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Matti Narkia

Anticancer Properties of Ganoderma Lucidum Methanol Extracts In Vitro and In Vivo - Nut... - 0 views

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    Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo.
    Harhaji Trajković LM, Mijatović SA, Maksimović-Ivanić DD, Stojanović ID, Momcilović MB, Tufegdzić SJ, Maksimović VM, Marjanović ZS, Stosić-Grujicić SD.
    Nutr Cancer. 2009;61(5):696-707.
    PMID: 19838944
    DOI: 10.1080/01635580902898743

    Anticancer activities of various extracts of the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with the presence of different bioactive polysaccharides and triterpenoids. We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in vitro, whereby GLme exhibited stronger effect. Furthermore, anticancer activity of GLme was demonstrated for the first time against two other rodent tumor cell lines, L929-mouse fibrosarcoma and C6-rat astrocytoma. The mechanism of antitumor activity of GLme comprised inhibition of cell proliferation and induction of caspase-dependent apoptotic cell death mediated by upregulated p53 and inhibited Bcl-2 expression. Moreover, the antitumor effect of the GLme was associated with intensified production of reactive oxygen species, whereas their neutralization by the antioxidant, N-acetyl cysteine, resulted in partial recovery of cell viability. Thus, our results suggest that GLme might be a good candidate for treatment of diverse forms of cancers.
Matti Narkia

Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficie... - 0 views

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    Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth.
    Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB.
    Cancer Res. 2007 Jul 15;67(14):6745-52.
    PMID: 17638885
    doi: 10.1158/0008-5472.CAN-06-4447
Matti Narkia

Flax In Diet Means Fewer Tumors - 0 views

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    "Results indicated that mice on diets supplemented with flaxseed meal and flaxseed oil had, on average, 45 percent fewer tumors in the small intestine and the colon compared to the control group."

    The scientists published their research findings in February in the academic peer-reviewed international journal Nutrition and Cancer.
Matti Narkia

Cancer Journal: Latest cancer research Bio-engineered proteins: trial confirms new way ... - 0 views

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    Re-engineering a protein that helps prevent tumours spreading and growing has created a potentially powerful therapy for people with many different types of cancer. In a study published in the first issue of EMBO Molecular Medicine, Canadian researchers modified the tumour inhibiting protein, von Hippel-Lindau (VHL), and demonstrated that it could suppress tumour growth in mice.
Matti Narkia

Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2... - 0 views

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    Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.
    Blázquez C, Salazar M, Carracedo A, Lorente M, Egia A, González-Feria L, Haro A, Velasco G, Guzmán M.
    Cancer Res. 2008 Mar 15;68(6):1945-52.
    PMID: 18339876
    doi: 10.1158/0008-5472.CAN-07-5176
Matti Narkia

Cannabis compound slows lung cancer in mice - health - 18 April 2007 - New Scientist - 0 views

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    The active compound in marijuana, THC, can slow the growth of lung tumours and reduce the spread of the cancer in mice, a preliminary study reveals.

    Human lung cancer tumours grew less than half as fast in mice that received moderate doses of the compound, the researchers reveal. They hope that drugs mimicking the apparent anti-cancer effects of tetrahydrocanabinol (THC) could one day help treat patients. The team strongly discourage people from self-medicating by smoking marijuana, noting that doing so could potentially encourage tumour growth.
Matti Narkia

Access : Tumours with PI3K activation are resistant to dietary restriction : Nature - 0 views

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    Tumours with PI3K activation are resistant to dietary restriction.
    Nada Y. Kalaany & David M. Sabatini
    Nature. Published online 11 March 2009
    doi:10.1038/nature07782
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