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Matti Narkia

Omega-3 fatty acids may reduce risk of colon cancer - 0 views

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    "ScienceDaily (Dec. 7, 2009) - Long-chain omega-3 fatty acids, primarily found in fish and seafood, may have a role in colorectal cancer prevention, according to results presented at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference, held Dec. 6-9, 2009, in Houston."
Matti Narkia

Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids - Journal... - 0 views

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    Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids.
    Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Smith A, Edwards IJ, D'Agostino R, Zhang H, Wu H, Kang JX, Chen YQ.
    J Clin Invest. 2007 Jul;117(7):1866-75.
    PMID: 17607361

    Our data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. This study highlights the importance of gene-diet interactions in prostate cancer.
Matti Narkia

Israeli 'cancer shift' over heart disease mortality may be led by greater risk in women... - 0 views

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    Israeli 'cancer shift' over heart disease mortality may be led by greater risk in women with high intake of n-6 fatty acids.
    Shapira N.
    Eur J Cancer Prev. 2007 Oct;16(5):486-94.
    PMID: 17923822
    doi: 10.1097/CEJ.0b013e3280145b6d

    Population studies of Israeli Jews, Arabs, and women support the association of high n-6 polyunsaturated fatty acid intake with increased cancer risk and higher female sensitivity. Research findings suggest that gender and sex hormones may influence n-6 polyunsaturated fatty acid metabolism and carcinogenesis. This appears to be the first time gender has been proposed to modulate national cancer epidemiology, suggesting implications for differential nutritional prevention, warranting further research.
Matti Narkia

Welcome to to VITamin D and omegA-3 triaL (VITAL) Web site - 0 views

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    What is VITAL?

    The VITamin D and OmegA-3 TriaL (VITAL) is a research study in 20,000 U.S. men and women investigating whether taking daily dietary supplements of vitamin D (about 2000 IU) or fish oil (about 1 gram of omega-3 fatty acids) reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses. Recruitment for the study will begin in January 2010.
Matti Narkia

Nutritional intervention with omega-3 Fatty acids in a case of malignant fibrous histio... - 0 views

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    Nutritional intervention with omega-3 Fatty acids in a case of\nmalignant fibrous histiocytoma of the lungs.
    Pardini RS, Wilson D, Schiff S, Bajo SA, Pierce R.
    Nutr Cancer. 2005;52(2):121-9.
    PMID: 16201843
Matti Narkia

n-3 Fatty acids, cancer and cachexia: a systematic review of the literature - 0 views

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    Our findings suggest that administration of n-3 FA (EPA and DHA) in doses of at least 1.5 g/day for a prolonged period of time to patients with advanced cancer is associated with an improvement in clinical, biological and QoL parameters.

    N-3 fatty acids, cancer and cachexia: a systematic review of the literature.
    Colomer R, Moreno-Nogueira JM, García-Luna PP, García-Peris P, García-de-Lorenzo A, Zarazaga A, Quecedo L, del Llano J, Usán L, Casimiro C.
    Br J Nutr. 2007 May;97(5):823-31. Review.
    PMID: 17408522
    doi:10.1017/S000711450765795X
Matti Narkia

Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer c... - 0 views

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    It was concluded that omega-3 fatty acid could inhibit the proliferation of pancreatic cancer cell line SW1990 cells and promote their apoptosis. The down-regulation of the cyclin E expression by omega-3 fatty acid might be one of the mechanisms for its anti-tumor effect on pancreatic cancer.

    Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells.
    Zhang W, Long Y, Zhang J, Wang C.
    J Huazhong Univ Sci Technolog Med Sci. 2007 Oct;27(5):547-50.
    PMID: 18060632
Matti Narkia

Fish oil and treatment of cancer cachexia - Genes Nutr. 2008 Apr. - 0 views

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    Fish oil and treatment of cancer cachexia.
    Giacosa A, Rondanelli M.
    Genes Nutr. 2008 Apr;3(1):25-8.
    PMID: 18850196
Matti Narkia

Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 f... - 0 views

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    Mice fed fish oil and curcumin showed a significantly reduced tumor volume, 25% (P < 0.04) and 43% (P < 0.005), respectively, and importantly, a combination of curcumin and fish oil diet showed > 72% (P < 0.0001) tumor volume reduction. Expression and activity of iNOS, COX-2, and 5-LOX are downregulated, and p21 is upregulated in tumor xenograft fed curcumin combined with fish oil diet when compared to individual diets. The preceding results evidence for the first time that curcumin combined with omega-3 fatty acids provide synergistic pancreatic tumor inhibitory properties.

    Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids.
    Swamy MV, Citineni B, Patlolla JM, Mohammed A, Zhang Y, Rao CV.
    Nutr Cancer. 2008;60 Suppl 1:81-9.
    PMID: 19003584
Matti Narkia

PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexae... - 0 views

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    The combination effects index (CI) analysis confirmed the synergy of clioquinol and clofibrate on inhibiting cancer cell viability. Using inhibitors to block PPARalpha signaling diminished the synergistic cytotoxicity of clioquinol and DHA. These results provide pharmacological evidence that the synergistic anticancer action of clioquinol and DHA is mediated by PPARalpha signaling in human cancer cells.

    PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells.
    Tuller ER, Brock AL, Yu H, Lou JR, Benbrook DM, Ding WQ.
    Biochem Pharmacol. 2009 May 1;77(9):1480-6. Epub 2009 Feb 13.
    PMID: 19426685
Matti Narkia

Anticancer properties of oxidation products of docosahexaenoic acid - [Chem Phys Lipids... - 0 views

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    Anticancer properties of oxidation products of docosahexaenoic acid.
    Siddiqui RA, Harvey K, Stillwell W.
    Chem Phys Lipids. 2008 May;153(1):47-56. Epub 2008 Feb 23. Review.
    PMID: 18343223
Matti Narkia

Effects of Dietary Flaxseed on Intestinal Tumorigenesis in ApcMin Mouse - Nutrition and... - 0 views

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    Effects of dietary flaxseed on intestinal tumorigenesis in Apc(Min) mouse.
    Bommareddy A, Zhang X, Schrader D, Kaushik RS, Zeman D, Matthees DP, Dwivedi C.
    Nutr Cancer. 2009;61(2):276-83.
    PMID: 19235044
    DOI: 10.1080/01635580802419764
Matti Narkia

Flax In Diet Means Fewer Tumors - 0 views

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    "Results indicated that mice on diets supplemented with flaxseed meal and flaxseed oil had, on average, 45 percent fewer tumors in the small intestine and the colon compared to the control group."

    The scientists published their research findings in February in the academic peer-reviewed international journal Nutrition and Cancer.
Matti Narkia

Multi-targeted therapy of cancer by omega-3 fatty acids - Cancer Lett. 2008 Oct 8 - 0 views

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    Multi-targeted therapy of cancer by omega-3 fatty acids.
    Berquin IM, Edwards IJ, Chen YQ.
    Cancer Lett. 2008 Oct 8;269(2):363-77. Epub 2008 May 13. Review.
    PMID: 18479809
    doi:10.1016/j.canlet.2008.03.044
Matti Narkia

Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and prefe... - 0 views

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    Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer.
    Cerchietti LC, Navigante AH, Castro MA.
    Nutr Cancer. 2007;59(1):14-20.
    PMID: 17927497
Matti Narkia

Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and... - 0 views

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    Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial.
    Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F.
    Cancer. 1998 Jan 15;82(2):395-402.
    PMID: 9445198
Matti Narkia

Nutrient Intake and Immune Function of Elderly Subjects - J Am Diet Assoc. 2008 Dec - 0 views

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    Nutrient intake and immune function of elderly subjects.
    Wardwell L, Chapman-Novakofski K, Herrel S, Woods J.
    J Am Diet Assoc. 2008 Dec;108(12):2005-12.
    PMID: 19027403
    doi:10.1016/j.jada.2008.09.003
Matti Narkia

CANCER VACCINES AND IMMUNOTHERAPY - lefeurope.com - 0 views

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    Cancer immunotherapies, including cancer vaccines, are novel investigational cancer therapies. In contrast to chemotherapy and radiotherapy regimens that are often associated with severe side effects, cancer immunotherapy stimulates the body's immune system and natural resistance to cancer, thus offering a gentler means of cancer treatment that is less damaging to the rest of the body. Surgery is generally (but not always) performed, prior to immunotherapy, to remove most of the tumor (Hanna MG, Jr. et al 2001; Jocham D et al 2004). Vaccination or immunotherapy prompts the immune system to kill residual cancer cells that persist after surgery and could result in the cancer recurring.
Matti Narkia

Omega-3 Fatty Acids May Benefit Cancer Patients Undergoing Major Operations - 0 views

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    ScienceDaily (Apr. 10, 2009) - New research from Trinity College Dublin published in this month's Annals of Surgery points to a potentially significant advance in the treatment of patients undergoing major cancer surgery. The study was carried out by the oesophageal research group at Trinity College Dublin and St James's Hospital. A randomised controlled trial showed omega-3 fatty acids given as part of an oral nutritional supplement resulted in the preservation of muscle mass in patients undergoing surgery for oesopahageal cancer, a procedure normally associated with significant weight loss and quality of life issues.
Matti Narkia

Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human... - 0 views

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    Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells.
    Habbel P, Weylandt KH, Lichopoj K, Nowak J, Purschke M, Wang JD, He CW, Baumgart DC, Kang JX.
    World J Gastroenterol. 2009 Mar 7;15(9):1079-84.
    PMID: 19266600
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