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Matti Narkia

Targeted Breast Cancer Drug Shrinks Tumors - Medscape - 2 views

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    "December 17, 2009 (San Antonio) - A new targeted cancer drug has been shown to shrink tumors in women with metastatic breast cancer after an average of seven other drugs, including Herceptin, failed.

    The new drug, called T-DM1, combines Herceptin with a potent chemotherapy drug. It's a Trojan horse approach, where Herceptin homes in on cancer cells and delivers the cancer-killing agent directly to its target.

    Tumors shrank in one-third of women with metastatic breast cancer given T-DM1, says Ian Krop, MD, of the Dana-Farber Cancer Institute in Boston. In another 12%, tumors stopped growing for at least six months.

    The women remained cancer-free for an average of seven months -- results unheard of in patients this sick, he says.

    All the women, who had breast tumors for an average of three years, had cancer that had metastasized, or spread to other parts of the body. They had been treated with an average of seven different therapies, including Herceptin, Tykerb, and Xeloda, and each had failed."
Matti Narkia

Alcohol may raise chances of breast cancer return | Reuters - 0 views

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    "CHICAGO (Reuters) - Post-menopausal women who have three to four alcoholic beverages a week of any sort have a significantly higher risk that their breast cancer will come back, U.S. researchers said Thursday."
Matti Narkia

JAMA -- Soy Food Intake and Breast Cancer Survival, December 9, 2009, Shu et al. 302 (2... - 0 views

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    Soy Food Intake and Breast Cancer Survival.
    Xiao Ou Shu et al.
    JAMA Vol. 302 No. 22, December 9, 2009; 302(22):2437-2443.

    Results During the median follow-up of 3.9 years (range, 0.5-6.2 years), 444 deaths and 534 recurrences or breast cancer-related deaths were documented in 5033 surgically treated breast cancer patients. Soy food intake, as measured by either soy protein or soy isoflavone intake, was inversely associated with mortality and recurrence. The hazard ratio associated with the highest quartile of soy protein intake was 0.71 (95% confidence interval [CI], 0.54-0.92) for total mortality and 0.68 (95% CI, 0.54-0.87) for recurrence compared with the lowest quartile of intake. The multivariate-adjusted 4-year mortality rates were 10.3% and 7.4%, and the 4-year recurrence rates were 11.2% and 8.0%, respectively, for women in the lowest and highest quartiles of soy protein intake. The inverse association was evident among women with either estrogen receptor-positive or -negative breast cancer and was present in both users and nonusers of tamoxifen.

    Conclusion Among women with breast cancer, soy food consumption was significantly associated with decreased risk of death and recurrence.
Matti Narkia

Vitamin D for cancer prevention: global perspective. Garland CF et al. -Ann Epidemiol. ... - 0 views

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    Vitamin D for cancer prevention: global perspective.
    Garland CF, Gorham ED, Mohr SB, Garland FC.
    Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
    PMID: 19523595
Matti Narkia

Vitamin D levels associated with survival in lymphoma patients - 0 views

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    ScienceDaily (Dec. 5, 2009) - A new study has found that the amount of vitamin D in patients being treated for diffuse large B-cell lymphoma was strongly associated with cancer progression and overall survival. The results will be presented at the annual meeting of the American Society of Hematology in New Orleans.

    Also, several recent reports have concluded that vitamin D deficiency is associated with poor outcomes in other cancers, including breast, colon and head and neck cancer. This is the first study to look at lymphoma outcome.
Matti Narkia

A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in brea... - 0 views

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    A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in breast cancer patients with bone metastases.
    Amir E, Simmons CE, Freedman OC, Dranitsaris G, Cole DE, Vieth R, Ooi WS, Clemons M.
    Cancer. 2009 Nov 13. [Epub ahead of print]
    PMID: 19918922
    DOI: 10.1002/cncr.24749

    METHODS:
    Patients with bone metastases treated with bisphosphonates were enrolled into this single-arm phase 2 study. Patients received 10,000 IU of vitamin D3 and 1000 mg of calcium supplementation each day for 4 months. The effect of this treatment on palliation, bone resorption markers, calcium metabolism, and toxicity were evaluated at baseline and monthly thereafter.


