Researchers investigating the role of cannabis in cancer therapy reveal it has the potential to destroy leukaemia cells, in a paper published in the March 2006 edition of Letters in Drug Design & Discovery. Led by Dr Wai Man Liu, at Barts and the London, Queen Mary's School of Medicine and Dentistry, the team has followed up on their findings of 2005 which showed that the main active ingredient in cannabis, tetrahydrocannabinol, or THC, has the potential to be used effectively against some forms of cancer. Dr Liu has since moved to the Institute of Cancer in Sutton where he continues his work into investigating the potential therapeutic benefit of new anti-cancer agents.
"Compounds similar to those found in cannabis have been shown to stop prostate cancer cells from multiplying. Two cannabinoid compounds, JWH-015 and MET, stopped prostate tumour growth in human prostate cells in Petri dishes and also in mice with the disease. They halted the cell-division cycle and killed the cancer cells, and had the greatest effect on aggressive prostate cancer cell types, which do not respond to hormone treatments.
Some 192,000 men in the US alone are diagnosed with prostate cancer each year, and researchers Inés Díaz-Laviada Marturet at the University of Alcalá, Spain, and her colleagues say the results could offer hope to those affected. But before you go looking for a dealer, New Scientist answers a few questions"
The active compound in marijuana, THC, can slow the growth of lung tumours and reduce the spread of the cancer in mice, a preliminary study reveals.
Human lung cancer tumours grew less than half as fast in mice that received moderate doses of the compound, the researchers reveal. They hope that drugs mimicking the apparent anti-cancer effects of tetrahydrocanabinol (THC) could one day help treat patients. The team strongly discourage people from self-medicating by smoking marijuana, noting that doing so could potentially encourage tumour growth.
Cannabinoids and cancer: causation, remediation, and palliation.
Hall W, Christie M, Currow D.
Lancet Oncol. 2005 Jan;6(1):35-42. Review.
PMID: 15629274
doi:10.1016/S1470-2045(04)01711-5
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.
Blázquez C, Salazar M, Carracedo A, Lorente M, Egia A, González-Feria L, Haro A, Velasco G, Guzmán M.
Cancer Res. 2008 Mar 15;68(6):1945-52.
PMID: 18339876
doi: 10.1158/0008-5472.CAN-07-5176
Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents.
Pisanti S, Malfitano AM, Grimaldi C, Santoro A, Gazzerro P, Laezza C, Bifulco M.
Best Pract Res Clin Endocrinol Metab. 2009 Feb;23(1):117-31.
PMID: 19285265
doi:10.1016/j.beem.2009.02.001
By Randy Dotinga
HealthDay Reporter
MONDAY, Jan. 11 (HealthDay News) -- Preliminary research suggests that a combination of compounds in marijuana could help fight off a particularly deadly form of brain cancer.
But the findings shouldn't send patients rushing to buy pot: the levels used in the research appear to be too high to obtain through smoking. And there's no sign yet that the approach works in laboratory animals, let alone people.
proven to kill cancer tumors in mice in 1 hit, They have said 18 months in the daily mail to start clinical trials, Why then fecikn wait that long!Its a bloody flower!! The government have no intention on curing cancer and never will have! ''conspiracy'' how much money would they lose if the cured it! billions, greedy wankers... why give people hope just another load of bollocks.. Just like that guy on the run who proved that cannabis cures cancer in oil form, why's he on the run? from curing people of cancer,......... after watching my dad the last 6 months suffer going through endless chemo sessions i get so angry when i see stuff like this say 18 months before clinical trials start and 7-8 years b4 it comes out!! although it has proven results! 100's of thousands of terminal cancer patients will be dead before they pull there greedy fat cat fingers out there arses, sorry rant over just makes me so angry! my dad and my best friend both suffering and they say 7-8 years b4 it will even be realised with a proven record of killing 90% of most tumors !
ScienceDaily (June 15, 2009) - Using a highly sensitive new test, scientists in Europe are reporting "convincing evidence" that marijuana smoke damages the genetic material DNA in ways that could increase the risk of cancer.
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
Casanova ML, Blázquez C, Martínez-Palacio J, Villanueva C, Fernández-Aceñero MJ, Huffman JW, Jorcano JL, Guzmán M.
J Clin Invest. 2003 Jan;111(1):43-50.
PMID: 12511587
doi:10.1172/JCI16116
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