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Matti Narkia

Sloan-Kettering - Coriolus Versicolor - 1 views

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    Coriolus versicolor is a mushroom of the Basidiomycetes class. It was used initially in Traditional Chinese medicine as a tonic, but recent studies suggest that it has immunostimulant and anti-tumor properties. Polysaccharide-K (PSK), a proprietary product derived from Coriolus, was developed for cancer treatment in Japan. When used as an adjuvant, PSK appears to improve survival rates in patients with gastric (1) (2) and colorectal (3) (4) (5) cancers. Other Coriolus extracts, such as polysaccharide-peptide (PSP) and VPS, are available as dietary supplements. When used in conjunction with chemotherapy, PSP may benefit patients with advanced non-small cell lung cancer (7). Other clinical studies using Coriolus extract alone or in combination with other botanicals also suggest positive immunomodulatory effects (8) (9). However, studies on breast cancer (10), hepatocellular carcinoma (11), and leukemia (12) produced mixed results. A hot water extract of Coriolus, VPS, was found to enhance development of large intestinal tumors in mice (21). Coriolus extracts are generally well tolerated but minor adverse effects have been reported.

    Many over-the-counter Coriolus products are not standardized, making it difficult to compare potency between brands. It is also unclear if PSK, PSP and other Coriolus extracts have comparable effects.
Matti Narkia

White Button Mushroom (Agaricus Bisporus) Exhibits Antiproliferative and Proapoptotic P... - 0 views

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    White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth in athymic mice.
    Adams LS, Phung S, Wu X, Ki L, Chen S.
    Nutr Cancer. 2008;60(6):744-56.
    PMID: 19005974
    DOI: 10.1080/01635580802192866
Matti Narkia

Definition of white button mushroom extract - National Cancer Institute Drug Dictionary - 0 views

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    A heat-stable extract of white button mushrooms (Agaricus bisporus) with potential chemopreventive and immunomodulating activities. Phytochemicals, such as polysaccharides and especially beta-D-glucans found in the white button mushroom extract, bind to and inhibit the activity of aromatase, an enzyme responsible for the conversion of androgens to estrogens and which is often upregulated in breast cancer cells. The consequent decrease in estrogen production may result in the suppression of estrogen-dependent cellular proliferation. In addition, this extract may promote dendritic cell (DC) maturation, increase interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production, and may enhance natural killer (NK) cell activity, thus amplifying both innate and T cell-mediated immune responses against cancer cells. Check for active clinical trials or closed clinical trials using this agent.
Matti Narkia

White button mushrooms appear to boost immune function - Tufts Journal: Briefs: Healthy... - 0 views

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    White button mushrooms appear to boost immune function

    It appears that a little fungus may be good for what ails you. That's the conclusion of a new study that found that eating white button mushrooms may boost the immune system and protect against infection.

    If the research, done on animals, translates to people, it could raise the health-benefit profile of the fungus, which also contains high concentrations of the super-antioxidant ergothioneine, which protects cells from damaging free radicals.

    "This is the first published study showing the effect of white button mushrooms on immune function," Dayong Wu, a scientist in the Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts and lead author of the study, published in the June issue of the Journal of Nutrition, told NutraIngredients.com.

    The research also suggests that the mushroom may boost both innate and acquired immune system health. The innate immune system, the one you're born with, is the body's first line of defense. The acquired immune system revs up if a pathogen makes its way past the innate system and customizes the immune response to target the invader.
Matti Narkia

Eating mushrooms may boost immune system (ASU Research) - 0 views

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    Edible mushrooms are a versatile functional food and have been touted as a way to preserve youth, longevity and overall health for centuries. Now nutrition researchers from Arizona State University and Pennsylvania State University are finding that they may even help boost the immune system and reduce inflammation, especially in the colon.

    Keith R. Martin, ASU assistant professor in nutrition, along with his Penn State colleagues, experimented with various types of mushrooms, from the more common white button to the exotic like shiitake and oyster, to see what sort of effect they had on the immune system. Their paper was published in late February in BMC Immunology, a peer reviewed online journal.

    "We found that the white button mushroom seemed to be the most effective in boosting the immune system, which is good because they are the most affordable," said Martin.
Matti Narkia

Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell... - 0 views

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    Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer.
    Tsang KW, Lam CL, Yan C, Mak JC, Ooi GC, Ho JC, Lam B, Man R, Sham JS, Lam WK.
    Respir Med. 2003 Jun;97(6):618-24.
    PMID: 12814145
    doi:10.1053/rmed.2003.1490
Matti Narkia

Coriolus versicolor and cancer (June 2003) - 0 views

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    Attached please find the final draft of Dr. Kenyon's non-controlled observational study on the use of Coriolus versicolor (non-extracted) in 30 solid tumour cancer patients. The final report will be published in the February edition of Mycology News 7.
    The patients were Stage III and Stage IV patients in which chemotherapy and radiotherapy were not considered successful. Below please find a synopsis of patient type.
Matti Narkia

CIMER - Coriolus versicolor - M. D. Anderson Cancer Center - 0 views

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    Mushrooms have traditionally been valued in Asia for their nutritional and medicinal qualities. The Coriolus versicolor or "Turkey Tail" mushroom has been investigated in numerous laboratory, animal and human clinical studies. Most of these studies have demonstrated that it does appear to have significant antimicrobial, antiviral and antitumor properties when used as a supplement to chemotherapy and/or radiotherapy. Human trials have included randomization, a process that decreases bias, but only one has used blinding, which would make them even more protected against biases.
Matti Narkia

