Group items tagged

Capitalising on strong demand for its obesity therapies, Novo Nordisk's growing appetite for deals has fuelled a bet on a U.S. gene-editing company called Life Edit Therapeutics. The Danish drugmaker's collaboration with Durham, North Carolina-based Life Edit Therapeutics - owned by ElevateBio, a cell and gene therapy company in Waltham - is focused on up to seven programs for rare genetic disorders as well as cardiometabolic diseases. At the heart of the tie-up is Life Edit's technology, called base editing, which is designed to make precise changes to the human genome by tweaking one base - or letter - into a different one without affecting other letters. Single-letter mistakes, called point mutations, can give rise to genetic diseases.

A new analysis says that fat ladies who smoke cigarettes might not have the interest towards sweets.

Stroke is a cerebrovascular syndrome that involves the blockage and bursting of blood vessels in the brain. It shows a multifactorial pattern of inheritance. High cholesterol levels, high blood pressure, hypertension and obesity are the key causes of stroke besides inherited genes.

Childbirth is an emotional, intimate moment for new parents. Unfortunately, there are plenty of cases where, during the birth process, the newborn may suffer a physical injury. Parents need to know their rights to check their child's medical records if they suspect that medical malpractice caused the damage. In our following guide, we're sharing some top facts on birth injuries and what one can do when facing this complex scenario. THE MAIN CAUSES BEHIND BIRTH INJURIES No parent walks into the hospital during childbirth expecting the worst-case scenario. However, one of the primary ways families can reduce the chances of dealing with this complex situation is to plan with their attending medic and check for any obstetrical risk factors before birth. A difficult birth can happen because the baby weighs over 8 pounds or 4 kilograms, or labor has started before 37 weeks. Other common factors detected during these cases occur when the mother's pelvis doesn't have the ideal conditions for natural childbirth, maternal obesity is present, or labor has extended for more than 12 hours. However, if medical professionals cannot deal with these factors and make mistakes during the procedure, the chances of suffering any birth injury increase significantly.

A diet supplemented with vitamin D can help support healthy weight loss and reduce fat percentage, a new clinical study revealed. A trial was conducted over a three-month period with 125 overweight and obese Southeastern European Caucasians with vitamin D deficiency or insufficiency. Participants were prescribed vitamin D3 3000 IU/d oral spray supplementation, or a placebo, alongside a calorie-restricted diet programme of 600 kcal less than the total energy expenditure of each individual. The report stated that the group who were prescribed vitamin D witnessed significant improvements in serum 25(OH)D level and a greater reduction in body weight, BMI, and fat percentage in all individuals within this group. The study supported by BetterYou found that with the prevalence of low vitamin D becoming a serious global health problem in all ages, even in areas with natural sun exposure throughout the year, the study shines a light on the importance of vitamin D supplementation.

Adults who are overweight or obese and have type 2 diabetes or prediabetes are at a higher risk of developing severe health issues, according to authors of a recent study. Experts. however, disagree on the best dietary regimens and supportive measures to suggest. The latest study was published in the journal 'The Annals of Family Medicine'. In the findings, researchers used a 2×2 diet-by-support factorial design to randomise 94 adults with the aforementioned conditions, contrasting a very low-carbohydrate (VLC) or ketogenic diet with a Dietary Approaches to Stop Hypertension (DASH) diet. They also determined the outcomes of interventions that included and excluded additional support practices like mindful eating, effective emotion regulation, social support, and cooking instruction. Using intent-to-treat analyses, the VLC diet led to greater improvement in estimated mean systolic blood pressure (SBP; -9.8 mmHg vs. -5.2 mmHg, P =.046), greater improvement in glycosylated haemoglobin (HbA1c; -.4 per cent vs. -.1 per cent, P = 0.034), and greater improvement in weight (-19.14 lbs vs. -10.33 lbs, P = 0.0003), compared to the DASH diet. The addition of extra support did not have a statistically significant effect on outcomes.

