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Neal

Brain Training in Children and Adolescents: Is It Scientifically Valid? - 2 views

  • Brain training products are becoming increasingly popular for children and adolescents. Despite the marketing aimed at their use in the general population, these products may provide more benefits for specific neurologically impaired populations. A review of Brain Training (BT) products analyzing their efficacy while considering the methodological limitations of supporting research is required for practical applications.
  • Overall, few independent studies have found far transfer and long-term effects. The majority of independent results found only near transfer. There is a lack of double-blind randomized trials which include an active control group as well as a passive control to properly control for contaminant variables. Based on our results, Brain Training Programs as commercially available products are not as effective as first expected or as they promise in their advertisements.
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    2018
Neal

Development of the adolescent brain: implications for executive function and social cog... - 0 views

  • Adolescence is a time of considerable development at the level of behaviour, cognition and the brain. This article reviews histological and brain imaging studies that have demonstrated specific changes in neural architecture during puberty and adolescence, outlining trajectories of grey and white matter development. The implications of brain development for executive functions and social cognition during puberty and adolescence are discussed. Changes at the level of the brain and cognition may map onto behaviours commonly associated with adolescence. Finally, possible applications for education and social policy are briefly considered.
  • Recent MRI studies indicate that the time at which the brain reaches maturity may be much later than the end of adolescence. One such study of participants aged between 7 and 30 revealed that the loss of grey matter in the frontal cortex accelerated during adulthood between the early 20s and up to the age of 30 (Sowell et al., 2001).
  • The non‐linear decrease in grey matter was concomitant with a linear increase in white matter, consistent with earlier MRI data and with post‐mortem studies.
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  • post‐mortem cellular studies of human brains have revealed an extended period of development, in particular in the frontal and parietal cortices.
  • The term executive function is used to describe the capacity that allows us to control and coordinate our thoughts and behaviour (Luria, 1966; Shallice, 1982).
  • These skills include selective attention, decision‐making, voluntary response inhibition and working memory. Each of these executive functions has a role in cognitive control, for example filtering out unimportant information, holding in mind a plan to carry out in the future and inhibiting impulses.
  • Behavioural studies show that performance of adolescents on tasks including inhibitory control (Leon‐Carrion, Garcia‐Orza, & Perez‐Santamaria, 2004; Luna, Garver, Urban, Lazar, & Sweeney, 2004a), processing speed (Luna et al., 2004a), working memory and decision‐making (Luciana, Conklin, Cooper, & Yarger, 2005; Hooper, Luciana, Conklin, & Yarger, 2004) continues to develop during adolescence.
  • Different aspects of executive function, therefore, may have different developmental trajectories.
  • prospective memory continues to develop during adolescence, in line with the notion of frontal maturation in the brain. It is possible that the lack of improvement in performance between the 10‐ and 14‐year‐olds was related to their pubertal status.
  • The results suggest that there is a dip in performance on this kind of task at the onset of puberty.
  • The researchers linked this pubertal dip in performance to the proliferation of synapses that occurs at the onset of puberty.
  • the sudden proliferation of synapses that occurs at puberty results in a perturbation of cognitive performance.
  • In addition to neural development, there are major changes in hormones at puberty. While it is impossible to tease apart all of the important influences on the social and emotional behaviour of adolescents, significant neural development and hormonal changes are likely to influence social cognition.
  • Perspective taking is the ability to take on the viewpoint of another person. The ability to take another's perspective is crucial for successful social communication.
  • Functional neuroimaging studies have revealed that the parietal and frontal cortices are associated with making the distinction between 1PP and 3PP at the motor (Ruby & Decety, 2001), visuo‐spatial, (Vogeley et al., 2004), conceptual (Ruby & Decety, 2003) and emotional (Ruby & Decety, 2004) level.
  • It is proposed that ‘mirror neurons’ that fire when an agent both performs an action or observes another person performing the action provide a basis for integrating perceptual, motor and social functions (see Rizzolatti, Fogassi, & Gallese, 2001 for review).
  • Several neuroimaging studies have implicated the inferior parietal cortex in the distinction between the self and others at the sensorimotor level (Blakemore, Wolpert, & Frith, 1998; Farrer & Frith, 2002; Ruby & Decety, 2001).
  • hese data suggest that development of social perspective taking undergoes a perturbation during puberty in parallel with the discontinuous processes of brain maturation.
  • Cognitive processes that depend on the prefrontal cortex might undergo a perturbation at puberty due to the synaptic reorganisation that occurs at this time.
  • The greater and more diffuse activity in the dorsal region of the prefrontal cortex in children suggests that there is a heavier dependence on this region in children compared with in adults. The researchers suggested that during adolescence, the network recruited for this task is modified until adulthood, at which stage activation of a smaller, more focal region of the prefrontal cortex is used to perform the same task.
  • Thus, reaction times and imaging data together suggest that in children, an immature stage of the brain where excess synapses, possibly as a result of a burst of proliferation, accounts for the poorer performance and extensive and less efficient frontal activation. A pruned and more myelinated adult brain could explain the faster reaction times and focal activation of the frontal cortex, the area associated with generativity (Frith, Friston, Liddle, & Frackowiak, 1991) and the inhibitory response (Konishi et al., 1999).
  • One possibility is that extensive activation in children is a compensatory strategy used while the brain is less efficient in integrating executive functions.
  • To explain risky behaviour commonly associated with adolescence, the authors postulated that adolescents are driven to seek more extreme incentives to compensate for low recruitment of motivational brain circuitry.
  • It was proposed that when confronted with a risky scenario, adults’ relatively efficient responses were driven by mental images of possible outcomes and the visceral response to those images, in line with the somatic marker hypothesis (Damasio, 1996). However, adolescents relied more on reasoning capacities and therefore activated the DLPFC, hence the relatively effortful responses compared to adults.
  • Neural plasticity of the developing brain may underpin different propensities for learning new skills, such as problem solving, at different stages of the life cycle.
Neal