Sloan-Kettering - Astragalus - 0 views

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    Astragalus root is used in traditional medicine for its immunestimulating properties. Chinese studies suggest that astragalus, when used with angelica, has renal protective effects (6). In addition, astragalus decreases the proteinuria associated with idiopathic membranous nephropathy (7) as well as possesses natriuretic action (8). Astragalus may also suppress airway hyperreactivity associated with allergic asthma in vivo (9). An herbal formula using astragalus as a major ingredient has been shown to reduce fatigue in athletes (10). Furthermore, astragalus increases M-cholinergic receptor density in senile rats (11), which suggests that it may have a role in combating senility.
Matti Narkia

Sloan-Kettering - Maitake - 0 views

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    Derived from the cap and stem of the mushroom. The active constituent is thought to be a beta-glucan polysaccharide. The whole mushroom is used primarily as a dietary element, but extracts and supplements are sold as immune stimulants for patients with HIV or cancer. While no adverse effects have been reported, some studies reveal a hypoglycemic effect following administration of maitake extract (9) (12). Maitake was shown to enhance bone marrow colony formation, reduce doxorubicin toxicity in vitro (11), and to inhibit tumor metastasis
Matti Narkia

Sloan-Kettering - Shiitake Mushroom - 0 views

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    Shiitake mushroom, native to East Asia, is cultivated worldwide for its purported health benefits. The fresh and dried forms of the mushroom are commonly used in East Asian cooking. It is also valued as an anticancer agent.
    Lentinan (1,3 Beta-D-glucan), a polysaccharide isolated from Shiitake, has been well studied and is thought responsible for its beneficial effects.
    It was shown to have anticancer effects in colon cancer cells (1), which may be due to its ability to suppress cytochrome P450 1A enzymes that are known to metabolize pro-carcinogens to active forms
Matti Narkia

PSK - Coriolus versicolor and Cancer - 0 views

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    In 1994, I was introduced to PSK, and all-natural, high-quality extract product from the mushroom Coriolus versicolor. A neighbor introduced me to a local mycologist who enthusiastically told me about this remarkable product being used in Japan for the treatment of cancer.
Matti Narkia

In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membr... - 0 views

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    In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus.
    Cho WC, Leung KN.
    J Ethnopharmacol. 2007 Aug 15;113(1):132-41. Epub 2007 May 31.
    PMID: 17611061
    doi:10.1016/j.jep.2007.05.020    
Matti Narkia

PSK: A Non-Toxic Polysaccharide Drug - 0 views

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    If you're from Japan, you're probably wondering why I've listed PSK under alternative therapies. In Japan, PSK is an approved anti-cancer drug with 20 years of research behind it. PSK sales in Japan account for hundreds of millions dollars worth of sales each year. But in the US, PSK is little known, is not used by mainstream doctors, and until recently nothing like it was readily available. Now a nutritional supplement designed to be identical to PSK is available in the US, but very few mainstream doctors, and actually not many alternative practitioners are aware of it. So in the US, PSK has the status of a little known nutritional supplement or alternative therapy. Which is too bad in light of its proven benefits, easy administration, and lack of toxicity. Before I start sounding too much more like an advertisement, let me confess. I really am excited about it, but I have no financial interest in it; I'm not selling it.
Matti Narkia

[Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of ... - 0 views

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    [Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor]
    Duan P, Wang ZM.
    Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Jul;22(7):515-7. Chinese.
    PMID: 12592686
Matti Narkia

Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and thei... - 0 views

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    Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients.
    Wei H, Sun R, Xiao W, Feng J, Zhen C, Xu X, Tian Z.
    Oncol Rep. 2003 Sep-Oct;10(5):1507-12.
    PMID: 12883732
Matti Narkia

In vitro and in vivo anti-tumor effects of Astragalus membranaceus - Cancer Lett. 2007 ... - 0 views

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    In vitro and in vivo anti-tumor effects of Astragalus membranaceus.
    Cho WC, Leung KN.
    Cancer Lett. 2007 Jul 8;252(1):43-54. Epub 2007 Jan 16.
    PMID: 17223259
    doi:10.1016/j.canlet.2006.12.001
Matti Narkia

Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells - ... - 0 views

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    Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells.
    Rhode J, Fogoros S, Zick S, Wahl H, Griffith KA, Huang J, Liu JR.
    BMC Complement Altern Med. 2007 Dec 20;7:44.
    PMID: 18096028
    doi:10.1186/1472-6882-7-44
Matti Narkia

Summary Of Research On And Clinical Application Of Silymarin - 0 views

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    "The clinical potential for a liver-protective supplement in cancer care is significant, as I've observed in many years of integrative medical practice," writes Dr. Keith Block, ICT editor. "Several chemotherapy drugs, as well as many of the other drugs cancer patients take, have extremely problematic liver toxicities. With this exclusive edition, the scientific community will have a resource to guide and inspire further research on this very interesting herbal medicine."
Matti Narkia

The blueberry drink that can shrink tumours | Mail Online - 0 views

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    Blueberry Punch is an Australian product but is available for sale on the internet at £16 a bottle.\n\nIt also includes a host of other natural ingredients thought to boost health, including green tea, olive leaves, the herb tarragon and the spices turmeric and ginger.\n\nIt is thought the ingredients act together to cut inflammation and block a cancer gene.\n\nDr Jas Singh, who conducted the research on mice at Sydney University, said: "We have undertaken efficacy studies on individual components of Blueberry Punch in the same laboratory setting and found these effective in suppressing cell growth in culture.\n\n"We reasoned that synergistic or additive effects are likely to be achieved when they are combined."\n\nThe researchers looked at the effect of Blueberry Punch on both cancer cell cultures in the laboratory and genetically engineered mice with human prostate tumours. After only two weeks of having the syrupy solution added to their drinking water, their tumours had shrunk by
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