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The Metropolitan Atlanta Developmental Disabilities Study (MADDS) was the first U.S., population-based epidemiologic study of the prevalence of intellectual disabilities, cerebral palsy, hearing loss, vision impairment, and epilepsy in school-aged children. National Center on Birth Defects and Developmental Disabilities (NCBDDD) staff have written scientific papers using information from MADDS. These papers look at such topics as how common autism spectrum disorders are and what causes hearing loss in children. You can see a list of these papers (starting in 1990) by using the keyword search on the NCBDDD publications Web page. Choose "MADDS (Metropolitan Atlanta Developmental Disabilities Study)" in the keyword box on the search page. You can choose whether you want the list to be sorted by author or by date

This study compared the rate and extent of absorption of ranitidine 300 rng tablets versus Zantac. The study products were administered as a single oral dose of 1 x 300 mg tablet using a randomized, two-way crossover fasting study in non-smoker healthy volunteers with a washout period of 7 days

Completed study. In this feasibility study, hyperoxemia, as proximated by transcutaneous hemoglobin saturation with oxygen (Sp02), at the time of birth will cause sustained pulmonary oxidative stress as demonstrated by elevation of ulmonary protein carbonyl. Furthermore, this oxidative stress will be directly proportional to the imposed oxygen-burden during resuscitation at the time of birth. This study will give us information regarding the magnitude of protein carbonyl elevation in the preterm infant. With these results we will be able to 1. establish the technique for the running or protein carbonyl assays and 2. calculate an appropriate sample size for a future randomized control trial.

NIH Clinical Study - This multi-center collaborative study will establish a database of information about stroke in infants and children

Completed study examined tongue strength and endurance, how the tongue applies pressure during swallowing, and how the chin muscles react during swallowing in healthy volunteers and in patients with dysphagia (difficulty swallowing). The information from this study may be helpful in developing better treatments for people with swallowing problems

NINDS sponsored and multi-center collaborative study will establish a database of information about stroke in infants and children

Study to determine if the drug 17-hydroxyprogesterone caproate can help reduce the risk of preterm delivery in women with certain risk factors for preterm birth. We hope to learn whether this same medication can be used to prolong pregnancy in a group of patients in whom this medication has not been previously studied. Specifically, we hope to learn whether progesterone supplementation will delay delivery in women with pre-term, premature rupture of membranes (PPROM).

Information on ongoing study being sponsored by Medical College of Georgia to test the safety and effectiveness of cord blood infusion in children with motor disabilities due to cerebral palsy.

Study is to obtain preliminary information about the efficacy and potential adverse effects of platelet concentrate injections in patients undergoing arthroscopic Sub-acromial Decompression (SD), arthroscopic Acromio-Clavicular (AC) joint resection, and arthroscopic Rotator Cuff (RC) repair. Investigators wish to determine whether the PRP shows efficacy in healing and learn of possible side-effects

This study is being conducted to gather medium and long-term information regarding the performance and safety of the commercially available DURALOC® Option Ceramic-on-Ceramic Hip Prosthesis System.

London study to determine if acupuncture helps delayed gastric emptying

University of Weatern Ontario, Canada study to estimate to what extent computerized fetal heart rate (FHR) parameters are affected by labor and to estimate the relationship between FHR parameters and the degree of fetal metabolic acidosis in laboring patients at term. Study concluded that in term pregnant women with reassuring FHR tracing, labor causes an increase in both short- and long-term FHR variation, which was abolished in the presence of nonreassuring FHR tracing. Computer-derived FHR parameters studied during the last hour of labor were not correlated with the degree of metabolic acidosis as measured in the umbilical artery at birth.

Agency for Healthcare Research and Quality (AHRQ) Study Shows Using Bar-Code Technology with eMAR Reduces Medication Administration and Transcription Errors. Press Release, May 5, 2010. Agency for Healthcare Research and Quality, Rockville, MD.

ClinicalTrials.gov - Provides information on an ongoing study and evaluation of hyperbaric treatment for children with Cerebral Palsy. Study being conducted in collaboration with the Departmnet of Defense, Children's Medical Center of Dayton and Kettering Medical Center. Information provided by Wright State University. Last Updated: December 2009

Provides information on study conducted and completed at the NIH and Children's National Medical Center to evaluation how well different physician's agree on how they classify cerebral palsy subtypes based on patient examination.

"The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility of efficacy) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts."

The objective of this study is to gather clinical and survivorship information for the C2a-Taper™ Acetabular System, a ceramic on ceramic hip articulating system

Study will provide information about changes that occur in the motor neurons of the spinal cord (the nerve cells that control the muscles) when the motor cortex (the region of the brain that controls movement) is unable to send messages to the spinal cord and muscles in the normal way. This information will help elucidate how the nervous system adapts after injury or disease of the motor cortex.

Dr. Christine Houlihan of the University of Virginia is conducting a clinical study to look at how childrens bones grow and mature when they have Cerebral Palsy. This information will be compared to growth in children that do not have Cerebral Palsy

How does the brain monitor the location of the limbs and guide movement ? Lab Research focuses on human neuroimaging experiments and computational modeling studies of motor and premotor cortex.