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If Democrats get their wish-a landslide victory leading to a Joe Biden presidency, as well as a Democratic Senate and House-they will face an immediate challenge to getting things done. No matter the size of that landslide, the Republican response will be undeterred: a united opposition, akin to a parliamentary minority party, blocking what they can and delegitimizing what they cannot. It will be little different from their approach in the aftermath of the 2008 Democratic landslide. That formula led to huge GOP gains in the 2010 midterm election, and, after Barack Obama's big reelection victory in 2012, even more gains in the 2014 midterms.

Globally, the USA has recorded the highest number of COVID-19 cases and deaths,1 and still needs to simultaneously respond to another looming potential pandemic. The rise in multidrug-resistant bacterial infections that are undetected, undiagnosed, and increasingly untreatable threatens the health of people in the USA and globally. In 2020 and beyond, we cannot afford to ignore antimicrobial resistance (AMR).