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Neal

Brain Training in Children and Adolescents: Is It Scientifically Valid? - 2 views

  • Brain training products are becoming increasingly popular for children and adolescents. Despite the marketing aimed at their use in the general population, these products may provide more benefits for specific neurologically impaired populations. A review of Brain Training (BT) products analyzing their efficacy while considering the methodological limitations of supporting research is required for practical applications.
  • Overall, few independent studies have found far transfer and long-term effects. The majority of independent results found only near transfer. There is a lack of double-blind randomized trials which include an active control group as well as a passive control to properly control for contaminant variables. Based on our results, Brain Training Programs as commercially available products are not as effective as first expected or as they promise in their advertisements.
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    2018
Neal

Development of the adolescent brain: implications for executive function and social cog... - 0 views

  • Adolescence is a time of considerable development at the level of behaviour, cognition and the brain. This article reviews histological and brain imaging studies that have demonstrated specific changes in neural architecture during puberty and adolescence, outlining trajectories of grey and white matter development. The implications of brain development for executive functions and social cognition during puberty and adolescence are discussed. Changes at the level of the brain and cognition may map onto behaviours commonly associated with adolescence. Finally, possible applications for education and social policy are briefly considered.
  • Recent MRI studies indicate that the time at which the brain reaches maturity may be much later than the end of adolescence. One such study of participants aged between 7 and 30 revealed that the loss of grey matter in the frontal cortex accelerated during adulthood between the early 20s and up to the age of 30 (Sowell et al., 2001).
  • The non‐linear decrease in grey matter was concomitant with a linear increase in white matter, consistent with earlier MRI data and with post‐mortem studies.
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  • post‐mortem cellular studies of human brains have revealed an extended period of development, in particular in the frontal and parietal cortices.
  • The term executive function is used to describe the capacity that allows us to control and coordinate our thoughts and behaviour (Luria, 1966; Shallice, 1982).
  • These skills include selective attention, decision‐making, voluntary response inhibition and working memory. Each of these executive functions has a role in cognitive control, for example filtering out unimportant information, holding in mind a plan to carry out in the future and inhibiting impulses.
  • Behavioural studies show that performance of adolescents on tasks including inhibitory control (Leon‐Carrion, Garcia‐Orza, & Perez‐Santamaria, 2004; Luna, Garver, Urban, Lazar, & Sweeney, 2004a), processing speed (Luna et al., 2004a), working memory and decision‐making (Luciana, Conklin, Cooper, & Yarger, 2005; Hooper, Luciana, Conklin, & Yarger, 2004) continues to develop during adolescence.
  • Different aspects of executive function, therefore, may have different developmental trajectories.
  • prospective memory continues to develop during adolescence, in line with the notion of frontal maturation in the brain. It is possible that the lack of improvement in performance between the 10‐ and 14‐year‐olds was related to their pubertal status.
  • The results suggest that there is a dip in performance on this kind of task at the onset of puberty.
  • The researchers linked this pubertal dip in performance to the proliferation of synapses that occurs at the onset of puberty.
  • the sudden proliferation of synapses that occurs at puberty results in a perturbation of cognitive performance.
  • In addition to neural development, there are major changes in hormones at puberty. While it is impossible to tease apart all of the important influences on the social and emotional behaviour of adolescents, significant neural development and hormonal changes are likely to influence social cognition.
  • Perspective taking is the ability to take on the viewpoint of another person. The ability to take another's perspective is crucial for successful social communication.
  • Functional neuroimaging studies have revealed that the parietal and frontal cortices are associated with making the distinction between 1PP and 3PP at the motor (Ruby & Decety, 2001), visuo‐spatial, (Vogeley et al., 2004), conceptual (Ruby & Decety, 2003) and emotional (Ruby & Decety, 2004) level.
  • It is proposed that ‘mirror neurons’ that fire when an agent both performs an action or observes another person performing the action provide a basis for integrating perceptual, motor and social functions (see Rizzolatti, Fogassi, & Gallese, 2001 for review).
  • Several neuroimaging studies have implicated the inferior parietal cortex in the distinction between the self and others at the sensorimotor level (Blakemore, Wolpert, & Frith, 1998; Farrer & Frith, 2002; Ruby & Decety, 2001).
  • hese data suggest that development of social perspective taking undergoes a perturbation during puberty in parallel with the discontinuous processes of brain maturation.
  • Cognitive processes that depend on the prefrontal cortex might undergo a perturbation at puberty due to the synaptic reorganisation that occurs at this time.
  • The greater and more diffuse activity in the dorsal region of the prefrontal cortex in children suggests that there is a heavier dependence on this region in children compared with in adults. The researchers suggested that during adolescence, the network recruited for this task is modified until adulthood, at which stage activation of a smaller, more focal region of the prefrontal cortex is used to perform the same task.
  • Thus, reaction times and imaging data together suggest that in children, an immature stage of the brain where excess synapses, possibly as a result of a burst of proliferation, accounts for the poorer performance and extensive and less efficient frontal activation. A pruned and more myelinated adult brain could explain the faster reaction times and focal activation of the frontal cortex, the area associated with generativity (Frith, Friston, Liddle, & Frackowiak, 1991) and the inhibitory response (Konishi et al., 1999).
  • One possibility is that extensive activation in children is a compensatory strategy used while the brain is less efficient in integrating executive functions.
  • To explain risky behaviour commonly associated with adolescence, the authors postulated that adolescents are driven to seek more extreme incentives to compensate for low recruitment of motivational brain circuitry.
  • It was proposed that when confronted with a risky scenario, adults’ relatively efficient responses were driven by mental images of possible outcomes and the visceral response to those images, in line with the somatic marker hypothesis (Damasio, 1996). However, adolescents relied more on reasoning capacities and therefore activated the DLPFC, hence the relatively effortful responses compared to adults.
  • Neural plasticity of the developing brain may underpin different propensities for learning new skills, such as problem solving, at different stages of the life cycle.
Neal

