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Matti Narkia

Vitamin D and Its Role in Cancer and Immunity: A Prescription for Sunlight -- Mullin an... - 0 views

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    Vitamin d and its role in cancer and immunity: a prescription for sunlight.
    Mullin GE, Dobs A.
    Nutr Clin Pract. 2007 Jun;22(3):305-22. Review.
    PMID: 17507731
    DOI: 10.1177/0115426507022003305
Matti Narkia

Antitumor Activity of Human Papillomavirus Type 16 E7-Specific T Cells against Virally ... - 0 views

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    Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neck.
    Albers A, Abe K, Hunt J, Wang J, Lopez-Albaitero A, Schaefer C, Gooding W, Whiteside TL, Ferrone S, DeLeo A, Ferris RL.
    Cancer Res. 2005 Dec 1;65(23):11146-55.
    PMID: 16322265
Matti Narkia

CD40L - a multipotent molecule for tumor therapy. - Bentham Science Publishers - Endocr... - 0 views

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    CD40L - a multipotent molecule for tumor therapy.
    Loskog A, Tötterman TH.
    Endocr Metab Immune Disord Drug Targets. 2007 Mar;7(1):23-8. Review.
    PMID: 17346201
Matti Narkia

Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tu... - 0 views

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    Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer.
    Lönnroth C, Andersson M, Arvidsson A, Nordgren S, Brevinge H, Lagerstedt K, Lundholm K.
    Cancer Immun. 2008 Feb 29;8:5.
    PMID: 18307280

    MHC II protein (HLA-DP, -DQ, -DR) levels and infiltration by CD4+ T-helper cells of tumor stroma increased upon NSAID treatment, while CD8+ cytotoxic T-lymphocytes increased in both tumor stroma and epithelium. Molecules associated with immunosuppressive T regulatory cells (FOXP3, IL-10) were significantly decreased in indomethacin-exposed tumors. Standard oral administration of NSAID three days preoperatively was enough to increase tumor infiltration by seemingly activated immune cells. These findings agree with previous information that high pr
Matti Narkia

Multiple roles for CD4+ T cells in anti-tumor immune responses. - Wiley InterScience ::... - 0 views

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    Multiple roles for CD4+ T cells in anti-tumor immune responses.
    Kennedy R, Celis E.
    Immunol Rev. 2008 Apr;222:129-44. Review.
    PMID: 18363998
    DOI: 10.1111/j.1600-065X.2008.00616.x
Matti Narkia

The inflammatory Th 17 subset in immunity against self and non-self antigens - Autoimmu... - 0 views

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    The inflammatory Th 17 subset in immunity against self and non-self antigens.
    Jin D, Zhang L, Zheng J, Zhao Y.
    Autoimmunity. 2008 Mar;41(2):154-62. Review.
    PMID: 18324485
    DOI: 10.1080/08916930701776605
Matti Narkia

Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells ... - 0 views

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    Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells.
    Leveque L, Deknuydt F, Bioley G, Old LJ, Matsuzaki J, Odunsi K, Ayyoub M, Valmori D.
    J Immunother. 2009 Feb-Mar;32(2):101-8.
    PMID: 19238008
    doi: 10.1097/CJI.0b013e318195b59e

    Thus, although the impact of TH17 cells on the evolution of EOC remains to be established, our data suggest that local IL-2 treatment in ovarian cancer may result in the conversion of tumor-associated Treg into TH17 cells, relieve Treg-mediated suppression, and contribute to enhance antitumor immunity.
Matti Narkia

T-helper/T-regulator lymphocyte ratio as a new immunobiological index to quantify the a... - 0 views

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    T-helper/T-regulator lymphocyte ratio as a new immunobiological index to quantify the anticancer immune status in cancer patients.
    Brivio F, Fumagalli L, Parolini D, Messina G, Rovelli F, Rescaldani R, Vigore L, Vezzo R, Vaghi M, Di Bella S, Lissoni P.
    In Vivo. 2008 Sep-Oct;22(5):647-50.
    PMID: 18853761

    RESULTS: The mean TH/TR ratio observed in patients with metasytases was significantly lower with respect to that found in both patients without metastases and controls. On the contrary, the absolute mean number of T-reg cells was higher in patients with metastases than in those without, but the difference was not statistically significant. CONCLUSION: The evaluation of T-reg cells in terms of their proportion with respect to T-helper cell total number seems to be more appropriate than the simple measurement of their absolute count, in order to quantify cancer-related immunosuppression. Thus, the TH/TR ratio could represent a useful biological marker to explore the immune status of cancer patients.
Matti Narkia

Inhibition of suppressor T lymphocytes (Ts) by cimetidine. - J Immunol. 1987 May - 0 views

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    Inhibition of suppressor T lymphocytes (Ts) by cimetidine.
    Sahasrabudhe DM, McCune CS, O'Donnell RW, Henshaw EC.
    J Immunol. 1987 May 1;138(9):2760-3.
    PMID: 2952721

