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Pharmaceutical giant AstraZeneca will acquire biotechnology company Neogene Therapeutics for up to $320 million, the London-listed drugmaker said on Tuesday (November 29) as it seeks to build its pipeline of cell-based cancer treatments. Though AstraZeneca's oncology portfolio accounted for more than a third of the company's revenue last year, it does not have an approved cell-based cancer therapy and is behind rivals such as Novartis and Gilead. "Neogene's leading (T-cell receptor) discovery capabilities and extensive manufacturing experience complement the cell therapy capability we have built over the last three years," said Susan Galbraith, AstraZeneca's executive vice president of oncology research. Cell-based treatments are a relatively new approach to treating cancer, most of which involve drawing the body's own immune cells and processing them in the lab to target and kill cancer cells. Neogene's approach goes one step further in that its experimental T-cell receptor therapies seek to target DNA mutations specific to tumours, not only certain proteins on the surface of cancer cells.

The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a class 3 medicines recall for Sildenafil 100mg Film-coated Tablets (Strandhaven Limited T/A Somex Pharma). Manufacturer of drug, Strandhaven Limited T/A Somex Pharma has informed the MHRA that the pack size on some cartons of the batch state 8 tablets instead of 4 tablets. This is an error due to cartons being mixed at the printers. All cartons with batch number ET22028 contain one blister strip of 4 tablets regardless of whether it states 8 tablets or 4 tablets on the pack. Only the batch number ET22028 is affected. Due to the low number of complaints received, only the packs labelled as containing 8 tablets are being recalled at this time. The batch is comprised of 60340 packs, to date 195 packs have been found to be mislabelled.

The Medicines & Healthcare products Regulatory Agency has initiated a recall of three batches of Quantum Pharmaceutical's Diltiazem HCl 2% Cream, which is an unlicensed medicine. MHRA issued a precautionary recall of the cream due to a change in the product's appearance that affected its thickness. Pharmacists are instructed to halt supply, quarantine remaining stock, and contact Quantum Pharmaceutical to return affected batches M1402497, M1402574, and M1402680. Patients using this product may encounter application issues with the cream due to its consistency. However, MHRA said that this has not impacted the product's effectiveness or posed any risk to patient safety. The MHRA also reported that medac GmbH (t/a medac Pharma LLP) is conducting a recall of two batches of Sodiofolin 50 mg/ml solution for injection/infusion (400mg/8ml vial) with batch numbers G220393B and G220393C. This class 2 medicines recall is a result of particles detected during long-term stability tests.

In a mutual agreement with the STADA board, Roger Scarlett-Smith has stepped down from his role as head of UK. The company has assigned the responsibility of UK operation to Rudolf Bär with current responsibilities as cluster head for Mid-Sized European Markets. Scarlett-Smith joined STADA in October 2018 to lead the UK operation upon the retirement of Dieno George. Prior to this, he had enjoyed an illustrious career in the Consumer Healthcare sector, largely with GlaxoSmithKline, for which he held positions including as President North America, President EMEA and Head of Global Categories. Under his leadership, the STADA UK business has grown sales by 50 per cent and profitability has more than doubled. He has reshaped the business to improve efficiency. There has been a marked acceleration of product innovation including key line extensions to the Zoflora disinfectant range as well as the introduction of a salmeterol and fluticasone inhaler in the Rx respiratory sector. Meanwhile, T+R has developed a fine reputation regionally, being voted number 1 regional company last year and winning many national industry awards.

Immunogenicity refers to the capacity of a vaccine to provoke an immune response in the body. An effective immune response is characterized by the production of specific antibodies, activation of immune cells, and the development of immunological memory. The goal is to elicit a durable and robust response that can prevent or control infections. Leveraging Viral Vector Technology Viral vectors serve as essential vehicles for delivering antigenic proteins or genetic material into target cells, triggering an immune response. Biotechnology companies have been exploring advanced strategies to optimize viral vector design, aiming to enhance immunogenicity and improve vaccine effectiveness. Vector Selection: The choice of viral vector plays a crucial role in determining immunogenicity. Different viruses have unique properties and characteristics that can impact immune responses. Biotechnology companies meticulously select viral vectors that possess the desired attributes, such as the ability to infect target cells efficiently and induce strong immune responses. Genetic Engineering: Advanced genetic engineering techniques are employed to modify viral vectors, tailoring them to specific vaccine requirements. By introducing specific antigenic proteins or genetic material, researchers can stimulate the immune system to mount a targeted response. This precise manipulation enhances the vaccine's ability to elicit a robust immune reaction. Immunomodulatory Elements: Biotechnology companies are incorporating immunomodulatory elements into viral vector designs. These elements can enhance the immune response by stimulating various components of the immune system, such as antigen-presenting cells and T cells. By activating and priming these immune cells, the vaccine can generate a more potent and sustained immune response. Adjuvants: Adjuvants are substances added to vaccines to enhance their immunogenicity. They stimulate and amplify the immune response, improving the

The Pharmacists' Defence Association (PDA) has republished a three-year-old report which underscores the vital role of community pharmacists and pharmacy t echnicians in a 'modern NHS' amid speculations that the government is set to announce plans to enhance the role of community pharmacy teams. PDA's 2019 report which "took three year to compile" highlighted significant empirical evidence and made recommendations to develop the roles of both community pharmacists and pharmacy technicians, and the skill mix required to meet patients' needs. It examined in detail the role of pharmacy technicians in community pharmacy. The PDA still that pressure on the NHS can be managed much more effectively through the better use of pharmacists and pharmacy technicians. In the community pharmacy setting, it is evident that if the further development of the pharmacist's role is to be facilitated and pharmacists are to become more patient facing in the future, an extended role and greater responsibility for pharmacy technicians is not only desirable, but ultimately it is essential.

