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The Medicines and Healthcare Products Regulatory Agency (MHRA) has authorised an innovative and first-of-its-kind gene-editing treatment for sickle-cell disease and transfusion-dependent β-thalassemia. Known as Casgevy (exagamglogene autotemcel), the treatment is based on the innovative gene-editing tool CRISPR, for which its inventors were awarded the Nobel Prize in 2020. Casgevy is the first medicine to be licensed that uses CRISPR, and it is to be used for treating patients aged 12 and over. To date, a bone marrow transplant has been the only permanent treatment option for these life-long conditions, which in some cases can be fatal. The MHRA's authorisation came after a rigorous assessment of its safety, quality and effectiveness.

The Medicines and Healthcare products Regulatory Agency (MHRA) has cautioned people to stop using certain eye gels, highlighting a potential risk of microbial contamination that can cause an infection. As a precaution, the agency on Friday announced recall of specific batches of carbomer-containing lubricating eye gels branded Aacarb, Aacomer and Puroptics, which are generally used to relieve the symptoms of dry eye. Burkholderia cenocepacia is suspected to have caused the microbial contamination, and the issue was raised after an ongoing investigation conducted by UK Health Security Agency (UKHSA) identified a small number of cases of infection. Investigations are on to determine if there is a link between these products and the infections which have been identified. Meanwhile, retailers have been told to withdraw the affected products, and users are asked to return their product to the place of purchase immediately.

Pharmacy owners have less than a week to complete the mandatory 2023 Community Pharmacy Workforce Survey, which closes on Sunday, December 17. The NHS Business Services Authority sent an email with a survey link to pharmacy owners on October 23, 2023. In certain cases, such as Company Chemists' Association member companies and other multiple pharmacy groups, head offices will centrally complete the survey. "If you're unsure whether the survey will be completed centrally, please seek guidance from your head office," Community Pharmacy England has said. Since 2022, completing the annual NHS England community pharmacy workforce survey has been a Terms of Service requirement for pharmacy owners.

There were an estimated 408,700 hospital admissions due to smoking in 2022-23, an increase of 4.8 per cent from 389,800 in 2021-22, latest statistics published by NHS England have shown. In 2020-21, there were 314,100 admissions attributed to smoking, which was consistent with fewer hospital admissions overall that year, according to the health service's Statistics on Public Health, 2023 report. However, smoking-related admissions in each of the past three years remained lower than in 2019-20, prior to the Covid pandemic, when there were 446,400 cases. Smoking accounted for around one in six (16 per cent) of all hospital admissions for respiratory diseases last year, eight per cent of all admissions for cancers and seven percent of admissions for cardiovascular diseases.

The Pharmacists' Defence Association (PDA) says the pharmacy regulator should maintain a two-year post qualification eligibility criteria, in addition to the qualitative measures being introduced which would be in the best interest of patient safety, before a pharmacist is allowed to commence an IP course. The association was responding to an announcement by the GPhC's move to scrap the two year requirement for Independent Prescribing (IP) course. "The PDA accepts that the qualitative approach could mean greater individual consideration of potential IP course candidates and the two-year measure could have sometimes been a blunt tool. However, the PDA is already seeing cases of patient harm and allegations around fitness to practice arising from IP," the association said. The association also said that it supports individual pharmacists with near misses, as well as actual incidents, giving the organisation possibly the most comprehensive understanding of risk. Frontline pharmacists also recognise these issues and in a survey of over 1,000 pharmacists undertaken by the PDA in late 2021, of those who had 2+ years' experience of practice and who were already independent prescribers, 90 per cent said the qualifying period should be two years or more.

Daily hospital admissions in Britain could soon hit a new high because the Omicron variant of the coronavirus is spreading so fast, piling pressure on a health service struggling with staff sickness, England's chief medical officer said on Thursday (December 16). Britain recorded on Wednesday its highest number of daily coronavirus cases since the start of the pandemic at 78,610. Omicron is so transmissible that even if it proves to be milder than other variants, it could still cause a surge in hospital admissions, Chris Whitty told lawmakers. The record for the number of people admitted to hospital with Covid-19 is 4,583 set in January. "It is possible, because this is going to be very concentrated over a short period of time, even if it's milder, you could end up with a higher number than that going into hospital on a single day," he said.