    Cyclophosphamide (CY) is the most extensively studied inhibitor of suppressor T lymphocyte (Ts) function. However, repeated administration of CY can abrogate sensitization. Therefore, we were interested in identifying noncytotoxic inhibitors of Ts function as adjuncts in the immunotherapy of Ts-inducing murine tumors. The effect of cimetidine (a histamine type 2 receptor antagonist) and diphenhydramine (a histamine type 1 receptor antagonist) on the Ts mediating tolerance to 2,4-dinitrofluorobenzene was studied. We report our data regarding the specific inhibition of Ts by cimetidine.
Matti Narkia

Effects of perioperative cimetidine administration on peripheral blood lymphocytes and ... - 0 views

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    Effects of perioperative cimetidine administration on peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: results of a randomized controlled clinical trial.
    Li Y, Yang GL, Yuan HY, Bai DJ, Wang K, Lin CR, Hu MB, Feng MH.
    Hepatogastroenterology. 2005 Mar-Apr;52(62):504-8.
    PMID: 15816467
Matti Narkia

Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disea... - 0 views

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    Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.
    Kidd P.
    Altern Med Rev. 2003 Aug;8(3):223-46. Review.
    PMID: 12946237

    Th1 pathways typically produce activation
    of cytotoxic T lymphocytes (Tc), NK cells,
    macrophages, and monocytes, all of which can
    attack cancer cells and generally defend against
    tumors.55 IFN-gamma and other Th1 cytokines are
    typically lower in advanced cancer patients, while
    the Th2 marker IL-4 can be higher or unchanged
Matti Narkia

Molecular immunological approaches to biotherapy of human cancers--a review, hypothesis... - 0 views

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    Molecular immunological approaches to biotherapy of human cancers--a review, hypothesis and implications.
    Becker Y.
    Anticancer Res. 2006 Mar-Apr;26(2A):1113-34. Review.
    PMID: 16619514
Matti Narkia

Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and... - 0 views

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    Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial.
    Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F.
    Cancer. 1998 Jan 15;82(2):395-402.
    PMID: 9445198
Matti Narkia

Nutrient Intake and Immune Function of Elderly Subjects - J Am Diet Assoc. 2008 Dec - 0 views

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    Nutrient intake and immune function of elderly subjects.
    Wardwell L, Chapman-Novakofski K, Herrel S, Woods J.
    J Am Diet Assoc. 2008 Dec;108(12):2005-12.
    PMID: 19027403
    doi:10.1016/j.jada.2008.09.003
Matti Narkia

The effect of dietary omega-3 polyunsaturated fatty acids on T-lymphocyte subsets of pa... - 0 views

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    The effect of dietary omega-3 polyunsaturated fatty acids on T-lymphocyte subsets of patients with solid tumors.
    Gogos CA, Ginopoulos P, Zoumbos NC, Apostolidou E, Kalfarentzos F.
    Cancer Detect Prev. 1995;19(5):415-7.
    PMID: 7585727
Matti Narkia

A platelet cloak for tumor cells - Blood, January 1, 2005 - 0 views

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    H. Weiler
    A platelet cloak for tumor cells
    Blood, January 1, 2005; 105(1): 5 - 6.

    Palumbo and colleagues show that platelets and fibrinogen protect metastatic tumor cells from elimination by NK cells, confirming a striking mechanistic link between activation of the blood coagulation system and the spread of tumor metastases
Matti Narkia

Is regular exercise a friend or foe of the aging immune system? A systematic review. - ... - 0 views

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    Is regular exercise a friend or foe of the aging immune system? A systematic review.
    Haaland DA, Sabljic TF, Baribeau DA, Mukovozov IM, Hart LE.
    Clin J Sport Med. 2008 Nov;18(6):539-48. Review.
    PMID: 19001887
    doi: 10.1097/JSM.0b013e3181865eec
Matti Narkia

Exercise affects platelet-impeded antitumor cytotoxicity of natural killer cell. - [Med... - 0 views

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    Exercise affects platelet-impeded antitumor cytotoxicity of natural killer cell.
    Wang JS, Chung Y, Chow SE.
    Med Sci Sports Exerc. 2009 Jan;41(1):115-22.
    PMID: 19092699
Matti Narkia

Human natural killer cell subsets and acute exercise: a brief review - .[Exerc Immunol ... - 0 views

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    Human natural killer cell subsets and acute exercise: a brief review.
    Timmons BW, Cieslak T.
    Exerc Immunol Rev. 2008;14:8-23. Review.
    PMID: 19203081
Matti Narkia

Effect of moderate exercise training on T-helper cell subpopulations in elderly people.... - 0 views

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    Effect of moderate exercise training on T-helper cell subpopulations in elderly people.
    Shimizu K, Kimura F, Akimoto T, Akama T, Tanabe K, Nishijima T, Kuno S, Kono I.
    Exerc Immunol Rev. 2008;14:24-37.
    PMID: 19203082
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