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Matti Narkia

Safety Study of Seneca Valley Virus in Patients With Solid Tumors With Neuroendocrine F... - 0 views

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    Safety Study of Seneca Valley Virus in Patients With Solid Tumors With Neuroendocrine Features
    This study is currently recruiting participants.
    Verified by Neotropix, September 2008

    This is the first study in man of Seneca Valley Virus, a virus which seeks and kills certain tumors in non-human model systems. Subjects in this trial will be patients with advanced cancer displaying certain specified neuroendocrine features, pathologically; they will have exhausted standard methods of treatment for their tumor. The primary purpose of the trial is to determine if the virus may be administered safely. Additional purposes are to learn about the distribution of the virus in the body, the elimination of the virus from the body, the immune response to the virus and whether the virus might have some beneficial effects upon the tumors which the patients have. The first patients will be treated with low amounts of virus and subsequent patients may receive higher amounts. At the end of the trial, it is intended to select a dose for further study.
Matti Narkia

Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatme... - 0 views

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    Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatment of neuroendocrine cancers.
    Reddy PS, Burroughs KD, Hales LM, Ganesh S, Jones BH, Idamakanti N, Hay C, Li SS, Skele KL, Vasko AJ, Yang J, Watkins DN, Rudin CM, Hallenbeck PL.
    J Natl Cancer Inst. 2007 Nov 7;99(21):1623-33. Epub 2007 Oct 30.
    PMID: 17971529
    doi:10.1093/jnci/djm198
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