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Matti Narkia

Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tu... - 0 views

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    Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer.
    Lönnroth C, Andersson M, Arvidsson A, Nordgren S, Brevinge H, Lagerstedt K, Lundholm K.
    Cancer Immun. 2008 Feb 29;8:5.
    PMID: 18307280

    MHC II protein (HLA-DP, -DQ, -DR) levels and infiltration by CD4+ T-helper cells of tumor stroma increased upon NSAID treatment, while CD8+ cytotoxic T-lymphocytes increased in both tumor stroma and epithelium. Molecules associated with immunosuppressive T regulatory cells (FOXP3, IL-10) were significantly decreased in indomethacin-exposed tumors. Standard oral administration of NSAID three days preoperatively was enough to increase tumor infiltration by seemingly activated immune cells. These findings agree with previous information that high pr
Matti Narkia

Multiple roles for CD4+ T cells in anti-tumor immune responses. - Wiley InterScience ::... - 0 views

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    Multiple roles for CD4+ T cells in anti-tumor immune responses.
    Kennedy R, Celis E.
    Immunol Rev. 2008 Apr;222:129-44. Review.
    PMID: 18363998
    DOI: 10.1111/j.1600-065X.2008.00616.x
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