association of the British Pharmaceutical Industry (ABPI). His statement is based on recent government data indicating that the UK is not fully capitalizing on its strong historical and institutional advantages in life sciences across a range of economic, health, and research indicators. The latest 'Life sciences competitiveness indicators 2024' report from the government's Office for Life Sciences revealed that while the pharmaceutical industry leads in R&D spending with £9 billion in 2022, representing a fifth of total business investment, the country saw a notable decline in foreign direct investment (FDI), industry clinical trials, and exports. In 2023, FDI dropped by 21 per cent to £0.8 billion, following a trend that saw a 52 per cent decrease over the previous two years, including a £0.9 billion fall in FDI the year prior.

A new study has revealed that UK adolescents get around two-thirds of their daily calories from ultra-processed foods (UPFs), which have been linked to the rising levels of obesity, type 2 diabetes and cancer. The research, funded by the National Institute for Health and Care Research (NIHR)'s School for Public Health Research, was published in the European Journal of Nutrition. Ultra-processed foods are often characterized by poor dietary quality due to their high content of added sugars, saturated fats, and salt, along with lower levels of fibre, protein, and micronutrients. The study, conducted by researchers from the Universities of Cambridge and Bristol, analysed data from four-day food diaries of almost 3,000 adolescents, sourced from the UK National Diet and Nutrition Survey. After examining trends in the UK between 2008/9 and 2018/19, the researchers found that UPFs accounted for 66 per cent of adolescents' energy intake on average during this period.

Most people in Great Britain believe that new junior doctors, nurses and health care assistants are underpaid, senior doctors and matrons are paid about right, and NHS CEOs are paid too much, according to a new study. About half the people surveyed indicated that newly qualified junior doctors are paid too little, with this sentiment increasing to three in five (60 per cent) among Labour voters. The research conducted by the Policy Institute at King's College London, King's Business School, and Ipsos also showed that more people believe NHS staff overall were badly paid than well paid. Dr Nick Krachler, senior lecturer in Human Resource Management at King's Business School, said: "Our survey shows considerable alignment between public perception of NHS pay levels and the claims of trade unions and professional associations that pay levels - which are determined by government after consultation from a Pay Review Body - ​are unsatisfactory for frontline NHS roles." He highlighted the urgent need to address healthcare workers' economic wellbeing, hoping that the new government will consider it in its upcoming negotiations with junior doctors this week.

India is in great need of developing a strong base for conducting medical and clinical research in the country. Medical research in India is still at large limited to some apex medical institutes and central laboratories.

US-based biotech startup DesignMedix has received a grant of $3m from the National Institutes of Health (NIH) to continue the development and manufacturing of a new anti-malarial drug.

As of 28th May 2018, 15 people have been tested positive for NiV in Kozhikode and Malappuram districts, of Kerala.

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Reportedly, physicians are struggling with ethical concerns amidst the coronavirus pandemic. Johns Hopkins Hospital and Berman Institute of Bioethics in Baltimore has launched a moral round program where physicians find a solution to their problems by interacting with other colleagues and learn to deal with the COVID situation.