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Matti Narkia

Benefits of Vitamin D Supplementation - Journal of American Physicians and Surgeons Vol... - 0 views

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    Benefits of Vitamin D Supplementation
    Joel M. Kauffman, Ph.D.
    Journal of American Physicians and Surgeons
    Volume 14 Number 2 - Summer 2009

    Clinical trials show that vitamin D supplementation at higher
    levels than previously recommended is beneficial for many
    conditions. It decreases the frequency of falls and fractures, helps
    prevent cardiovascular disease, and reduces symptoms of colds or
    influenza. Benefits are also seen in diabetes mellitus, multiple
    sclerosis, Crohn disease, pain, depression, and possibly autism.
    Sunlight does not cause an overdose of vitamin D production,
    and toxicity from supplementation is rare. Dose recommendations
    are increasing, but appear to be lagging the favorable trial results. A
    number of common drugs deplete vitamin D levels, and others may
    limit its biosynthesis from sunlight.
    People with adequate levels from sun exposure will not benefit
    from supplementation. While dietary intake is helpful,
    supplementation is better able to raise serum 25-hydroxyvitamin D ,
    the major circulating metabolite, to the level now thought adequate,
    30-50 ng/mL.
    Where there is inadequate daily sun exposure, oral doses of
    1,000-2,000 IU/d are now considered routine, with much higher
    doses (up to 50,000 IU) for rapid repletion now considered safe.
Matti Narkia

Vitamin D for cancer prevention: global perspective. Garland CF et al. -Ann Epidemiol. ... - 0 views

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    Vitamin D for cancer prevention: global perspective.
    Garland CF, Gorham ED, Mohr SB, Garland FC.
    Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
    PMID: 19523595
Matti Narkia

Factors Associated With Clinical Benefit From Epidermal Growth Factor Receptor Inhibito... - 0 views

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    Factors associated with clinical benefit from epidermal growth factor receptor inhibitors in recurrent and metastatic squamous cell carcinoma of the head and neck.
    Cohen EE, Halpern AB, Kasza K, Kocherginsky M, Williams R, Vokes EE.
    Oral Oncol. 2009 Oct;45(10):e155-60. Epub 2009 Jul 7.
    PMID: 19586795
Matti Narkia

Vitamin D for Cancer Prevention: Global Perspective - 1 views

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    Vitamin D for cancer prevention: global perspective.
    Garland CF, Gorham ED, Mohr SB, Garland FC.
    Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
    PMID: 19523595

    RESULTS/CONCLUSIONS: It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such intakes also are expected to reduce case-fatality rates of patients who have breast, colorectal, or prostate cancer by half. There are no unreasonable risks from intake of 2000 IU per day of vitamin D(3), or from a population serum 25(OH)D level of 40 to 60 ng/mL. The time has arrived for nationally coordinated action to substantially increase intake of vitamin D and calcium.
Matti Narkia

Vitamin D and prevention of breast cancer: pooled analysis. - ScienceDirect - The Journ... - 0 views

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    Vitamin D and prevention of breast cancer: pooled analysis.
    Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC.
    J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.
    PMID: 17368188

    CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.
Matti Narkia

How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptati... - 0 views

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    How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
    Vieth R.
    Anticancer Res. 2009 Sep;29(9):3675-84. Review.
    PMID: 19667164
Matti Narkia

Review Article: Vitamin D Acquisition and Breast Cancer Risk -- Pérez-López e... - 0 views

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    Review article: vitamin D acquisition and breast cancer risk.
    Pérez-López FR, Chedraui P, Haya J.
    Reprod Sci. 2009 Jan;16(1):7-19. Review.
    PMID: 19144887
    DOI: 10.1177/1933719108327595

    Conclusions: Although there are controversial results, it seems plausible that sufficient endogenous vitamin D levels may have a protective function on mammary cells, reducing breast cancer risk.
Matti Narkia

Vitamin D and Its Role in Cancer and Immunity: A Prescription for Sunlight -- Mullin an... - 0 views

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    Vitamin d and its role in cancer and immunity: a prescription for sunlight.
    Mullin GE, Dobs A.
    Nutr Clin Pract. 2007 Jun;22(3):305-22. Review.
    PMID: 17507731
    DOI: 10.1177/0115426507022003305
Matti Narkia

Calcium, Vitamin D and Cancer - Anticancer Research - 0 views

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    Calcium, vitamin D and cancer.
    Peterlik M, Grant WB, Cross HS.
    Anticancer Res. 2009 Sep;29(9):3687-98. Review.
    PMID: 19667166
Matti Narkia

The Role of Vitamin D in Cancer Prevention -- Garland et al. 96 (2): 252 -- American Jo... - 1 views

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    The role of vitamin D in cancer prevention.
    Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
    Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
    PMID: 16380576
    DOI: 10.2105/AJPH.2004.045260

    Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.