Gut microbiome is the combined genetic material (genomes) of the microorganisms residing in the gut. The term microbiota is used to describe the community of microorganisms themselves. Lower microbiota diversity indicates a microbial imbalance within the gut, and is often found in people with autoimmune diseases, obesity and cardiometabolic conditions. Studies have found that while there is a heritable component to gut microbiota, the role of environmental factors such as diet, drugs and anthropometric measures play a key role in one's microbiota composition. Pharmacy teams are best placed to advise their patients on ways to improve their gut heath. Popular media suggests the key to solving all health problems is to nurture the gut through drinking kombucha and avoiding gluten. But how true is this really? Ask your patients to consider implementing the following five tips, informed by scientific literature, into their diet and lifestyle, to improve the microbiota diversity.

Danish drug developer Novo Nordisk on Wednesday (February 1) warned of supply constraints on its best-selling drug. The company, which develops diabetes and obesity drugs, said it expected "periodic supply constraints" this year, partly driven by higher than expected demand for its blockbuster diabetes drug, Ozempic, and manufacturing constraints. "Supply of Ozempic cannot keep up with demand in some markets," Novo's Chief Financial Officer Karsten Munk Knudsen told journalists on Wednesday, but said Ozempic was available in the United States, the firm's biggest single market. Shortages of human growth hormone would also cause sales in its rare disease franchise to drop by a "mid-single digit" percentage in 2023, as its Norditropin drug would be out of stock in certain markets, Knudsen said.

There are several benefits to losing weight, including higher self-esteem, better mood, improved sleep pattern, and better health in general. In addition, you can prevent various health concerns associated with obesity, such as heart problems and diabetes. There are different ways to help reduce weight, including lifestyle changes. It requires discipline, perseverance, and commitment to reach your goal and maintain it. The first step to making these changes can be challenging, but you must push yourself and keep moving forward to achieve your objective. If you are a beginner, the weight loss tips can be overwhelming, and some may be too hard to do that it could demotivate you or make you give up. So, we listed some tips for losing weight that are ideal for beginners. Set your goal Although you may want to lose weight immediately, the truth is that it will not happen overnight. Remember that it did not take one day to gain all those extra pounds, so you cannot lose them instantly. Setting your expectations straight is essential, so you won't be disappointed if you do not see an immediate result. You need consistency to be where you want to be, so make sure you have a clear objective. You can set smaller goals that you can achieve within a shorter period, then set another goal after that until you reach your ideal weight. You will feel motivated by these small wins, making you want to keep going.

Whether you believe it or not, following a vegan diet can be quite eventful for your body. For instance, it can help you lose weight, get a better body structure, and so on. However, is that all? You can get that by following a thorough exercise plan as well, no? Well, yes, you can. Nevertheless, following a vegan diet plan can help you out in more than a single manner. Please keep reading this article till the end to know more about it. WHAT IS A VEGAN DIET? As a vegan, you can eat dairy food, including cheese and milk, without any boundaries. If you want to get a little bit of protein, you may consume eggs (boiled or in a gravy) too. Also, yes, plants are going to be an integral part of your diet plan too. However, you won't be able to eat meat anymore. So, no chicken, mutton, or beef for the rest of your life. Instead, you will need to focus solely on plant-based protein. BENEFITS OF FOLLOWING A VEGAN DIET A plant-based diet structure can be highly beneficial for your health. For example, it can - LOWER YOUR BLOOD PRESSURE. Hypertension, also known as high blood pressure, can increase your risk of a heart attack. It's also known to be a close counterpart of type-2 diabetes too. Fortunately, though, the diet you follow can make quite a massive difference here. For example, following a vegan diet can help you reduce the amount of oily food you're taking on a daily basis. This, in turn, can decrease the amount of cholesterol in your blood and make it easier for you to lose weight. And, the less obese you are, the lower your blood pressure will be.