AstraZeneca said on Monday (June 27) two of its existing therapies were recommended for treating patients with some forms of high-risk breast cancers in the European Union, in a boost to the company's oncology portfolio. Lynparza, a cancer drug developed jointly with U.S.-based Merck, was backed for standalone use or in combination with endocrine therapy in adults with a form of genetically mutated early-stage breast cancer. The drug, which has received a similar recommendation in the United States in March, is a key asset for AstraZeneca. It was recommended in patients with low-to-normal levels of a protein known as HER2 that is the target of several new therapies. Enhertu - developed jointly with Japan's Daiichi Sankyo (4568.T) - was the other drug that was endorsed by the European Medicines Agency for treating an aggressive form of breast cancer characterised by a high rate of HER2.

BioNTech and Pfizer are to start tests on humans of next-generation vaccines that protect against a wide variety of coronaviruses in the second half of the year. Their experimental work on shots that go beyond the current approach include T-cell-enhancing shots, designed to primarily protect against severe disease if the virus becomes more dangerous, and pan-coronavirus shots that protect against the broader family of viruses and its mutations. In presentation slides posted on BioNTech's website for its investor day, the German biotech firm said its aim was to "provide durable variant protection". The two companies are currently discussing with regulators enhanced versions of their established shot to better protect against the Omicron variant and its sublineages. The virus' persistent mutation into new variants that more easily evade vaccine protection, as well as waning human immune memory, have added urgency to the search by companies, governments and health bodies for more reliable tools of protection. As part of a push to further boost its infectious disease business, BioNTech said it was independently working on precision antibiotics that kill superbugs that have grown resistant to currently available anti-infectives.

If you have low testosterone levels, there is a good chance you have felt some physical side effects from that. You may have heard that certain physical activity helps combat the depletion, and there is truth in this. There is a link between increasing and fine-tuning an exercise agenda and raising testosterone levels. Below, the relationship is explored in more detail. WHAT DOES TESTOSTERONE DO? There is more to the function of testosterone than just in relation to your sex drive. Of course, that is important, but it also impacts muscle building, strength, energy levels, hair growth, and red blood cells. When levels are low, there are big consequences for anybody from hair loss to weak muscles and even exhaustion too. TESTOSTERONE AND OBESITY One of the biggest things that affects testosterone is being overweight. If you are carrying a few extra pounds, it would be beneficial to try to get into some healthier habits if you want to promote an organic increase in T-levels. HOW EXERCISE PLAYS A ROLE Exercise seems to be a natural inhibitor of testosterone, especially when you focus on particular strategies and workout styles such as strength training. Levels have been shown to rise immediately after exercise for anything from fifteen minutes to an hour plus. While it is different for everyone, the link is clear.

An online newspaper that collects together the week's news relating to health education. Read and subscribe free at: http://paper.li/f-1327779598

An online newspaper that collects together the week's news relating to health education. Read and subscribe free at: http://paper.li/f-1327779598

Find out more about the work of a physician assistant, how to qualify as one, and find online physician assistant programs for this satisfying career...

This page provides help if you want online and distance learning health degree programs that will prepare you for a career in health and medical professions.

Find out more about health education degree programs, where you can study it online, the career and salary prospects after completion, and more ...

An online newspaper that collects together the week's news relating to health education. Read and subscribe free at:  http://paper.li/f-1327779598

An online newspaper that collects together the week's news relating to health education. Read and subscribe free at: http://paper.li/f-1327779598

Nuôi con vất vả nhưng cha mẹ nào cũng vui vì con khỏe mạnh. Và lúc cha mẹ thấy buồn nhất chính là lúc con không khỏe, con ốm. Nhưng không phải cha mẹ nào cũng viết cách chăm sóc con. Chăm sóc con sẽ cần những kiến thức gì? Anh chị hãy cùng tìm hiểu qua cuốn sách 230 lời giải về bệnh tật trẻ em sau đây nhé!

Acne, pimples, and zits make us look unappealing and we tend to rob ourselves from social activities. #pimples #acne #acnetreatment https://youtu.be/_Dhid4cVreQ

We wrote five rules to keep your front desk fully functional and discover the true potential of your medical practice. After all, it is your patients that matter the most in the end. So, these tips can come in handy for a grand patient experience.

Usually, when getting pregnant becomes difficult, it leads to a situation where a woman faces infertility issues. As infertility is a never-ending illness in which conceiving becomes impossible either due to health conditions or a poor environment. Here find out the reasons why it becomes challenging to become pregnant?