Labour Party leader Keir Starmer leader has tested positive for Covid-19 for a second time, a spokesperson confirmed on Wednesday (January 5). Starmer had been due to face prime minister Boris Johnson at a question and answer session in parliament later today. His deputy, Angela Rayner, will take his place, the spokesperson added. Starmer had tested positive for Covid-19 last October and self-isolated four times after coming into contact with other positive cases on several occasions.

Increased demand and shortages of lateral flow tests are pushing staff at pharmacies to bear the brunt from frustrated customers who are unable to get their free lateral flow tests, Daily Mail reported. Some Britons claimed that they have been unable to get lateral flow tests at their local pharmacies for up to a fortnight while some pharmacies were forced to put up sign warning stating they have run out of free tests. Given the patchy supply of test kits, pharmacy bosses warned that staff are facing 'unfair' and 'abusive' behaviour by customers, the newspaper reported.Dr Leyla Hannbeck, chief executive of the Association of Independent Multiple Pharmacies (AIMP), told the newspaper: "Up until yesterday the supply to pharmacies was still patchy. The past few days the situation has not improved. "Pharmacies are having to put up with a lot of abuse and aggressive behaviours by members of the public because of this situation which is unfair. "The demand is still very high now because the governments guidelines put a lot of emphasis on testing as a key out of self isolation, so naturally as Omicron cases are high people are reliant on tests to get on with daily life."

Attempts to deal with record waiting lists for hospital treatment caused by the Covid-19 pandemic are at risk of being derailed by a staffing crisis, which is being exacerbated by the Omicron wave, a cross-party lawmakers' report said on Thursday (January 6). The report entitled 'Clearing the backlog caused by the pandemic' calls for a broader national health and care recovery plan - one that would embrace A&E, mental health, GPs, community and social care. Hospitals are facing extreme pressure as they try to catch up on months of operations that have been delayed and suspended during the pandemic, as Covid-19 hospitalizations rise once more and self-isolation hits staffing levels. There is a record 5.8 million waiting list for elective care, the Health and Social Care Committee said, adding that a recent surge in the Omicron variant has pushed cases to record highs and intensified pre-existing issues.

The Pharmacists' Defence Association has reported an increase in the number of pharmacists calling its advice line to inform about the incidences of violence and intimidation from protesters opposing the Covid-19 vaccination programme. The association noted that such incidents have become more common with protesters "gaining entry to premises in groups and trying to disrupt Covid-19 vaccinations from taking place." In many cases, pharmacists, staff, and members of the public have been subjected to verbal threats, causing distress and anxiety among those working to deliver the vaccination programme in a safe environment. The PDA reminded that employers, having a contract with the NHS for the Covid-19 vaccinations, have a duty to keep their staff safe whilst at work. The General Pharmaceutical Council (GPhC) standards for pharmacy premises also carry a duty to ensure the safety of staff and the public receiving services on those premises.

The Pharmaceutical Services Negotiating Committee (PSNC) is encouraging community pharmacy contractors and their teams to take part in the negotiator's latest Pharmacy Advice Audit. The audit has been extended but results must be submitted by 23.59 on Friday (March 11). Under the audit, pharmacy teams need to record information about the informal healthcare advice that they give in a single day, which would provide a critical check on how people continue to rely on community pharmacies. The results of the audit will provide key evidence for use in funding discussions with the government and the NHS. Last year's Advice Audit highlighted the scale of the informal consultations that took place in pharmacies during the pandemic, and helped the PSNC to persuade MPs to support the case for Covid-19 costs.

The General Pharmaceutical Council (GPhC) has removed a pharmacist from its register who black-marketed 'zolpidem' along with another pharmacist between 2015 and 2016. Dean Zainool Dookhan, a pharmacist first registered with the Royal Pharmaceutical Society of Great Britain on 18 October 2004 and whose registration was later transferred to the General Pharmaceutical Council under registration number 2059808, was jailed last year for exporting 20,000 packets of zolpidem to the Caribbean. While hearing the case on 24-25 May, GPhC's Fitness to Practise Committee stated that "removal of the Registrant's name from the register is the appropriate and proportionate response to his convictions." "The public interest includes protecting the public, maintaining public confidence in the profession, and maintaining proper standards of behaviour. The Committee is entitled to give greater weight to the public interest than the Registrant's own interest in remaining on the register." "The Committee recognises the sanction has a punitive effect in that the Registrant's ability to practise and earn an income as a pharmacist and 28 his professional reputation will be curtailed; it will be five years before he can seek restoration to the register. However, that is the price he must pay for failing to comply with the fundamental tenets of his profession."