Sleep disorders in children with ADHD treated with off-label medications | MDedge Psych... - 2 views

  • Sleep problems in children diagnosed with attention-deficit/hyperactivity disorder are treated with a variety of medications, many off label for sleep and unstudied for safety and effectiveness in children, a study of Medicaid prescriptions has found.
Neal

Partly randomised, controlled study in children aged 6-10 years to investigate motor an... - 1 views

  • The aim of this study is to investigate motor and cognitive effects of a 9-week exercise intervention in children aged 6–10 years.
  • It is hypothesised that all groups gain motor and cognitive effects, but highest benefits are expected for the combination of automatised coordination exercises with mental tasks.
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    2018
Neal

Exploring synergistic effects of aerobic exercise and mindfu... : Medicine - 2 views

  • Abstract 1 Introduction 2 Methods and analysis 2.1 Study design and setting 2.2 Population 2.3 Recruitment 2.4 Screening and consent procedures 2.5 Study interventions 2.6 Safety considerations 2.7 Study assessments 2.7.1 Screening assessments 2.7.2 Primary outcomes 2.7.3 Secondary outcomes 2.7.4 Posited mediators 2.7.5 Covariates and moderators 2.8 Statistical analyses 2.9 Quality control and monitoring 2.10 Ethics and dissemination 3 Discussion 3.1 Strengths and limitations 4 Conclusion Author contributions References
Neal

MAP training: combining meditation and aerobic exercise reduces depression and ruminati... - 1 views

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  • These data indicate enhanced neural responses during the detection and resolution of conflicting stimuli. Although previous research has supported the individual beneficial effects of aerobic exercise and meditation for depression, these findings indicate that a combination of the two may be particularly effective in increasing cognitive control processes and decreasing ruminative thought patterns.
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    2016
Neal

Academic Achievement in Adults with a History of Childhood Attention-Deficit/Hyperactiv... - 1 views