    CONCLUSIONS:
    Daily doses of 10,000 IU vitamin D3 for 4 months appear safe in patients without comorbid conditions causing hypersensitivity to vitamin D. Treatment reduced inappropriately elevated parathyroid hormone levels, presumably caused by long-term bisphosphonate use. There did not appear to be a significant palliative benefit nor any significant change in bone resorption. Cancer 2010. © 2009 American Cancer Society.
Matti Narkia

Meta-analysis of vitamin D, calcium and the prevention of breast cancer. - [Breast Canc... - 0 views

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    Meta-analysis of vitamin D, calcium and the prevention of breast cancer.
    Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H.
    Breast Cancer Res Treat. 2009 Oct 23. [Epub ahead of print]
    PMID: 19851861

    These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.
Matti Narkia

Women With Breast Cancer Have Low Vitamin D Levels - 0 views

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    "ScienceDaily (Oct. 8, 2009) - Women with breast cancer should be given high doses of vitamin D because a majority of them are likely to have low levels of vitamin D, which could contribute to decreased bone mass and greater risk of fractures, according to scientists at the University of Rochester Medical Center."

    Scientists funded by the NCI analyzed vitamin D levels in each woman, and the average level was 27 nanograms per milliliter; more than two-thirds of the women had vitamin deficiency. Weekly supplementation with high doses of vitamin D -- 50,000 international units or more -- improved the levels, according to Peppone's study.

    The U.S. Institute of Medicine suggests that blood levels nearing 32 nanograms per milliliter are adequate.
Matti Narkia

Experimental Drug May Work In Many Cancers - 2 views

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    "SCIENTISTS have shown that a new class of cancer drugs called PARP inhibitors, currently being tested in clinical trials to treat breast and ovarian cancer could have dramatic results when used to treat other solid tumours, according to work presented at the NCRI Cancer Conference today. "
Matti Narkia

Vitamin D for Cancer Prevention: Global Perspective - 1 views

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    Vitamin D for cancer prevention: global perspective.
    Garland CF, Gorham ED, Mohr SB, Garland FC.
    Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
    PMID: 19523595

    RESULTS/CONCLUSIONS: It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such intakes also are expected to reduce case-fatality rates of patients who have breast, colorectal, or prostate cancer by half. There are no unreasonable risks from intake of 2000 IU per day of vitamin D(3), or from a population serum 25(OH)D level of 40 to 60 ng/mL. The time has arrived for nationally coordinated action to substantially increase intake of vitamin D and calcium.
Matti Narkia

Christiane Northrup, MD: Protect Your Breasts With Vitamin D - 0 views

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    "A study conducted by Cedric Garland and other prominent vitamin D researchers determined that women with vitamin D levels above 52 ng/ml have half the risk of developing breast cancer as those with 13 ng/ml! Garland (et al) estimates that 58,000 new cases of breast cancer in the U.S. could be prevented per year by raising vitamin D levels to 52 ng/ml. Imagine what the global impact could be! "
Matti Narkia

Incident Invasive Breast Cancer, Geographic Location of Residence, and Reported Average... - 0 views

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    ncident invasive breast cancer, geographic location of residence, and reported average time spent outside.
    Millen AE, Pettinger M, Freudenheim JL, Langer RD, Rosenberg CA,
    Mossavar-Rahmani Y, Duffy CM, Lane DS, McTiernan A, Kuller LH, Lopez AM, Wactawski-Wende J.
    Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):495-507. Epub 2009 Feb 3.
    PMID: 19190147
    doi: 10.1158/1055-9965.EPI-08-0652

    In conclusion, region of residence and geographic solar irradiance are not consistently related to risk of breast cancer and may not be sufficient proxy measures for sunlight/vitamin D exposure. The observed association between time spent outside and breast cancer risk support the hypothesis that vitamin D may protect against breast cancer.
Matti Narkia

The Relevance of Vitamin D Receptor (VDR) Gene Polymorphisms for Cancer: A Review of th... - 0 views

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    The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature.
    Köstner K, Denzer N, Müller CS, Klein R, Tilgen W, Reichrath J.
    Anticancer Res. 2009 Sep;29(9):3511-36. Review.
    PMID: 19667145

    CONCLUSION: Significant associations with VDR polymorphisms have been reported in cancer of the breast (Fok1, Bsm1, Taq1, Apa1, poly (A)), prostate (Fok1, Bsm1, Taq1, poly (A)), skin (Fok1, Bsm1, A-1210), colorectum (Fok1, Bsm1), ovary (Fok1, Apa1) and bladder (Fok1), and in renal cell carcinoma (Taq1, Apa1). However, conflicting data have been reported for most malignancies. After careful evaluation of the actual literature, it can be summarized that data indicating an association of VDR polymorphisms and cancer risk are strongest for breast cancer (Bsm1, Fok1), prostate cancer (Fok1) and malignant melanoma (MM) (Fok1). Data indicating an association of VDR polymorphisms and cancer prognosis are strongest for prostate cancer (Fok1), breast cancer (Bsm1, Taq1), MM (Bsm1) and renal cell carcinoma (Taq1).
Matti Narkia