An oral drug combination by Novartis showed promise in treating a subgroup of patients suffering from a common childhood brain cancer in a trial. In the mid-stage trial, 47 per cent of the patients that were given the two drugs Tafinlar and Mekinist saw their tumours shrink, far above a rate of 11 per cent in a comparative group of participants on standard chemotherapy, the drugmaker said on Monday, June 6. The participants, aged one to 17 years, were suffering from low-grade gliomas (LGG), the most common childhood brain cancer. The trial only included those who were found to have a mutation known as BRAF V600, a genetic contributor in about 15 per cent to 20 per cent of paediatric LGG cases. Among further results of the trial with 110 participants, the median time without disease progression was 20.1 months for those given the Novartis drug combo, compared to 7.4 months on chemotherapy. The new oral treatment candidate also caused less severe side effects than burdensome chemotherapy.

Following concerns raised about cracked cartridges and insulin leaks, the Medicines and Healthcare products Regulatory Agency (MHRA) has issued a national patient safety alert for the NovoRapid PumpCart prefilled insulin cartridge and the Roche Accu-Chek Insight Insulin pump system. The regulator have asked patients to check the pre-filled glass insulin cartridge for cracks before use. It advised against using the cartridge if it has been dropped even if no cracks are visible and urged to closely follow the updated handling instructions in the pump user manual when changing pre-filled glass insulin cartridges. In some of the reported leakage incidents, the cartridges were found to be cracked and provided an inadequate supply of insulin to patients. Leakages also occurred in cases where no cracks in the cartridge were visible, the regulator said. In some patients there were consequences of not receiving enough insulin from their pump system, including reports of severely high blood sugar and diabetic ketoacidosis, a serious complication of diabetes when the body produces high levels of blood acids called ketones. Healthcare professionals are being advised to contact patients over the next six months using said device to discuss their individual needs and source an alternative pump where appropriate. "Because of the rare risk of insulin leakage from the Roche Accu-Chek Insight Insulin Pump, patients should check the pre-filled glass insulin cartridge for any cracks prior to usage," Dr June Raine, MHRA chief executive, said.

The National Pharmacy Association (NPA) is asking independents to vote 'yes' to reform of pharmacy representation in England as a three-week voting period opens on Friday, May 27. The NPA is also calling on PSNC to complete unfinished business and present 'the compelling case for change' that the Review Steering Group was unable to deliver. The Associations says it is "on balance" and with some degree of reluctance supporting an affirmative vote, because the benefits marginally outweigh the several valid arguments for a "no" vote. NPA chief executive, Mark Lyonette, said on Thursday (May 19): "After much deliberation and engagement with members, we are recommending our members vote yes, because the alternatives are either the flawed status quo or a further period of uncertainty for the sector, with months or even years of introspection to come. There is no guarantee that going back to the drawing board, particularly with the same actors, would bring about a better outcome.

The Joint Committee on Vaccination and Immunisation (JCVI) on Thursday (May 19) said that an anticipated autumn Covid booster campaign would be aimed at people aged over 65, care home residents, frontline health and social care workers and all adults in a clinical risk group. The UK is offering a spring booster to the over-75s, care home residents and immunosuppressed people, and ministers have spoken openly of plans for a further booster campaign in the autumn. In interim advice, the JCVI stopped short of recommending another shot for all adults, though said the advice would be reviewed and updated. "The JCVI's current view is that in autumn 2022, a Covid-19 vaccine should be offered to: residents in a care home for older adults and staff; frontline health and social care workers; all those 65 years of age and over; and adults aged 16 to 64 years who are in a clinical risk group," the UK Health Security Agency said in a statement. Prime minister Boris Johnson, who was fiercely criticised for his handling of the early stages of the pandemic, lifted Covid restrictions in England in February, crediting Britain's quick initial vaccine rollout and the rollout of boosters with breaking the link between cases and deaths.