  • Childhood ADHD cases scored from 3 to 5 grade equivalents lower on all academic tests compared to referents, with mean (SD) standard scores of 95.7 (8.4) versus 101.8 (8.1) in Basic Reading; 95.0 (9.3) versus 101.9 (8.5) in Letter-Word Identification; 98.2 (8.6) versus 103.2 (9.2) in Passage Comprehension; 95.7 (9.1) versus 100.9 (9.0) in Word Attack; and 87.8 (12.9) versus 98.0 (12.0) in Arithmetic
  • This is the first prospective, population-based study of adult academic outcomes of childhood ADHD. Our data provide evidence that childhood onset ADHD is associated with long term underachievement in reading and math that may negatively impact ultimate educational attainment and occupational functioning in adulthood.
Neal

Frontiers | Mediators of Physical Activity on Neurocognitive Function: A Review at Mult... - 1 views

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  • Physical activity (PA) is known to maintain and improve neurocognitive health. However, there is still a poor understanding of the mechanisms by which PA exerts its effects on the brain and cognition in humans.
  • Consistent with the cross-sectional work, RCTs also support the argument that changes in brain structure and function may be mechanisms underlying the relationship between PA and cognitive performance. Specifically, the majority of RCTs have reported changes in brain structure or function, as well as in cognition following the exercise intervention. However, of the 13 RCTs including both cognitive and neuroimaging measures conducted to date, only 1 has used a statistical mediation model. Thus, it has not been possible in the majority of RCTs to rule out the possibility that another, unmeasured factor that covaries with both the treatment and outcome is underlying the intervention effects observed in the brain and/or cognitive performance.
  • Along these lines, if PA is thought to enhance cognition by improving brain structure and function, then eliminating PA should have the opposite effect. Examination of the effects of PA cessation has been comparatively unexplored to date. However, there have been two recent studies on this topic that support this idea (Alfini et al., 2016; Thomas et al., 2016). Alfini et al. (2016), showed that cortical and hippocampal resting brain perfusion decreases following PA cessation after just 10 days in older adult athletes. In addition, Thomas et al. (2016) found that hippocampal volume gains following an exercise intervention in young-middle aged adults, were abolished following 2-weeks of exercise cessation. These results are interesting and important for the field because they support PA as the causal variable in mechanistic models (i.e., removing PA reverses the brain effects attributed to this behavior).
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  • However, Alfini et al. (2016) did not administer a full cognitive battery, thereby limiting an interpretation of their results with regard to cognition. Thomas et al. (2016) administered a brief cognitive battery, but found no change in cognition following their 6-week intervention. It was therefore not possible to thoroughly evaluate whether cognition (our outcome variable of interest) also decreased following PA cessation. Such evidence is needed, as it would further strengthen the causal role Level 2 mediators play in PA-related cognitive effects.
  • However, only one study to date (Wilckens et al., in press) has combined all three variables in a statistical model to test whether sleep can account for the relationship between PA and cognitive performance—the results of this initial study suggest that it can. Similarly, mood is linked both to cognitive performance and PA. While several studies have considered mood along with other behavioral or socioemotional factors in statistical models assessing mechanisms of PA, virtually none have considered the unique or independent contribution of mood to the PA-cognition relationship.
  • Additional studies including both psychological and neurocognitive functioning as outcome variables are needed to enhance our understanding of this level of analysis.
Neal

Get Off the Couch! Exercise Your Way to a Healthy Brain · Frontiers for Young... - 0 views

  • Glossary Cognitive function: ↑ The way we process and think about the world around us. Cognitive functions include attention, memory, and ability to solve problems. Neuroplasticity: ↑ Changes that happen in the brain as the result of our experiences. Alzheimer’s disease: ↑ A disease that affects the brain in older age. The main characteristic of Alzheimer’s disease is a problem with cognitive functions, especially memory.
Neal