    The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.
Matti Narkia

Vitamin D in Cancer Patients: Above All, Do No Harm -- Goodwin 27 (13): 2117 -- Journal... - 0 views

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    Vitamin D in cancer patients: above all, do no harm.
    Goodwin PJ.
    J Clin Oncol. 2009 May 1;27(13):2117-9. Epub 2009 Apr 6.
    PMID: 19349538
Matti Narkia

The Role of Vitamin D in Cancer Prevention -- Garland et al. 96 (2): 252 -- American Jo... - 0 views

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    The role of vitamin D in cancer prevention.
    Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
    Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
    PMID: 16380576
    DOI: 10.2105/AJPH.2004.045260

    Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.

    The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects
Matti Narkia

Vitamin D and the epidemiology of prostate cancer. - Semin Dial. 2005 Jul-Aug;18(4):276... - 0 views

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    Vitamin D and the epidemiology of prostate cancer.
    Schwartz GG.
    Semin Dial. 2005 Jul-Aug;18(4):276-89. Review.
    PMID: 16076349
    DOI: 10.1111/j.1525-139X.2005.18403.x
Matti Narkia

Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. - Wi... - 0 views

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    Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk.
    Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H.
    Aliment Pharmacol Ther. 2009 Jul 1;30(2):113-25. Epub 2009 Apr 15.
    PMID: 19392870
    DOI: 10.1111/j.1365-2036.2009.04022.x

    Conclusions Our results support suggestions that serum 25(OH)D is inversely related to CRC risk.
Matti Narkia

An estimate of cancer mortality rate reductions in Europe and the US with 1,000 IU of o... - 0 views

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    An estimate of cancer mortality rate reductions in Europe and the US with 1,000 IU of oral vitamin D per day.
    Grant WB, Garland CF, Gorham ED.
    Recent Results Cancer Res. 2007;174:225-34. Review.
    PMID: 17302200
Matti Narkia

Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk -- Raimond... - 0 views

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    Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk.
    Raimondi S, Johansson H, Maisonneuve P, Gandini S.
    Carcinogenesis. 2009 Jul;30(7):1170-80. Epub 2009 Apr 29. Review.
    PMID: 19403841
Matti Narkia

Epidemiology of Vitamin D Insufficiency and Cancer Mortality - Anticancer Research - 0 views

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    Epidemiology of vitamin D insufficiency and cancer mortality.
    Pilz S, Tomaschitz A, Obermayer-Pietsch B, Dobnig H, Pieber TR.
    Anticancer Res. 2009 Sep;29(9):3699-704. Review.
    PMID: 19667167

    In conclusion, we still need further studies to evaluate the association of vitamin D insufficiency and cancer incidence and mortality, but the multiple health benefits of vitamin D and the easy, safe and inexpensive way by which vitamin D can be supplemented should already guide current public health strategies to achieve 25(OH)D levels of at least 75 nmol/l (30 ng/ml) in the general population.
Matti Narkia

Ecological Studies Of Ultraviolet B, Vitamin D And Cancer Since 2000 - 0 views

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    Ecological studies of ultraviolet B, vitamin D and cancer since 2000.
    Grant WB, Mohr SB.
    Ann Epidemiol. 2009 Jul;19(7):446-54. Epub 2009 Mar 9.
    PMID: 19269856

    CONCLUSION: These findings provide strong evidence that vitamin D status plays an important role in controlling the outcome of cancer. Support for the UVB-vitamin D-cancer theory is now scientifically strong enough to warrant use of vitamin D in cancer prevention, and as a component of treatment. More research studies would help to explore whether there are benefits beyond the substantial effects that have been observed.
Matti Narkia

Not enough vitamin D: Health consequences for Canadians -- Schwalfenberg 53 (5): 841 --... - 0 views

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    Not enough vitamin D: health consequences for Canadians.
    Schwalfenberg G.
    Can Fam Physician. 2007 May;53(5):841-54. Review
    PMID: 17872747

    Conclusion

    Low levels of VTD are considered a major public health problem in Canada, especially during the winter. Those with risk factors should be screened for low 25(OH)D levels and repletion therapy instituted if needed. Researchers have estimated that the oral dose of vitamin D3 to attain and maintain 25(OH)D levels >80 nmol/L is 2200 IU/d if baseline levels are 20 to 40 nmol/L, 1800 IU/d if levels are 40 to 60 nmol/L, and 1160 IU/d if levels are between 60 and 80 nmol/L.64

    We need to ensure that patients have healthy blood levels of 25(OH)D to prevent levels of parathyroid hormone from rising and to maximize absorption of calcium, magnesium, and phosphate. Positive effects on bone are marginal at best unless patients consume at least 800 IU/d of VTD. The emerging and exciting role of the VTD receptor and the actions of VTD in maintaining health in other cell types have become more apparent during the last decade.
Matti Narkia

Vitamin D and Cancer Mini-Symposium: The Risk of Additional Vitamin D - 0 views

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    Evidence from clinical trials shows, with a wide margin of confidence, that a prolonged intake of 10,000IU/d of vitamin D3 poses no risk of adverse effects for adults, even if this is added to a rather high physiologic background level of vitamin D.

    Vitamin D and cancer mini-symposium: the risk of additional vitamin D.
    Vieth R.\nAnn Epidemiol. 2009 Jul;19(7):441-5. Epub 2009 Apr 11.
    PMID: 19364661
    doi:10.1016/j.annepidem.2009.01.009
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