Skip to main content

Home/ Cancer/ Group items tagged 2009 scchn September

Rss Feed Group items tagged

Matti Narkia

Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xeno... - 0 views

  •  
    Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model.
    Ho YT, Yang JS, Lu CC, Chiang JH, Li TC, Lin JJ, Lai KC, Liao CL, Lin JG, Chung JG.
    Phytomedicine. 2009 Sep;16(9):887-90. Epub 2009 Mar 20.
    PMID: 19303753

    Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10mg/kg of body weight) and doxorubicin (4mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4mg/kg of doxorubicin or with 10mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic.
Matti Narkia

Dietary vitamin D and cancers of the oral cavity and esophagus -- Lipworth et al. 20 (9... - 0 views

  •  
    Dietary vitamin D and cancers of the oral cavity and esophagus.
    Lipworth L, Rossi M, McLaughlin JK, Negri E, Talamini R, Levi F, Franceschi S, La Vecchia C.
    Ann Oncol. 2009 Sep;20(9):1576-81. Epub 2009 Jun 1.
    PMID: 19487490

    Conclusion: We observed inverse associations between dietary vitamin D intake and risk of SCCE and, perhaps, oral/pharyngeal cancer, which were most pronounced among heavy current smokers and heavy consumers of alcohol.
1 - 2 of 2
Showing 20 items per page