One evening whilst I was watching TV, my phone pinged with an all too familiar WhatsApp alert with a message preview saying "Can you help". I recognised the name as one of our Titan pharmacy customers who was clearly in a state of panic. I replied offering my assistance and asked him what was up. What followed over the next 24 hours was an interesting case study of how innovative technology can genuinely solve real challenges in pharmacies. Mr P (let's call him that) had booked a locum to cover in his dispensary on the next day so he could focus on his vaccination service. The problem - his locum had just called to cancel his booking (no reason given) and now he had no cover. Meanwhile, he was fully booked with back to back appointments and could not cancel them. He had phoned round his usual network of pharmacists and no one was available at short notice. He was asking if there was anything that Titan could do to reduce his workload and said he had heard about Titan's artificial intelligence module. Unfortunately, Titan. X had not been installed at this site and was not an option at this late stage. Equally, Titan's digital workflow cannot be circumvented so there was no way steps could be taken out of the process.

Smoking increases the risk of developing schizophrenia and depression, a report by academics from the University of Bristol published on 20 June claims. It says smoking raises the risk of developing schizophrenia by between 53 per cent and 127 per cent and the risk of developing depression by from 54 per cent to 132 per cent. The authors of the report say more research is needed to identify why this is the case and that more evidence is needed to understand its impact on other mental health conditions such as anxiety or bipolar disorder. The evidence, presented at the Royal College of Psychiatrist's international congress, has been shared with the government which is currently developing a new Tobacco Control Plan for publication later this year. Action on Smoking and Health (ASH) said: "Rates of smoking are much higher among people with mental health conditions than those without, and among England's six million smokers there are an estimated 230k smokers with severe mental illness (e.g., schizophrenia and bi-polar disorder) and 1.6 million with depression and anxiety."

A group of drugs commonly used to treat erectile dysfunction may be able to boost the effect of chemotherapy in oesophageal cancer, according to new research funded by Cancer Research UK and the Medical Research Council. The research, published on Tuesday (June 22) in Cell Reports Medicine, found that the drugs, known as PDE5 inhibitors can reverse chemotherapy resistance by targeting cells called cancer-associated fibroblasts (CAFs) residing in the area surrounding the tumour. Although this is early discovery research, PDE5 inhibitors combined with chemotherapy, may be able to shrink some oesophageal tumours more than chemotherapy could alone, tackling chemotherapy resistance, which is one of the major challenges in treating oesophageal cancer. Oesophageal cancer affects the food pipe that connects the mouth to the stomach, and while it is a relatively rare cancer, the UK has one of the higher rates in the world, with 9,300 new oesophageal cancer cases in the UK every year. Resistance to chemotherapy in oesophageal cancer is influenced by the tumour microenvironment, the area that sounds the tumour. This is made up of molecules, blood vessels, and cells such as cancer associated fibroblasts (CAFs), which are important for tumour growth. It feeds the tumour and can act as a protective cloak, preventing treatments like chemotherapy from having an effect.

Statistics show that 1 in 8 women will develop breast cancer at some point in their lives. While this disease can be deadly, it is also preventable. This blog post will discuss six things you need to know about breast cancer prevention. Knowledge is power when it comes to fighting cancer, so read on and learn how you can protect yourself. UNDERGO ROUTINE CHECKUPS One of the first things you can do to prevent breast cancer is to undergo routine checkups. This means going for mammograms and clinical breast exams regularly. In this case, your doctor may even recommend using ultrasound technology to get a clear picture of the breast tissue. Rest assured that your doctor will be able to detect any changes in your breasts and will be able to determine if there is anything to worry about. The earlier you catch any abnormalities, the better your chances of beating cancer. BE AWARE OF YOUR FAMILY HISTORY Another important factor to consider is your family history. If you have close relatives who have been diagnosed with breast cancer, your risk may be higher. This is because some forms of breast cancer can be hereditary. As such, it is important to be aware of your family history and to let your doctor know if there is a history of breast cancer in your family. From there, you should discuss your options with your doctor and make sure to get regular screenings. More often than not, early detection is key when it comes to surviving breast cancer which is why family history is so important.