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2007 Icelandic study to assess the incidence, obstetric risk factors and the squela of severe asphyxia at Landspitali university hospital.

NIH PubMed Central Archives of Disease in Childhood - Umbilical venous blood ph: a useful aid in the diagnosis of asphyxia at birth. Umbilical venous blood, and umbilical arterial blood pH, PO2, PCO2, and base excess were determined in 453 term infants at birth. The results indicate that umbilical venous blood pH, and umbilical arterial blood pH are significantly related to each another.

Study sponsored by Imperial College London - Hypothesis: Study aims to determine whether whole body cooling to 33-34°C is a safe treatment that improves survival, without severe neurological or neurodevelopmental impairments at 18 months, of term infants suffering perinatal asphyxial encephalopathy

Eunice Kennedy Shriver National Institute of child Health and Human Development (NICHD) Study to evaluate the safety of high-dose Erythropoietin (Epo) in infants who did not get enough oxygen during birth. Erythropoietin is a hormone normally found in the body that may protect brain cells from damage due to lack of oxygen.

NCBI PubMed.gov Abstract -Cerebral inflammatory response after fetal asphyxia and hyperoxic resuscitation in newborn sheep. Department of Pediatrics, Lund Uiversity, Sweden Publication

Italian sponsored and NIH PubMed published abstract of study in the role of foetal lactate in the prevention of cerebral palsy during labor

PEDIATRICS Journal Abstract of study to determine whether serial head circumference measurements and decreased rate of head growth in asphyxiated full-term newborns during the first few months of life may predict the development of eventual microcephaly.

PubMed Study Abstract: Vasoparalysis associated with brain damage in asphyxiated term infants - Dept of Neonatalogy, Rigshospitalet, Copenhagaon, Denmark, 1990

Study to determine the potential benefits of a home stimulation program to treat infants who have suffered from brain asphyxiation (lack of oxygen).

Completed study sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD and conducted in two cities in Zambia to determine if the combined Neonatal Resuscitation Program/Essential Newborn Care Program compared to the new World Health Organization (W.H.O.) basic perinatal care education of health care providers (Essential Newborn Care Program) results in reduced mortality due to perinatal asphyxia

NICHD program focuses on developing research that links PCCR medicine and science to the epidemiology, prevention, and treatment of childhood disabilities. The effort sponsors competitive research on all aspects of PCCR-including critical analyses of outcomes for children who are survivors of trauma, congenital anomalies, neonatal asphyxia, infectious processes, septic shock, and many other less common, but still devastating hildhood processes. The PCCR program also provides support for the Pediatric Critical Care Scientist Development Program (PCCSDP) , a national faculty training and career development program that develops successful pediatric critical care physician scientists conducting research to enhance the scientific understanding, clinical management, and rehabilitation of pediatric critical illness.

Study is to determine whether nerve growth factor (cerebrolysin®) therapy will improve the psychomotor outcome in infants with moderate and severe hypoxic ischemic encephalopathy.

Completed Zhengzhou University study to investigate whether systemic hypothermia induced up to 10 hrs after birth would improve the neurodevelopmental outcome at 18 months in infants with moderate or severe HIE.

NCBI PubMed Abstract, Department of Pediatrics, University of Tennessee Study involving piglets to determine whether the generation of superoxide anion occurs primarily during asphyxia or whether reventilation must take place, 2) to investigate the effects of indomethacin pretreatment at a therapeutic dose of 0.2 mg/kg i.v. on superoxide anion generation, and 3) to investigate the effects of oxypurinol, an oxygen free radical scavenger, on superoxide anion production during asphyxia/reventilation

Hundreds of babies in the world are being treated with brain cooling to prevent brain injury after they lose oxygen at birth. This study will use the newly developed information from the magnet resonance image to determine the actual temperature of the brain. This will enable researchers to determine if the brain is being uniformly cooled and if techniques that provide cooling need to be changed to improve the injury prevention from cooling

National Institute of Neurological Disorders and Stroke (NINDS) Cerebral Hypoxia Information Page

Objective of this study was to determine whether Apgar scores at 10 minutes are associated with death or disability in early childhood after perinatal hypoxic-ischemic encephalopathy.

Article abstract of French study assessing neonatal outcomes after instrumental vaginal delivery. Many of the most severe neonatal complications are observed when perinatal asphyxia has occurred. Extractor types and quality of use under defined criteria are closely associated with neonatal adverse outcomes in operative vaginal delivery. Forceps deliveries are as safe as vacuum deliveries to the neonate. In conclusion, operative vaginal delivery performed for maternal or fetal reasons are associated with several neonatal adverse events, usually non specific and with a short term good prognosis.

PEDIATRICS - Official Journal of the American Academy of Pediatrics - Declining Diagnosis of BirthAsphyxia in California: 1991-2000 PEDIATRICS Vol. 114 No. 6 Dec 2004

Study to obtain pharmacokinetic and safety data of bumetanide in newborns with refractory seizures. The overall hypothesis is that bumetanide, added to conventional antiepileptic (antiseizure) medications, will be a safe and well tolerated medication, compared with conventional antiepileptic drugs alone.