Sleep disorders in children with ADHD treated with off-label medications | MDedge Psych... - 2 views

  • Sleep problems in children diagnosed with attention-deficit/hyperactivity disorder are treated with a variety of medications, many off label for sleep and unstudied for safety and effectiveness in children, a study of Medicaid prescriptions has found.
Neal

Partly randomised, controlled study in children aged 6-10 years to investigate motor an... - 1 views

  • The aim of this study is to investigate motor and cognitive effects of a 9-week exercise intervention in children aged 6–10 years.
  • It is hypothesised that all groups gain motor and cognitive effects, but highest benefits are expected for the combination of automatised coordination exercises with mental tasks.
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    2018
Neal

Exploring synergistic effects of aerobic exercise and mindfu... : Medicine - 2 views

  • Abstract 1 Introduction 2 Methods and analysis 2.1 Study design and setting 2.2 Population 2.3 Recruitment 2.4 Screening and consent procedures 2.5 Study interventions 2.6 Safety considerations 2.7 Study assessments 2.7.1 Screening assessments 2.7.2 Primary outcomes 2.7.3 Secondary outcomes 2.7.4 Posited mediators 2.7.5 Covariates and moderators 2.8 Statistical analyses 2.9 Quality control and monitoring 2.10 Ethics and dissemination 3 Discussion 3.1 Strengths and limitations 4 Conclusion Author contributions References
Neal

MAP training: combining meditation and aerobic exercise reduces depression and ruminati... - 1 views

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  • These data indicate enhanced neural responses during the detection and resolution of conflicting stimuli. Although previous research has supported the individual beneficial effects of aerobic exercise and meditation for depression, these findings indicate that a combination of the two may be particularly effective in increasing cognitive control processes and decreasing ruminative thought patterns.
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    2016
Neal

Academic Achievement in Adults with a History of Childhood Attention-Deficit/Hyperactiv... - 1 views

  • Childhood ADHD cases scored from 3 to 5 grade equivalents lower on all academic tests compared to referents, with mean (SD) standard scores of 95.7 (8.4) versus 101.8 (8.1) in Basic Reading; 95.0 (9.3) versus 101.9 (8.5) in Letter-Word Identification; 98.2 (8.6) versus 103.2 (9.2) in Passage Comprehension; 95.7 (9.1) versus 100.9 (9.0) in Word Attack; and 87.8 (12.9) versus 98.0 (12.0) in Arithmetic
  • This is the first prospective, population-based study of adult academic outcomes of childhood ADHD. Our data provide evidence that childhood onset ADHD is associated with long term underachievement in reading and math that may negatively impact ultimate educational attainment and occupational functioning in adulthood.
Neal

Frontiers | Mediators of Physical Activity on Neurocognitive Function: A Review at Mult... - 1 views

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  • Physical activity (PA) is known to maintain and improve neurocognitive health. However, there is still a poor understanding of the mechanisms by which PA exerts its effects on the brain and cognition in humans.
  • Consistent with the cross-sectional work, RCTs also support the argument that changes in brain structure and function may be mechanisms underlying the relationship between PA and cognitive performance. Specifically, the majority of RCTs have reported changes in brain structure or function, as well as in cognition following the exercise intervention. However, of the 13 RCTs including both cognitive and neuroimaging measures conducted to date, only 1 has used a statistical mediation model. Thus, it has not been possible in the majority of RCTs to rule out the possibility that another, unmeasured factor that covaries with both the treatment and outcome is underlying the intervention effects observed in the brain and/or cognitive performance.
  • Along these lines, if PA is thought to enhance cognition by improving brain structure and function, then eliminating PA should have the opposite effect. Examination of the effects of PA cessation has been comparatively unexplored to date. However, there have been two recent studies on this topic that support this idea (Alfini et al., 2016; Thomas et al., 2016). Alfini et al. (2016), showed that cortical and hippocampal resting brain perfusion decreases following PA cessation after just 10 days in older adult athletes. In addition, Thomas et al. (2016) found that hippocampal volume gains following an exercise intervention in young-middle aged adults, were abolished following 2-weeks of exercise cessation. These results are interesting and important for the field because they support PA as the causal variable in mechanistic models (i.e., removing PA reverses the brain effects attributed to this behavior).
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  • However, Alfini et al. (2016) did not administer a full cognitive battery, thereby limiting an interpretation of their results with regard to cognition. Thomas et al. (2016) administered a brief cognitive battery, but found no change in cognition following their 6-week intervention. It was therefore not possible to thoroughly evaluate whether cognition (our outcome variable of interest) also decreased following PA cessation. Such evidence is needed, as it would further strengthen the causal role Level 2 mediators play in PA-related cognitive effects.
  • However, only one study to date (Wilckens et al., in press) has combined all three variables in a statistical model to test whether sleep can account for the relationship between PA and cognitive performance—the results of this initial study suggest that it can. Similarly, mood is linked both to cognitive performance and PA. While several studies have considered mood along with other behavioral or socioemotional factors in statistical models assessing mechanisms of PA, virtually none have considered the unique or independent contribution of mood to the PA-cognition relationship.
  • Additional studies including both psychological and neurocognitive functioning as outcome variables are needed to enhance our understanding of this level of analysis.
Neal