Review Article: Vitamin D Acquisition and Breast Cancer Risk -- Pérez-López e... - 0 views

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    Review article: vitamin D acquisition and breast cancer risk.
    Pérez-López FR, Chedraui P, Haya J.
    Reprod Sci. 2009 Jan;16(1):7-19. Review.
    PMID: 19144887
    DOI: 10.1177/1933719108327595

    Conclusions: Although there are controversial results, it seems plausible that sufficient endogenous vitamin D levels may have a protective function on mammary cells, reducing breast cancer risk.
Matti Narkia

Association between Plasma 25-Hydroxyvitamin D and Breast Cancer Risk -- Crew et al. 2 ... - 0 views

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    Association between plasma 25-hydroxyvitamin D and breast cancer risk.
    Crew KD, Gammon MD, Steck SE, Hershman DL, Cremers S, Dworakowski E, Shane E, Terry MB, Desai M, Teitelbaum SL, Neugut AI, Santella RM.
    Cancer Prev Res (Phila Pa). 2009 Jun;2(6):598-604. Epub 2009 May 26.
    PMID: 19470790

    In summary, these results add to a growing body of evidence that adequate vitamin D stores may prevent breast cancer development. Whereas circulating 25-OHD levels of >32 ng/mL are associated with normal bone mineral metabolism, our data suggest that the optimal level for breast cancer prevention is ≥40 ng/mL. Well-designed clinical trials are urgently needed to determine whether vitamin D supplementation is effective for breast cancer chemoprevention.
Matti Narkia

Prognostic Effects of 25-Hydroxyvitamin D Levels in Early Breast Cancer -- Goodwin et a... - 0 views

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    Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer.
    Goodwin PJ, Ennis M, Pritchard KI, Koo J, Hood N.
    J Clin Oncol. 2009 Aug 10;27(23):3757-63. Epub 2009 May 18.
    PMID: 19451439
    DOI: 10.1200/JCO.2008.20.0725

    Conclusion Vitamin D deficiency may be associated with poor outcomes in breast cancer.
Matti Narkia

Ecological Studies Of Ultraviolet B, Vitamin D And Cancer Since 2000 - 0 views

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    Ecological studies of ultraviolet B, vitamin D and cancer since 2000.
    Grant WB, Mohr SB.
    Ann Epidemiol. 2009 Jul;19(7):446-54. Epub 2009 Mar 9.
    PMID: 19269856

    CONCLUSION: These findings provide strong evidence that vitamin D status plays an important role in controlling the outcome of cancer. Support for the UVB-vitamin D-cancer theory is now scientifically strong enough to warrant use of vitamin D in cancer prevention, and as a component of treatment. More research studies would help to explore whether there are benefits beyond the substantial effects that have been observed.
Matti Narkia

High Prevalence of Vitamin D Deficiency Despite Supplementation in Premenopausal Women ... - 0 views

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    High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy.
    Crew KD, Shane E, Cremers S, McMahon DJ, Irani D, Hershman DL.
    J Clin Oncol. 2009 May 1;27(13):2151-6. Epub 2009 Apr 6.
    PMID: 19349547
    DOI: 10.1200/JCO.2008.19.6162

    Conclusion Vitamin D deficiency is highly prevalent in women with breast cancer. The current recommended dietary allowance of vitamin D is too low to increase serum 25-OHD greater than 30 ng/mL. Optimal dosing for bone health and, possibly, improved survival has yet to be determined.
Matti Narkia

Novel therapy for cancer? from medicineworld.org - 0 views

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    A ground-breaking Canada-wide clinical trial led by Dr. Katherine Borden, at the Institute for Research in Immunology and Cancer (IRIC) of the Universit de Montral, has shown that a common anti-viral drug, ribavirin, can be beneficial in the treatment of cancer patients. Published in the journal Blood (First Edition), the study demonstrates that ribavirin suppresses the activities of the eIF4E gene in patients. This gene is dysregulated in 30 percent of cancers including breast, prostate, head and neck, colon and stomach cancer.
Matti Narkia

Ecological Studies Of Ultraviolet B, Vitamin D And Cancer Since 2000. - ScienceDirect -... - 0 views

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    Ecological Studies Of Ultraviolet B, Vitamin D And Cancer Since 2000.
    Grant WB, Mohr SB.
    Ann Epidemiol. 2009 Mar 6. [Epub ahead of print]
    PMID: 19269856
    doi:10.1016/j.annepidem.2008.12.014
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