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Only medical center in the state that's 100% focused on caring for children, from babies to teens. Teaching hospital and home of the University of Connecticut School of Medicine Department of Pediatrics Connecticut Children's Medical Center is the largest pediatric primary care service for children between Boston and New York. Pediatricians provide primary care services such as well-child checkups and immunizations, and care for minor illnesses. Emergency room staffed serves approximately 30,000 patients annually. Surgical unit nearly 6,000 surgeries performed annually. Intensive care unit serves children with traumatic injuries, life-threatening illness and children recovering from major surgery. We're a neonatal intensive care unit caring for about 500 critically ill or premature newborn babies a year; some children who weigh one pound at birth.

To evaluate the safety and multi-dose pharmacokinetics and dose ranging of intravenous followed by enteral myo-inositol (inositol) given at three dosage levels in extremely preterm neonates.

Neuropathology online - Course material - Asphyxia and hypoxic-ischemic encephalopathy in mature infants

Observational study tests the feasibility of enrolling subjects and obtaining an amplitude-integrated electroencephalogram (aEEG) within the first 72 hours of life, a second aEEG recording between 72-168 hours of life, and weekly thereafter up to 36 weeks post-menstrual age. It will enroll 85-100 infants between 401-1,000 grams birth weight OR between 23 0/7 and 28 6/7 weeks gestational age born at the 7 participating NICHD Neonatal Research Network sites.

NIH PubMed Abstrat - Prediction for developmental delay on Neonatal Oral Motor Assessment Scale in preterm infants without brain lesion

NIH PubMed Article Abstract illustrating the importance of evaluating oral motor function in the neonate

PubMed Abstract of study to assess the relationship between intrapartum maternal fever and neonatal acidosis as risk factors for neonatal encephalopathy

PubMed.gov Study Abstract - Study to identify neonatal risk factors for cerebral palsy among very preterm babies and in particular the associations independent of the coexistence of antenatal and intrapartum factors.

The Fern Lab - The Fern lab is located in the Department of Neurology at the University of Washington in Seattle. The lab's research focuses on ischemic injury of the brain, in particular the neonatal/developing brain. Ischemia is the term given to a loss of blood supply and can arise due to obstruction of a blood vessel (leading to a stroke), or from factors that are currently not well understood but which produce the brain injury that underlies cerebral palsy.

2010 Study - Increased morbidity in severe early intrauterine growth restriction.CONCLUSIONS: Infants born prematurely who are also severely IUGR have higher neonatal morbidity and mortality when compared to infants of similar gestational age. The surviving IUGR infants had less intraventricular hemorrhage and periventricular leukomalacia than less mature infants of comparable birth weight, but a similar incidence of ROP and length of stay. They had a higher incidence of NEC, direct hyperbilirubinemia and chronic lung disease, probably due to end-organ damage in utero from chronic placental insufficiency. These findings highlight the unique pattern of mortality and morbidity seen in infants with severe early IUGR.

Policy revision of the AAP policy posted in 2003. Clinical Report Hearing Assessment in Infants and Children: Recommendations Beyond Neonatal Screening

Objective is to determine if a connection exists between proton pump inhibitor antacids and decreased rate of bone mineralization in neonates

Future planned study being conducted by the University of California to determine the safety and pharmacokinetics of moderate to high doses of erythropoietin in newborn infants with birth asphyxia.

Completed study which compared the effectiveness of silver nitrate drops, erythromycin ointment, or no medication in preventing neonatal conjunctivitis caused by Chlamydia trachomatis and other eye infections. Additionally study compared side effects of the two prophylactic agents.

Study sponsored by Assistance Publique-Hopitaux de Paris investigating Early Prevention of Broncho-pulmonary Dysplasia and Neonatal Mortality in Very Preterm Infants Using Low Dose of Hydrocortisone

"For over 60 years the most appropriate oxygen level for preterm babies remains unknown. To answer this, we will combine data from over 5300 babies to be sure the expected benefits of lower oxygen for babies' eyes and lungs does not come at the expense of increasing death or major disability in these children. Planning to do this before the results of any of the trials are known is called a prospective meta-analysis. This is the first time this technique has been used in neonatal medicine.

Study is to determine if a weekly dose of 17P (Progesterone) given to women with preterm rupture of the membranes will: increase the probability of continuing the pregnancy until a favorable gestational age.Increase the interval between randomization and delivery. Decrease neonatal morbidity.

New England Journal of Medicine abstract of study to evaluate the effects of induction of moderate hypothermia in infants who had perinatal asphyxia. Study concluded that Induction of moderate hypothermia for 72 hours in infants who had perinatal asphyxia did not significantly reduce the combined rate of death or severe disability but resulted in improved neurologic outcomes in survivors. (Current Controlled Trials number, ISRCTN89547571 [controlled-trials.com] .)

PubMed Abstract - Pulmonary surfactant therapy. Surfactant replacement therapy and neonatal care.

NIH PubMed Abstract of study assessing sucking behavior of preterm neonates as a predictor of developmental outcomes.The relationship between the pattern of sucking behavior of preterm infants during the early weeks of life and neurodevelopmental outcomes during the first year of life was evaluated