Get Off the Couch! Exercise Your Way to a Healthy Brain · Frontiers for Young... - 0 views

  • Glossary Cognitive function: ↑ The way we process and think about the world around us. Cognitive functions include attention, memory, and ability to solve problems. Neuroplasticity: ↑ Changes that happen in the brain as the result of our experiences. Alzheimer’s disease: ↑ A disease that affects the brain in older age. The main characteristic of Alzheimer’s disease is a problem with cognitive functions, especially memory.
Neal

Brains and Brawn: Complex Motor Activities to Maximize CognitiveEnhancement - 0 views

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  • Ultimately, the rationale for an early start to a successful and healthy education goes beyond the classroom—the goal is to educate the next generations about the benefits of sustained motor activities across the lifespan.
  • The recent growth in the number of people affected by cognitive disorders has underlined the central role our brains play in daily life. Once our sophisticated neural machinery is impaired, we come to realize how important normal cognitive functioning really is. Together with growing evidence for the malleable property of the brain, this heightened awareness drives the current trend of research based on behavioral training programs that can remedy or alleviate cognitive disorders
  • Childhood is an ideal period to implement behavioral interventions aimed at cognitive enhancement, because neural plasticity at this age is the norm rather than the exception. This allows larger behaviorally induced cognitive improvement (Green et al. 2012; Steiner et al. 2014), and ultimately the identification and remediation of limitations before they spark off more sizeable difficulties (Franceschini et al. 2013).
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  • To date, one of the most effective way to trigger neurogenesis appears to be physical exercise (van Praag et al. 1999). Importantly, physical exercise is noninvasive and includes numerous beneficial by-products, such as general health improvement and psychological benefits
  • However, it is important to note that if newly formed neurons are not integrated within existing neural networks, they typically die within a couple of weeks
  • Interestingly, one of the most effective ways to integrate these new neurons within the existing network—and therefore to maximize their chance of survival—is to challenge the brain and force neural adaptation (Shors et al. 2012). Learning a new skill and acquiring new knowledge appear to be especially promising in this regard (Gould et al. 1999).
  • Based on the idea that brain function greatly benefits from physical exercise and that challenging cognitive stimulations ensure these benefits are maintained over time, researchers have proposed that coupling physical and cognitive demands could be especially interesting when targeting cognitive enhancement
  • Our findings showed that designed sport, an activity specifically tailored to tax working memory and spatial ability by incorporating complex motor coordination in three-dimensional space, outperformed interventions solely focused on either physical or cognitive demands on measures of working memory capacity, spatial ability, and biomarkers of general health, such as resting heart rate and blood pressure (Moreau et al. 2015). This is particularly promising because the cognitive abilities designed sport targeted are critical in many activities—working memory capacity is thought to be a central component of cognition and correlates highly with fluid intelligence (Engle et al. 1999), whereas spatial ability is a significant predictor of success in many academic and professional domains
  • The field of cognitive training is still in its infancy, and the consequences of combining interventions have yet to be fully understood, but this is undoubtedly a promising venue for research with direct applications to society.
  • combine cognitive challenges with physical motion should also be encouraged, as they allow creating ecological situations that have the potential to trigger important and transferable cognitive improvement.
  • The specific design of this combination— whether it is martial arts (Diamond and Lee 2011), physical activity games (Tomporowski et al. 2008), exergames (Staiano and Calvert 2011), or designed sport (Moreau et al. 2015)—is to be determined based on the objective of the intervention, the suitability of the approach to the educator or the school, and the infrastructures available.
  • In closing, complex motor activities that combine cognitive and physical demands provide a promising direction for the field of cognitive training. Beyond the cognitive benefits, they can induce when designed adequately, the physiological and psychological improvements complex motor activities allow present critical advantages over computerized training regimens, favored thus far. Eventually, the goal is to integrate motor activities durably within the community, so that habits formed in schools can lead to long-term changes in fitness and cognitive health.
Neal

Heart Rate Variability: A Review - 0 views

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