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The U-Pace instructional approach combines self-paced, mastery-based learning with instructor-initiated Amplified Assistance in an online learning environment. Extensive evaluation showed that, compared to conventional instruction approaches, U-Pace instruction facilitated greater learning and greater academic success for all students in Introduction to Psychology courses. In terms of resources, U-Pace requires only a learning management system (such as Blackboard, Desire2Learn, or Moodle). U-Pace can be applied in any course or discipline, and resources to help instructors adopt the U-Pace approach are freely available.