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Matti Narkia

A systematic review of the anticancer properties of berberine, a natural product from C... - 0 views

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    A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs.
    Sun Y, Xun K, Wang Y, Chen X.
    Anticancer Drugs. 2009 Oct;20(9):757-69.
    PMID: 19704371
Matti Narkia

Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xeno... - 0 views

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    Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model.
    Ho YT, Yang JS, Lu CC, Chiang JH, Li TC, Lin JJ, Lai KC, Liao CL, Lin JG, Chung JG.
    Phytomedicine. 2009 Sep;16(9):887-90. Epub 2009 Mar 20.
    PMID: 19303753

    Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10mg/kg of body weight) and doxorubicin (4mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4mg/kg of doxorubicin or with 10mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic.
Matti Narkia

Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficie... - 0 views

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    Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth.
    Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB.
    Cancer Res. 2007 Jul 15;67(14):6745-52.
    PMID: 17638885
    doi: 10.1158/0008-5472.CAN-06-4447
Matti Narkia

Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid r... - 0 views

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    Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
    Casanova ML, Blázquez C, Martínez-Palacio J, Villanueva C, Fernández-Aceñero MJ, Huffman JW, Jorcano JL, Guzmán M.
    J Clin Invest. 2003 Jan;111(1):43-50.
    PMID: 12511587
    doi:10.1172/JCI16116
Matti Narkia

Cannabinoids: potential anticancer agents : Abstract : Nature Reviews Cancer - 0 views

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    Cannabinoids: potential anticancer agents.
    Guzmán M.
    Nat Rev Cancer. 2003 Oct;3(10):745-55. Review.
    PMID: 14570037
    doi:10.1038/nrc1188
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