New data on weight loss drugs that could compete with Novo Nordisk's Wegovy are raising expectations there will soon be more options, and possibly lower prices, in an estimated $100 billion marketplace, doctors and pharmaceutical executives say. Drugmakers are ratcheting up their research and aiming for new formulations that can be taken as pills, options to deliver higher weight loss or drugs that reduce fat while maintaining muscle. "It has really been an explosion of innovation," said Dr. Robert Gabbay, chief science officer at the American Diabetes Association (ADA), which receives funding from both Novo and Eli Lilly and Co and just concluded its annual meeting in San Diego, California. "If there are multiple (treatments) in the market, that will lead to some level of competition and greater access."

The National Institute for Health and Care Excellence (NICE)'s independent committee has called for more research to ensure liposuction for treatment of chronic lipoedema is safe and effective enough for use on the NHS. Lipoedema is more prevalent in women and very rarely affects men. It is characterised by an abnormal, usually symmetrical, accumulation of fat in the legs, hips, buttocks, and occasionally arms. It is a separate condition to obesity and lymphoedema. The cause of lipoedema is unknown, but hormonal changes, weight gain and genetics are thought to be involved. The size and shape of legs, and the resultant mobility issues and pain, can have a profoundly negative effect on quality of life, and physical and mental health. The interventional procedures advisory committee reviewed evidence from several sources, including eight before-and-after studies. The committee was informed that several different liposuction techniques are used and that they may have different safety and efficacy profiles.

If you have low testosterone levels, there is a good chance you have felt some physical side effects from that. You may have heard that certain physical activity helps combat the depletion, and there is truth in this. There is a link between increasing and fine-tuning an exercise agenda and raising testosterone levels. Below, the relationship is explored in more detail. WHAT DOES TESTOSTERONE DO? There is more to the function of testosterone than just in relation to your sex drive. Of course, that is important, but it also impacts muscle building, strength, energy levels, hair growth, and red blood cells. When levels are low, there are big consequences for anybody from hair loss to weak muscles and even exhaustion too. TESTOSTERONE AND OBESITY One of the biggest things that affects testosterone is being overweight. If you are carrying a few extra pounds, it would be beneficial to try to get into some healthier habits if you want to promote an organic increase in T-levels. HOW EXERCISE PLAYS A ROLE Exercise seems to be a natural inhibitor of testosterone, especially when you focus on particular strategies and workout styles such as strength training. Levels have been shown to rise immediately after exercise for anything from fifteen minutes to an hour plus. While it is different for everyone, the link is clear.

The UK based Pharma giant Futura Medical Plc's lead product, Eroxon, a topical Stim-gel is now available on NHS prescription in England and Wales for the treatment of Erectile Dysfunction (ED). The Muti-Drug Resistant (MDR) approved alternative to PDE5i, Eroxon is available as an over-the counter off shelf at retailers like Boots and Superdrug; and is available on NHS prescription in England and Wales as a CE-marked medical device. Erectile dysfunction (ED), also known as impotence, is the inability to get and maintain an erection, typically concerning men over the age of 40 due to both, psychological and physical causes such as anxiety, depression, diabetes, and obesity. According to UK Conformity Assessed (UKCA), the approval of the medication is based on evidence from 2 Phase three clinical studies, which showed that 60 per cent of patients taking Eroxon achieved Minimal Clinically Important Differences (MCID) at 12 weeks.

Less time spent in watching Tv leads to better school results

How To Prevent Diabetes Type 2? You have just discovered that you are prediabetic. You can take meaningful steps to reduce your risk of diabetes. You can actually prevent diabetes simply by changing what you eat and how you invest in your physical health. The ball, my friend, is still in your court.

Around 8.3 percent population in the US has diabetes. Type II is the most prevalent form of diabetes. It is common among the young and the obese. Diabetes Mellitus or simply diabetes is a group of metabolic disorders characterized by an increase in your blood sugar. This results from an inadequate amount of insulin in the body or the cells' inability to respond to insulin.