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The Institute opened its research facility in 1999. It was the first independent institution in the United States to respond to a call from the National Institute of Medicine to establish ten centers to study aging. The majority of the Institute’s funding now comes from federal grants, foundations, and donations.

Beryl Buck was trained as a nurse. Prior to her death in 1975, she asked that the Buck estate be used, in part, “to extend help toward the problems of the aged.”

In March 1966, NASA told Congress the "run-out cost" of the Apollo program to put men on the moon would be an estimated $22.718 Billion for the 13-year program which eventually accomplished six successful missions between July 1969 and December 1972. According to Steve Garber, the NASA History website curator, the final cost of project Apollo was between $20 and $25.4 billion in 1969 dollars (or approximately $135 billion in 2005 dollars). The costs associated with the Apollo spacecraft and Saturn rockets amounted to about $83 billion [Apollo spacecraft: $28 billion (Command/Service Module: $17 billion; Lunar Module: $11-billion), Saturn I, Saturn IB, Saturn V launch vehicles: about $46 billion] in 2005 dollars.