Executive function in children with ADHD. - 0 views

  • Luria's concept of three functional units (blocks) of the brain (Luria, 1973) permits an understanding of the many problems associated with abnormal child development. The last unit that is maturated is the brain, providing the control and voluntary regulation of activities, later called executive function. The voluntary regulation of mental activity includes the following: (i) an objective setting, in accordance with motivation and the purpose of actual or planned activity, (ii) planning a program and the best ways to achieve a goal, (iii) monitoring the implementation of the program and the timely correction of inadequate actions and associations, and (iv) comparisons of objectives with intermediate and final results.
  • Broadly defined, executive function refers to a complex set of cognitive abilities that underlie adaptive, goal-directed behaviors and enable individuals to override more automatic or established thoughts and responses (Garon, Bryson, & Smith, 2008; Diamond, 2013). At a more fine-grained level, a set of cognitive control skills (e.g., attention, inhibitory control, self-monitoring, and flexibility) is defined as specific interrelated information-processing abilities that are involved in the control and coordination of information in the service of goal-directed actions and has been studied in the cognitive development literature
Neal

Higher-level cognitive functions in Dutch elite and sub-elite table tennis players - 0 views

shared by Neal on 15 Jan 19 - No Cached
  • Dutch elite and sub-elite table tennis players are characterized by above-average scores on higher-level cognitive functions compared to norm scores. A relation with performance level has been shown, which may be explained by the greater exposure to table tennis for elite compared to sub-elite players. However, longitudinal research is needed to indicate the direction of this association.
Neal

Specificity of Executive Functioning and Processing Speed Problems in Common Psychopath... - 1 views

  • Granular approaches are likely to be most productive for linking EF to psychopathology, whereas response speed has underutilized potential as an endophenotype for psychopathology liability. Results are discussed in terms of an integrated conceptualization of neuropsychological processes and putative neural systems involved in general and specific aspects of psychopathology.
  • Contemporary definitions emphasize a set of at least partially independent top-down functions that support goal-directed action (Marie T. Banich, 2009; Blair, Raver, & Finegood, 2016; Diamond, 2013; Friedman & Miyake, 2016; Miyake et al., 2000) as well as complex cognition (Barkley, 1997; Diamond, 2013). EF are invoked when automatized routines will not work or are not possible (e.g., novel situations).
  • (1) set-shifting (and maintenance), (2) interference control, (3) response inhibition, and (4) working memory.
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  • While not always included in older EF models, there is considerable contemporary interest in response consistency/variability (Karalunas, Geurts, Konrad, Bender, & Nigg, 2014), which may be a correlate of either EF or Speed. We included it and determined empirically its association with latent variables for our main constructs.
  • The unity and diversity of EF processes provides the opportunity to examine EF from a holistic perspective, with a focus on the combined measurement of EF, as well as from a component perspective.
  • cognitive retraining
  • Better understanding of how and when such interventions should be considered relies on clarifying how and in which respects executive functioning and slow processing speed relate to psychopathology at different levels of analysis and granularity.
  • Separating Speed from efficiency of EF is an important aspect of evaluating shared phenotypes for cognition (Salthouse, 1996) and thus for psychopathology.
  • studies of EF generally fail to consider processing speed. This is notable because hierarchal models of human cognition (e.g.(Botvinick, 2008) suggest that lower order processes, such a processing speed, inform higher order processes, such as EF.
  • It has been hypothesized that Speed may underlie EF
  • One possibility, in fact, is that Speed accounts for some of the EF effects, because EF measures are often confounded with Speed. We consider that by modeling EF and Speed simultaneously in some models. Three other hypotheses can be proposed.
  • The first model, here termed the “Specificity model,” proposes that different disorders are associated with different types of EF deficits.
  • The second, “Severity model,” proposes that EF or Speed impairment are related nonspecifically to overall severity of psychopathology rather than a specific form of psychopathology.
  • The third, “Dimension” model, proposes that EF or Speed deficits are related to one or more shared, underlying psychopathology liability dimensions rather than specific disorders.
  • Part A is generally recognized as a measure of output speed, while part B entails additional demands on scanning and motor speed in addition to switching; however it’s validity in relation to other switching measures is recognized
  • We refer to it as working memory for simplicity, recognizing its complexity.
Neal

"Keep That in Mind!" The Role of Positive Affect in Working Memory for Maintaining Goal... - 1 views

  • relevant information in WM, such that even a highly disruptive state is not
  • sufficient to corrupt this relationship.
  • These data suggest a tangible role of trait Positive Affect in the cognitive ability of maintaining goal-
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